|
Invite par: Alexandre Pierga Tags: Neutralizing antibody, Humoral immunity, Antibody, Viral vector vaccine Annonce publiée le 06-12-2024 |
  |
| IMAGINE IMAGINE, auditorium du 6eme etage, 24 boulevard du Montparnasse - 75015 |
Pour afficher les séminaires d'un seul institut, appuyer d'abord sur 'None' puis sur l'institut de votre choix.
-
-
Plus d'infos...
Annonce publiée le 29-11-2024
Academie des Sciences
23 quai de Conti - 75006 Paris -
TBA.
Plus d'infos...
Annonce publiée le 18-10-2024
Laboratoire Jean Perrin
Salle de seminaires 4eme etage - LJP - Tours 22-23 -
Invite par: CIRB - College de France
Plus d'infos...
Tags: Weinreich, Sociolinguists, Andrew Weinreich, Uriel Weinreich
Annonce publiée le 03-10-2024
College de France
au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris -
Invite par: CIRB - College de France
Plus d'infos...
Tags: @cirbcdf.bsky.social
Annonce publiée le 21-10-2024
College de France
au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris -
Invite par: Paris PostDoc seminar
Plus d'infos...
Tags: Brain tumor, Chromatin, IDH, Glioma
Annonce publiée le 06-12-2024
Centre de Recherche des Cordeliers
amphitheatre Gustave Roussy, 15 rue de l'Ecole de Medecine - 75006 -
Malaria still poses a threat to public health in tropical and sub-tropical countries with 250 million cases and 608 thousands deaths reported in year 2022 (1). The first generation of malaria vaccines, RTS,S and R21, are based on virus-like particles (VLPs) consisting of the Plasmodium falciparum (Pf) cirmcumsporozoite protein (PfCSP) fused to the surface antigen of Hepatitis B virus (HBsAg). RTS,S and Rv21 have recently being licensed and showed an efficacy of 40% (2) and 70% (3), respectively. Even though these studies have validated PfCSP as a vaccine candidate for malaria, there is a need for more effective vaccines (4). In addition, P. vivax (Pv) infection is more prevalent in the world outside Africa (5) and yet, there is no licensed vaccine for P. vivax. In this study, we have shown that PfCSP or PvCSP fused with HBsAg and delivered by mRNA secretes chimeric VLPs in HEK293 cells. Importantly, immunization with mRNA encoding these PfCSP or PvCSP fusions elicits protent antibody responses that protects mice against infection of transgenic P. berghei sporozoites expressing PfCSP or PvCSP. Therefore, these studies demonstrated it is possible to use mRNA constructs based on HBsAg fusions with malaria parasite antigens to develop vaccines for P. vivax and P. falciparum malaria. Paris Post-docs seminar series.
Plus d'infos...
Tags: Malaria, Malaria vaccine, Virus-like particle, RTS,S, HBsAg, Plasmodium falciparum, Plasmodium vivax, Vaccine, Plasmodium, Hepatitis B, Gametocyte, Malaria prophylaxis
Annonce publiée le 13-07-2024
Institut Cochin
Salle Rosalind Franklin -
Plus d'infos...
Tags: Non-coding RNA, RNA, Long non-coding RNA
Annonce publiée le 06-12-2024
NeuroDiderot
Neurodiderot, salle de conferences 6eme etage du batiment Bingen, Point Rouge, Hopital Robert Debre, 48 boulevard Serurier - 75019 ou en visio : contact = sylvie.berrard at inserm.fr -
Invite par: Julien Ferent
Plus d'infos...
Tags: Cilium, Organelles, Transition zone, Stem cells, Transcription factors, Developmental biology
Annonce publiée le 01-12-2024
Insitut du Fer à Moulin
17 rue du Fer a Moulin - 75005 -
Invite par: Nabila Bouatia-Naji
Plus d'infos...
Tags: Sudden death syndrome, Heart diseases
Annonce publiée le 06-12-2024
PARCC-HEGP
salle de conference au RDC du PARCC, 56 rue Leblanc - 75015 -
Invite par: BOUVIER Guy
Plus d'infos...
Tags: Embodiment
Annonce publiée le 05-11-2024
NeuroPSI
Salle de conference Albe-Fessard -
Plus d'infos...
Tags: Mangin, Durand, LBD, Hattab
Annonce publiée le 26-11-2024
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Plus d'infos...
Tags: Mangin, Durand, Hattab
Annonce publiée le 29-11-2024
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
My group is focused on the discovery of microproteins relevant for cellular plasticity and cancer. Using a computational method for phylogenetic analysis, we have identified 5 novel and evolutionary conserved microproteins dysregulated in cancer and in cellular differentiation/de-differentiation processes. We have experimentally validated their translation and characterized their molecular functions in vitro and in vivo. Our results demonstrate that our newly identified microproteins are novel regulators of cell identity that play important roles in diverse functions such as induction of cellular differentiation, inhibition of EMT and mitochondrial metabolism, all of them under the umbrella of tumor suppression. Our group also hypothesized that the microproteins' small size makes them ideal candidates to be shed by the cell and act as extracellular messengers. We have mined the pancreatic cancer-secreted microproteome for novel regulators of tumor progression and metastasis. Using proteogenomics in patient-derived samples, we have identified hundreds of microproteins secreted -soluble or coated in exosomes- by pancreatic tumors. The characterisation of our top candidates so far has shown that they can extrinsically promote tumor growth and metastasis. Altogether, our data advances our knowledge on the underexplored microproteome and provides pioneering evidence of its role in cancer cell plasticity and tumor communication.
