Invite par: Sylvie Granon Plus d'infos... Annonce publiée le 22-02-2023 Tweet |
![]() ![]() |
NeuroPSI Salle de conference Albe-Fessard |
Invite par: Sylvie Granon Plus d'infos... Annonce publiée le 22-02-2023 Tweet |
![]() ![]() |
NeuroPSI Salle de conference Albe-Fessard |
Integrating information over long-time scales is a critical component of most circuit computations in the brain across species. However, it remains poorly understood how such dynamics are implemented mechanistically. One idea is that slow time constants are implemented via recurrent connectivity of balanced excitation and inhibition. Dissecting such neural circuits requires precise knowledge of functional neural properties and correlating dynamics with the underlying wiring diagram, ideally, within the same individual animal (neurotransmitter identity, anatomy, and connectivity).
To address this issue, we have developed a visual motion integration task in larval zebrafish and tools to combine functional calcium imaging with ultrastructural circuit reconstruction. We have recently complemented this approach involving an existing whole-brain connectomics resource as well as targeted fluorescent labeling of functionally identified neuronal response types. Our results will allow us to rapidly validate and constrain existing network models, and add resolution and confidence to previously proposed circuit arrangements at a reduced cost. Tags: Neuroscience, Computational neuroscience, Anatomy, Connectomics, Brain, Neural circuit, Biology Annonce publiée le 18-01-2023 Tweet |
![]() ![]() |
Ecole Polytechnique To be annonced |
Invite par: Emmanuelle Fabre Stem cells play a fundamental role in the maintenance of adult tissue architecture and must be shielded from viral infections. However, the protection conferred by the interferon pathway is severely compromised stem cells, which lack key components of the pathway. Despite this, stem cells are largely resistant to viruses, which can be attributed in part to the steady-state expression of interferon-stimulated genes. Nonetheless, immune responses in stem cells remain poorly characterised. In invertebrates and plants, antiviral immunity relies on RNA interference (RNAi), which is initiated by the cleavage of viral double-stranded RNA (dsRNA) by a Dicer protein. In mammals, a single Dicer gene has been described, which encodes a Dicer protein that cleaves dsRNA only poorly. Whether antiviral RNAi exists in mammalian cells remains highly controversial. In this work, we identify a new Dicer isoform produced from the human and mouse Dicer gene that is better able to process dsRNA than canonical Dicer. This isoform, termed antiviral Dicer (aviD) is preferentially expressed in stem cells within adult tissues. Using a model of brain organoid infected with Zika virus or SARS-CoV-2, we demonstrate that aviD protects adult stem cells from RNA viruses by mounting a canonical antiviral RNAi response. This work highlights the composite nature of antiviral immunity in mammals, tailored to the differentiation status of the cell. Plus d'infos... Annonce publiée le 13-03-2023 Tweet |
![]() ![]() |
UMR7212-U944 Batiment Jean Bernard INSERM U944 UMR7212 Hopital St Louis 16 rue de la Grange aux Belles 75010 PARIS |
Invite par: Jean-Antoine Girault Plus d'infos... Annonce publiée le 14-01-2023 Tweet |
![]() ![]() |
Insitut du Fer à Moulin 17 Rue du Fer a Moulin - 75005 Paris |
Invited by Michaela Fontenay Plus d'infos... Tags: Sarry, Fontenay Annonce publiée le 12-01-2023 Tweet |
![]() ![]() |
Institut Cochin Salle Rosalind Franklin |
Plus d'infos... Annonce publiée le 04-03-2023 Tweet |
![]() ![]() |
NeuroPSI Salle de conference Albe-Fessard |
