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Plus d'infos... Tags: Ontology, Intrinsics, Intrinsic and extrinsic properties, Breast cancer, Hormone receptor positive breast tumor, Finality, Cellular noise Annonce publiée le 07-01-2025 |
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| Institut Curie Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) |
Pour afficher les séminaires d'un seul institut, appuyer d'abord sur 'None' puis sur l'institut de votre choix.
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Tags: Aldehydes, Formaldehyde, Indoor air pollution, DNA damage
Annonce publiée le 25-01-2025
Institut Gustave Roussy
salle Roger Monier du PR2 -
Plus d'infos...
Annonce publiée le 28-11-2024
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
TBA
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Tags: Valentin, Draft:Rincn Bomba massacre
Annonce publiée le 15-01-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - Tours 22-32 - 4e etage - Piece 407 -
Invite par: CIRB - College de France
Plus d'infos...
Tags: @cirbcdf.bsky.social
Annonce publiée le 11-12-2024
College de France
au College de France - Salle D2 acces restreint, merci de passer par l'accueil du CDF : 11 place Marcelin Berthelot - 75005 Paris -
TBA
Plus d'infos...
Tags: Draft:List of wars lost by israel, Mister RNB Espaa
Annonce publiée le 18-05-2024
Laboratoire Jean Perrin
Salle de seminaires 4eme etage - LJP - Tours 22-23 -
Plus d'infos...
Tags: Immunology
Annonce publiée le 25-01-2025
Academie des Sciences
Grande Salle des seances, Academie des Sciences, 23 Quai de Conti 75006 -
Invite par: Fabrice Andre
Breast cancer is a highly heterogeneous disease, stratified clinically by the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2). Despite advances in treatment, a significant proportion of patients, particularly those with ER-positive (ER+) subtypes, face persistent risks of distant metastases and mortality decades after diagnosis. Previously, we established a genome-driven breast cancer classification scheme that defines 11 integrative subgroups (ICs) with distinct molecular features and clinical trajectories. Specifically, we identify four subgroups of ER+ disease (IC1, IC2, IC6, IC9) with a persistent risk of lethal distant relapse up to two decades after diagnosis, each with focal copy number drivers and two distinct subgroups of triple-negative disease (Curtis et al. Nature 2012; Rueda et al. Nature 2019). These findings nominate new therapeutic strategies, however, it is not known how mutational processes and genomic architecture differ across the ICs to sculpt the development and evolution of disease, nor how their microenvironments differ. Methods: To investigate the tumor-intrinsic and extrinsic factors underpinning breast cancer progression and immune evasion, we analyzed a meta-cohort of 2,877 breast tumors, including 1,865 whole-genome and 1,824 whole-transcriptome sequences. This dataset spans ductal carcinoma in situ, primary invasive, and metastatic breast cancer, with 812 samples profiled using both modalities. We employed a containerized bioinformatics workflow to characterize copy number alterations, structural variations, mutational signatures, as well as the impact on genetic mechanisms of immune escape and the tumor-immune microenvironment (TME) (Houlahan, Mangiante et al. Nature, 2025). Encouraged by the interconnection of genomic archetypes with distinct TME subtypes, single-cell spatial transcriptomic profiling was also performed on 267 clinically curated ER+ breast cancer patients, encompassing 936 tissue images and capturing over one million cells. Quantitative spatial omic analyses were used to define 16 cell types, six spatial niches, and 1,252 spatial features (Mangiante et al. In preparation). Results: Our integrative analysis revealed that high-risk ER+ and HER2+ tumors acquire focal copy number alterations and complex structural variants early in disease progression and are associated with immune-depleted microenvironments, persisting from primary to metastatic stages. In contrast, triple-negative tumors displayed global genomic instability and an immune-enriched profile, with increased immune depletion during metastasis. Spatial transcriptomic profiling of ER+ tumors identified significant differences in cell type organization between high-risk and typical-risk groups. Four cancer cell archetypes were defined, each with distinct spatial associations within the tumor microenvironment, with notable evolution from primary to metastatic lesions in spatial features and archetype distributions. Conclusion: This comprehensive study underscores the interplay of tumor-intrinsic genomic alterations and tumor-extrinsic microenvironmental factors in shaping breast cancer progression and immune evasion. High-risk ER+ and HER2+ subgroups exhibit persistent immune suppression driven by complex structural variants, while spatial transcriptomics highlights distinct cellular and spatial niches predictive of relapse. These findings provide a foundation for developing personalized therapeutic strategies targeting both the genomic drivers and microenvironmental features of breast cancer.
Tags: Breast cancer, Oncology, Hereditary cancers, Breast cancer classification, Breast neoplasia, Cancer staging, Tumor microenvironment, HER2, Metastatic breast cancer, Cancer, Metastasis, Patient derived xenograft
Annonce publiée le 25-01-2025
Institut Gustave Roussy
salle Pierre Denoix, etage 15 - ascenseur C du batiment principal, 114 rue Edouard-Vaillant, 94 800 Villejuif Contact = cecile.tableau at gustaveroussy.fr -
Invite par: Jessica Quintin
With global warming, fungal infections represent a rising threat to health, which is likely partially mediated by mycotoxins. We have been using theDrosophila melanogastergenetic model organism to decipher the interactions of this host with ...
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Tags: Aspergillus fumigatus, Aspergillus, Microbial toxin, Mycotoxin
Annonce publiée le 27-01-2025
Institut Pasteur
Batiment: Fernbach Salle: Jean-Paul Aubert -
Invite par: Les Mercredis du CRI
Plus d'infos...
