Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 25-10-2022 Tweet |
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College de France au College de France - Amphitheatre Bude 11 place Marcelin Berthelot - 75005 Paris |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 25-10-2022 Tweet |
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College de France au College de France - Amphitheatre Bude 11 place Marcelin Berthelot - 75005 Paris |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 21-09-2022 Tweet |
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College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Plus d'infos... Annonce publiée le 25-01-2023 Tweet |
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NeuroPSI |
Invite par: Fondation FondaMental Plus d'infos... Tags: Neurosciences, Innovation Annonce publiée le 29-01-2023 Tweet |
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IMRB online |
Daniel Holoch carried out his doctoral studies in the lab of Danesh Moazed at Harvard University, where he studied how small RNAs are loaded onto Argonaute in Schizosaccharomyces pombe and discovered that conserved GW-repeat-containing interactors of Argonaute proteins act as critical sensors of small-RNA loading status (Holoch and Moazed, Nat. Struct. Mol. Biol., 2015). He then joined Raphaël Margueron’s lab at the Institut Curie in 2016 for his postdoc to examine the role of histone modifications in the epigenetic memory of transcription states in mammals. It is sometimes taken for granted that histone modifications are faithfully copied during genome replication, and that this is important for the memory of active and inactive transcription states at individual genes. Using histone H3 lysine 27 trimethylation (H3K27me3) by Polycomb Repressive Complex 2 (PRC2) as a model, he found that this histone modification indeed enables a local, cis-acting memory of transcription states, but not through the classical copy-and-paste mechanism previously envisioned by the field. Indeed, existing H3K27me3 does not appear to be generally necessary for guiding new PRC2 activity. Instead, epigenetic memory requires conditions in which PRC2 and activating transcription factors are in a balanced competition for access to a gene, allowing transient signals to trigger lasting switches between two self-stabilizing transcription states. Genome-wide analyses, locus-directed manipulations and computational modeling they have conducted all support these conclusions (Holoch*, Wassef* et al., Nat. Genet., 2021). His ongoing investigations aim to understand why pluripotent stem cells appear to lack this form of PRC2-dependent epigenetic memory, as well as the degree to which long-lasting memory of transient transcription events extends beyond genes controlled by PRC2. Daniel Holoch is invited by Djihad Hadjadj. Plus d'infos... Tags: Branches of biology, Genetics, Biology, Epigenetics, Proteins, Protein families, Posttranslational modification, H3K27me3, PRC2, Polycomb-group proteins, Histone, XIST Annonce publiée le 12-01-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Invite par: Pierre-Jean Corringer Speaker: Vladan Lu?i? (Max Planck Institute of Biochemistry, Germany) Title: Architecture of synaptic protein assemblies by cryo-electron tomography Abstract Synaptic transmission, as well as many other cellular processes, is characterized by complex signaling pathways ... Plus d'infos... Tags: Education in Munich, Max Planck Society, Max Planck Institute of Biochemistry, Draft:Stefan Raunser, Herbert Zimmermann Annonce publiée le 28-01-2023 Tweet |
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Institut Pasteur Salle: Amphitheater Duclaux |
Plus d'infos... Tags: Chemistry, Ego, Comite Creek, Propargite Annonce publiée le 08-12-2022 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Genetic and environmental factors increase autism spectrum disorder (ASD) incidence and this has led to the generation of corresponding animal models, with some showing strong construct and face validity. In this line, we have recently published a series of several studies on ASD environmental and genetic animal models. We focused on motor and gait disorders which are currently not included in the diagnosis criteria, but which may provide new insights to ASD pathophysiology potentially leading to innovative therapies for a disease that currently has none. In all these models, we reported behavioral, cellular and molecular alterations related to the cerebellum. Motor and gait deficits were observed to various degrees in animal models and when strongly present they were correlated to the severity of social deficits as well as to the number of cerebellar Purkinje cells. Additionally, we also reported that, like in humans, males are more severely affected than females in these ASD models. These findings, along with an increasing body of literature, open new hopes in the ASD field pointing to brain regions, such the cerebellum, that are at the crossroads between cognitive, social and motor deficits. Targeting these brain regions and their underlying pathways and synaptic connections may prove of significant benefits. Plus d'infos... Tags: Psychiatry, Autism, Abnormal psychology, Psychiatric diagnosis, Neuroscience, Pervasive developmental disorders, Neurological disorders, RTT, Purkinje cell, Cerebellum, Heritability of autism, Causes of autism Annonce publiée le 29-01-2023 Tweet |
