Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 16-01-2023 Tweet |
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College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 16-01-2023 Tweet |
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College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Mononuclear phagocytes (MNP) consist of Langerhans cells, macrophages and dendritic cells (DC). They can become infected by HIV and transport the virus to its primary target cells (CD4 T cells) in association with their antigen presenting cell function. We have revealed that the MNPs within anogenital tissues significantly differ to those in other parts of the body and we have defined three that preferentially transmit HIV; (i) epithelial cDC2, (ii) lamina propria langerin+ cDC2 and CD14+ monocyte derived DCs. We have also shown HIV causes MNP to form clusters with T cells within 2 hours of topical application and that the virus preferentially localises to DCs. Furthermore, DCs traffic HIV to lymphoid follicles which provide a conduit for the virus to enter the submucosa where it preferentially interacts with macrophages. These observations significantly advance our understanding of HIV transmission by (i) defining the specific MNPs that capture and transmit HIV (ii) demonstrating that transfer of HIV by MNPs to CD4 T cells occurs within mucosal tissue within 2 hours (rather than lymph nodes) and (iii) that HIV is actively trafficked between mucosal tissue compartments. This is essential information for vaccine design and adds important data regarding early seeding of the viral reservoir. Plus d'infos... Annonce publiée le 19-04-2023 Tweet |
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Institut Curie Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) |
Paul Gougis from the RT2 group will be conducting a presentation on the topic of chatGPT for scientific writing on Tuesday, June 6th at 14:00. During the presentation, he will address practical aspects of utilizing chatGPT for medical writing, as well as some broader considerations. The session will be conducted in English and will be recorded for future reference. Plus d'infos... Tags: Scientists, Physicists, Science and technology in France, Langevin family, Curie Institute, Hlne Langevin-Joliot, Eliane Montel Annonce publiée le 31-05-2023 Tweet |
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Institut Curie Centre de recherche - Paris - Webinar |
During vertebrate development, clustered Hox genes are activated in a precise time-sequence, leading to patterns necessary to properly establish the body plan. The mechanism underlying this in cis timing phenomenon (the Hox timer), which is implemented throughout the neck of the developmental hourglass, has remained elusive ever since its initial observation in 1989, due to the difficulty to approach it using early gastrulating mouse embryos. I will discuss our recent results using pseudo-embryos produced out of ES cells (‘gastruloids’) as an alternative approach to address this question and will show that the temporal dynamic of the system may rely upon the use of series of CTCF sites as successive boundary elements, the directionality of the mechanism being fixed by the asymmetric loading of cohesin complexes. While this mechanism can secure the deployment of Hox gene transcription and hence the proper establishment of axial structures within any given vertebrate species, it also offers some evolutionary flexibility, for minimal modifications in the number, position or affinity of these sites would translate into heterochronic transcription. Plus d'infos... Tags: Denis Duboule, Hox gene, Biology, HOX, cole Polytechnique Fdrale de Lausanne Annonce publiée le 22-05-2023 Tweet |
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Institut Curie Centre de recherche - Paris - Amphitheatre IPGG - 6 rue Jean Calvin, Paris 5e |
Le domaine de l'imagerie médicale a connu un essor important au cours des 20 dernières années, avec la démocratisation de l'IRM multiparamétrique tant en préclinique qu'en clinique. Ces évolutions technologiques en matière d'acquisition se sont accompagnées du développement de nouvelles méthodes d'analyse permettant d'extraire des informations quantitatives de ces images. Des approches de radiomique et d'apprentissage profond ont notamment été développées. Au final, de nombreuses études ont montré des corrélations entre certaines métriques et un diagnostic ou une évolution pathologique. Ces métriques sont communément appelées biomarqueurs d'imagerie. Cliquez ici pour rejoindre le séminaire Plus d'infos... Annonce publiée le 26-05-2023 Tweet |
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Institut Curie Centre de recherche - Orsay - Webinar |
Plus d'infos... Annonce publiée le 20-05-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Invite par: PERRON Muriel Plus d'infos... Annonce publiée le 21-03-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
On Friday, June 9, 2023, the Monod-Diderot conferences will welcome in the Buffon amphitheatre, Denis Duboule (College de France Paris and Ecole Polytechnique Federale de Lausanne (EPFL) Lausanne) who will speak on the topic : Understanding the Hox timer using pseudo-embryos Denis Duboule is professor of genetics and genomics at the University of Geneva and at the EPFL. He is also a professor at the College de France since 2017, holding the international chair Evolution of genomics and development. His research is in the field of mammalian developmental genetics and genomics, interfacing with human genetics and evolutionary sciences. His laboratory seeks to understand how genes control how our bodies are made, including the function and regulation of Hox genes (architect genes) during vertebrate animal development. Plus d'infos... Tags: Denis Duboule, Evolutionary developmental biology, Biology, Hox gene, cole Polytechnique Fdrale de Lausanne Annonce publiée le 12-04-2023 Tweet |
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Institut Jacques Monod Usually at 11.45 am in the Buffon amphitheater |
https://www.ualberta.ca/cellbiology/people/faculty/edan-foley.html Plus d'infos... Tags: Medical specialties, Infectious diseases, Bacteria, Vibrionales, Gram-negative bacteria, Waterborne diseases, Cholera, Vibrio cholerae, Vibrio, Zebrafish, G. Balakrish Nair, Karla Satchell Annonce publiée le 26-05-2023 Tweet |
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Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie |
More information on the Corces Lab Plus d'infos... Annonce publiée le 07-03-2023 Tweet |
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Centre de Recherche en Myologie |
The range of vaccines developed against SARS-CoV-2 gave a unique opportunity to study immunization across different platforms. In a single-center cohort with more than 400 volunteers, we analysed the humoral and cellular immune compartments following five COVID-19 vaccines spanning three technologies (adenoviral, mRNA, and inactivated-virus) administered in 16 combinations. Quantification of specific IgG and IgA anti-spike together with the evaluation of the neutralizing activity of the sera, measurement of spike-specific IFNϒ production, and single cell proteomic analysis of spike-binding memory B cells allowed us to determine four clearly distinct immune signatures elicited by the different vaccine combinations. Our data indicate that the immune response is shaped by the type of vaccines applied and by the order in which they are delivered. Our data provide a framework for improving future vaccines strategies against pathogens and cancer. Plus d'infos... Tags: Medical specialties, Medicine, Immunology, Vaccination, Vaccine, Virology, Vaccines, Tumor antigen vaccine, Adjuvant Annonce publiée le 17-05-2023 Tweet |
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Institut Curie Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e |
Les interférons de type I (IFN) activent les programmes antimicrobiens intracellulaires et influencent le développement des réponses immunitaires innées et adaptatives. Nous discuterons de nos résultats en abordant la biologie des IFN dans le syndrome de Down (DS). Ce syndrome est la conséquence d'une anomalie chromosomique appelée " trisomie 21 " dans laquelle le chromosome 21 est partiellement ou totalement triplé. Les sous-unités qui composent le récepteur de l'IFN-I (IFNAR1 et IFNAR2), comme d'autres gènes importants pour l'immunologie, sont codés sur ce chromosome et leur expression est fortement augmentée. Cela génère une importante dysrégulation immunologique. Nous discuterons des caractéristiques du compartiment des cellules T, de la fonctionnalité des Tregs, et de l'impact de la signalisation IFN sur les différents sous-ensembles de cellules T, qui pourraient expliquer les différentes susceptibilités de cette population à développer certaines pathologies telles que les tumeurs solides et l'auto-immunité. D'autre part, la signalisation compétente de l'IFN de type I est à la base de la plupart des mécanismes immunitaires anti-tumoraux et s'est récemment avérée essentielle à l'efficacité de plusieurs agents anticancéreux et de l'immunothérapie. Dans cet exposé, nous discuterons de nos récentes découvertes concernant le potentiel des agonistes TLR en tant qu'inducteurs de l'IFN de type I et, par conséquent, en tant que modulateurs puissants de la composition de l'infiltrat tumoral, capables de faire basculer l'environnement tumoral immunosuppressif vers une immunité anti-tumorale. Plus d'infos... Annonce publiée le 18-10-2022 Tweet |
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Institut Curie Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 03-04-2023 Tweet |
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College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Invited by Sylvaine You. Plus d'infos... Tags: Medical specialties, Animal anatomy, Immune system, Organ systems, Lymph fluid, Lymphatic system, Lymphatic tissue, Lymphocyte Annonce publiée le 15-05-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Invite par: Rogerio Amino Professor Rita TEWARI School of Life Sciences - University of Nottingham Nottingham UK Divide and Rule : Unique biology of cell division in Plasmodium jeudi 15 juin 2023, 12h00 Salle Retrovirus - RDC ... Plus d'infos... Tags: Malaria, Plasmodium, Rita Tewari, Parasitism, Infectious diseases, Medical specialties, Branches of biology Annonce publiée le 03-06-2023 Tweet |
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Institut Pasteur Batiment Lwoff, salle Retrovirus, |
Invited by Nicolas Minc, Rut Carballido-Lopez will present an IJM seminar on the theme: Actin-like MreB proteins: from single molecules to cell morphogenesis Abstract: How cells control their shape is a long-standing question in cell biology. In bacteria, the external peptidoglycan cell wall -one of the most prominent targets for antibiotics- is the primary determinant of cell shape. Many rod-shaped bacteria elongate their sidewalls by the action of cell wall synthesizing machineries that are associated to circumferentially-moving nanofilaments of MreB, the structural homolog of eukaryotic actin. The prevailing model is that actin-like MreB assemblies are used as platforms that restrict the diffusion and orient the motion of peptidoglycan-synthesizing enzymes in the membrane, thereby patterning new cell wall insertion and controlling cylindrical expansion. We use cutting-edge fluorescence microscopy techniques combined with automated single particle and single molecule tracking to monitor the dynamics of MreB isoforms, as a proxy for cell wall synthesis, in live cells of the model Gram-positive bacterium Bacillus subtilis. We also use super-resolution techniques to elucidate the nanostructure and orientation of MreB cortical assemblies in the cell. In parallel, we are using biochemical and single filament imaging approaches to investigate the polymerization properties of recombinant MreB of B. subtilis in vitro, to fill in the gap between structure and cellular function. Based on our results, we have recently proposed a model for the mechanism of MreB polymerization, which displays some actin-like and some unexpected actin-unlike properties. Plus d'infos... Tags: Branches of biology, Proteins, Cytoskeleton, Cell biology, MreB, Actin, Cell wall, Cell, Prokaryotic cytoskeleton Annonce publiée le 10-05-2023 Tweet |
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Institut Jacques Monod Usually at 11.45 am in the François Jacob room |
Invite par: SHULZ Daniel Plus d'infos... Annonce publiée le 21-03-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Plus d'infos... Tags: Branches of biology, Academic disciplines, Neuroscience, Developmental neuroscience, Artificial intelligence, Computational neuroscience, Emerging technologies, Stem cells, Neuroethics, Artificial brain Annonce publiée le 06-04-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Dr. Artyomov will present his work in immune aging where his laboratory using characterized immune aging in mouse tissues identifying GZMK+ CD8 T cells as uniform hallmark of aging. In parallel effort profiling of human circulating immune cells revealed existence of dedicated GZMK+ CD8 effector memory T cells in the peripheral blood that accumulate with age. We will discuss their transcriptional regulation and potential biological implications. Plus d'infos... Tags: Medical specialties, Immunology, Medicine, Robert D. Schreiber, Aubrey de Grey Annonce publiée le 22-05-2023 Tweet |
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Institut Curie Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e |
University of Sao Paulo, Brazil Plus d'infos... Tags: Malaria, Plasmodium, Plasmodium tomodoni, Plasmodium vacuolatum Annonce publiée le 31-05-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 16-01-2023 Tweet |
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College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Invite par: Odile Launay et Florence Niedergang Plus d'infos... Tags: Vaccine Annonce publiée le 14-05-2023 Tweet |
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Institut Cochin salle Rosalind Franklin, etage 2, 22 rue Mechain 75014 |
Invite par: Jean-Louis Mergny Apart from the double-helix B-DNA structure discovered by Watson and Crick, approximately 13% of the human genome comprises sequence motifs that can form non-canonical, or non-B, DNA conformations. Recent in vivo experiments showed that non-B DNA forms in living cells and regulates key cellular processes (e.g., replication and transcription). This presentation will focus on our recent research related to non-B DNA. Based on the analysis of long-read sequencing data, we demonstrated decreased polymerization speed and increased polymerization errors at non-B DNA loci genome-wide. We next hypothesized that the same phenomena occur in human cells and lead to increased mutagenesis at non-B DNA loci. Indeed, analyzing human diversity and human-orangutan divergence data, we found that non-B DNA are indeed hotspots of mutagenesis and contribute substantially to local and global regional variation in mutation rates across the human genome. Furthermore, we discovered that G-quadruplex motifs, capable of forming one type of non- B DNA, evolve under purifying selection, are more stable, and are overrepresented when located in different important genic (e.g., promoters) and non-genic (e.g., enhancers and replication origins) regions. Thus, Gquadruplex structures forming in such regions are likely to be functional. In contrast, G-quadruplex motifs do not evolve under selection, are less stable, and are underrepresented when located in the non-transcribed strands of exons. Finally, we showed that caution should be exercised when studying non-B DNA motifs because they exhibit elevated rates of sequencing errors. Tags: Genomics, Molecular biology, DNA, Genetic mapping, Biotechnology, Human genome, G-quadruplex, Gene, Mutagenesis, Mutation Annonce publiée le 22-03-2023 Tweet |
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Ecole Polytechnique Conference room to be announced |
Invited by Florence Margottin-Goguet. Plus d'infos... Annonce publiée le 15-05-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Soon to be completed... Plus d'infos... Tags: Amino acids, Enzymes, Branches of biology, Tryptophan, Ferroptosis Annonce publiée le 05-06-2023 Tweet |
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Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie |
Invite par: PERRON Muriel Plus d'infos... Tags: Branches of biology, Glial cells, Biology, Cells, Mller glia, Glia, Retina, Mller, Stem cells, Developmental neuroscience Annonce publiée le 18-04-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
https://www.bdr.riken.jp/en/research/labs/obata-f/index.html
Plus d'infos... Tags: Branches of biology, Bacteriology, Microbiology, Organisms, Bacteria, Environmental microbiology, Drosophila, Microbiota, Human gastrointestinal microbiota, Riken, Drosophila quinaria species group, Microbiome in the Drosophila gut Annonce publiée le 26-05-2023 Tweet |
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Institut Curie Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) |
A role of a new RAD51/DMC1 remodeler in mammalian recombination Plus d'infos... Tags: Branches of biology, Biology, DNA repair, DMC1, RAD51, Cellular processes, Genetic recombination, Genetics, Telomeres, Recombinase, Molecular cytogenetics Annonce publiée le 02-06-2023 Tweet |
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Institut Curie Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e |
TBA Plus d'infos... Tags: Pierobon, Hpital Cochin, Cochin Annonce publiée le 15-05-2023 Tweet |
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Laboratoire Jean Perrin salle de seminaires 5eme etage - LJP - Tour 32-33 |
Invite par: Gabrielle Girardeau Plus d'infos... Annonce publiée le 15-05-2023 Tweet |
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Insitut du Fer à Moulin 17 Rue du Fer a Moulin - 75005 Paris |
Plus d'infos... Annonce publiée le 15-05-2023 Tweet |
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Inst. Bio. Paris Seine 7-9 quai Saint Bernard, 75005 Paris |
Evénement organisée par Dr Etienne Brain et Dr Elisabeth Lucchi, avec le soutien de la Direction de l’Enseignement, ce séminaire aura lieu le 30 juin 2023, à partir de 09h00, en format présentiel, au sein de l’Institut Curie, site de Saint-Cloud (Salle Bourdin, 35 rue Dailly, 92210) Plus d'infos... Annonce publiée le 01-06-2023 Tweet |
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Institut Curie Hopital site de Saint-Cloud - Salle Jacques-Sylvain Bourdin - 3e etage |
Invite par: BARNIER Jean-Vianney Plus d'infos... Annonce publiée le 14-12-2022 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
to be completed soon Plus d'infos... Tags: Cancer immunotherapy, Medical specialties, National Cancer Institute, Health Annonce publiée le 19-04-2023 Tweet |
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Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie |
Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the development of innate and adaptive immune responses. We will discuss our results by addressing the biology of IFN in Down syndrome (DS). This syndrome is the consequence of a chromosomal anomaly known as "trisomy 21" in which chromosome 21 is partially or totally tripled. The subunits that make up the IFN-I receptor (IFNAR1 and IFNAR2), like other genes of immunological relevance, are encoded on this chromosome and their expression is severely increased. This generates an important immunological dysregulation. We will discuss the features of the T cell compartment, Tregs functionality, and the impact of IFN signalling on the different T cell subsets, that could explain the different susceptibilities of this population to develop some pathologies such as solid tumors and autoimmunity. On the other hand, competent type I IFN signalling underlies most anti-tumor immune mechanisms and has recently proven critical to the efficacy of several anticancer agents and immunotherapy. In this talk, we will discuss our recent findings regarding the potential of TLR agonists as type I-IFN inducers and consequently, as strong modulators of the tumor infiltrate composition, capable of switching the immune suppressive tumor environment to anti-tumor immunity. Plus d'infos... Tags: Branches of biology, Genetics, Chromosomal abnormalities, Cytogenetics, Antivirals, Cytokines, Trisomy, Interferon, Aneuploidy, Down syndrome, Interferon-alpha/beta receptor Annonce publiée le 05-06-2023 Tweet |
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Institut Curie Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e |
Dr. Cheryl Lyn Walker directs the Center for Precision Environmental Health at Baylor College of Medicine, where she holds the Alkek Presidential Chair in Environmental Health. Her research focuses on the epigenetic machinery responsible for “reading, writing and erasing” histone modifications, and the newly discovered role for this machinery outside the nucleus, where it acts directly on the cytoskeleton to regulate the function of microtubules and actin filaments. Several histone methyltransferases, including SETD2 and NSD3 add methyl marks to key lysine residues of microtubules on the mitotic spindle and neuronal cytoskeleton. Chromatin remodeling proteins that recognize histone PTMs also “read” these methyl marks on microtubules, including PBRM1 of the pBAF SWI/SNF complex. In the case of methyl marks on the mitotic spindle, both the SETD2 “writer” and the PBRM1 “reader” are required for genomic stability. In addition to studying how defects in this machinery drive cancer via perturbation of both chromatin and cytoskeletal functions, her group is also elucidating cell signaling pathways and post-translational modifications that alter the activity of these dual-function chromatin and cytoskeleton remodelers. Dr. Walker is the recipient of an R35 Outstanding Investigator Award from the NCI and is a member of the National Academy of Medicine. Plus d'infos... Tags: Branches of biology, Epigenetics, Biology, Chromatin, Methylation Annonce publiée le 05-06-2023 Tweet |
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Institut Curie Centre de recherche - Orsay - Amphitheatre du Batiment 111 |
Séminaire proposé par Pierre LEOPOLD Animals from cockroaches to baboons in the wild instinctively mix a healthy, balanced diet. Why can’t we? In this lecture I describe my 35-year research journey with colleague David Raubenheimer to discover the answers to this question. Our scientific detective story involves (among other things) a mediaeval woodland in Oxford, biblical African swarms, cannibal Mormons crickets, a new explanation for the human obesity epidemic, the gift of a Picasso painting, and the establishment of a cathedral to multidisciplinary research in Australia. We show that mixing a nutritionally balanced diet relies on a small number of nutrient-specific appetites, which are universal across the animal kingdom. We discover that we too have these appetites, but they have been hijacked in the modern industrialized food environment, causing the epidemics of obesity and the serious diseases that come with it. We need to listen to our appetites and to place them in a whole-food environment where they can guide us towards a healthy balanced diet - without the need for apps or diet fads. Plus d'infos... Tags: Diets, Dietetics, Healthy diet Annonce publiée le 23-05-2023 Tweet |
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Institut Curie Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e |
Plus d'infos... Tags: cne, Revue de Mdecine Interne Annonce publiée le 15-05-2023 Tweet |
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Laboratoire Jean Perrin Salle de seminaires 5eme etage - LJP - Tours 32-33 |
Invite par: Pierre PAOLETTI - Section Neurosciences Plus d'infos... Tags: Cartography, Terra Incognita, Creative works, Terra incognita, Terra, Neuromodulation, Films, Sculptures Annonce publiée le 24-05-2023 Tweet |
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IBENS salle Favard, IBENS 46 rue d'Ulm 75005 Paris |
Cell plasticity plays an essential role in chronic pancreatitis, human pancreatic cancer (PDAC) and development of diabetes. The morphological processes are closely related to molecular programs known from early embryonic development of the pancreas. Based on these analogies, we have developed new disease models to decipher the causes of the aforementioned pathophysiologies and to design innovative, personalized therapies. One of the core areas in the lab is pancreatic differentiation of human pluripotent stem cells (hPSC). Here , we have differentiated hPSCs into pancreatic duct-like organoids (PDLOs) with morphological, transcriptional, proteomic, and functional characteristics of human pancreatic ducts, further maturing upon transplantation into mice. This model enabled in vitro and in vivo studies of pancreatic plasticity, dysplasia, and cancer formation from a genetically defined background. Using similar models, we also approached the endocrine lineage and revealed that loss of ONECUT1 impairs pancreatic progenitor formation and a subsequent endocrine program. Loss of ONECUT1 altered transcription factor binding and enhancer activity and NKX2.2/NKX6.1 expression in pancreatic progenitor cells. Collectively, we demonstrate that ONECUT1 controls a transcriptional and epigenetic machinery regulating endocrine development, involved in a spectrum of diabetes, encompassing monogenic (recessive and dominant) as well as multifactorial inheritance. In this seminar, I will summarize these seminal papers and give an overview about our unpublished efforts to model pancreatic disorders. Invited by Cécile Julier Plus d'infos... Tags: Branches of biology, Biology, Life sciences, Stem cells, Developmental biology, Biotechnology, Induced stem cells, Cell biology, Organoid, Pancreatic progenitor cell, Pancreas, Progenitor cell Annonce publiée le 15-05-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Plus d'infos... Annonce publiée le 18-03-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
TBA Plus d'infos... Tags: GUIDO music notation, Draft:Valley Vista Elementary School Annonce publiée le 15-05-2023 Tweet |
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Laboratoire Jean Perrin salle de seminaires 5eme etage - LJP - Tour 32-33 |
Invited by Sandra Duharcourt, Peter Sarkies (Department of Biochemistry, University of Oxford) will give an IJM Seminar entitled: Using evolution to understand epigenetic mechanisms Epigenetics and Evolution Epigenetics allows different types of cells in the body to turn different sets of genes on or off without changing the underlying DNA sequence. epimutations could lead to differences between individuals and therefore drive evolutionary changes. & https://psarkies.wixsite.com/epievo Plus d'infos... Tags: Branches of biology, Epigenetics, Biology, Genetics, Pharmacoepigenetics, Transgenerational epigenetic inheritance Annonce publiée le 03-02-2023 Tweet |
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Institut Jacques Monod Usually at 11.45 am in the François Jacob room |
Plus d'infos... Annonce publiée le 30-05-2023 Tweet |
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Inst. Bio. Paris Seine 7-9 quai Saint Bernard, 75005 Paris |
I will present two discoveries from my team dealing with precision medicine approaches and possibilities. The first part deals with widely used genotoxic cancer therapy, such as irradiation. These modalities operate through extensive induction of DNA breaks, yet cancer cells frequently display resistance to such interventions. Intriguingly, studies following the dynamics of radiation-induced DNA lesions have identified a temporally distinct and unexplained secondary wave of DNA breaks. Here, I will present our findings on a new pathway that allows tolerance to genotoxic stress. We uncovered that cancer cells actively and reversibly elevate levels of DNA breaks, a mechanism that acts to strengthen the G2/M cell cycle checkpoint thereby limiting premature re-entry into the cell cycle. I will explain the mechanisms underlying this response, which is distinct for cancer cells. Collectively, our findings highlight an unanticipated discovery in cancer biology, demonstrating that tumor cells deploy regulated DNA breaks as a mechanism to delimit the detrimental effects of exogenous DNA double-strand breakage and ensure survival. Finally, in the second part of my presentation I will outline our new approach to determine the phenotypic impact of genetic variants including their impact on drug responses. We call our approach CRISPR-Select, which allows for precise, quantitative, and rapid analysis without the need for generation of clones or selection. It provides unique opportunities for example to identify cancer-causing or drug-response predicting mutations. Plus d'infos... Tags: Carcinogenesis, Genotoxicity, Mutation, DNA, Life sciences Annonce publiée le 05-06-2023 Tweet |
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Institut Curie Centre de recherche - Orsay - Amphitheatre du Batiment 111 |
TBA Plus d'infos... Annonce publiée le 15-05-2023 Tweet |
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Laboratoire Jean Perrin salle de seminaires 5eme etage - LJP - Tour 32-33 |
KEYNOTE SPEAKER Fatima AL-SHAHROUR - ES
SPEAKERS Reka ALBERT - US Ozgun BABUR - US Valentina BOEVA - CH Giovanni CIRIELLO - CH Asmund FLOBAK - NO Connie R. JIMENEZ - NL Ina KOCH - DE Vera PANCALDI - FR Luca PINELLO - US Julio SAEZ-RODRIGUEZ - DE Oznur TASTAN – TR Denis THIEFFRY - FR Kim THRANE – SE Vassily HATZIMANIKATIS - CH Thomas WALTER - FR Lodewijk WESSELS – NL Séminaire proposé par Marine Poupon, The diversity across tumors from different patients and even across cancer cells from the same patient makes the picture very complex. The idea of ‘personalized’ or ‘precision’ medicine has been suggested, aiming to find tailored treatment regimen for each patient according to the individual genetic background and tumor molecular profile. This attempt is achievable thanks to sufficient molecular characterization of cancers accumulated using high-throughput technologies and advanced imaging technologies. However, despite availability of cancer multi-scale data, they are not fully exploited to provide the clue on deregulated mechanisms that would guide better patients stratification and to specific treatment in cancer. Plus d'infos... Annonce publiée le 16-05-2023 Tweet |
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Institut Curie Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) |
TBA Plus d'infos... Tags: Alexis, Draft:Valley Vista Elementary School, Undichna britannica Annonce publiée le 03-06-2023 Tweet |
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Laboratoire Jean Perrin salle de seminaires 5eme etage - LJP - Tour 32-33 |
Hematopoietic stem cells (HSCs) are the rare cells responsible for the lifelong curative effects of hematopoietic cell transplantation. The demand for clinical-grade HSCs has increased significantly in recent decades, leading to major difficulties in treating patients. A promising but not yet achieved goal is the generation of HSCs from pluripotent stem cells. Here, we have obtained vector- and stroma-free transplantable HSCs by differentiating human induced pluripotent stem cells (hiPSCs) using an original one-step culture system. After injection into immunocompromised mice, cells derived from hiPSCs settle in the bone marrow and form a robust multilineage, hematopoietic population that can be serially transplanted. Single cell RNA sequencing shows that this repopulating activity is due to a hematopoietic population that is transcriptionally similar to human embryonic aorta-derived HSCs. Overall, our results demonstrate the generation of HSCs from hiPSC and will help identify key regulators of HSC production during human ontogeny. Thierry Jaffredo is invited by Pascal Maire. Plus d'infos... Tags: Branches of biology, Biology, Life sciences, Stem cells, Hematopoietic stem cell, Haematopoiesis, Induced pluripotent stem cell, Hematopoietic stem cell niche, Stemcell Technologies Annonce publiée le 25-05-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Plus d'infos... Annonce publiée le 30-05-2023 Tweet |
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Inst. Bio. Paris Seine 7-9 quai Saint Bernard, 75005 Paris |
Plus d'infos... Annonce publiée le 30-05-2023 Tweet |
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Inst. Bio. Paris Seine 7-9 quai Saint Bernard, 75005 Paris |
Invite par: Yannick Allanore, Julie Chaumeil, Molly Ingersoll, Catherine Postic, Carina Prip-buus, Dominique Zeliszewski Many recent works demonstrate that biological sex - or whether it is female or male - as well as the number of sex chromosomes carried by an individual, can have a profound impact on various aspects of biology, in homeostasis and in many diseases. The influence of biological sex is still poorly understood and too often ignored both in basic research practices and by the medical profession. The French High Council for Equality between Women and Men noted, in its 2020 report, the importance of taking sex and gender into account to provide better care, as a public health issue. The Institut Cochin symposium Why sex matters in health and disease will highlight the impact of sex on gene regulation, cancer, immunology and metabolism. In these areas, both the physiological mechanisms involved and the development of chronic diseases such as cancer, autoimmune diseases, diabetes, chronic liver diseases will be addressed. Plus d'infos... Tags: Gender in Health Annonce publiée le 14-05-2023 Tweet |
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Institut Cochin amphitheatre Luton, UFR de Medecine site Cochin, 24 rue du Fg St Jacques 75014 |