Tags: Gynaecological cancer, Ovarian cancer, Chemotherapy, Ovary
Annonce publiée le 25-01-2025
Centre de Recherche sur l'Inflammation
salle 241B, Faculte de Medecine site Bichat, 16 rue Henri Huchard - 75018 ou en visioconference -
Mercredi 5 fevrier, Eva-Maria Geigl (directrice de recherche au CNRS, Universite Paris Cite, CNRS, UMR 7592, Institut Jacques Monod) presentera la conference grand-public » Nouveaux apports de l'archeogenetique dans l'etude du Neolithique en France« au Musee d’Archeologie Nationale du chateau de Saint Germain-en-Laye. Cette conference est gratuite sur reservation : lien de reservation Resume : En Europe il y a 8500 - 6000 ans, le mode de vie d'agriculteurs a ete introduit et a supplante le mode de vie de chasseurs-cueilleurs mesolithiques. L'analyse des genomes d'individus ayant vecu a cette epoque a montre que cette transition culturelle a ete la consequence d'une migration des descendants des premiers agriculteurs du Proche-Orient qui sont partis d'Anatolie vers 6500 avant l'ere commune (AEC commencant a l'an zero) pour arriver dans le Bassin parisien vers 5100 AEC. Durant les millenaires suivants, de nouvelles cultures emergent. Notre analyse genomique d'individus associes a differentes cultures neolithiques nous a permis d'identifier migrations, metissages avec les chasseurs-cueilleurs mesolithiques et certains aspects du fonctionnement de ces societes neolithiques. A la fin du 4emeet au debut du 3ememillenaire AEC, des populations originaires des steppes pontiques-caspiennes ont migre vers l'ouest. Leur signature genomique caracteristique est alors trouve dans les genomes d'individus en Europe centrale et septentrionale associees a la culture de la ceramique cordee. Nous avons caracterise, au travers d'une analyse archeogenetique des individus de la fin du Neolithique dans le Bassin parisien, des dynamiques de metissage non detectees auparavant qui coincident avec les transitions culturelles de la ceramique cordee et du campaniforme. Conference par Eva-Maria Geigl,directrice de recherche au CNRS, Universite Paris Cite, CNRS, UMR 7592, Institut Jacques Monod
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Annonce publiée le 31-01-2025
Institut Jacques Monod
Musee d#8211; Domaine National du chateau de Saint-Germain-en-Laye, Musee d Place Charles de Gaulle, 78& 105 Saint-Germain-en-Laye cedex, France -
Invited by Florence Margottin-Goguet
Plus d'infos...
Tags: Lentiviruses, Antiviral protein, HIV, Virus, Zinc finger, Antiviral drug, Virology, Simian immunodeficiency virus
Annonce publiée le 28-11-2024
Institut Cochin
Salle Rosalind Franklin -
Invite par: Benoit Arcangioli
Plus d'infos...
Tags: Mutation, Cellular processes, Genetic mapping, Genome, Genomics, DNA repair, Poly (ADP-ribose) polymerase, PARP inhibitor
Annonce publiée le 21-01-2025
Institut Pasteur
Batiment Metchnikoff , salle Jules Bordet, -
Invite par: Gilles Crambert
Summary: Solid tumors are heterogeneous environments, containing niches of varying hypoxia, acidosis, and nutrient deprivation. Evidence from us and others shows that such hostile conditions can endow cancer cells with highly aggressive traits, including increased growth, invasiveness, and rewired metabolism. Such niches can also support cancer stem cells and protect cancer cells against chemotherapeutic and immune-oncological therapies. Accordingly, we recently demonstrated that acid-adapted pancreatic cancer cells give rise to highly aggressive tumors with increased metastatic potential in vivo. Understanding these niches and their impact can uncover new targets for improving treatment of aggressive cancers. I will present our recent work in which we combine in vitro and in vivo cancer models, microfluidics, and spatial transcriptomics to study the mechanisms through which tumor acidosis may drive cancer aggressiveness.
Plus d'infos...
Tags: Oncology, Tumor, Tumor microenvironment, Cancer stem cell, Metastasis, Patient derived xenograft, Oncometabolism
Annonce publiée le 22-12-2024
Centre de Recherche des Cordeliers
Amphi Gustave Roussy -
Conference dansee : MOVE YOUR SCIENCE Jeudi 6 fevrier a 19h | Hall Buffon, Institut Jacques Monod Gratuit sur inscription Creation collective avec les doctorant.esKenzaAlaoui Sosse,AmandineAlbizzati,MariamBougma,StephanieBrunot, Mert Can, JohannaExenberger, AudreyGosset,CapucineGros,EmileLe LievreetJosephineSchelle Choregraphie etrecherche danse/sciences: Cosetta Graffione et Namiko Gahier-Ogawa Coordination scientifiqueet recherche danse/sciences : Melina Heuze,enseignante-chercheuse Depuis septembre, dixdoctorant·es de l'Universite Paris Cite toutes disciplinesconfondues,travaillent avec les choregraphesCosetta GraffioneetNamiko Gahier-Ogawa ainsi quel'enseignante-chercheuse Melina Heuze pour partager leur projet scientifique dans un esprit de mediation vers le grand public. Dans undialogue art et sciences, le public pourraeprouverles principes scientifiques de leur travail de these a travers des sequences dansees faisant emerger une poesie des corps. Cette conference dansee en quatre tableaux sera suivie d'un echange avec le public autour d'un verre de l'amitie.
Plus d'infos...
Annonce publiée le 15-01-2025
Institut Jacques Monod
Institut Jacques Monod Amphitheatre Buffon, 15 rue Helene Brion, Paris, France -
Invite par: YAMAMOTO Kei
Plus d'infos...
Tags: 5th arrondissement of Paris, National Museum of Natural History, France, Triune brain
Annonce publiée le 21-12-2024
NeuroPSI
Salle de conference Albe-Fessard -
Plus d'infos...
Annonce publiée le 23-01-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Levendredi 7 fevrier 2025, Sophie G. Martin (Department of Molecular and Cellular Biology, University of Geneva, Switzerland) presentera une Conference de l'Institut Jacques Monod sur le theme : Signaling and actin focus architecture for cell-cell fusion Resume : Sexual reproduction is ubiquitous amongst eukaryotes. This requires alternation of cell-cell (gamete) fusion and genome reduction through meiosis. My lab has been using the yeast sexual reproduction pathway to study how cells polarize to find a mate and mount a fusion reaction. In the fission yeast Schizosaccharomyces pombe, sexual reproduction occurs between P and M cells, which communicate through pheromone-GPCR-MAPK signaling, driving the formation of cell pairs. Transition from gametes to zygote involves local cell wall digestion at the point of gamete contact, while preserving cell integrity. We have shown that cell-cell fusion requires the actin fusion focus, an aster-like assembly of linear actin filaments assembled by the formin Fus1, which concentrates both signaling molecules and secretory vesicles carrying cell wall digestion enyzmes. I will present our recent work on the molecular mechanisms of formation of the actin fusion focus, which require both formation of a formin biomolecular condensate and cytoskeletal focusing through formin-myosin feedback. I will also describe our progress in understanding the roles of local MAPK and PAK signaling for cells to pierce their cell wall once and only once.
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Annonce publiée le 04-01-2025
Institut Jacques Monod
Institut Jacques Monod Amphitheatre Buffon, 15 rue Helene Brion, Paris, France -
Invite par: Peter van Endert
Prof. L. Zitvogel, MD (Clinical Oncology), PhD (Tumor Immunology), full professor at the University Paris Saclay, graduated in Medical Oncology in 1992. Scientific career first at the University of Pittsburgh, US. Became Research Director at Institut National de la Sante et Recherche Medicale U1015, and Scientific Director of the Clinicobiome program at Gustave Roussy, the largest cancer Center in Europe in 1998. Actively contributed to the field of cancer immunology and immunotherapy. Pionneer of the concepts of immunogenic cell death and gut microbiota in cancer immunosurveillance and therapies. Recipient of many awards: Translation Research INSERM Prize, the ASCO-SITC, Brupbacher Awards 2017, ESMO Immuno-Oncology Award 2017, Baillet Latour Prize 2019, the Griffuel Prize 2019, the Duquesne Ligue Prize, and ITOC9 german award. Knighted Officer of Legion dgt;500 publications on PubMed, 108 265 citations in Clarivate analytics (highly cited researchers 2021, 2020, 2019, 2018, 2017, 2016). Scientific founder of everImmune. Seminar topic: The dirty secrets of cancer immunotherapy
Plus d'infos...