Plus d'infos...
Tags: Oncology, Exosome, Vesicles, Metastasis, Pancreatic cancer, NOV, Cancer, Carcinogenesis, Tumor microenvironment
Annonce publiée le 06-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
The intricate interplay between metabolism, stress, and epigenetics in immune cells plays a pivotal role in the pathogenesis of diseases such as Glioblastoma and Sepsis. My external seminar will explore how metabolic reprogramming and epigenetic modifications influence immune cell function in these diseases, with a focus on myeloid cells. Leveraging advanced single-cell technologies, we are investigating how these internal and external cues shape immune responses, and whether these changes are present in immune cell precursors. I will introduce novel tools developed by our team to study metabolism and epigenetics at single-cell resolution in patient samples, aiming to shed light on the early immunometabolic states that dictate long-term immune responses. These innovative platforms, including SCENITH™ and its expantion into the spatial and epigenetics fields enable detailed metabolic profiling with spatial and multi-omic potential at the single-cell level, offering new insights into cellular function within the tumor microenvironment and septic conditions. In addition, I will present SNUPR, a cutting-edge methodology designed to profile the unfolded protein response (UPR) and predict therapeutic responses to Bortezomib in patients with multiple myeloma. SNUPR holds promise for improving patient outcomes by identifying biomarkers that can guide personalized treatment strategies. By integrating spatial, multi-omics, and single-cell technologies, our goal is to translate these discoveries into clinical applications, improving diagnostic precision and therapeutic interventions in cancer and sepsis. The findings I will discuss represent a step forward in understanding immunometabolism and its implications for trained immunity in both pediatric and adult patients, ultimately aiming to bridge the gap between fundamental research and clinical impact.
Plus d'infos...
Tags: Immunology, Molecular biology, Immunometabolism, Metabolism, Biotechnology, Multiomics, Omics, Trained immunity, Induced pluripotent stem cell, Immunological memory
Annonce publiée le 06-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Invite par l’equipe Gazave, Laurent Formery (Department of Biology, Stanford University) presentera un seminaire de l’Institut Jacques Monod sur le theme : Echinoderm evolution: Testing the limits of axial patterning plasticity Resume : The discovery that distantly related animals establish their body plans through conserved developmental programs is one of the most transformative findings in evolutionary biology. Similar antero-posterior (AP) and dorso-ventral (DV) patterning programs have now been identified in a large sample of bilaterian animals. However, because most of the species that we have investigated so far follow the basic blueprint of the bilateral symmetry, it remains unclear whether, in case of drastically divergent body plan evolution, these patterning program are flexible enough to support major deviation from bilateral symmetry, or if they act as developmental constraint on body plan diversity that need to be disassembled first. My research aims to investigate this question using echinoderms, which evolved a unique pentaradial symmetry and represent a fascinating natural experiment on body plan plasticity. By looking at adult body plan development in sea stars, brittle stars and sea cucumbers using modern molecular tools, I have been able to identify that some part of the antero-posterior patterning program are highly conserved during the formation of the pentaradial body plan, albeit in an unexpected spatial configuration. This indicates that despite the absence of a morphological AP axis, the molecular system used for AP patterning is surprisingly tolerant to radical morphological changes. With these new molecular data, we are now starting to piece together the evolution of axial properties across echinoderm classes and with their bilateral relatives. Beyond the fascinating history of this particular phylum, these data are important to decipher to what extent conserved molecular programs have shaped the evolution of morphological novelty.
Plus d'infos...
Tags: Evolutionary biology, Animal anatomy, Developmental biology, Symmetry, Symmetry in biology, Bilateria, Body plan, Evolution
Annonce publiée le 19-11-2024
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Invite par: Ahmed Hamai - GH and PRL pathophysiology (V. Goffin)
Raphael Rodriguez is a Research Director at the CNRS and a Principal Investigator at Institut Curie where he holds the Sk?odowska-Curie Chair of Chemical Biology. He acquired the knowledge of chemistry and biology in the United Kingdom under the mentorships of Sirs J. E. Baldwin, S. Balasubramanian and S. P. Jackson (2004-2012). He then established his lab in France to investigate the molecular bases of cancer metastasis and inflammation. He discovered the central role of metals as regulators of cell identity and elucidated basic cellular mechanisms of ferroptosis. Rodriguez has received a Knighthood of the National Order of Merit from Jean-Marie Lehn and a few accolades including the Liliane Bettencourt Prize for Life Sciences and the Tetrahedron Young Investigator Award in Bioorganic and Medicinal Chemistry.Seminar topic: Chemical control of cell identity
Plus d'infos...