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Saints Peres Neuroscience salle de conferences R229, Campus Saint Germain des Pres de l'Universite de Paris Cite, 45 rue des Saints Peres 75006 |
Invite par: Mikael Laredo Lorsque la pharmacotherapie echoue, l'ablation des veines pulmonaires reste une option pour traiter la fibrillation auriculaire symptomatique. Neanmoins, malgre cette intervention, 4 patients sur 10 ne seront pas gueris de leur arythmie. Une reconnexion electrique des veines pulmonaires est consideree comme etant la cause principale de cet echec. Cependant, il y a potentiellement dautres facteurs impliques. Ce seminaire sera une discussion autour de la physiopathologie de la veine pulmonaire et du role joue par l'etirement et les cicatrices rigides qui apparaissent a l'endroit des lesions d'ablation. Plus d'infos... Tags: Cardiac disease, Atrial fibrillation Annonce publiée le 29-01-2023 Tweet |
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UMRS 1166 - IHU ICAN salle 514 au 5eme etage de la Faculte de Medecine, 105 avenue de l'Hopital 75013 et en visio |
Plus d'infos... Annonce publiée le 09-01-2023 Tweet |
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Ecole Polytechnique Batiment 84 (Conference room) |
Integrating information over long-time scales is a critical component of most circuit computations in the brain across species. However, it remains poorly understood how such dynamics are implemented mechanistically. One idea is that slow time constants are implemented via recurrent connectivity of balanced excitation and inhibition. Dissecting such neural circuits requires precise knowledge of functional neural properties and correlating dynamics with the underlying wiring diagram, ideally, within the same individual animal (neurotransmitter identity, anatomy, and connectivity).
To address this issue, we have developed a visual motion integration task in larval zebrafish and tools to combine functional calcium imaging with ultrastructural circuit reconstruction. We have recently complemented this approach involving an existing whole-brain connectomics resource as well as targeted fluorescent labeling of functionally identified neuronal response types. Our results will allow us to rapidly validate and constrain existing network models, and add resolution and confidence to previously proposed circuit arrangements at a reduced cost. Tags: Neuroscience, Computational neuroscience, Anatomy, Connectomics, Brain, Neural circuit, Biology Annonce publiée le 18-01-2023 Tweet |
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Ecole Polytechnique Amphitheatre Becquerel |
Invite par: Gabrielle Girardeau Plus d'infos... Tags: Nijmegen, Radbod, Radboud University Nijmegen, Education in the Netherlands, Remieg Aerts Annonce publiée le 04-12-2022 Tweet |
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Insitut du Fer à Moulin 17 Rue du Fer a Moulin - 75005 Paris |
Invités par Jean-Christophe Deschemin Plus d'infos... Annonce publiée le 12-01-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Invite par: Sebastian Baumgarten Seminaire du Departement des Parasites et Insectes Vecteurs Mara Lawniczak Sanger Institute UK Anopheles genomics and the Malaria Cell Atlas? jeudi 16 fevrier 2023, 12h00 Salle Retrovirus - RDC Batiment Lwoff Contact : sebastien.baumgarten@pasteur.fr Plus d'infos... Tags: Infectious diseases, Medical specialties, Malaria, Anopheles, Vector Annonce publiée le 02-02-2023 Tweet |
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Institut Pasteur Batiment Lwoff, salle Retrovirus, |
Invite par: LEVRAUD Jean-Pierre Plus d'infos... Tags: Marie Franois Xavier Bichat, Vitalists, Sonneville Annonce publiée le 15-11-2022 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Invited by the Ladoux/Mege team, Prisca Liberali (Senior Group Leader, Friedrich Miescher Institute for Biomedical Research -FMI) will an IJM seminar entitled: Design principles of tissue organization SELF-ORGANISATION DURING COLLECTIVE BEHAVIOUR Robust experimental model systems have recently been developed from adult or induced pluripotent stem cells that self-organise into organoid structures in vitro. In particular, intestinal organoids recapitulate most of the spatial and temporal processes of morphogenesis and patterning observed in the intestinal tissue. Starting from a single cell, they provide a unique experimental system in which every cell is fully tractable. This system also allows systematic perturbation by established gene perturbation methods. Our laboratory aims to understand the collective properties of these multi-cellular systems and their patterns, including how such properties arise from single-cell behaviour and organisation. Moreover, we develop and apply experimental and theoretical frameworks for the study of cellular heterogeneity during collective cell behaviour. We use high-content genetic perturbation screens and live-cell imaging with single-cell resolution, combined with advanced quantitative imaging, single cell genomics, and modelling of stem cells. Plus d'infos... Tags: Branches of biology, Biology, Life sciences, Stem cells, Organoid Annonce publiée le 17-01-2023 Tweet |
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Institut Jacques Monod Usually at 11.45 am in the François Jacob room |