Tags: Immunotherapy, Laurence Zitvogel, Women in medicine, Guido Kroemer
Annonce publiée le 22-01-2025
Institut Necker Enfants Malades
Auditorium 3 -
Invite par: Marie-Odile Krebs, Gwenaelle Le Pen
During his PhD in robotics, Dr de Chaumont designed an autonomous robot to help people with motor disabilities (paraplegics, hemiplegics). In 2007 at Institut Pasteur, he created a 3D engine based on the OpenGL library to represent biological samples and image analysis results in the unit's internal software. He then created a new image analysis software, Icy. He was working on tracking C. elegans in a screen analysis context. To achieve this, he created a tracking method based on a physical engine. An object is represented by primitives (rectangles, squares, circles) connected to each other via joints (piston, axis of rotation, rope, elastic). The whole is animated by a set of forces applied to each element, and calculated from the video. This system was finally applied to mouse tracking. It is with Sylvie Granon who works on mouse behavior that he applies this system to track mice with precision. It allows a finer understanding of the interaction of mice: it provides new details during animal contacts that were impossible to detect before. In addition, this system allows to follow the temporal evolution of social contact between individuals, which did not exist either. Finally, this method allows to obtain a considerable amount of information for each animal observed and thus contributes to limiting the number of animals used in experiments. This work was published in 2012 in Nature methods.
Plus d'infos...
Tags: Behaviour, Environment, Cognition
Annonce publiée le 24-01-2025
Institut de Psychiatrie et Neurosciences de Paris
salle Deborah Levy, 102-108 rue de la Sante 75014 -
Invite par: Kevin JEAN - Section Ecologie et Biologie de l’Evolution
Antimicrobial resistance is undeniably a global public health threat. But how does it spread ? At the human level, we can sometimes observe transmission events where individuals acquire bacteria from someone else. However, there are multiple instances where we simply can't find a good explanation for the origin of a resistant bacteria. To solve this mystery, we need to go one step further : at the bacterial level. In this seminar, I will present our work on the invisible dynamics of horizontal gene transfer in S. aureus bacterial populations, which dictate the prevalence of antimicrobial resistance at the human level. Through an interdisciplinary approach combining lab work and mathematical modelling, we explored the strange interactions between bacteria and their viral predators (bacteriophage), and the conditions under which these interactions can lead to evolution of antimicrobial resistance? or total bacterial eradication !
Plus d'infos...
Tags: Evolutionary biology, Pharmaceuticals policy, Veterinary medicine, Immunology, Antimicrobial resistance, Antimicrobial, Bacteriophage, Drug resistance, Staphylococcus aureus, Antimicrobial peptides, Multiple drug resistance
Annonce publiée le 26-01-2025
IBENS
salle Favard, IBENS 46 rue d'Ulm 75005 Paris -
Abstract will appear here.
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Tags: Boisbriand
Annonce publiée le 10-09-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
Abstract : In the visual system, the signals available to the brain are limited to the two-dimensional images formed on the retinae. To reconstruct the three-dimensional location of objects in the environment, visual circuits must infer the missing depth information. This ability is innate in most mammals, not requiring visual experience, and involves the neocortex. While animals take advantage of both monocular and binocular signals to estimate depth, binocular vision is not necessary for depth perception. Animals' innate capacity for depth perception is thought to rely on motion parallax - visual motion resulting from animals movements. I will show that neurons in the mouse primary visual cortex are selective for depth from motion parallax as a result of integration of visual and locomotion-related signals. Consequently, V1 neurons have three-dimensional receptive fields - they are selective for both retinotopic location and depth of visual stimuli. I will also present our unpublished work exploring the circuits supporting such computations.
Plus d'infos...
Tags: Vision, Visual perception, Stereoscopy, Perception, Sensory systems, Visual cortex, Depth perception, Retinotopy, Visual system, Cerebral cortex, Binocular vision, Binocular neurons
Annonce publiée le 30-01-2025
IBENS
salle Favard, IBENS 46 rue d'Ulm 75005 Paris -
Biosketch: Corinne Albiges-Rizo received a PhD in Cellular and Molecular biology from the University of Grenoble in 1990. She worked as a PhD student at EMBL in Grenoble and completed her post-doctoral research as a fellow in HHMI in Chicago. She moved back to Grenoble as a CNRS Scientist. Her team is based within the Institute for Advanced Biosciences (Institut Albert Bonniot) and she also heads the department of microenvironment and cell plasticity. She was President of the French Society for Cell Biology (SBCF). Using transdisciplinary approach, her team is investigating how adhesion sites sense varied external cues to modulate downstream signaling networks and force transmission to elucidate the sensory mechanisms underlying invasion and tissue architecture. The team is specifically exploring the biological and physiological relevance of integrin activation. The question is to know how cells integrate physical and biochemical cues of their environment and intertwine signaling networks that ultimately control their shape, their contractile state, their communication capacity and their migratory behavior. To address how cells detect temporally close but spatially distant signals, such as growth factors and extracellular matrix components to control multi-decisional signaling, the team combines biomaterials, optogenetics, advanced live cell imaging including single-particle-tracking localization microscopy (SPT-PALM) along with morphometric and dynamic measurements. The team has shown the property of BMP2 signal to override the effects of soft biomaterial-induced signaling through an integrin-dependent biomechanical response and a segregation of BMP2 receptor subpopulation in adhesion sites to couple cell differentiation and cell migration. 3 integrin-mediated spreading induced by matrix-bound BMP-2 controls Smad signaling in a stiffness-independent manner. J Cell Biol. 2016 Mar 14;212(6):693-706. doi: 10.1083/jcb.201508018. Epub 2016 Mar 7. PMID: 26953352; PMCID: PMC4792076. Guevara-Garcia A, Fourel L, Bourrin-Reynard I, Sales A, Oddou C, Pezet M, Rossier O, Machillot P, Chaar L, Bouin AP, Giannone G, Destaing O, Picart C, Albiges-Rizo C. Integrin-based adhesion compartmentalizes ALK3 of the BMPRII to control cell adhesion and migration. J Cell Biol. 2022 Dec 5;221(12):e202107110. doi: 10.1083/jcb.202107110. Epub 2022 Oct 7. PMID: 36205720; PMCID: PMC9552562. Kyumurkov A, Bouin AP, Boissan M, Manet S, Baschieri F, Proponnet-Guerault M, Balland M, Destaing O, Regent-Kloeckner M, Calmel C, Nicolas A, Waharte F, Chavrier P, Montagnac G, Planus E, Albiges-Rizo C. Force tuning through regulation of clathrin-dependent integrin endocytosis. J Cell Biol. 2023 Jan 2;222(1):e202004025. doi: 10.1083/jcb.202004025. Epub 2022 Oct 17. PMID: 36250940; PMCID: PMC9579986
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Tags: Integrin
Annonce publiée le 31-01-2025
Centre de Recherche en Myologie -
Plus d'infos...
Annonce publiée le 21-01-2025
NeuroPSI
Salle de conference Albe-Fessard -
The swimming motion of bacteria has recently seen an increasing interest from physicists, utilizing the recent progresses in microscopy and the development of microfluidics to study this interdisciplinary subject. In this seminar, I will present our two main experimental findings on the motile soil bacteria Burkholderia contaminans : its reaction to oxygen and its ability to gather micron-sized beads in clusters. First, we quantitatively studied its aerotaxis, i.e. its behaviour in an oxygen gradient. We notably characterized the aerotactic coefficient dependency on the oxygen concentration, with both a macroscopic (population scale analysis) and microscopic approaches (bacterial scale analysis), and compared it to the literature. Second, we uncovered a rich clustering phenomena happening when some micron-sized passive beads ( 2 - 40 mu; m ) are added to the bacterial suspension. Besides the enhanced bead diffusivity, the swimming bacteria are also responsible for a short-range attractive force between the beads. This results in a dynamical clustering of the beads, with a dynamics similar to Ostwald ripening and a characteristic cluster size slowly growing in t 1 / 3 without any apparent saturation.
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Tags: Bacteriology, Biotechnology, Microfluidics, Nanotechnology, Aerotaxis, Motility, Bacteria
Annonce publiée le 14-01-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - Tours 22-32 - 4e etage - Piece 407 -
Le mardi 11 fevrier, Richard Benton (Center for Integrative Genomics, University of Lausanne) presentera une Conference de l’Institut Jacques Monod sur le theme : Fatal chemosensation, and how insects fight back Resume : Insecticide resistance is a widespread challenge for the management of vectors transmitting pathogens and agricultural pests, requiring a better understanding of the genetic mechanisms underlying the evolution of resistance. Drosophila sechellia is a compelling model for such studies as it naturally evolved resistance to octanoic acid, an abundant chemical of its noni fruit host that is toxic for other insects, including close relatives D. simulans and D. melanogaster. We have used a multi-pronged strategy to identify genes contributing to octanoic acid resistance. We began by experimentally-evolving D. simulans strains with higher tolerance to octanoic acid and determined the resulting genetic architecture. To identify specific candidate genes, we integrated this analysis with a genome-wide association study of octanoic acid resistance in D. simulans and a genome-wide CRISPR selection screen upon octanoic acid exposure in D. melanogaster S2R+ cultured cells. We identified four candidates, with diverse predicted molecular and expression properties, and validated their relevance using genetic analyses in D. melanogaster. Two of these genes displayed an increased expression in the experimentally-evolved strains, paralleling their higher levels of expression in D. sechellia. Our results suggest an adaptive role of these genes in shaping toxin resistance both under laboratory conditions and during D. sechellia's evolutionary history.
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Annonce publiée le 04-01-2025
Institut Jacques Monod
Batiment Condorcet Amphitheatre Pierre Gilles de Gennes, 4 rue Elsa Morante, Paris, France -
Invite par: CIRB - College de France
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Tags: @cirbcdf.bsky.social
Annonce publiée le 11-12-2024
College de France
au College de France - Salle D2 acces restreint, merci de passer par l'accueil du CDF : 11 place Marcelin Berthelot - 75005 Paris -
Invite par le Centre for Genomic Regulation, Felix Ruhnow va presenter un seminaire sur le theme : NuMA is a mitotic adaptor protein that activates dynein and connects it to microtubule minus ends Resume : Nuclear mitotic apparatus protein (NuMA) is indispensable for the mitotic functions of the major microtubule minus-end directed motor cytoplasmic dynein 1. NuMA and dynein are both essential for correct spindle pole organization. How these proteins cooperate to gather microtubule minus ends at spindle poles remains unclear. Here we use microscopy-based in vitro reconstitutions to demonstrate that NuMA is a dynein adaptor, activating processive dynein motility together with dynein’s cofactors dynactin and Lissencephaly-1 (Lis1). Additionally, we find that NuMA binds and stabilizes microtubule minus ends, allowing dynein/dynactin/NuMA. to transport microtubule minus ends as cargo to other minus ends. We further show that the microtubule-nucleating ?-tubulin ring complex (?TuRC) hinders NuMA binding and that NuMA can only cap minus ends of ?TuRC-nucleated microtubules after ?TuRC release. These results provide new mechanistic insight into how dynein, dynactin, NuMA, Lis1 together with ?TuRC and uncapping proteins cooperate to organize spindle poles in cells.
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Tags: Motor proteins, Mitosis, Cytoskeleton, Dynein, Dynactin, Microtubule, Spindle apparatus, Tubulin, Cell biology, Microtubule plus-end tracking protein, MAPRE1
Annonce publiée le 28-01-2025
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Anti-PD-1 therapy targets intratumoral CD8+ T cells to promote clinical responses in cancer patients. Recent evidence has suggested that anti-PD-1 also act in the periphery. In particular, new T cell clonotypes emerge during anti-PD-1 therapy within the tumor microenvironment, suggesting de novo priming in the periphery. However, the underlying mechanism remains incompletely understood. In this presentation, I will show the importance of TDLN during anti-PD-1 therapy and discuss unexpected mechanisms for the peripheral activity of anti-PD-1 antibodies Paris Post-docs seminar series.
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Tags: Immune system, Immunology, Clusters of differentiation, Programmed cell death protein 1, Tumor microenvironment, T cell, Pd1, Antibody, Cancer immunotherapy, Dario Angelo Alberto Vignali
Annonce publiée le 29-11-2024
Institut Cochin
Salle Rosalind Franklin -
Antimicrobial resistance develops as a major problem in infectious diseases treatment. Starting with a high-density Transposon insertion library in Vibrio cholerae and following its evolution by TN-seq in the presence of antibiotics, we have linked 23 tRNA and rRNA modification enzymes with specific responses to various antibiotics. In particular, deletion of tRNA guanine transglycosylase tgt leads to strong aminoglycoside sensitivity. Tgt is responsible for the queuosine (Q) modification of tRNA-tyrosine at the anti-codon loop wobble position. We used molecular reporters for translation fidelity and efficiency as well as a proteomics analysis to further characterize molecular mechanisms behind the aminoglycoside sensitive phenotype in the absence of tgt/Q modification.