Invited by Sebastien Leon, Isabelle Sagot (Institut de Biochimie et Genetique Cellulaires #8211; IBGC, Bordeaux) will give an IJM Seminar entitled: The cell biology of quiescent yeast Cells perpetually face the decision to proliferate or to enter a non-dividing state. Quiescence, a state defined as a reversible arrest of proliferation, is the most common cellular situation found on earth, as it concerns all kind of cells, from microbes to human stem cells. Quiescent cells not only have to survive and face age but they must also preserve their ability to re-enter the cell cycle in a tightly regulated manner, and give rise to a healthy progeny. Therefore quiescence is at the heart of crucial biological issues including development, aging and evolution. Yet, astonishingly little is known about the molecular determinants that orchestrate quiescence establishment and exit. We are using both single cell eukaryotes and mammalian models to study the cell biology of quiescence. In the past years, we have shown that upon quiescence entry, cells assemble specific structures that display original properties, including actin and microtubule hyper-stable arrangements. Our project is to study these structures and use them as tools to address central questions such as: how do quiescent cells survive and what are the cascade of molecular switches that tightly control the transitions between quiescence and proliferation. Plus d'infos... Tags: Branches of biology, Cell biology, Cell cycle, Cellular senescence, Biology, Quiescence, Actin, G0 phase Annonce publiée le 03-02-2023 Tweet |
|
Institut Jacques Monod Usually at 11.45 am in the François Jacob room |
Invite par: Sylvie Chollet-Martin Plus d'infos... Tags: Air pollution, Respiratory health Annonce publiée le 12-03-2023 Tweet |
![]() ![]() |
UMR-996 INSERM UMR-996 INSERM, batiment Henri Moissan -HM1, 17 avenue des Sciences, Orsay |
Invite par: Andrew Davison Plus d'infos... Tags: Computational Neurophysics computing systems Annonce publiée le 10-03-2023 Tweet |
![]() ![]() |
NeuroPSI Salle de conference Albe-Fessard |
Invite par: Xavier MORIN - Section Biologie du Developpement Plus d'infos... Tags: Branches of biology, Centrosome, Cell biology, Centriole Annonce publiée le 14-03-2023 Tweet |
![]() ![]() |
IBENS salle Favard, IBENS 46 rue d'Ulm 75005 Paris |
Invite par: Peter van Endert Plus d'infos... Tags: Vaccination, Vaccine, Virology Annonce publiée le 18-03-2023 Tweet |
![]() ![]() |
INEM amphitheatre 1 de la Faculte Necker, 160 rue de Vaugirard 75015 |
In response to stress, the brain activates neuropeptide-secreting systems. This eventually leads to the secretion of adrenal corticosteroid hormones, which subsequently feedback on the brain and bind to two types of receptors that act not only as transcriptional regulators but also mediate rapid non-genomic actions of the steroids. The receptors function in a binary fashion and serve as a master switch in the coordination of neuronal and network responses that underlie behavioral coping and adaptation. In individuals, predisposed by genetic background and/or early life trauma, a stress-induced imbalance in this binary control mechanism may introduce a bias towards psychiatric (depression and anxiety), and neurodegenerative (Alzheimer) diseases. Corticosteroid receptor modulators are becoming available that may reset a dysregulated stress response system to promote resilience to these diseases. Plus d'infos... Tags: Sympathetic nervous system, Corticosteroids, Hormones, Stress, Adrenal gland Annonce publiée le 13-03-2023 Tweet |
![]() ![]() |
Centre de Recherche des Cordeliers amphitheatre Bilski-Pasquier,15 rue de l'Ecole de Medecine 75006 |
Invite par: Marc Graille Tags: RNA, Protein biosynthesis, Gene expression, Messenger RNA, Spliceosome, Cell nucleus Annonce publiée le 01-02-2023 Tweet |
![]() ![]() |
Ecole Polytechnique Amphi Lagarrigue |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 20-02-2023 Tweet |
![]() ![]() |
College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Invite par: Marc Graille In all kingdoms of life, the dynamic regulation of cellular processes relies on posttranslational modification (PTM) of the proteome. During this process, a protein becomes structurally altered, leading to changes in activity, localisation, interactions, and half-life of a protein. In this talk, I will use my work on different types of PTMs (phosphorylation, ADP-ribosylation, ubiquitylation, and SUMOylation) to propose some general insights into how PTMs are produced and how they perform regulatory roles in both bacteria and eukaryotes. Among other topics, I will talk about the ADPribosylation enzymes PARP1 and PARP2, which are targets of clinical cancer drugs. In the last part of the talk, I will present our work in progress on regulation of transcription factors by oligomerisation. Tags: Branches of biology, Biology, Cell biology, Gene expression, Posttranslational modification, Signal transduction, Post-translational modification, Protein structure, ADP-ribosylation, PARP1, PTMS Annonce publiée le 06-03-2023 Tweet |
![]() ![]() |
Ecole Polytechnique Seminar room, building 84 |
Invite par: Gabrielle Girardeau Plus d'infos... Tags: Songs, Pardi, Belen, Draft:Inah de belen Annonce publiée le 14-01-2023 Tweet |
![]() ![]() |
Insitut du Fer à Moulin 17 Rue du Fer a Moulin - 75005 Paris |
Invite par: Lucy Glover Seminaire du Departement des Parasites et Insectes Vecteurs Virginia HOWICK University of Glasgow School of Biodiversity, One Health et Veterinary Medicine Understanding adaptation of P. falciparum to diverse Anopheles vectors? Jeudi 30 mars 2023, ... Plus d'infos... Tags: Infectious diseases, Malaria, Medical specialties, Parasitology, Branches of biology, Anopheles, Plasmodium falciparum, Vector, Parasitism Annonce publiée le 07-03-2023 Tweet |
![]() ![]() |
Institut Pasteur Batiment Lwoff, salle Retrovirus, |
En 1959, le principe ethique des 3R Remplacer, Reduire, Raffiner a ete developpe par deux scientifiques pour les scientifiques. Cependant, 64 ans plus tard, cest toujours un defi pour les centres 3R davoir un impact direct sur les chercheurs dans leur travail quotidien. Le ministere francais de lenseignement superieur et de la recherche et les principaux operateurs de la recherche publique ont cree le Centre francais des 3R (FC3R), dont la priorite est dencourager et de mettre en oeuvre les 3R en France par la promotion dune recherche, dune education et dune communication transparente responsables et innovantes en ciblant specifiquement les generations actuelles et futures de scientifiques. Pour ce faire, la FC3R a developpe des strategies proactives, sengageant dans des actions concretes pour federer une communaute synergique autour des besoins et des objectifs des chercheurs. La FC3R travaille a : 1) diffuser et developper des offres de formation adaptees aux besoins specifiques des etudiants et des chercheurs ; 2) accompagner les chercheurs dans leur conception experimentale et le partage de leurs resultats non publies/negatifs par la creation dune plateforme dediee ; 3) communiquer sur les methodes innovantes non animales, les subventions, levolution des pratiques et de la reglementation, mais aussi reconnaitre par des interviews, des conferences et des prix les acteurs dont les realisations font avancer la promotion et la mise en oeuvre des 3R en France ; 4) financer des projets de recherche : deux appels ont ete realises en 2022/23 recompensant des initiatives collaboratives federant la communaute scientifique francaise autour du principe des 3R et des projets favorisant le Remplacement de lutilisation danimaux ou de produits dorigine animale en science. FC3R facilitera egalement les collaborations scientifiques entre les communautes de recherche academique et industrielle, en biologie et en chimie. Plus d'infos... Tags: Ethics Annonce publiée le 13-03-2023 Tweet |
![]() ![]() |
Centre de Recherche des Cordeliers amphitheatre Gustave Roussy, 15 rue de l'Ecole de Medecine 75006 |
Invited by the Romet-Lemonne/Jegou Team, Gregory Giannone will give a seminar entitled : #8220;Deciphering the spatiotemporal and mechanical regulation of integrin and actin regulators at the nanoscale#8221; Giannone Lab: Cells have the ability to adjust their adhesive and cytoskeletal organizations according to changes in the biochemical and physical nature of their surroundings. In return, by adhering and generating forces on neighboring cells and extracellular matrices cells control their environment, shape and movement. This is true from integrin-based adhesive structures of migrating cells to synapses of neurons. Those adhesive structures are the converging zones integrating biochemical and biomechanical signals arising from the extracellular space and the actin cytoskeleton. Thus, the life-cycle of adhesive and cytoskeletal structures are involved in critical cellular functions such as migration, proliferation and differentiation, and regulate cell behavior in many physiological responses such as development. Alterations of adhesive and cytoskeletal organizations contribute to pathologies including cancer, but also cognitive disorders. At the molecular, sub-cellular, and cellular levels, cell shaping and motility proceed through cycles lasting from seconds to minutes. During those cycles, critical proteins undergo stochastic motions and transient interactions that are essential to their functions. Regulation of these interactions by forces is at the base of mechano-transduction events controlling cell behavior. Therefore, to understand the molecular mechanisms controlling the life cycle of motile structures, it is crucial to study the position and dynamics of proteins but also their interactions and how mechanical forces control these molecular events. Our goal is to decipher at the molecular level the spatiotemporal and mechanical mechanisms which control the architecture and dynamics of motile structures including integrin-based AS, the lamellipodium and dendritic spines. Exploration of these new dimensions requires an innovative and multidisciplinary approach combining cell biology, biophysics, biomechanics and advanced optical microscopy techniques including super-resolution microscopy, single protein tracking and quantitative image analysis. We are developing three specific axes: 1/ Integrin adhesion 2/ Actin in dendritic spines 3/ Super-resolution developments Plus d'infos... Tags: Proteins, Branches of biology, Cell biology, Actin, Autoantigens, Cytoskeleton, Integrin, Dendritic spine, Talin, Focal adhesion Annonce publiée le 05-01-2023 Tweet |
|
Institut Jacques Monod Usually at 11.45 am in the François Jacob room |
Invite par: DENEUX Thomas Plus d'infos... Tags: Chinese art, Artists, Hong Kong, The Hong Kong Research Institute of Textiles and Apparel, Ho Sin Tung Annonce publiée le 22-03-2023 Tweet |
![]() ![]() |
NeuroPSI Salle de conference Albe-Fessard |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 16-01-2023 Tweet |
![]() ![]() |
College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Invited by Antoine Zalc Plus d'infos... Tags: Education in Paris, Vincent Manceau, Collge de France, Association football Annonce publiée le 12-01-2023 Tweet |
![]() ![]() |
Institut Cochin Salle Rosalind Franklin |
Plus d'infos... Tags: Fellows of the Royal Society Annonce publiée le 11-09-2022 Tweet |
|
Inst. Bio. Paris Seine 7-9 quai Saint Bernard, 75005 Paris |
Invite par: RENCONTRE NATIONALE D ENDOCRINOLOGIE COCHIN 9h-9h15 : Introduction - Jerome Bertherat __ 9h15-9h45 : Recepteurs des peptides hypothalamiques et obesite - Ralf Jockers (Institut Cochin) __ 9h45-10h15 : Regulation hypothalamique du comportement alimentaire - Christophe Magnan (Universite Paris Cite) __ 10h15-10h45 : Traitement pharmacologique des obesites genetiques - Christine Poitou- Bernert (Hopital Pitie-Salpetriere) __ 10h45-11h15 : PAUSE __ 11h15-11h45 : Modifications des peptides digestifs au cours de l obesite et de la chirurgie bariatrique Aspects physiopathologiques - Maude Le Gall (CRI, Paris) __ 11h45-12h15 : Modifications des peptides digestifs au cours de l obesite et la chirurgie bariatrique Implications cliniques - Severine Ledoux (Hopital Louis Mourier, Colombes) __ 12h15-14h00 : PAUSE DEJEUNER LIBRE __ 14h00-14h30 : Les traitements medicaux de l obesite : benefices contre risques - Sebastien Czernichow (Hopital HEGP) __ 14h30-15h00 : Analogues du GLP-1 dans les obesites hypothalamiques - Blandine Gatta-Cherifi (CHU de Bordeaux, Pessac) __ 15h00-15h30 : Diabete : remission et rechute apres chirurgie bariatrique - Claire Carette (Hopital HEGP) __ 15h30-16h00 : Pharmacogenetique de la reponse aux AGLP1 : le point de vue du pharmacologue Nicolas Pallet (Hopital HEGP) __ 16h00-16h30 : Les maladies rares eclairent les maladies frequentes : comment le GIP peut entrainer un Cushing ? - Lucas Bouys (Hopital Cochin) __ 16h30-17h00 : Conclusion Plus d'infos... Tags: Obesity, Hormone, Endocrinology Annonce publiée le 14-03-2023 Tweet |
![]() ![]() |
Institut Cochin amphitheatre du batiment Jean Dausset de l Hopital Cochin, 27 rue du Faubourg Saint-Jacques 75014 |
Invite par: BOUVIER Julien Plus d'infos... Tags: Branches of biology, Neuroscience, Memory, Neural circuits, Neurophysiology, Brain, Neuroplasticity, Neurotrauma, Plasticity Annonce publiée le 18-06-2022 Tweet |
![]() ![]() |
NeuroPSI Salle de conference Albe-Fessard |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 16-01-2023 Tweet |
![]() ![]() |
College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Invite par: Fiona Francis Plus d'infos... Tags: Senescence, Aging brain, Brain, Central nervous system Annonce publiée le 04-12-2022 Tweet |
![]() ![]() |
Insitut du Fer à Moulin 17 Rue du Fer a Moulin - 75005 Paris |
Invite par: BOUVIER Julien Plus d'infos... Tags: Neurons, Interneuron Annonce publiée le 07-02-2023 Tweet |
![]() ![]() |
NeuroPSI Salle de conference Albe-Fessard |
Invite par: Neetu Gupta-Rossi seminaire 04_17_2023 Ulrike EGGERT This event will not be streamed, attendance in person only. Plus d'infos... Tags: Underwater diving physiology, Membrane biology, Cell biology, Lipids Annonce publiée le 21-02-2023 Tweet |
![]() ![]() |
Institut Pasteur Batiment: Metchinikoff Salle: Jules Bordet |
PAMELA SHAW BIOSKETCH CV MARCH 2023 Plus d'infos... Tags: Neurological disorders, Organ systems, Nervous system, Rare diseases, Senescence, Neurodegeneration, Neuroscience, Degenerative disease, Neuron, Amyotrophic lateral sclerosis, Motor neuron disease Annonce publiée le 07-03-2023 Tweet |
![]() ![]() |
Centre de Recherche en Myologie |
Plus d'infos... Annonce publiée le 15-03-2023 Tweet |
![]() ![]() |
NeuroPSI Salle de conference Albe-Fessard |
Invite par: GRANON Sylvie Plus d'infos... Tags: le-de-France, Departments of France, Pelloux, University of Paris-Saclay, Paris-Saclay, Saclay Annonce publiée le 10-03-2023 Tweet |
![]() ![]() |
NeuroPSI Salle de conference Albe-Fessard |
Invite par: Pierre-Regis Burgel - Veronique Witko-Sarsat Plus d'infos... Tags: Cystic fibrosis Annonce publiée le 03-03-2023 Tweet |
![]() ![]() |
Institut Cochin Hopital Cochin, amphitheatre Dausset, 27 rue du Fg St Jacques 75014 |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 08-03-2023 Tweet |
![]() ![]() |
College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Invite par: Mario Pende Plus d'infos... Tags: Stem cells, Biotechnology, Organoid, Induced stem cells Annonce publiée le 12-02-2023 Tweet |
![]() ![]() |
INEM Mercredi 3 mai a 12h, amphitheatre 2 au -1 de lINEM, 160 rue de Vaugirard 75015 |
Invité par Raphael Scharfmann. Plus d'infos... Tags: Modernist architects, Sbastien Balibar Annonce publiée le 12-01-2023 Tweet |
![]() ![]() |
Institut Cochin Salle Rosalind Franklin |
Invite par: Mario Pende Plus d'infos... Tags: Stem cells, Biotechnology, Organoid Annonce publiée le 12-02-2023 Tweet |
![]() ![]() |
INEM amphitheatre 2 au -1 de lINEM, 160 rue de Vaugirard 75015 |
Invité par Pascal Maire. Plus d'infos... Tags: Auvergne, Clermont-Ferrand, Massif Central, Ferrand, Clermont, Auvergne-Rhne-Alpes, Lyce Blaise Pascal, Geography of France, University of Clermont Auvergne Annonce publiée le 12-01-2023 Tweet |
![]() ![]() |
Institut Cochin Salle Rosalind Franklin |
Plus d'infos... Tags: Humancomputer interaction, Wearable devices, Distributed computing architecture, Clothing, Ambient intelligence, Fashion accessories, Internet of things, Wearable computer, Technology mining, Wearable technology Annonce publiée le 03-03-2023 Tweet |
|
Centre de Recherche en Myologie |
Plus d'infos... Annonce publiée le 18-03-2023 Tweet |
![]() ![]() |
NeuroPSI Salle de conference Albe-Fessard |
Invite par: ROUYER Francois Plus d'infos... Annonce publiée le 21-03-2023 Tweet |
![]() ![]() |
NeuroPSI Salle de conference Albe-Fessard |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 16-01-2023 Tweet |
![]() ![]() |
College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Invite par: PERRON Muriel Plus d'infos... Annonce publiée le 21-03-2023 Tweet |
![]() ![]() |
NeuroPSI Salle de conference Albe-Fessard |
More information on the Corces Lab Plus d'infos... Annonce publiée le 07-03-2023 Tweet |
![]() ![]() |
Centre de Recherche en Myologie |
Les interférons de type I (IFN) activent les programmes antimicrobiens intracellulaires et influencent le développement des réponses immunitaires innées et adaptatives. Nous discuterons de nos résultats en abordant la biologie des IFN dans le syndrome de Down (DS). Ce syndrome est la conséquence d'une anomalie chromosomique appelée " trisomie 21 " dans laquelle le chromosome 21 est partiellement ou totalement triplé. Les sous-unités qui composent le récepteur de l'IFN-I (IFNAR1 et IFNAR2), comme d'autres gènes importants pour l'immunologie, sont codés sur ce chromosome et leur expression est fortement augmentée. Cela génère une importante dysrégulation immunologique. Nous discuterons des caractéristiques du compartiment des cellules T, de la fonctionnalité des Tregs, et de l'impact de la signalisation IFN sur les différents sous-ensembles de cellules T, qui pourraient expliquer les différentes susceptibilités de cette population à développer certaines pathologies telles que les tumeurs solides et l'auto-immunité. D'autre part, la signalisation compétente de l'IFN de type I est à la base de la plupart des mécanismes immunitaires anti-tumoraux et s'est récemment avérée essentielle à l'efficacité de plusieurs agents anticancéreux et de l'immunothérapie. Dans cet exposé, nous discuterons de nos récentes découvertes concernant le potentiel des agonistes TLR en tant qu'inducteurs de l'IFN de type I et, par conséquent, en tant que modulateurs puissants de la composition de l'infiltrat tumoral, capables de faire basculer l'environnement tumoral immunosuppressif vers une immunité anti-tumorale. Plus d'infos... Annonce publiée le 18-10-2022 Tweet |
![]() ![]() |
Institut Curie Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e |
Invite par: SHULZ Daniel Plus d'infos... Annonce publiée le 21-03-2023 Tweet |
![]() ![]() |
NeuroPSI Salle de conference Albe-Fessard |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 16-01-2023 Tweet |
![]() ![]() |
College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Invite par: Jean-Louis Mergny Apart from the double-helix B-DNA structure discovered by Watson and Crick, approximately 13% of the human genome comprises sequence motifs that can form non-canonical, or non-B, DNA conformations. Recent in vivo experiments showed that non-B DNA forms in living cells and regulates key cellular processes (e.g., replication and transcription). This presentation will focus on our recent research related to non-B DNA. Based on the analysis of long-read sequencing data, we demonstrated decreased polymerization speed and increased polymerization errors at non-B DNA loci genome-wide. We next hypothesized that the same phenomena occur in human cells and lead to increased mutagenesis at non-B DNA loci. Indeed, analyzing human diversity and human-orangutan divergence data, we found that non-B DNA are indeed hotspots of mutagenesis and contribute substantially to local and global regional variation in mutation rates across the human genome. Furthermore, we discovered that G-quadruplex motifs, capable of forming one type of non- B DNA, evolve under purifying selection, are more stable, and are overrepresented when located in different important genic (e.g., promoters) and non-genic (e.g., enhancers and replication origins) regions. Thus, Gquadruplex structures forming in such regions are likely to be functional. In contrast, G-quadruplex motifs do not evolve under selection, are less stable, and are underrepresented when located in the non-transcribed strands of exons. Finally, we showed that caution should be exercised when studying non-B DNA motifs because they exhibit elevated rates of sequencing errors. Tags: Genomics, Molecular biology, DNA, Genetic mapping, Biotechnology, Human genome, G-quadruplex, Gene, Mutagenesis, Mutation Annonce publiée le 22-03-2023 Tweet |
![]() ![]() |
Ecole Polytechnique Conference room to be announced |
Invite par: BARNIER Jean-Vianney Plus d'infos... Annonce publiée le 14-12-2022 Tweet |
![]() ![]() |
NeuroPSI Salle de conference Albe-Fessard |