Invite par: SHULZ Daniel Plus d'infos... Tags: Muhsin, Names, Humans, Sans titre Annonce publiée le 22-11-2022 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Invite par: Timothy Wai seminaire 06 03 2023 Romain LEVAYER This event will not be streamed, attendance in person only. Plus d'infos... Tags: Epithelium Annonce publiée le 02-02-2023 Tweet |
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Institut Pasteur Batiment Francois Jacob, salle Auditorium Francois Jacob, |
Invite par: Guillaume Dumenil seminaire 13 03 2023 Gregory GIANNONE This event will not be streamed, attendance in person only. Plus d'infos... Tags: Proteins, Actin, Autoantigens, Cytoskeleton, Integrin Annonce publiée le 02-02-2023 Tweet |
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Institut Pasteur Batiment Francois Jacob, salle Auditorium Francois Jacob, |
Plus d'infos... Tags: Brain, Frontal lobe, Cerebral cortex, Prefrontal cortex, Prefrontal, Cortex, Brodmann area 10, Lateral prefrontal cortex Annonce publiée le 29-11-2022 Tweet |
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NeuroPSI 47, bd de l#039;hopital, Paris |
Invited by Molly Ingersoll and Emmanuel Donnadieu Plus d'infos... Tags: Max Planck Society Annonce publiée le 12-01-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Invited by Sandra Duharcourt, Peter Sarkies (Department of Biochemistry, University of Oxford) will give an IJM Seminar entitled: Using evolution to understand epigenetic mechanisms Epigenetics and Evolution Epigenetics allows different types of cells in the body to turn different sets of genes on or off without changing the underlying DNA sequence. epimutations could lead to differences between individuals and therefore drive evolutionary changes. & https://psarkies.wixsite.com/epievo Plus d'infos... Tags: Branches of biology, Epigenetics, Biology, Genetics, Pharmacoepigenetics, Transgenerational epigenetic inheritance Annonce publiée le 03-02-2023 Tweet |
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Institut Jacques Monod Usually at 11.45 am in the François Jacob room |
Invite par: PERRON Muriel Plus d'infos... Tags: UCL Institute of Ophthalmology Annonce publiée le 18-10-2022 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Invite par: Jean-Antoine Girault Plus d'infos... Annonce publiée le 14-01-2023 Tweet |
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Insitut du Fer à Moulin 17 Rue du Fer a Moulin - 75005 Paris |
Invited by Michaela Fontenay Plus d'infos... Tags: Sarry, Fontenay Annonce publiée le 12-01-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Invited by Sebastien Leon, Isabelle Sagot (Institut de Biochimie et Genetique Cellulaires #8211; IBGC, Bordeaux) will give an IJM Seminar entitled: The cell biology of quiescent yeast Cells perpetually face the decision to proliferate or to enter a non-dividing state. Quiescence, a state defined as a reversible arrest of proliferation, is the most common cellular situation found on earth, as it concerns all kind of cells, from microbes to human stem cells. Quiescent cells not only have to survive and face age but they must also preserve their ability to re-enter the cell cycle in a tightly regulated manner, and give rise to a healthy progeny. Therefore quiescence is at the heart of crucial biological issues including development, aging and evolution. Yet, astonishingly little is known about the molecular determinants that orchestrate quiescence establishment and exit. We are using both single cell eukaryotes and mammalian models to study the cell biology of quiescence. In the past years, we have shown that upon quiescence entry, cells assemble specific structures that display original properties, including actin and microtubule hyper-stable arrangements. Our project is to study these structures and use them as tools to address central questions such as: how do quiescent cells survive and what are the cascade of molecular switches that tightly control the transitions between quiescence and proliferation. Plus d'infos... Tags: Branches of biology, Cell biology, Cell cycle, Cellular senescence, Biology, Quiescence, Actin, G0 phase Annonce publiée le 03-02-2023 Tweet |
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Institut Jacques Monod Usually at 11.45 am in the François Jacob room |
Invite par: Marc Graille Tags: RNA, Protein biosynthesis, Gene expression, Messenger RNA, Spliceosome, Cell nucleus Annonce publiée le 01-02-2023 Tweet |
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Ecole Polytechnique Amphi Lagarrigue |
Invite par: Gabrielle Girardeau Plus d'infos... Tags: Songs, Pardi, Belen, Draft:Inah de belen Annonce publiée le 14-01-2023 Tweet |
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Insitut du Fer à Moulin 17 Rue du Fer a Moulin - 75005 Paris |