Tags: Carnot label, Curie Institute, Marie Curie, Curie
Annonce publiée le 18-11-2024
Institut Necker Enfants Malades
Auditorium 1 -
Invite par: Helene MORLON - Section Ecologie et Biologie de l’Evolution
Abstract : The genetics of speciation is often underpinned by relatively simple genetic determinisms, such as pairwise genetic incompatibilities, which form the conceptual basis for barrier loci. Barrier loci restrict gene flow between the genomes of diverging species, both genome-wide and more intensively within specific chromosomal regions surrounding them. Barrier loci are traditionally identified through three approaches : (i) mapping chromosomal islands of divergence across hybrid zones, (ii) mapping segregation distortions in hybrid crosses, and (iii) mapping ancestry outliers in admixed populations. In the marine mussels Mytilus edulis and M. galloprovincialis, we applied all three approaches. While islands of divergence were detected between these two species, which diverged approximately 2 million years ago, the latter two methods yielded inconclusive results. In order to reconcile these observations, we developed a simple multigenic fitness landscape model. The model predicts that, in a novel environment where parental species are maladapted, an admixed population can rapidly achieve higher fitness than either parent by combining advantageous parental mutations in recombined mosaic genomes. Notably, this result does not contradict the persistence of a strong barrier to gene flow between parental species or the resistance of genomic islands to secondary introgression. Our model therfore explains the absence of ancestry outliers in a newly admixed lineage of mussels adapted to a human-altered environment. Furthermore, the model’s high-dimensional epistasis predicts that strong selection against an introgressed mutation does not necessarily result in pronounced segregation distortions in a uniformly admixed F2 hybrid background. This approach introduces a genome-wide alternative to the ancestry outlier framework and provides insights into the genetic mechanisms underlying hybrid fitness in changing environments.
Plus d'infos...
Tags: Population genetics, Evolutionary biology, Genetic admixture, Hybrid, Introgression, Gene flow, Mutation, Reproductive isolation, Eukaryote hybrid genome
Annonce publiée le 30-11-2024
IBENS
salle Favard, IBENS 46 rue d'Ulm 75005 Paris -
Plus d'infos...
Tags: PAK3, Paris-Saclay University, Intellectual disability
Annonce publiée le 16-11-2024
NeuroPSI
Salle de conference Albe-Fessard -
Abstract will appear here.
Plus d'infos...
Tags: ESPCI Paris, ParisTech
Annonce publiée le 31-08-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
Invite par: ESCARTIN Carole
Plus d'infos...
Tags: STXBP1
Annonce publiée le 19-10-2024
NeuroPSI
Salle de conference Albe-Fessard -
Invite par: Barbara Pistilli
Raffaele Colombo is an Associate Director, Medicinal Chemistry at Zymeworks [a global biotechnology company committed to the discovery, development, and commercialization of novel, multifunctional biotherapeutics]. He has 15 years of experience in drug conjugates and is passionate about the intricacies and nuances of ADCs. He earned his Ph.D. in Organic and Medicinal Chemistry from the University of Milan (Italy), working on small molecule drug conjugates. He then moved to the University of Pittsburgh as part of the NCI's Chemical Biology Consortium (CBC), a discovery engine for the NCI Experimental Therapeutics (NExT) program. In 2014, he was awarded one of the prestigious Lilly Innovation Fellowship Award (LIFA) and joined Eli Lilly in Indianapolis, where he developed novel ADC payloads and linkers. He then moved to MedImmune/AstraZeneca, focusing solely on ADC research. In 2020, he joined Zymeworks to lead the medicinal chemistry team to develop novel technologies for ADCs. This year, he has been named an honoree of prestigious PharmaVoice 100 list, which recognizes the most inspiring leaders in the life sciences industry.
Tags: Biotechnology, Antineoplastic drugs, Immunology, Antibodydrug conjugate
Annonce publiée le 06-12-2024
Gustave Roussy
Gustave Roussy, salle Pierre Denoix +15 du batiment principal (ascenseur C) -
TBA
Plus d'infos...
Tags: Pascal, Ms. Pat Settles It, Draft:2024 Ferrari Challenge Europe
Annonce publiée le 03-09-2024
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407 -
Prof. Yaniv is the Head of the Aharon Katzir-Katchalsky Center (Weizmann Institute of Science). Her lab seeks to elucidate the cellular and molecular mechanisms governing the formation of blood and lymphatic vessels during embryonic development, organogenesis and regeneration. During her postdoctoral studies Dr. Yaniv identified and characterized the well-established lymphatic system of the zebrafish (Nat. Med., 2006), and has since continued studying the cellular origins and molecular mechanisms controlling the formation of lymphatic vessels, at her own lab. Taking advantage of the ability of zebrafish to efficiently regenerate most of their organs, the Yaniv lab investigates the involvement of lymphatic vessels in the processes of tissue inflammation, fibrosis, repair and regeneration. Among her academic and professional awards and honors are the Levinson Prize in Biology (2017), the Wendy Chaite Leadership Award by the Lymphatic Education and Research Network (2016), ERC-StG (2013), ERC-CoG (2018), the Israel Cancer Research Foundation Career Development Award (2012), the Werner-Risau-Prize for outstanding research in vascular biology (2007), an EMBO postdoctoral fellowship (2005-2007), a Susan G. Komen Young Investigator Scholarship from the Lymphatic Research Foundation (2006), and a Golda Meir Foundation prize for excellence (2003), EVBO Lecture Award (2024) and the most recent one ERC-SyG (2024). Karina Yaniv is invited by Diana Passaro.
Plus d'infos...
Tags: Karina Yaniv
Annonce publiée le 03-12-2024
Institut Cochin
Salle Rosalind Franklin -
The last decade of research in the field of experimental hematology revealed an extensive degree of heterogeneity in the hematopoietic stem and progenitor (HSPCs) compartment. Evidence of lineage priming and diverse differentiation potential for otherwise homogeneous populations have been collected, for both mouse and human cells. In stark contrast, little is known about the proliferative potential of those cells, beside stem cell quiescence. Cell division control and the impact on cellular dynamics is largely unknown. In this talk, I will describe how HSPCs sharing a common ancestry divide and differentiate, extrapolating some of the organising principles underlying the normal hematopoietic system. I will show how pathological hematopoiesis (acute and chronic leukemia) reveals a degradation of those properties, and how it can be reverted ex vivo.
Plus d'infos...
Tags: Developmental biology, Hematopoiesis, Histology, Stem cells, Biotechnology, Haematopoietic system, Haematopoiesis, Cellular differentiation, Hematopoietic stem cell, Adult stem cell
Annonce publiée le 06-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Invited by Anne Hosmalin.
Plus d'infos...
Tags: Solan, Karolinska Institute
Annonce publiée le 25-10-2024
Institut Cochin
Salle Rosalind Franklin -
Invited by Molly Ingersoll.
Plus d'infos...
Tags: Ingersoll, Ontario, Ingersoll, Molly
Annonce publiée le 04-12-2024
Institut Cochin
Salle Rosalind Franklin -
In this talk, I will discuss our latest advancements in both experimental and computational cellular barcoding. Firstly, I will introduce our novel computational tools designed for both biologists and bioinformaticians to study cell lineages using artificial and natural barcodes. Next, I will present the in situ DRAG barcoding system, which enables the study of hematopoietic stem and progenitor cells (HSPCs) in their native niche. Combining DRAG barcoding with single-cell transcriptomics and metabolomics, we revealed that a subset of multipotent progenitors that have higher activity of the pentose phosphate pathway are myeloid-biased. These results show that HSPCs undergo significant metabolic changes to facilitate the bioenergetic and epigenetic demands of myeloid lineage specification. Finally I will present a new method we have developed to count division in vivo, the DivisionCounter. While approximately 44 divisions are needed to produce without death all 10^13 cells in the human body, current methods are limited to count 10 cell divisions in vivo across diverse mammalian cell types. The DivisionCounter, counts cell division in vivo over large division ranges (~70 divisions) using an easy fluorescence readout. We demonstrate that the DivisionCounter accurately measures the average cell division count of cells both in vitro and in vivo. Its use revealed that leukemia tumor division rates are independent of the organ&'s specific microenvironment and CAR-T cell treatment, providing an estimate of tumor death rates in vivo. The DivisionCounter method holds unique potential for quantifying contributions of cell division, death, and migration to the growth of healthy and pathological mammalian tissues.
Plus d'infos...
Tags: Cell cycle, Cellular processes, Cell division, Telomeres, Tumor microenvironment
Annonce publiée le 06-12-2024
Centre de Recherche des Cordeliers
amphitheatre Gustave Roussy, 15 rue de l'Ecole de Medecine - 75006 -
Plus d'infos...
Tags: Lung cancer, Cancer, Carcinoma, Lung cancer susceptibility, Lung cancer in Australia
Annonce publiée le 06-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Invite par: Simon Fillatreau amp; Peter van Endert
Alexander Scheffold studied Chemistry in Freiburg and Cologne from 1986-1992, Diploma thesis at Miltenyi Biotec. In 1997 he received his PhD at the University of Cologne with Andreas Radbruch. From 1997 to 2007 he established his own lab at the DRFZ Berlin focussing on the T cell-mediated regulation of inflammatory disease. From 2007-2011 he was heading a research group at Miltenyi Biotech developing T cell therapies. From 2012-2018 he was assistant professor of cellular immunology at the Charite-Universitatsmedizin Berlin. Since April 2018 he is the director of the Institute of Immunology at the Christian-Albrechts-Universitat zu Kiel and the Universitatsklinikum Schleswig-Holstein. His research focus is the T cell-mediated regulation of tolerance and immunity or immune pathology in humans. His group has developed sensitive methods to characterise in detail T cells that react against specific antigens relevant to allergies, inflammatory bowel diseases, infectious diseases or autoimmunity. His work provided insights into the role of antigen-specific T cells and regulatory T cells in human immune-mediated disease, such as autoimmunity, allergy and chronic inflammation. His work forms the basis for the development of antigen-specific diagnostics and therapies for chronic inflammatory diseases.Seminar topic: Autoantigen-specific CD4 T cell exhaustion in human autoimmune disease
Plus d'infos...
Tags: Immunology, T cells, Immune system, Clusters of differentiation, Infectious diseases, Autoimmunity, T helper cell, CD4, Immune tolerance, CD4 immunoadhesin, Protective autoimmunity
Annonce publiée le 19-11-2024
Institut Necker Enfants Malades
Auditorium 1 -
Prof. Erwei Song obtained his MD and Ph.D. at Zhongshan Medical School, and was trained as a surgeon at Sun Yat-sen Memorial Hospital, SYSU. He received post-doctoral training at Harvard Medical School in 2002 and became an instructor at the CBR Institute of Biomedical Research at Harvard in 2004. He is currently serving as Director of Health Science Center and President of Sun Yat-sen Memorial Hospital, SYSU. As a clinical scientist, he is keen to address scientific questions derived from clinical practice. He is the pioneer of breast-conserving surgery (BCS) in China, a new surgical concept in contrast to mastectomy, which preserves breast microenvironment tissues for the activation of anti-tumor immunity. As a surgeon, Erwei has compiled the first Chinese Experts Guidelines for Breast-conserving Surgeries of Early Breast Cancer. His early publication RNA interference targeting Fas protects mice from fulminant hepatitis ? in Nature Medicine was the first to report that siRNA could be used therapeutically in whole animal disease models. This finding was selected as one of the Top Ten breakthroughs of the year 2003? by Science , and has paved the foundation for clinical RNAi therapeutics. In 2022, Trends in Immunology published a feature review of his proposal of effector immune cell deployment (EICD)?, a revolutionary concept that depicts the most comprehensive approach to reflect cold and hot tumor immunotyping, which includes the priming, circulation, activity, trafficking, and fate of antitumor effector immune cells. In over 30 years of immunological research, he has uncovered important subtypes of cancer-associated immune cells, receptors, juxtracrine and pathways that has resulted in a paradigm shift in the field of cancer immunotherapy. He discovered various new subtypes of cancer-associated immune cells and mesenchymal cells, and elaborated on their mechanisms, providing new insights for cancer immunotherapy. Erwei recently proposed the Theory of Tumor Ecosystem ?, which emphasizes on the importance of viewing cancer as a viable ecosystem where host internal environment is vital for cancer cell survival and growth. On November, 2022, Erwei was awarded with The World Academy of Sciences (TWAS) in Medical Sciences for proposing and reinforcing the Theory of Tumor Ecosystem?. His latest book on Tumor Ecosystem: an ecological view of cancer growth and survival? was published by Springer Nature Publishing in June 2023.
Plus d'infos...
Tags: Cancer immunotherapy, Tumor microenvironment, Immunotherapy, Biotechnology, Cancer vaccines, Genomics
Annonce publiée le 06-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
Plus d'infos...
Annonce publiée le 28-11-2024
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Two researchers recruited by Inserm in 2024 will present their research projects: Delphine Judith and Luca Simula.
Plus d'infos...
Tags: Munimuni, Simula, Inserm, Delphine, Simula Research Laboratory
Annonce publiée le 25-10-2024
Institut Cochin
Salle Rosalind Franklin -
Invite par: Laurie Menger
The current price for cellular gene therapy products like CAR-T and stem cell gene therapy, not including hospital costs, is at least $350,000 and can be up to and over $3,000,000 per dose. Such pricing is not sustainable in high-income countries, let alone in low- and middle-income countries, leaving many without access to these potentially life-saving therapies. A centralized model currently used for the manufacture and distribution of commercial CAR-T cells drives up their cost due to the logistical and infrastructure needs of this model. A more cost-effective way is to manufacture the final CAR-T cell product locally at the point-of-care. Multiple studies have shown that the overall response rate of a CAR-T cell therapy for adult B-cell Lymphoma and Pediatric Leukemia using locally manufactured CAR-T cells produced outstanding clinical outcomes. Caring Cross is collaborating with clinical centers around the world to develop and improve the access of CAR-T and other gene-modified cellular therapies that are manufactured locally at, or close to, the hospitals treating the patients needing these therapies. This place-of-care manufacturing, when combined with short, economical and robust manufacturing processes, significantly reduces the costs of manufacturing CAR-T and other gene-modified cellular products and promises to improve their affordability and access around the world. Caring Cross is making available a pipeline of cellular gene therapy products to hospital-based investigators for clinical development with the aim to take these products to regulatory approval and reimbursement
Tags: Biotechnology, Genetic engineering, Cell biology, Medicinal chemistry, CAR T cell, Immune system, Gene therapy, Cell therapy, Therapy, Engineered CAR T cell delivery
Annonce publiée le 06-12-2024
Gustave Roussy
Gustave Roussy, salle Pierre Denoix, +15 du batiment principal (ascenseur C) -
Abstract will appear here.