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Tags: Vibrionales, Protein biosynthesis, Food microbiology, RNA, Nucleic acids, Vibrio cholerae, Transfer RNA, Wobble base pair, Vibrio, Antimicrobial resistance, Drug resistance, TGT
Annonce publiée le 30-01-2025
Institut Micalis
Auditorium 442 - Institut Micalis -
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Tags: Cancer
Annonce publiée le 22-12-2024
Centre de Recherche des Cordeliers
Amphi Gustave Roussy -
Invite par: Benoit Chassaing
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Tags: Microbiomes, Microbiology, Bacteriology, Childbirth, Bacteria, Human microbiome, Microbiota, Caesarean section, Vaginal seeding, Vaginal delivery
Annonce publiée le 29-01-2025
Institut Pasteur
Batiment Duclaux , salle Duclaux amphitheater , -
Plus d'infos...
Tags: Germ cells, Cell cycle, Meiosis, Plant sexuality, Starfish, Oocyte, Melina Schuh
Annonce publiée le 23-01-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Invite par l’equipe Courtier, Peter Andolfatto (Professor, Dept. of Biological Sciences, Columbia University) presentera un seminaire de l’Institut Jacques Monod sur le theme : The evolution of toxin-resistant Na+,K+-ATPases: new insights from frogs and fireflies We study the process of adaptive evolution through the lens of repeated adaptation of many distantly species to a similar selection pressure (i.e. «parallel evolution»). Over the past decade, we have explored patterns of adaptation in the context of animals that have specialized in eating plants, or other animals, that contain toxic cardiotonic steroids (CTS). CTS are toxic to animals because they inhibit sodium-potassium ATPase, a key enzyme in animals needed in everything from maintaining cell homeostasis, muscle contraction to neuron activity. Here I review our most recent work combining comparative molecular evolution, molecular and biochemical assays andin vivoengineering of Drosophila to deduce the rules governing the adaptive evolution of CTS resistance in animals. Together, our results have interesting implications for how epistasis and pleiotropy both limit the rate of adaptive protein evolution and increase its predictability.
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Annonce publiée le 04-01-2025
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Invite par: Fabiola Terzi
After completing a PhD in immuno-oncology in 2001 at GIMAP (INSERM), Jean-Philippe Herbeuval was awarded a 5-year Fogarty Fellowship at the NIH (USA) in Dr. G. Shearer's lab to work on the antiviral response to HIV. His work earned him the Norman P. Salzman Award (NIH, FDA, CDC) and the NIH Cash Award in 2005. He was recruited as a CR1 researcher by the CNRS in 2001 at Necker Hospital (UMR8147), where he established a research group. In 2012, Jean-Philippe Herbeuval founded the interdisciplinary team CBMIT at the Saints-Peres Biomedical Faculty to develop interdisciplinary and translational projects integrating immunology, virology, chemistry, and in silico modeling. In 2019, he founded the start-up Ermium Therapeutics with the investment fund Kurma Partners and Domain Therapeutics. He was awarded the national i-Lab Innovation Prize (BPI, Ministry of Research), and named Ambassadeur innovation du CNRS.Seminar topic: Control of type I interferon production by CXCR4 minor pocket agonists (MiPAs): from HIV sexual transmission to novel therapeutic strategies for interferonopathies
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Tags: Sexually transmitted diseases and infections, HIV, Lentiviruses, CXCR4, Interferon
Annonce publiée le 22-01-2025
Institut Necker Enfants Malades
Auditorium 1 -
Save the date! The Single Cell Initiative, the Cell and Tissue Imaging Platform (PICT) and the Experimental Pathology (PATHEX) core facilities co-organise an afternoon dedicated to spatial omics at Institut Curie. Meet the core facilities and discover how your colleagues apply spatial omics technologies in their research! Agenda, registration link and more information to come soon.
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Tags: Genomics, Omics, OMICS Publishing Group
Annonce publiée le 06-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Invite par: Wilfried Le Goff and Anatol Kontush
The remarkable energy burning capacity of thermogenic brown adipocytes represents a valuable therapeutic target for the treatment of obesity, dyslipidemia and atherosclerosis. The Heeren group demonstrated that activated brown and beige adipocytes have profound metabolic effects and can lower blood triglyceride and atherogenic lipoprotein levels. Using state-of-the-art technologies to visualize and quantify metabolite flux, systemic and local mechanisms controlling energy and lipid metabolism in adipose tissue under conditions of adaptive thermogenesis will be shown. Furthermore, the molecular and cellular mechanisms that initiate inflammatory degeneration of the BAT, as observed in obesity and ageing, and their relevance to systemic energy metabolism will be presented. The background, concepts and original findings of the Heeren group can be found in Siracusa et al (Nat Immunol 2023), Niemann et al (Nature 2022), Fischer et al (Cell Metab 2021), Scheja and Heeren (Nat Rev Endocrinol 2019), Heine et al (Cell Metab 2018), Worthmann et al (Nat Med 2017).
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Tags: Connective tissue, Obesity, Adipocyte, Adipose tissue, Brown adipose tissue, Thermogenesis
Annonce publiée le 25-01-2025
Umrs 1166 - IHU-ICAN
salle bordeaux au 5eme etage de la Faculte de Medecine Sorbonne Universite, 105 boulevard de l'Hopital 75013 -
Invited by Pascal Maire.
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Tags: Maire, Municipal governments in Saint Pierre and Miquelon, When Do You Commit Suicide?
Annonce publiée le 04-12-2024
Institut Cochin
Salle Rosalind Franklin -
Invite par: Lubka Roumenina
Joshua M. Thurman, MD is the Temple Hoyne Buell Professor of Medicine in the Division of Nephrology and Hypertension at the University of Colorado. His laboratory studies the underlying causes of autoimmunity and inflammation of the kidney. Dr. Thurman has developed several novel anti-inflammatory therapeutic agents. His laboratory has also created new methods for monitoring tissue inflammation, including magnetic resonance imaging (MRI) and positron emission tomography (PET) based probes.
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Tags: Animal physiology, Human physiology, Immunology, Inflammation, Nephrology, Magnetic resonance imaging, Systemic inflammation
Annonce publiée le 22-01-2025
Centre de Recherche des Cordeliers
Amphi Gustave Roussy -
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Tags: Physiology
Annonce publiée le 23-01-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Invite par: MARTIN Jean-Rene
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Tags: Glial cells, Glia
Annonce publiée le 23-01-2025
NeuroPSI
Salle de conference Albe-Fessard -
Invite par l’equipe Courtier, Marla Sokolowski (Department of Ecology and Evolutionary Biology, University of Toronto) va presenter un seminaire de l’Institut Jacques Monod sur le theme : The foraging gene: will that be for here or to go? Resume : The Drosophila melanogaster foraging (for) gene, with its rover and sitter larval foraging variants, is an established behaviour genetics model. Orthologues of the foraging gene also modulate the individual and social behaviour of a wide range of species including the regulation of behaviour in eusocial insects. In Drosophila, foraging modifies the expression of multiple traits, including feeding and foraging, stress tolerance, sleep, metabolism, dispersal, escape responses, social behaviour, and learning and memory. From a social context perspective, Drosophila foraging affects larval clustering during foraging under high larval densities, adult social behaviour and social networks, and social learning. We wondered how foraging accomplishes its behavioural pleiotropy at the molecular level. We found that D. melanogaster foraging has a complex modular genomic structure with four promoters, 21 transcripts, and eight protein isoforms. The four promoter modules are differentially regulated during development and in a timescale, tissue, and cell-type dependent manner. Two examples illustrate these findings: the epigenetic regulation of the adult rover-sitter foraging-related phenotypes by G9a, a histone methyltransferase, and the regulation of differences in the latency of rover compared to sitter larval escape responses to noxious stimuli such as parasitoid wasps. Our work provides a nuanced picture of the molecular basis of foraging's pleiotropy.
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Tags: Animal models, Foraging, Behavioral ecology, Marla Sokolowski, Drosophila melanogaster, Drosophila, Eusociality, Period
Annonce publiée le 29-01-2025
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Invite par l’Institut Jacques Monod, Nathaniel Henneman (team of Ganna Panasyuk at Institut Necker Enfants Malades (INEM)) va presenter un Paris Postdoc Seminar sur le theme : Nuclear functions of nutrient sensing signaling for metabolic adaptation Presentation et resume : I am a Postdoc in the team of Ganna Panasyuk at Institut Necker Enfants Malades (INEM). I graduated from Bates College (USA) in 2016, majoring in Biology. I then spent two years working on retinal degeneration at Emory University beforeobtaining my master's degree at University of Paris Descartes in 2019 and defended my PhD in December 2023. One of the key questions I am to address in my work is how cellular metabolism, gene expression and transcription, are all coordinated. Energy stress in fasting is managed by activating autophagy and promoting the transcriptional remodeling of metabolism. Cytosolic nutrient sensors coordinate extracellular nutrient availability with intracellular metabolic processes to allow for cell survival. Class 3 PI3K is a highly conserved nutrient sensor known to regulate autophagy and endocytosis in response to varying nutrient conditions. It's direct role in transcription, however, was only suggested in few studies in yeast and plants. However, we believe there is a nuclear pool of class 3 PI3K that directly regulates gene expression for metabolic adaptation. My work aims to address this unmet burden in the field. We find that nuclear class 3 PI3K regulates the transcriptional response to nutrient stress by controlling RNA Polymerase II, the Set1/COMPASS methyltransferase, and nuclear methionine to SAM flux. I aim to understand how these players are needed for our fasting adaptation and how these mechanisms could affect our metabolic resilience.
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Tags: Metabolism, Nutrient sensing, Nutrition, Receptors, Necker, Autophagy, Starvation response, Fasting
Annonce publiée le 24-01-2025
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
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Annonce publiée le 28-11-2024
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
TBA
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Tags: Mathieu, Rivire, Draft:Rincn Bomba massacre, Daniel Riviere
Annonce publiée le 17-01-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - Tours 22-32 - 4e etage - Piece 407 -
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Tags: Intravital microscopy, Microscopy, Carcinogenesis, Tumor initiation
Annonce publiée le 22-01-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Mitochondria are double membrane-bound organelles that perform biosynthetic and signaling roles to control the life and death of the cell. Mitochondria are paramount to the metabolism and survival of cardiomyocytes, which have the most densely packed inner mitochondrial membrane of all cells. Cardiomyocytes are exquisitely sensitive to perturbations of mitochondrial structure, which can lead trigger downstream maladaptive and compensatory responses. In my talk, I will share our latest, unpublished findings using mouse models we have developed that have revealed the importance of inner mitochondrial membrane integrity in restraining cardiac inflammation and the emerging effects that biological sex can have on these phenomena. Timothy Wai is invited by Molly Ingersoll and Catherine Postic.
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Tags: Membrane biology, Mitochondria, Cellular respiration, Mitochondrion, Inner mitochondrial membrane, Cell membrane, Cell biology, MFN2
Annonce publiée le 29-11-2024
Institut Cochin
Salle Rosalind Franklin -
Invite par: Marc Graille
Annonce publiée le 20-01-2025
Ecole Polytechnique
Amphi 1021004 BEM - Institut Polytechnique de Paris -
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Tags: DNA repair, DNA, DNA damage, Mutation, Postreplication checkpoint, DNA-SCARS
Annonce publiée le 15-01-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Invite par: Xavier Nassif
Peter Sebo got a PhD. (CSc.) in microbiology in 1990 in Prague and did his postdoc at Institut Pasteur in Paris (1990-95). Since 1995, he heads a lab at the Institute of Microbiology of the Czech Academy of Sciences (CAS) in Prague. He also founded the Institute of Biotechnology of the CAS and designed the BIOCEV research center in Vestec and also serves as professor of microbiology at the University of Chemistry and Technology in Prague. Peter Sebo's research focuses on bacterial pathogenesis and the mechanisms of Bordetella pertussis virulence and toxin action. Prof. Sebo is involved in therapeutic and prophylactic vaccine development, published over 165 papers (H=43) and was elected to EMBO and the European Academy of Microbiology. Seminar topic: Why is whooping cough a problem again and how it works
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Tags: Burkholderiales, Whooping cough, Vaccine-preventable diseases, Pediatrics, Bordetella, Jules Bordet, Cough, BIOCEV, Whooping
Annonce publiée le 27-01-2025
Institut Necker Enfants Malades
Auditorium 1 -
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Tags: Deep learning, Natural language processing, Computational linguistics, Artificial intelligence, Cybernetics, Data science, Foundation model, Neural scaling law
Annonce publiée le 31-01-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Plus d'infos...
Tags: ICM, Piti-Salptrire Hospital
Annonce publiée le 13-11-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
Our daily life is a succession of cognitive actions influenced by our emotions. Emotions, often referred to as feelings, are necessary to maintain a balance throughout the life of an individual, if not his survival: love, anger, pain and fear are the most common examples. While neuronal networks sustaining emotions are well studied, a tremendous question persists: how does our brain cellular networks supports the enduring effects of emotions?