Invited by the Romet-Lemonne/Jegou Team, Gregory Giannone will give a seminar entitled : #8220;Deciphering the spatiotemporal and mechanical regulation of integrin and actin regulators at the nanoscale#8221; Giannone Lab: Cells have the ability to adjust their adhesive and cytoskeletal organizations according to changes in the biochemical and physical nature of their surroundings. In return, by adhering and generating forces on neighboring cells and extracellular matrices cells control their environment, shape and movement. This is true from integrin-based adhesive structures of migrating cells to synapses of neurons. Those adhesive structures are the converging zones integrating biochemical and biomechanical signals arising from the extracellular space and the actin cytoskeleton. Thus, the life-cycle of adhesive and cytoskeletal structures are involved in critical cellular functions such as migration, proliferation and differentiation, and regulate cell behavior in many physiological responses such as development. Alterations of adhesive and cytoskeletal organizations contribute to pathologies including cancer, but also cognitive disorders. At the molecular, sub-cellular, and cellular levels, cell shaping and motility proceed through cycles lasting from seconds to minutes. During those cycles, critical proteins undergo stochastic motions and transient interactions that are essential to their functions. Regulation of these interactions by forces is at the base of mechano-transduction events controlling cell behavior. Therefore, to understand the molecular mechanisms controlling the life cycle of motile structures, it is crucial to study the position and dynamics of proteins but also their interactions and how mechanical forces control these molecular events. Our goal is to decipher at the molecular level the spatiotemporal and mechanical mechanisms which control the architecture and dynamics of motile structures including integrin-based AS, the lamellipodium and dendritic spines. Exploration of these new dimensions requires an innovative and multidisciplinary approach combining cell biology, biophysics, biomechanics and advanced optical microscopy techniques including super-resolution microscopy, single protein tracking and quantitative image analysis. We are developing three specific axes: 1/ Integrin adhesion 2/ Actin in dendritic spines 3/ Super-resolution developments Plus d'infos... Tags: Proteins, Branches of biology, Cell biology, Actin, Autoantigens, Cytoskeleton, Integrin, Dendritic spine, Talin, Focal adhesion Annonce publiée le 05-01-2023 Tweet |
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Institut Jacques Monod Usually at 11.45 am in the François Jacob room |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 16-01-2023 Tweet |
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College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Invited by Antoine Zalc Plus d'infos... Tags: Education in Paris, Vincent Manceau, Collge de France, Association football Annonce publiée le 12-01-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Plus d'infos... Tags: Fellows of the Royal Society Annonce publiée le 11-09-2022 Tweet |
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Inst. Bio. Paris Seine 7-9 quai Saint Bernard, 75005 Paris |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 16-01-2023 Tweet |
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College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Invite par: Fiona Francis Plus d'infos... Tags: Senescence, Aging brain, Brain, Central nervous system Annonce publiée le 04-12-2022 Tweet |
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Insitut du Fer à Moulin 17 Rue du Fer a Moulin - 75005 Paris |
Invité par Raphael Scharfmann. Plus d'infos... Tags: Modernist architects, Sbastien Balibar Annonce publiée le 12-01-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Invité par Pascal Maire. Plus d'infos... Tags: Auvergne, Clermont-Ferrand, Massif Central, Ferrand, Clermont, Auvergne-Rhne-Alpes, Lyce Blaise Pascal, Geography of France, University of Clermont Auvergne Annonce publiée le 12-01-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 16-01-2023 Tweet |
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College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Les interférons de type I (IFN) activent les programmes antimicrobiens intracellulaires et influencent le développement des réponses immunitaires innées et adaptatives. Nous discuterons de nos résultats en abordant la biologie des IFN dans le syndrome de Down (DS). Ce syndrome est la conséquence d'une anomalie chromosomique appelée " trisomie 21 " dans laquelle le chromosome 21 est partiellement ou totalement triplé. Les sous-unités qui composent le récepteur de l'IFN-I (IFNAR1 et IFNAR2), comme d'autres gènes importants pour l'immunologie, sont codés sur ce chromosome et leur expression est fortement augmentée. Cela génère une importante dysrégulation immunologique. Nous discuterons des caractéristiques du compartiment des cellules T, de la fonctionnalité des Tregs, et de l'impact de la signalisation IFN sur les différents sous-ensembles de cellules T, qui pourraient expliquer les différentes susceptibilités de cette population à développer certaines pathologies telles que les tumeurs solides et l'auto-immunité. D'autre part, la signalisation compétente de l'IFN de type I est à la base de la plupart des mécanismes immunitaires anti-tumoraux et s'est récemment avérée essentielle à l'efficacité de plusieurs agents anticancéreux et de l'immunothérapie. Dans cet exposé, nous discuterons de nos récentes découvertes concernant le potentiel des agonistes TLR en tant qu'inducteurs de l'IFN de type I et, par conséquent, en tant que modulateurs puissants de la composition de l'infiltrat tumoral, capables de faire basculer l'environnement tumoral immunosuppressif vers une immunité anti-tumorale. Plus d'infos... Annonce publiée le 18-10-2022 Tweet |
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Institut Curie Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 16-01-2023 Tweet |
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College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |