Invite par: DENEUX Thomas Plus d'infos... Tags: Chinese art, Artists, Hong Kong, The Hong Kong Research Institute of Textiles and Apparel, Ho Sin Tung Annonce publiée le 22-03-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Invite par: DENEUX Thomas Plus d'infos... Tags: Chinese art, Artists, Hong Kong, The Hong Kong Research Institute of Textiles and Apparel, Ho Sin Tung Annonce publiée le 22-03-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Genome editing mediated by CRISPR-Cas has shown promise for the treatment of retinal dystrophies. Transient delivery of CRISPR-Cas9 to the retina could be an interesting alternative to viral vector for therapeutic applications but has yet shown only limited efficacy in the retinal pigment epithelium and not in the other retinal layers.
We investigated if CRISPR-Cas9 could be transiently delivered, with or without non-viral vectors, to the neural retina in vivo Plus d'infos... Tags: Genetic engineering, Genome editing, Biotechnology, Cas9, CRISPR, Retina Annonce publiée le 31-03-2023 Tweet |
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Institut de la Vision salle de conference de lUCL, 13 rue Moreau 75012 |
Invite par: Romain Duval Plus d'infos... Tags: Host-microbe interactionss Annonce publiée le 26-03-2023 Tweet |
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CITCOM Faculte de Pharmacie de Paris, salle Quinine, 4 avenue de lObservatoire 75006 |
Invite par: IBENS - Equipe Sonia GAREL Plus d'infos... Tags: Glial cells, Branches of biology, Microglia, Glia, Beth Stevens, Dorothy P. Schafer Annonce publiée le 29-03-2023 Tweet |
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IBENS salle Favard, IBENS 46 rue d'Ulm 75005 Paris |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 16-01-2023 Tweet |
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College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Invite par: Pierre-Antoine Defossez Plus d'infos... Tags: Chromosomes, Centromere, DNA replication Annonce publiée le 31-03-2023 Tweet |
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Epigenetique et Destin Cellulaire salle des seminaires de lIJM (RB-18B), 15 rue Helene Brion 75013 ou en visio |
Invite par: Mercredi de Bichat-Beaujon Plus d'infos... Tags: Ischemic stroke Annonce publiée le 31-03-2023 Tweet |
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Centre de Recherche sur l'Inflammation salle 241B, 16 rue Henri Huchard 75018 |
Invited by Antoine Zalc Plus d'infos... Tags: Education in Paris, Vincent Manceau, Collge de France, Association football Annonce publiée le 12-01-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Plus d'infos... Tags: Fellows of the Royal Society Annonce publiée le 11-09-2022 Tweet |
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Inst. Bio. Paris Seine 7-9 quai Saint Bernard, 75005 Paris |
Invited by Nicolas Minc, Matteo Rauzi (Universite Cote dAzur, CNRS, Inserm, iBV, Nice, France) will give an IJM Seminar entitled: Composite morphogenesis: how can a tissue fold and extend at the same time During embryo development, epithelia can undergo different shape transformations. While these changes can be sequential, and thus driven by specific sequential cellular mechanisms, this is not always the case. A single tissue can undergo multiple simultaneous shape transformations resulting in a composite process. For instance, in vertebrates, during neurulation, the dorsal tissue folds forming the neural tube while elongating along the anterior-posterior axis separating the future head from the anus (Keller, 2002). This raises an important question: how can a tissue undergo multiple simultaneous shape transformations if each transformation is per se driven by different and functionally specific cellular mechanisms? In addition, which signaling pathways are controlling composite morphogenetic processes? We use the protostome Drosophila& and the deuterostome sea urchin P. lividus& embryo as model systems and focus on the process of simultaneous tissue folding and extension resulting in the formation of an epithelial tube at the onset of gastrulation. By using advanced multi-view light sheet microscopy coupled to infrared femtosecond laser manipulation, optogenetics and quantitative big data analysis, we aim to shed new light on evolutionary conserved signaling pathways, mechanisms and mechanics controlling and driving composite morphogenesis. Plus d'infos... Tags: Branches of biology, Biology, Developmental biology, Morphology, Evolutionary developmental biology, Morphogenesis, Morphogen, Neurulation Annonce publiée le 30-03-2023 Tweet |
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Institut Jacques Monod Usually at 11.45 am in the François Jacob room |
Invite par: RENCONTRE NATIONALE D ENDOCRINOLOGIE COCHIN 9h-9h15 : Introduction - Jerome Bertherat __ 9h15-9h45 : Recepteurs des peptides hypothalamiques et obesite - Ralf Jockers (Institut Cochin) __ 9h45-10h15 : Regulation hypothalamique du comportement alimentaire - Christophe Magnan (Universite Paris Cite) __ 10h15-10h45 : Traitement pharmacologique des obesites genetiques - Christine Poitou- Bernert (Hopital Pitie-Salpetriere) __ 10h45-11h15 : PAUSE __ 11h15-11h45 : Modifications des peptides digestifs au cours de l obesite et de la chirurgie bariatrique Aspects physiopathologiques - Maude Le Gall (CRI, Paris) __ 11h45-12h15 : Modifications des peptides digestifs au cours de l obesite et la chirurgie bariatrique Implications cliniques - Severine Ledoux (Hopital Louis Mourier, Colombes) __ 12h15-14h00 : PAUSE DEJEUNER LIBRE __ 14h00-14h30 : Les traitements medicaux de l obesite : benefices contre risques - Sebastien Czernichow (Hopital HEGP) __ 14h30-15h00 : Analogues du GLP-1 dans les obesites hypothalamiques - Blandine Gatta-Cherifi (CHU de Bordeaux, Pessac) __ 15h00-15h30 : Diabete : remission et rechute apres chirurgie bariatrique - Claire Carette (Hopital HEGP) __ 15h30-16h00 : Pharmacogenetique de la reponse aux AGLP1 : le point de vue du pharmacologue Nicolas Pallet (Hopital HEGP) __ 16h00-16h30 : Les maladies rares eclairent les maladies frequentes : comment le GIP peut entrainer un Cushing ? - Lucas Bouys (Hopital Cochin) __ 16h30-17h00 : Conclusion Plus d'infos... Tags: Obesity, Hormone, Endocrinology Annonce publiée le 14-03-2023 Tweet |
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Institut Cochin amphitheatre du batiment Jean Dausset de l Hopital Cochin, 27 rue du Faubourg Saint-Jacques 75014 |
Invite par: BOUVIER Julien Plus d'infos... Tags: Branches of biology, Neuroscience, Memory, Neural circuits, Neurophysiology, Brain, Neuroplasticity, Neurotrauma, Plasticity Annonce publiée le 18-06-2022 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Invite par: Mario Pende Plus d'infos... Tags: Metabolism, Apoptosis, P53, Programmed cell death, Metabolic disorder Annonce publiée le 31-03-2023 Tweet |
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INEM INEM, amphitheatre de la Faculte Necker, 160 rue de Vaugirard 75015 |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 16-01-2023 Tweet |
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College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Invite par: Mercredi du CRI Plus d'infos... Tags: Artificial-intelligence, Cancer biomarker Annonce publiée le 31-03-2023 Tweet |
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Centre de Recherche sur l'Inflammation salle 241B, 16 rue Henri Huchard 75018 ou en visio |
Invite par: Fiona Francis Plus d'infos... Tags: Senescence, Aging brain, Brain, Central nervous system Annonce publiée le 04-12-2022 Tweet |
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Insitut du Fer à Moulin 17 Rue du Fer a Moulin - 75005 Paris |
Invite par: BOUVIER Julien Plus d'infos... Tags: Neurons, Interneuron Annonce publiée le 07-02-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Invite par: Neetu Gupta-Rossi seminaire 04_17_2023 Ulrike EGGERT This event will not be streamed, attendance in person only. Plus d'infos... Tags: Underwater diving physiology, Membrane biology, Cell biology, Lipids Annonce publiée le 21-02-2023 Tweet |
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Institut Pasteur Batiment: Metchinikoff Salle: Jules Bordet |
PAMELA SHAW BIOSKETCH CV MARCH 2023 Plus d'infos... Tags: Neurological disorders, Organ systems, Nervous system, Rare diseases, Senescence, Neurodegeneration, Neuroscience, Degenerative disease, Neuron, Amyotrophic lateral sclerosis, Motor neuron disease Annonce publiée le 07-03-2023 Tweet |
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Centre de Recherche en Myologie |
Invite par: TechSocialClub Plus d'infos... Annonce publiée le 01-04-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Plus d'infos... Annonce publiée le 15-03-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Invite par: GRANON Sylvie Plus d'infos... Tags: le-de-France, Departments of France, Pelloux, University of Paris-Saclay, Paris-Saclay, Saclay Annonce publiée le 10-03-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Invite par: Pierre-Regis Burgel - Veronique Witko-Sarsat Plus d'infos... Tags: Cystic fibrosis Annonce publiée le 03-03-2023 Tweet |