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Tags: Interpersonal attraction, Glial cells, Central nervous system, Antidiuretics, Neurotransmitters, Oxytocin, Astrocyte, Amygdala, Biology of romantic love, Emotion
Annonce publiée le 25-01-2025
I. Cerveau et de la Moelle
Please join the conference in Paris Brain Institute auditorium. -
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Annonce publiée le 20-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
TBA
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Tags: Cantini, Draft:Rincn Bomba massacre, Trees in L'Estaque
Annonce publiée le 17-01-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - Tours 22-32 - 4e etage - Piece 407 -
Invite par: CIRB - College de France
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Tags: @cirbcdf.bsky.social
Annonce publiée le 27-01-2025
College de France
College de France au College de France - Salle D2 acces restreint, merci de passer par l'accueil du CDF : 11 place Marcelin Berthelot - 75005 Paris -
Le vendredi 7 mars, Andrea Musacchio (Max Planck Institute of Molecular physiology) presentera une Conference de l'Institut Jacques Monod sur le theme : Feedback control of mitosis in the context of the kinetochore Resume : Kinetochores provide chromosomes with points of attachment to spindle microtubules during cell division, and are therefore essential for genome inheritance and the propagation of life. In addition to binding microtubules, kinetochores control mitotic surveillance mechanisms that promote chromosome bi-orientation (the error correction mechanism) and prevent premature mitotic exit in presence of incomplete or incorrect microtubule attachments (spindle assembly checkpoint, SAC). Elimination of the NDC80 complex, the main microtubule receptor of kinetochores, causes a SAC deficiency, identifying this complex as a crucial regulatory focus for checkpoint function. In recent years, there has been considerable progress in understanding how the SAC effector, known as the mitotic checkpoint complex (MCC), assembles from its individual components to inhibit its target, the anaphase promoting complex/cyclosome (APC/C). Conversely, how microtubule attachment to kinetochores regulates the SAC remains incompletely understood. From a molecular perspective, answering this question implies investigating the mechanisms that promote targeting of the SAC proteins to unattached kinetochores, and suppress it upon microtubule binding and biorientation. In our recent work, we have combined biochemical reconstitutions, structural biology/modelling, and cell biology to gain insights into this fundamental biological question.
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Tags: Mitosis, Cell cycle, Organelles, Cell biology, Kinetochore, Meiosis, Spindle checkpoint, Spindle apparatus, Biorientation, Microtubule, Cell division, Mad1
Annonce publiée le 28-01-2025
Institut Jacques Monod
Institut Jacques Monod Amphitheatre Buffon, 15 rue Helene Brion, Paris, France -
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Tags: Epigenetics, Genetic mapping, Lamarckism, Edith Heard, Genevive Almouzni
Annonce publiée le 13-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
Proteins in cells are not homogeneously distributed, but often localized to specific compartments, which may or may not be enclosed by membranes.
Here I will first discuss the dynamic formation of membraneless compartments in the non-equilibrium environment of living cells and how this formation can be regulated, e.g. by kinases [1]. Then I will show how single-molecule FRET (smFRET) and tracking of biomolecules can be used to study conformational dynamics and time-resolved cellular localization in living cells [2]. Results with the transcription initiation factor TAF2 show that the same protein can be in different compartments and thereby have different functions [3]. For the heat shock protein Hsp90 we will determine how proteins may be recruited to different compartments and have different conformational dynamics.
Altogether, smFRET has the potential to change our view on compartment-specific protein dynamics and therefore signalling within living cells.
[1] C. Lan, J. Kim, S. Ulferts, F. Aprile-Garcia, A. Anandamurugan, R. Grosse, R. Sawarkar, A. Reinhardt and T. Hugel, Nat. Commun., 14:4831 2023 (https://doi.org/10.1038/s41467-023-40540-2)
[2] A. Anandamurugan, A. Eidloth, P. Wortmann, L. Schrangl, F. Aprile-Garcia, C. Lan, R. Sawarkar, G. J. Schütz, T. Hugel, bioRxiv 2023 (https://doi.org/10.1101/2023.09.15.557875)
[3] T. Bhuiyan, P. K. Mendoza Sanchez, N. Arecco, J. Kim, S. Nizamuddin, A. Prunotto, M. Tekman, M. L. Biniossek, S. Koidl, T. Hugel, S. J. Arnold, bioRxiv 2024, (https://doi.org/10.1101/2024.02.05.578926)
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Tags: Single-molecule FRET, Live single-cell imaging, DEP domain
Annonce publiée le 12-09-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Invited by Anne Hosmalin.
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Tags: Solan, Karolinska Institute
Annonce publiée le 25-10-2024
Institut Cochin
Salle Rosalind Franklin -
Invited by Anne Hosmalin.
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Tags: Karolinska Institute, Solna
Annonce publiée le 30-11-2024
Institut Cochin
Salle Rosalind Franklin -
Invite par: Marie-Agnes Petit
Evolution is an inexorable force that hinders our best efforts to control infectious diseases. When it comes to pathogenic bacteria, the conventional approach shoot antibiotics first, ask questions later? has undoubtedly saved many lives but has led to widespread resistance. To effectively address the challenges of the looming post-antibiotic era, we must seek solutions based on a comprehensive understanding of pathogen evolution in relevant ecological contexts. A crucial aspect of bacterial infections is that pathogens rarely exist in isolation within their respective niches. The host harbors diverse microbial communities that compete with invading pathogens, and mutants from pathogenic strains compete with each other during infections. Our work focuses on the key role of competitive exclusion in pathogen evolution. I will present recent findings that illustrate how this fundamental ecological concept can lead to evolutionary robust solutions to combat bacterial infections.
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Tags: Microbiology, Bacteriology, Pathogenic bacteria, Bacteria, Pathogen, Antimicrobial resistance, Infection, Pathogenomics, Hostpathogen interaction
Annonce publiée le 20-01-2025
Institut Micalis
Auditorium 442 - Institut Micalis -
TBA
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Tags: Morvan, Ghislain
Annonce publiée le 23-11-2024
Laboratoire Jean Perrin
Salle de seminaires 4eme etage - LJP - Tours 22-23 -
TBA
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Tags: Jami, Ludovic, Draft:Rincn Bomba massacre, Jami Masjid, Mangrol
Annonce publiée le 23-01-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - Tours 22-32 - 4e etage - Piece 407 -
Invited by Molly Ingersoll.
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Tags: NewYorkPresbyterian Healthcare System, Ingersoll, Ontario, Ingersoll, Donna Farber, Columbia University Irving Medical Center
Annonce publiée le 19-12-2024
Institut Cochin
Salle Rosalind Franklin -
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Tags: J. William Harbour, Melanoma, Uveal melanoma, Uvea, DecisionDx-UM, Draft:Carlos Rogerio Figueiredo
Annonce publiée le 14-01-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
Singing is a natural and universal human behavior uniquely processed by the brain. It offers a deeply enjoyable experience, particularly when per- formed in groups. As such, singing carries significant biological importance and holds great potential for promoting health and fostering social integration.
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Tags: Animal anatomy, Brain, Organs, Isabelle Peretz, Cognitive musicology
Annonce publiée le 25-01-2025
I. Cerveau et de la Moelle
Please join the conference in Paris Brain Institute auditorium. -
Ce cours explorera la polyvalence des elements d ADN non geniques et des ARN non codants dans un large eventail de processus cellulaires, chez l humain et les organismes modeles, ainsi que leur implication dans la physiologie et les maladies. Il elargira les sujets autour des domaines de la genomique, de l epigenetique et de la transcriptomique, y compris les technologies et analyses a cellule unique, la regulation de l'epigenome et de l expression des genes, l organisation du genome et la clonalite cellulaire. Des experts reconnus a l international presenteront leurs dernieres decouvertes concernant l identification et la caracterisation fonctionnelle du genome non codant, et discuteront des nouveaux concepts en matiere de regulation et d evolution du genome, avec un fort accent sur les outils experimentaux et informatiques. Les sessions thematiques incluront l analyse computationnelle de l heterogeneite cellulaire, les methodes d evaluation de l heterogeneite et de la plasticite cellulaire, l epigenome dans la regulation de l expression des genes, les retroelements dans la plasticite cellulaire, le genome "sombre" dans l identite et la clonalite cellulaire, ainsi que l organisation spatiale. Ce cours offrira aux jeunes etudiants et chercheurs l opportunite d elargir leurs connaissances et de discuter de leurs travaux avec une communaute scientifique internationale dans un environnement chaleureux et stimulant a l Institut Curie a Paris. Keynote speakers Stein AERTS - BE Maria Elena TORRES PADILLA - DE Intervenants Tugce AKTAS - DE Maria BRBIC - CH Chunlong CHEN - FR Bart DEPLANCKE - CH Dominic GRÜN- DE Amit IDO - IL Jop KIND - NL Gioele LA MANNO - CH Ana POMBO - DE Alex RADZISHEUSKAYA - UK Alejo RODRIGUEZ FRATICELLI - ES Arjun RAJ - USA Arnau SEBRE-PEDROS - ES Sydney SHAFFER - USA Angela TADDEI - FR Barbara TREUTLEIN - CH Didier TRONO - CH
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Annonce publiée le 06-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Plus d'infos...
Annonce publiée le 28-11-2024
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Invite par: CIRB - College de France
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Tags: @cirbcdf.bsky.social
Annonce publiée le 11-12-2024
College de France
au College de France - Salle D2 acces restreint, merci de passer par l'accueil du CDF : 11 place Marcelin Berthelot - 75005 Paris -
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Tags: Koukouli, Pierrette Gaudreau, Jean Garrab
Annonce publiée le 13-11-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
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Tags: Barbosa
Annonce publiée le 19-11-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
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Tags: Delayed open access journals, Cell, Cell and molecular biology, Transfersome
Annonce publiée le 21-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Oscillations moleculaires et mecaniques L objectif general du 7e cours de biologie cellulaire et du cancer est de couvrir differents sujets en biologie cellulaire, biologie du developpement et physique, en mettant l accent sur les oscillations moleculaires et mecaniques dans les systemes biologiques. Keynote speaker Alexandre Aulehla - DE Intervenants Annabelle Ballesta - FR Thibaut Brunet, FR Clotilde Cadart- FR Mathieu Coppey - FR Stephanie Descroix - FR Silvia Fre - FR Martijn Gloerich - NL Hanspeter Herzel - DE Jean-Leon Maitre - FR Franck Perez - FR Francois Schweisguth - FR Katharina Sonnen - NL Xavier Trepat - ES
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Annonce publiée le 15-01-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
The development of complex in vitro models, such as organoids, gastruloids and organ-on-chips systems, will allow the better understanding of human biological processes that are otherwise difficult to address with classical in vitro 2D culture and/or with animal models. Elucidating how pathogens, such as the SARS-CoV-2, invade human cells by evading the immune system and how this could be modulated by the host microbiota has been greatly facilitated by the advancement of 3D cell culture techniques. For example, mimicking the gut peristalsis in gut-on-a-chip device improves the maturation of colon epithelial cells and aid to unveil the role of mechanical stress in accelerating enteropathogen invasion. Our lab is working on establishing unique advanced microphysiological systems that can mimic the interaction between human epithelial barriers with the surrounding tissues, such as blood vessels, mesenchyme and immune cells. My scientific project is focused on the establishment of lung-on-chip devices that cover the entire respiratory tract (from the nasopharynx to the alveoli) as a platform to understand airborne infections and tropism of respiratory viruses. There we relay both on the use of lung multipotent stem cells grown as organoids, in order to produce the different cell population of the respiratory tract, and on microfluidic chips. Paris Post-docs seminar series.
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Tags: Tissue engineering, Biotechnology, Stem cells, Microfluidics, Nanotechnology, Organoid, Organ-on-a-chip, Respiratory tract, 3D cell culture, Lung, Organ, Intestine-on-a-chip
Annonce publiée le 08-01-2025
Institut Cochin
Salle Rosalind Franklin -
Invited by Pascal Maire.
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Annonce publiée le 10-01-2025
Institut Cochin
Salle Rosalind Franklin -
Invite par: Théo Hirsch
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Tags: University of Leuven, In Belgium, Pierre-Joseph van Beneden
Annonce publiée le 22-12-2024
Centre de Recherche des Cordeliers
Amphi Gustave Roussy -
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Annonce publiée le 20-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Invited by Anne Hosmalin.
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Tags: Dudziak, Diana
Annonce publiée le 16-01-2025
Institut Cochin
Salle Rosalind Franklin -
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Tags: Ens, Provincial road N765
Annonce publiée le 13-11-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
Plus d'infos...
Annonce publiée le 28-11-2024
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Invite par: CIRB - College de France
Plus d'infos...
Tags: @cirbcdf.bsky.social
Annonce publiée le 11-12-2024
College de France
au College de France - Salle D2 acces restreint, merci de passer par l'accueil du CDF : 11 place Marcelin Berthelot - 75005 Paris -
Invited by Katia Ancelin and Julie Chaumeil.
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Tags: Chaumeil
Annonce publiée le 24-01-2025
Institut Cochin
Salle Rosalind Franklin -
Plus d'infos...
Annonce publiée le 20-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Invite par: CIRB - College de France
Plus d'infos...
Tags: @cirbcdf.bsky.social
Annonce publiée le 21-10-2024
College de France
au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris -
Invited by Sophie Vaulont.
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Tags: Universities UK, Russell Group, University of Birmingham, Sophie
Annonce publiée le 20-12-2024
Institut Cochin
Salle Rosalind Franklin -
Invite par: Claire Deligne
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Tags: Midwood Books, Midwood, Brooklyn
Annonce publiée le 22-12-2024
Centre de Recherche des Cordeliers
Amphi Gustave Roussy