Plus d'infos...
Annonce publiée le 10-09-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
TBA
Plus d'infos...
Tags: Monaco at the 2013 Mediterranean Games, Damien Desprat
Annonce publiée le 20-09-2024
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407 -
Invite par: CIRB - College de France
Plus d'infos...
Tags: @cirbcdf.bsky.social
Annonce publiée le 21-10-2024
College de France
au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris -
Macrophages are phagocytic immune cells providing tissue-adapted and -imprinted homeostatic functions. Among key macrophage populations, splenic metallophilic marginal zone macrophages are positioned to sense and control dissemination of bloodborne threats. However, they have escaped thorough characterization for technical reasons. Using a novel purification protocol, we clearly defined MMMs phenotypically and identified their unique gene expression profile positioned for CD8+ T cell activation and MHC class I cross-presentation. In vitro, we showed that purified MMMs equal conventional dendritic cells type 1 (cDC1s) in cross-priming antigens yet employing a distinct, vacuolar processing pathway. In vivo biphoton and ex vivo light-sheet imaging showed long-standing contacts with cognate T cells differentiating to effectors. Moreover, we showed that MMMs cross-prime protective CD8+ T cell antitumor responses both by capturing blood-borne tumor antigens and by internalizing tumor cells seeding the spleen. Critically, this requires Batf3 expression by MMMs but is independent of cDC1s capturing tumor material for cross-presentation or cross-dressed with MHC-I molecules presenting tumor antigens. Paris Post-docs seminar series.
Plus d'infos...
Tags: Immunology, Immune system, T cells, Lymphatic system, Phagocytes, Cross-presentation, Macrophage, Marginal zone, Dendritic cell, Tumor antigen, Sialoadhesin, Priming
Annonce publiée le 29-10-2024
Institut Cochin
Salle Rosalind Franklin -
The two GDRs AQV (Quantitative approaches to living systems) and IMABIO (Imaging in Biology) are organising a joint workshop on 16 January 2025 at the Institut Jacques Monod in Paris on new microscopies in cell biology. The aim is to bring together scientists from biology, physics, engineering and data science to discuss new imaging strategies for : measuring physical descriptors of cellular organisation and function; improving imaging resolution; making smart microscopes more effective at capturing processes of interest. Confirmed speakers : Juliette Azimzadeh, Institut Jacques Monod, Paris Victor Barolle, Institut Langevin, Paris Ricardo Henriques, Instituto Gulbenkian de Ciencia, Oeiras and University College London Kheya Sengupta, Interdisciplinary Centre for Nanoscience, Marseille Vincent Studer, Interdisciplinary Neuroscience Institute, Bordeaux Ilaria Testa, KTH Royal Institute of Technology, Stockholm Oral presentations and posters will also be selected from the abstracts submitted. Registration is free but compulsory and is now open here: https://newmic4cellbio2.sciencesconf.org/ The organisers Pierre Bon, Nicolas Borghi, Cecile Leduc, Loic Le Goff, Pierre-Henri Puech
Plus d'infos...
Tags: Institut Jacques Monod, Jacques Monod
Annonce publiée le 11-11-2024
Institut Jacques Monod
Institut Jacques Monod Amphitheatre Buffon, 15 rue Helene Brion, Paris, France -
Plus d'infos...
Tags: Irene Miguel-Aliaga, Physiologists, Irene, Geely Geometry, Aliaga
Annonce publiée le 06-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Plus d'infos...
Tags: Pixelation, Immunology
Annonce publiée le 06-12-2024
Institut Curie
Centre de recherche - Paris - Webinar -
Plus d'infos...
Annonce publiée le 02-12-2024
Academie des Sciences
23 quai de Conti - 75006 Paris -
Invite par: Vincent Goffin - GH and PRL pathophysiology
Wilbert Zwart completed his PhD at the Netherlands Cancer institute (NKI; Amsterdam) in 2009, and received is post-doctoral training at the CRUK-CI in Cambridge (UK), in the lab of prof. Jason Carroll. Since 2011, Wilbert runs his independent research lab at the NKI studying hormone-dependent cancers, focusing on hormone receptor biology, epigenetics and gene regulation. His projects have a full circleFunctional Genomics in Oncology Hormones, Epigenetics and Cancer: From Clinical Trials to Molecular Mechanisms and Back Again
Plus d'infos...
Tags: Cancer, Oncology
Annonce publiée le 29-11-2024
Institut Necker Enfants Malades
Auditorium 3 -
Invite par: CIRB - College de France
Plus d'infos...