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Institut Cochin Hopital Cochin, amphitheatre Dausset, 27 rue du Fg St Jacques 75014 |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 08-03-2023 Tweet |
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College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Invited by the Young Scientist Club, Antoine Molaro (Universite de Clermont Auvergne, France) will give an IJM seminar on April 28 on the theme : Unusual Histones Mediate (epi)Genetic Conflicts during Reproduction Foreword I am broadly interested in understanding the function of the germline epigenome. In mammals, the germline epigenome is key to the inheritance of genetic and epigenetic information. It is also at the heart of intense evolutionary battles, known as genetic conflicts. These can arise between genetic elements within our genomes, whole chromosomes or between parents. In fact, these constant tugs of war shape fundamental aspect of reproduction and speciation and drive rapid evolutionary innovation. Thus, contrary to current paradigms that focus on evolutionary conservation, I study the rapid evolution of the epigenome to discover novel principles in reproduction and speciation. My research program interfaces epigenomics with evolutionary biology. Some prior research As a graduate student, I have uncovered some of the rules behind the co-evolution of the germline genome and epigenome in primates (Molaro, Hodgess adaptive evolution on the establishment of the germ cell epigenome in mice (Molaro& et al.,& 2014). During my postdoc, I have discovered adaptive evolution in germline DNA methyltransferases and in short H2A histone variants in mammals (Molaro& et al.,& 2018 and 2019). Using mouse models, I have uncovered that some short H2As have parental-effect functions that are crucial for embryogenesis (Molaro& et al.,& 2020). In collaboration with cancer biologists we have discovered that short H2As are ectopically expressed in many human cancer (Chew et al., 2021). Current research Currently, my team uses mouse models, mammalian cell culture and comparative epigenomics to answer some of the following questions: 1)& & & What are the functions of protein domains subject to diversification in chromatin modifying enzymes? 2)& & & Which evolutionary forces drive short histone H2A variants diversification in mammals? 3)& & & How do short H2As imprint parental epigenomes during mammalian reproduction? 4)& & & How does epigenome evolution shape normal development and disease progression in humans? Plus d'infos... Tags: Branches of biology, Genetics, Biology, Epigenetics, Proteins, Genomics, Extended evolutionary synthesis, Lamarckism, Histone H2A, Epigenome, Histone variants, Histone Annonce publiée le 30-03-2023 Tweet |
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Institut Jacques Monod Usually at 11.45 am in the François Jacob room |
Invite par: Mario Pende Plus d'infos... Tags: Stem cells, Biotechnology, Organoid, Induced stem cells Annonce publiée le 12-02-2023 Tweet |
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INEM Mercredi 3 mai a 12h, amphitheatre 2 au -1 de lINEM, 160 rue de Vaugirard 75015 |
Invité par Raphael Scharfmann. Plus d'infos... Tags: Modernist architects, Sbastien Balibar Annonce publiée le 12-01-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Invite par: Mario Pende Plus d'infos... Tags: Stem cells, Biotechnology, Organoid Annonce publiée le 12-02-2023 Tweet |
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INEM amphitheatre 2 au -1 de lINEM, 160 rue de Vaugirard 75015 |
Invité par Pascal Maire. Plus d'infos... Tags: Auvergne, Clermont-Ferrand, Massif Central, Ferrand, Clermont, Auvergne-Rhne-Alpes, Lyce Blaise Pascal, Geography of France, University of Clermont Auvergne Annonce publiée le 12-01-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Plus d'infos... Tags: Humancomputer interaction, Wearable devices, Distributed computing architecture, Clothing, Ambient intelligence, Fashion accessories, Internet of things, Wearable computer, Technology mining, Wearable technology Annonce publiée le 03-03-2023 Tweet |
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Centre de Recherche en Myologie |
Invite par: Societe des Neurosciences Plus d'infos... Tags: Paris Mtro line 11, Sports, World Athletics Championships, World Cup Annonce publiée le 23-03-2023 Tweet |
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NeuroPSI 50 Quai Charles de Gaulle, 69006 Lyon |
Invited by the team Grange/Geigl, Stephane Pereygne, will give a seminar on the theme : #8220;Reconstructing the evolutionary and population history of archaic and modern humans.#8221; Computational Ancient Genomics (Janet Kelso) The group develops and applies computational approaches for the analysis of ancient and modern human genomes. Ancient genomes In the last 10 years ongoing work in the Genetics department has made it possible to retrieve and sequence DNA from ancient biological samples dating to as much as 400,000 years old. We have sequenced whole and partial genomes of a number of Neandertals, as well as from early modern humans, and continue to work towards adding new archaic and early modern human genomes in order to improve our understanding of the relationships, population histories and interactions of early human groups. A number of challenges accompany the analysis of such ancient samples. Only very small amounts of endogenous DNA are typically present in such old materials, and the vast majority of the DNA obtained is from micro-organisms. In addition, the remaining DNA is usually degraded into very short, chemically damaged fragments. We therefore apply a combination of molecular and computational approaches to optimize the retrieval of DNA and to ensure that the sequences that are used in analysis are reliable. Efforts in the group focus on developing software and analysis methods for the analysis of ancient DNA sequences. These methods are constantly being updated and improved in order to improve our ability to work on even older and more poorly preserved specimens. We make all our software available under open source licenses. most recent publication Archaic Introgression One of the most striking findings of the Neandertal genome project was the discovery that Neandertals contributed approximately 2% of the genomes of present-day non-Africans, and that Denisovans contributed approximately 4-6% of the genomes of people who today live in Oceania. We have had a particular interest in understanding the timing and effects of interactions between Neandertals, Denisovans and early modern humans. Our most recent work has used a simple computational approach to identify haplotypes that are likely of archaic origin and to combine these with large public human genome, gene expression, and phenotype datasets to determine the likely functional consequences of these haplotypes. Our work has shown that Neandertal DNA influences a number of traits such as immunity and those influenced by sun-exposure. Software and Databases We develop software and databases for the analysis of ancient and modern genomes. A list of published software packages is available here:
https://bioinf.eva.mpg.de Plus d'infos... Tags: Branches of biology, Genetics, Genomics, Biology, Genetic mapping, Human evolution, Biotechnology, Altai Krai, Denisovan, Neanderthal, Human genome, Genome Annonce publiée le 30-03-2023 Tweet |
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Institut Jacques Monod Usually at 11.45 am in the François Jacob room |
Plus d'infos... Annonce publiée le 18-03-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Invite par: ROUYER Francois Plus d'infos... Annonce publiée le 21-03-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 16-01-2023 Tweet |
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College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Invite par: PERRON Muriel Plus d'infos... Annonce publiée le 21-03-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
More information on the Corces Lab Plus d'infos... Annonce publiée le 07-03-2023 Tweet |
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Centre de Recherche en Myologie |
Les interférons de type I (IFN) activent les programmes antimicrobiens intracellulaires et influencent le développement des réponses immunitaires innées et adaptatives. Nous discuterons de nos résultats en abordant la biologie des IFN dans le syndrome de Down (DS). Ce syndrome est la conséquence d'une anomalie chromosomique appelée " trisomie 21 " dans laquelle le chromosome 21 est partiellement ou totalement triplé. Les sous-unités qui composent le récepteur de l'IFN-I (IFNAR1 et IFNAR2), comme d'autres gènes importants pour l'immunologie, sont codés sur ce chromosome et leur expression est fortement augmentée. Cela génère une importante dysrégulation immunologique. Nous discuterons des caractéristiques du compartiment des cellules T, de la fonctionnalité des Tregs, et de l'impact de la signalisation IFN sur les différents sous-ensembles de cellules T, qui pourraient expliquer les différentes susceptibilités de cette population à développer certaines pathologies telles que les tumeurs solides et l'auto-immunité. D'autre part, la signalisation compétente de l'IFN de type I est à la base de la plupart des mécanismes immunitaires anti-tumoraux et s'est récemment avérée essentielle à l'efficacité de plusieurs agents anticancéreux et de l'immunothérapie. Dans cet exposé, nous discuterons de nos récentes découvertes concernant le potentiel des agonistes TLR en tant qu'inducteurs de l'IFN de type I et, par conséquent, en tant que modulateurs puissants de la composition de l'infiltrat tumoral, capables de faire basculer l'environnement tumoral immunosuppressif vers une immunité anti-tumorale. Plus d'infos... Annonce publiée le 18-10-2022 Tweet |
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Institut Curie Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e |
Invite par: SHULZ Daniel Plus d'infos... Annonce publiée le 21-03-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 16-01-2023 Tweet |
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College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Invite par: Jean-Louis Mergny Apart from the double-helix B-DNA structure discovered by Watson and Crick, approximately 13% of the human genome comprises sequence motifs that can form non-canonical, or non-B, DNA conformations. Recent in vivo experiments showed that non-B DNA forms in living cells and regulates key cellular processes (e.g., replication and transcription). This presentation will focus on our recent research related to non-B DNA. Based on the analysis of long-read sequencing data, we demonstrated decreased polymerization speed and increased polymerization errors at non-B DNA loci genome-wide. We next hypothesized that the same phenomena occur in human cells and lead to increased mutagenesis at non-B DNA loci. Indeed, analyzing human diversity and human-orangutan divergence data, we found that non-B DNA are indeed hotspots of mutagenesis and contribute substantially to local and global regional variation in mutation rates across the human genome. Furthermore, we discovered that G-quadruplex motifs, capable of forming one type of non- B DNA, evolve under purifying selection, are more stable, and are overrepresented when located in different important genic (e.g., promoters) and non-genic (e.g., enhancers and replication origins) regions. Thus, Gquadruplex structures forming in such regions are likely to be functional. In contrast, G-quadruplex motifs do not evolve under selection, are less stable, and are underrepresented when located in the non-transcribed strands of exons. Finally, we showed that caution should be exercised when studying non-B DNA motifs because they exhibit elevated rates of sequencing errors. Tags: Genomics, Molecular biology, DNA, Genetic mapping, Biotechnology, Human genome, G-quadruplex, Gene, Mutagenesis, Mutation Annonce publiée le 22-03-2023 Tweet |
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Ecole Polytechnique Conference room to be announced |
Invite par: BARNIER Jean-Vianney Plus d'infos... Annonce publiée le 14-12-2022 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Invited by Sandra Duharcourt, Peter Sarkies (Department of Biochemistry, University of Oxford) will give an IJM Seminar entitled: Using evolution to understand epigenetic mechanisms Epigenetics and Evolution Epigenetics allows different types of cells in the body to turn different sets of genes on or off without changing the underlying DNA sequence. epimutations could lead to differences between individuals and therefore drive evolutionary changes. & https://psarkies.wixsite.com/epievo Plus d'infos... Tags: Branches of biology, Epigenetics, Biology, Genetics, Pharmacoepigenetics, Transgenerational epigenetic inheritance Annonce publiée le 03-02-2023 Tweet |
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Institut Jacques Monod Usually at 11.45 am in the François Jacob room |