Tags: @cirbcdf.bsky.social
Annonce publiée le 21-10-2024
College de France
au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris -
Three researchers recruited by CNRS or Inserm in 2024 will present their research projects: Clotilde Cadart, Caroline Eozenou, Suzanne Faure-Dupuy.
Plus d'infos...
Tags: French National Centre for Scientific Research, Inserm, Dupuy
Annonce publiée le 30-10-2024
Institut Cochin
Salle Rosalind Franklin -
Ana-Maria Lennon Duménil is invited by Fatah Ouaaz.
Plus d'infos...
Tags: Carnot label, Curie Institute, Curie
Annonce publiée le 05-06-2024
Institut Cochin
Salle Rosalind Franklin -
Invite par: Fabiola Terzi
Philippe Pierre is an international leader in dendritic cell biology and innate immunity research. During his PhD at the EMBL (Heidelberg, Germany), his research focused on the characterization of the microtubule-binding protein CLIP-170. After a post-doctoral research period at Yale University School of Medicine (USA), he focused on MHC II-restricted antigen presentation and immune response. In 2000, he created his laboratory at the Centre d 2015 Prize" for molecular immunology from the French Academy of Sciences. He was the director of the CIML until 2024 and is professor-adjunct of the University of Aveiro (IBiMED, Portugal) and the Shanghai Institute of Immunology (SII, PRC).Seminar topic: Functional consequences of endo-lysosomes mispositioning in phagocytes: A RUFY3/4 story!
Plus d'infos...
Tags: Immune system, Vesicles, Centre d'immunologie de Marseille-Luminy, Phagocyte, Lysosome, Immunology, Dendritic cell, Innate immune system
Annonce publiée le 29-11-2024
Institut Necker Enfants Malades
Auditorium 3 -
Plus d'infos...
Annonce publiée le 28-11-2024
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
TBA
Plus d'infos...
Tags: Draft:List of wars lost by israel, Mister RNB Espaa
Annonce publiée le 18-05-2024
Laboratoire Jean Perrin
Salle de seminaires 4eme etage - LJP - Tours 22-23 -
Invited by Florence Margottin-Goguet
Plus d'infos...
Tags: Lentiviruses, Antiviral protein, HIV, Virus, Zinc finger, Antiviral drug, Virology, Simian immunodeficiency virus
Annonce publiée le 28-11-2024
Institut Cochin
Salle Rosalind Franklin -
Abstract will appear here.
Plus d'infos...
Tags: Boisbriand
Annonce publiée le 10-09-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
Anti-PD-1 therapy targets intratumoral CD8+ T cells to promote clinical responses in cancer patients. Recent evidence has suggested that anti-PD-1 also act in the periphery. In particular, new T cell clonotypes emerge during anti-PD-1 therapy within the tumor microenvironment, suggesting de novo priming in the periphery. However, the underlying mechanism remains incompletely understood. In this presentation, I will show the importance of TDLN during anti-PD-1 therapy and discuss unexpected mechanisms for the peripheral activity of anti-PD-1 antibodies Paris Post-docs seminar series.
Plus d'infos...
Tags: Immune system, Immunology, Clusters of differentiation, Programmed cell death protein 1, Tumor microenvironment, T cell, Pd1, Antibody, Cancer immunotherapy, Dario Angelo Alberto Vignali
Annonce publiée le 29-11-2024
Institut Cochin
Salle Rosalind Franklin -
Save the date! The Single Cell Initiative, the Cell and Tissue Imaging Platform (PICT) and the Experimental Pathology (PATHEX) core facilities co-organise an afternoon dedicated to spatial omics at Institut Curie. Meet the core facilities and discover how your colleagues apply spatial omics technologies in their research! Agenda, registration link and more information to come soon.
Plus d'infos...
Tags: Genomics, Omics, OMICS Publishing Group
Annonce publiée le 06-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Invited by Pascal Maire.
Plus d'infos...
Tags: Maire, Municipal governments in Saint Pierre and Miquelon, When Do You Commit Suicide?
Annonce publiée le 04-12-2024
Institut Cochin
Salle Rosalind Franklin -
Plus d'infos...
Annonce publiée le 28-11-2024
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Mitochondria are double membrane-bound organelles that perform biosynthetic and signaling roles to control the life and death of the cell. Mitochondria are paramount to the metabolism and survival of cardiomyocytes, which have the most densely packed inner mitochondrial membrane of all cells. Cardiomyocytes are exquisitely sensitive to perturbations of mitochondrial structure, which can lead trigger downstream maladaptive and compensatory responses. In my talk, I will share our latest, unpublished findings using mouse models we have developed that have revealed the importance of inner mitochondrial membrane integrity in restraining cardiac inflammation and the emerging effects that biological sex can have on these phenomena. Timothy Wai is invited by Molly Ingersoll and Catherine Postic.
Plus d'infos...
Tags: Membrane biology, Mitochondria, Cellular respiration, Mitochondrion, Inner mitochondrial membrane, Cell membrane, Cell biology, MFN2
Annonce publiée le 29-11-2024
Institut Cochin
Salle Rosalind Franklin -
Plus d'infos...
Tags: ICM, Piti-Salptrire Hospital
Annonce publiée le 13-11-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
Proteins in cells are not homogeneously distributed, but often localized to specific compartments, which may or may not be enclosed by membranes.
Here I will first discuss the dynamic formation of membraneless compartments in the non-equilibrium environment of living cells and how this formation can be regulated, e.g. by kinases [1]. Then I will show how single-molecule FRET (smFRET) and tracking of biomolecules can be used to study conformational dynamics and time-resolved cellular localization in living cells [2]. Results with the transcription initiation factor TAF2 show that the same protein can be in different compartments and thereby have different functions [3]. For the heat shock protein Hsp90 we will determine how proteins may be recruited to different compartments and have different conformational dynamics.
Altogether, smFRET has the potential to change our view on compartment-specific protein dynamics and therefore signalling within living cells.
[1] C. Lan, J. Kim, S. Ulferts, F. Aprile-Garcia, A. Anandamurugan, R. Grosse, R. Sawarkar, A. Reinhardt and T. Hugel, Nat. Commun., 14:4831 2023 (https://doi.org/10.1038/s41467-023-40540-2)
[2] A. Anandamurugan, A. Eidloth, P. Wortmann, L. Schrangl, F. Aprile-Garcia, C. Lan, R. Sawarkar, G. J. Schütz, T. Hugel, bioRxiv 2023 (https://doi.org/10.1101/2023.09.15.557875)
[3] T. Bhuiyan, P. K. Mendoza Sanchez, N. Arecco, J. Kim, S. Nizamuddin, A. Prunotto, M. Tekman, M. L. Biniossek, S. Koidl, T. Hugel, S. J. Arnold, bioRxiv 2024, (https://doi.org/10.1101/2024.02.05.578926)
Plus d'infos...
Tags: Single-molecule FRET, Live single-cell imaging, DEP domain
Annonce publiée le 12-09-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Invited by Anne Hosmalin.
Plus d'infos...
Tags: Karolinska Institute, Solna
Annonce publiée le 30-11-2024
Institut Cochin
Salle Rosalind Franklin -
TBA
Plus d'infos...
Tags: Morvan, Ghislain
Annonce publiée le 23-11-2024
Laboratoire Jean Perrin
Salle de seminaires 4eme etage - LJP - Tours 22-23 -
Invite par: CIRB - College de France
Plus d'infos...
Tags: @cirbcdf.bsky.social
Annonce publiée le 21-10-2024
College de France
au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris -
Ce cours explorera la polyvalence des elements d ADN non geniques et des ARN non codants dans un large eventail de processus cellulaires, chez l humain et les organismes modeles, ainsi que leur implication dans la physiologie et les maladies. Il elargira les sujets autour des domaines de la genomique, de l epigenetique et de la transcriptomique, y compris les technologies et analyses a cellule unique, la regulation de l'epigenome et de l expression des genes, l organisation du genome et la clonalite cellulaire. Des experts reconnus a l international presenteront leurs dernieres decouvertes concernant l identification et la caracterisation fonctionnelle du genome non codant, et discuteront des nouveaux concepts en matiere de regulation et d evolution du genome, avec un fort accent sur les outils experimentaux et informatiques. Les sessions thematiques incluront l analyse computationnelle de l heterogeneite cellulaire, les methodes d evaluation de l heterogeneite et de la plasticite cellulaire, l epigenome dans la regulation de l expression des genes, les retroelements dans la plasticite cellulaire, le genome "sombre" dans l identite et la clonalite cellulaire, ainsi que l organisation spatiale. Ce cours offrira aux jeunes etudiants et chercheurs l opportunite d elargir leurs connaissances et de discuter de leurs travaux avec une communaute scientifique internationale dans un environnement chaleureux et stimulant a l Institut Curie a Paris. Keynote speakers Stein AERTS - BE Maria Elena TORRES PADILLA - DE Intervenants Tugce AKTAS - DE Maria BRBIC - CH Chunlong CHEN - FR Bart DEPLANCKE - CH Dominic GRÜN- DE Amit IDO - IL Jop KIND - NL Gioele LA MANNO - CH Ana POMBO - DE Alex RADZISHEUSKAYA - UK Alejo RODRIGUEZ FRATICELLI - ES Arjun RAJ - USA Arnau SEBRE-PEDROS - ES Sydney SHAFFER - USA Angela TADDEI - FR Barbara TREUTLEIN - CH Didier TRONO - CH
Plus d'infos...
Annonce publiée le 06-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Plus d'infos...
Annonce publiée le 28-11-2024
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Plus d'infos...
Tags: Koukouli, Pierrette Gaudreau, Jean Garrab
Annonce publiée le 13-11-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
Plus d'infos...
Tags: Barbosa
Annonce publiée le 19-11-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
Plus d'infos...
Tags: Ens, Provincial road N765
Annonce publiée le 13-11-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
Plus d'infos...
Annonce publiée le 28-11-2024
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris