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Invite par: Delara Saberan-Djoneidi Tags: Developmental neuroscience, Cajal, Retzius, Development of the cerebral cortex, Guidepost cells Annonce publiée le 20-03-2025 |
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| Epigenetique et Destin Cellulaire salle des seminaires de l IJM (RB-18B), 15 rue Helene Brion - 75013 ou en visioconference. Contact = sophie.polo at univ-paris-diderot.fr |
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Teaser: My group is interested in understanding the mechanisms that govern functional specificity within the Endosomal Sorting Complex Required for Transport (ESCRT) pathway, a cellular machinery that mediates reverse membrane remodelling. In my talk I will discuss our work on how specific protein complexes are tailored to perform different functions by binding differentially to components of the pathway depending on the required activity. This way, the same cellular machinery can catalyse membrane constriction and scission of thin membranous stalks present in topologically equivalent processes such as endosomal sorting of ubiquitinated membrane cargo, cytokinetic abscission, membrane repair or enveloped virus budding.
Plus d'infos...
Tags: Organelles, ESCRT, Vesicles, Endosome, Protein families, VPS25, CHMP2B
Annonce publiée le 27-03-2025
Institut Cochin
Salle Rosalind Franklin -
Invite par: Pascale Serror
Metazoans, including Drosophila and mammals, maintain complex interactions with their gut microorganisms, which play a crucial role in host physiology, particularly juvenile growth under chronic undernutrition. Nutrient deprivation often leads to stunted growth and disrupted gut microbiota maturation, but microbial interventions, including Lactiplantibacillus plantarum (Lp), can mitigate these effects. Lp promotes juvenile growth in Drosophila by stimulating protease expression in intestinal cells through bacterial cell envelope components, notably peptidoglycan and d-alanylated lipoteichoic acids (d-Ala-LTA), via an NF-?B-dependent pathway. Similar effects have been observed in undernourished mice, where Lp cell envelopes alone are sufficient to promote growth.
Plus d'infos...
Tags: Bacteriology, Microbiomes, Digestive system, Microbiology, Environmental microbiology, Lipoteichoic acid, Microbiota, Drosophila, Peptidoglycan, Gut microbiota, NF-B, Lactiplantibacillus plantarum
Annonce publiée le 07-02-2025
Institut Micalis
Auditorium 442 - Institut Micalis -
Invite par: Romain Koszul
Plus d'infos...
Tags: Epigenetics, Histone, Proteins
Annonce publiée le 15-03-2025
Institut Pasteur
Batiment Metchnikoff , salle Jules Bordet , -
Invite par: Marc Graille
Life depends on extracellular energy to support growth, reproduction, and survival. However, the availability of energetic vectors (i.e., organic carbon, light, reductant) is variable in Nature, and the proper balance of dynamic energy fluxes is required to ensure cell health and organisms fitness. Yet how the balance between the cell energy supply and demand is achieved at the cellular level to survive and thrive in dynamic environments remains unclear. Arguably, the most versatile cell bioenergetic network is the one of photosynthetic organisms since natural factors like canopy movement, clouds, or water mixing quickly and dynamically affect the amount of light energy available. In this talk, we will explore how photosynthetic cells maintain their energetic homeostasis in a dynamic environment using the model green microalgae Chlamydomonas reinhardtii. First, by developing an approach inspired by frequency-domain analysis, we show that various molecular players of the photosynthetic electron transport chain harbor a specific domain of energetic fluctuation frequency for which it can support the cell energetic needs, which we term bandwidth. Our findings reveal how the flexibility of the electron transport chain maintains bioenergetic homeostasis at all timescales in dynamic light conditions. As the dynamic balance of the cell energy occurs at the cellular level, we further show how the development of systematic and genome-wide analyses of the response to light fluctuations allows us to describe the dynamic landscape of the bioenergetic network at the cellular level. We will further discuss the potential impacts of unravelling the dynamics of the cell bioenergetic network for improving energy systems, food production, and the health of plants and humans.
Annonce publiée le 19-03-2025
Ecole Polytechnique
Seminar room, building 84 -
Invite par: MARTIN Jean-Rene
Plus d'infos...
Tags: Medical terminology, Neuron, Astrocyte, Synaptopathy
Annonce publiée le 04-03-2025
NeuroPSI
Salle de conference Albe-Fessard -
Invite par l’equipe Minc, Lionel Christiaen (Michael Sars Centre, University of Bergen, Bergen, Norway) va presenter un seminaire de l’Institut Jacques Monod sur le theme : Regulation of deterministic development Resume : Christiaen's research aims at understanding how tissue-specific regulatory programs and cell-cell communication coordinate cellular behavior in the context of animal development, regeneration and evolution. His laboratory focuses on mesodermal lineages that produce both heart and head muscles, using the ascidianCionaas model. His laboratory has contributed seminal findings in developmental and evolutionary biology, identifying key processes contributing to human congenital disorders. The Ciona model provides a unique opportunity to study the regulation of chordate development at single cell resolution, thanks to a highly deterministic (hard-wired?) mode of embryogenesis. However, recent attempts to uncover the impact of varying temperatures in a changing world are beginning to reveal regulative mechanisms of thermal adaptation.
Plus d'infos...
Tags: Ascidiacea, Determinism
Annonce publiée le 25-03-2025
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Invite par: Henrique TEOTÓNIO - 2024-2025 EEB external seminar
Abstract : In many eukaryotes, meiotic recombination occurs preferentially at discrete sites, called recombination hotspots. In various lineages, recombination hotspots are located in regions with promoter-like features and are evolutionarily stable. Conversely, in some mammals, hotspots are driven by PRDM9 that targets recombination away from promoters. Paradoxically, PRDM9 induces the self-destruction of its targets and this triggers an ultra-fast evolution of mammalian hotspots. The reasons for the existence of these two categories of hotspots are unclear. PRDM9 is ancestral to all animals, suggesting a critical importance for the meiotic program, but has been lost in many lineages with surprisingly little effect on meiosis success. To try to understand the ?raison d'etre' of these different types of hotspots, we investigated the activity of Prdm9-dependent and Prdm9-independent recombination hotspots in several clades. I will present an overview of these analyses.
Plus d'infos...
Tags: Molecular genetics, Cellular processes, Cell cycle, PRDM9, Genetic recombination, Recombination hotspot, Meiosis, Lineage
Annonce publiée le 22-03-2025
IBENS
salle Favard, IBENS 46 rue d'Ulm 75005 Paris -
Invite par: Institut Necker Enfants Malades
Meryem B. Baghdadi is a researcher in the field of stem cell and development biology and has made significant contributions to the understanding of stem cell niches and their regulation in both homeostasis and disease contexts. Meryem's academic journey began at Universite Pierre et Marie Curie (UPMC), where she earned a Master's degree in Cellular and Molecular Biology, majoring in Stem Cell Biology. This was followed by a Ph.D. in Stem Cells and Development at Institut Pasteur. She then moved to Toronto, Canada for her postdoc at SickKids, exploring the role of enteric glial cells in stem cell niche regulation. In October 2022, she was awarded as a CNRS Research Associate position at the Institut Curie in Paris. In January 2025, Meryem began a new role as a Junior Group Leader at the Institut Necker Enfant Malades in Paris, where she leads a team studying the regulation of the intestinal stem cell niche in development and disease.Meryem has an impressive list of publications, including co-corresponding author papers in prestigious journals such as Science, Cell Stem Cell, and Nature. Her work has been recognized with several awards, including, 2025 ATIP-Avenir program, ATIP award from the Fondation Bettencourt-Schueller, the Young Researcher Prize from the French Society of Cell Biology in 2024 and the Young Rising Talent France award from the Fondation L&'Oreal-UNESCO in 2022.
Plus d'infos...
Tags: Stem cells, Biotechnology, Cell biology, Cloning, Developmental biology, Stem-cell niche
Annonce publiée le 11-03-2025
Institut Necker Enfants Malades
Auditorium 1 -
Plus d'infos...
Tags: Barbosa
Annonce publiée le 19-11-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
Plus d'infos...
Tags: Delayed open access journals, Cell, Cell and molecular biology, Transfersome
Annonce publiée le 21-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Oscillations moleculaires et mecaniques L objectif general du 7e cours de biologie cellulaire et du cancer est de couvrir differents sujets en biologie cellulaire, biologie du developpement et physique, en mettant l accent sur les oscillations moleculaires et mecaniques dans les systemes biologiques. Keynote speaker Alexandre Aulehla - DE Intervenants Annabelle Ballesta - FR Thibaut Brunet, FR Clotilde Cadart- FR Mathieu Coppey - FR Stephanie Descroix - FR Silvia Fre - FR Martijn Gloerich - NL Hanspeter Herzel - DE Jean-Leon Maitre - FR Franck Perez - FR Francois Schweisguth - FR Katharina Sonnen - NL Xavier Trepat - ES
Plus d'infos...
Annonce publiée le 15-01-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Invite par: Zehra Esra Ilhan
Endometriosis and adenomyosis are debilitating gynecologic conditions that affect millions of women worldwide, yet their pathophysiology remains poorly understood, leading to delayed diagnoses and limited treatment options. Emerging evidence suggests that genetic, immune, and hormonal factors contribute to disease progression, while environmental exposures may further influence disease onset and severity. Despite their significant impact on reproductive health and quality of life, these conditions remain understudied, highlighting an urgent need for innovative research approaches. By leveraging integrated multi-omics analyses, including the microbiome, immunoproteomics, and metabolomics, we can unravel the complex interactions driving these diseases. A deeper understanding of these factors will pave the way for improved diagnostics, personalized therapeutic strategies, and targeted interventions, ultimately enhancing patient outcomes.
Plus d'infos...
Tags: Gynaecologic disorders, Adenomyosis, Endometriosis, Omics, Multiomics, Microbiome
Annonce publiée le 04-03-2025
Institut Micalis
Auditorium 442 - Institut Micalis -
Invite par: Marianne de Paepe & Jeffrey Cornuault
Mushuvirus mushu is a temperate bacteriophage linked to human gut bacteria. I identified its genome in 1,300-year-old paleofeces, revealing near-identical sequence to modern references, highlighting its remarkable conservation across human history. In follow-up work, I characterized the entire Mushuviridae family across tens of thousands of metagenomes, uncovering their interactions with gut-associated bacteria like Faecalibacterium, Roseburia, Blautia, and others. This study showcases how computational methods can reveal bacteriophage diversity on a global scale and expand our understanding of the human gut virome.
Plus d'infos...
Tags: Bacteriophages, Virology, Microbiomes, Bacteriology, Environmental microbiology, Bacteriophage, Gut microbiota, Virome, Temperateness, Faecalibacterium, Phageome
Annonce publiée le 06-03-2025
Institut Micalis
Auditorium 442 - Institut Micalis -
Invite par: Anne-Gaelle Planson
Understanding bacterial adaptation is key to both fundamental biology and strain engineering. In this talk, I will present my work on deep mutational scanning (DMS) to explore adaptation mediated by mutations in essential genes-critical yet underexplored drivers of bacterial evolution. To overcome limitations in mutational library diversity and editing efficiency, I developed CRISPR/Cas9-mediated error-prone editing (CREPE), achieving mutation efficiencies of 70-80%. Using CREPE, I mapped the adaptive landscape of RNA polymerase, uncovering modular domains that control global traits of growth and maintenance, with implications for optimizing engineered strains. Beyond individual gene adaptations, tracking beneficial mutations in evolving bacterial populations remains a major challenge due to low detection limits in conventional sequencing. To address this, I developed a CRISPR/Cas9-based molecular barcoding system capable of tracking over 100,000 bacterial lineages at ultra-low frequencies (10??). Applying this system to a 20,000-generation evolution experiment, I identified 250 fitness-enhancing mutations in ~30 genes-dramatically improving upon traditional approaches. These insights demonstrate how a priori knowledge of adaptation mechanisms can enable knowledge-driven microbial engineering, accelerating the development of robust industrial strains.
Plus d'infos...
Tags: Genome editing, Cas9, CRISPR, Mutation, CRISPR gene editing, Protospacer adjacent motif
Annonce publiée le 20-03-2025
Institut Micalis
Auditorium 442 - Institut Micalis -
TBA
Plus d'infos...
Tags: Moreau, Draft:Rincn Bomba massacre, Moreau River
Annonce publiée le 28-03-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407 -
Invitee par l’Institut Jacques Monod, Suzette Lust (Postdoctoral researcher in Danijela Matic Vignjevic’s team – Cell migration and invasion Laboratory at Institut Curie) va presenter le seminaire sur le theme : Understanding the role of interstitial flow in vascular smooth muscle cell phenotype in the context of aortic aneurysms Ce seminaire se deroule dans le cadre des Paris Postdocs Seminars. Resume : Aortic aneurysms are abnormal enlargements of blood vessel diameter caused by aberrant extra-cellular matrix (ECM) remodelling. As the tissue dilates, it loses its mechanical integrity, exposing patients to risk of highly fatal aortic dissections or ruptures. This is mediated in part by phenotypic switching and or apoptosis of the intima-resident vascular smooth muscles (VSMCs). What drives this pathology is not well understood, particularly in the case of aneurysms in Bicuspid Aortic Valve disease (BAV) patients, a congenital condition characterised by the malformation of the aortic valve resulting in only 2 leaflets. Improvements in imaging techniques have now allowed pathological blood flow patterns to be correlated to aneurysm morphology and indeed there is increasing evidence that mechanotransduction from flow may be a driver of aneurysm development. Blood flow imparts mechanical forces to cells through stretching and frictional shear forces and we are focused here on the interstitial flow driven into the wall by differential pressure gradients within the aorta. We hypothesise that interstitial flow plays a crucial role in regulating VSMC phenotype and ECM interactions and that this may be used to correlate disrupted flow patterns seen in BAV patients to the morphology changes in their aortas. To test this hypothesis, we created a reductionist in-vitro model culturing VSMCs in 3D under interstitial flow. We combined a synthetic PEG based ECM mimicking hydrogel with primary cultures of VSCMs with a microfluidics setup. We showed hydrogels doctored with degradable bioactive peptides could be broken down by exogenous and cell derived MMPs. We measured hydrogel permeability using 2 separate techniques which confirmed the material to have a low permeability compared to other standard hydrogels, on the order of 10?16 m2. Furthermore, we characterised mass transport of solutes within hydrogels and were able to demonstrate a negligible impact of changing polymer solid content on diffusivity in hydrogels of up to 5% weight/volume for molecules up to 40 kDa in size. Via production of MMPs, VSMCs break down the hydrogel and importantly by day 7 of culture, we detected newly synthesised fibronectin, collagen 1 and 4 proteins. We stimulated encapsulated cells with interstitial flows demonstrating that cells align to the flow direction. Finally, we performed RNA sequencing on 3 human patient samples comparing standard culture conditions, non-flow stimulated encapsulated cells and interstitial-flow stimulated cells. The data set reveals significant upregulation of genes in multiple pathways associated with cyclic AMP production, which plays a crucial role in regulating VSMC contractility and calcium signalling and hence phenotype. The data suggests that this is mediated via activation of G-protein receptors leading to increased expression of adenylyl cyclase but this remains to be confirmed. In conclusion, we developed a novel in-vitro platform to study the impact of interstitial flow on VSMC behaviour. Our data suggests that interstitial flow may play a regulating role in determining VSMC phenotype with potential consequences for matrix remodelling in disease.
Plus d'infos...
Tags: Vascular surgery, IgG4-related disease, Vascular diseases, Bicuspid aortic valve, Valvular heart disease, Hydrogel, Aortic aneurysm, Aneurysm, Aortic dissection, Aortic valve
Annonce publiée le 27-03-2025
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Invite par: Judith Halewa
Tags: Genetics
Annonce publiée le 28-03-2025
IMAGINE
auditorium du 6eme etage, 24 boulevard du Montparnasse - 75015 -
La premiere reunion du cytoskeleton club de 2025 aura lieu ce mercredi a l’Institut Pasteur : – Charlotte Mallart (post-doc, Minc lab, Institute Jacques Monod) presentera : «Regulation of cytoplasm rheologyby bulk F-Actin networks». – Noemi Zollo (PhD student, Verlhac/ Terret lab, CIRB College de France) presentera : A novel RNP compartment allows mouse oocytes to adapt translational levels during late growth?.
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Annonce publiée le 14-01-2025
Institut Jacques Monod
Institut Pasteur, 28 rue du dr roux, 75015 Paris, France -
The development of complex in vitro models, such as organoids, gastruloids and organ-on-chips systems, will allow the better understanding of human biological processes that are otherwise difficult to address with classical in vitro 2D culture and/or with animal models. Elucidating how pathogens, such as the SARS-CoV-2, invade human cells by evading the immune system and how this could be modulated by the host microbiota has been greatly facilitated by the advancement of 3D cell culture techniques. For example, mimicking the gut peristalsis in gut-on-a-chip device improves the maturation of colon epithelial cells and aid to unveil the role of mechanical stress in accelerating enteropathogen invasion. Our lab is working on establishing unique advanced microphysiological systems that can mimic the interaction between human epithelial barriers with the surrounding tissues, such as blood vessels, mesenchyme and immune cells. My scientific project is focused on the establishment of lung-on-chip devices that cover the entire respiratory tract (from the nasopharynx to the alveoli) as a platform to understand airborne infections and tropism of respiratory viruses. There we relay both on the use of lung multipotent stem cells grown as organoids, in order to produce the different cell population of the respiratory tract, and on microfluidic chips. Paris Post-docs seminar series.
Plus d'infos...
Tags: Tissue engineering, Biotechnology, Stem cells, Microfluidics, Nanotechnology, Organoid, Organ-on-a-chip, Respiratory tract, 3D cell culture, Lung, Organ, Intestine-on-a-chip
Annonce publiée le 08-01-2025
Institut Cochin
Salle Rosalind Franklin -
Invite par: Nicolas Rascovan
Plus d'infos...
Tags: Genomics, Environmental microbiology, Bioinformatics, Bacteriology, Microbiology, Human microbiome, Metagenomics, Microbiome, Genome, Omics
Annonce publiée le 26-03-2025
Institut Pasteur
Batiment Francois Jacob , salle Auditorium Francois Jacob , -
Invite par: Manish KUSHWAHA
Therapeutic phages used alongside antibiotics show potential for combating antibiotic-resistant bacteria. Some antibiotics induce physiological changes in bacteria, such as filamentation, which enhances phage infection and replication, a phenomenom known as Phage-Antibiotic Synergy (PAS).
Plus d'infos...
Tags: Bacteriology, Bacteriophages, Filamentation, Microbiology, Antimicrobial resistance, Bacteriophage, Antibiotic, Bacteria, Phage therapy, Bacterial morphological plasticity
Annonce publiée le 12-02-2025
Institut Micalis
Auditorium 442 - Institut Micalis -
Plus d'infos...
Annonce publiée le 20-03-2025
NeuroPSI
Salle de conference Albe-Fessard -
Invitee par l’equipe Konstantinides, Dr. Marion Silies (Johannes-Gutenberg-University Mainz, Germany) presentera un seminaire de l’Institut Jacques Monod sur le theme : Heterogeneity of connectivity and function in the fly visual system Resume : Visual systems are considered homogeneous structures where repeating visual units contain the same circuit motifs that fulfil the same functional role, leading to translation invariance. However, our recent work, analyzing full fly brain connectomes, revealed remarkable heterogeneity, even within anatomically and genetically identifiable cell types. I will describe this heterogeneity in synaptic connectivity, and address where it arises developmentally. Furthermore, I will discuss how heterogeneous circuit motifs can lead to degeneracy of neuronal function, and thus to both, reliablility and flexiblity of neuronal information processing in the visual system.
Plus d'infos...
Tags: Computational neuroscience, Cognitive neuroscience, Connectome, Diagrams, Neuron, Brain
Annonce publiée le 14-03-2025
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Invite par: Laurence Arbibe
Philippe Sansonetti, MD, trained in infectious diseases in Paris and in bacterial genetics at Institut Pasteur, Paris, then at the Walter Reed Army Institute of Research as a post-doctoral scientist. He is currently Emeritus Professor at Institut Pasteur and at the College de France where he has been lecturing for 12 years at the interface between basic microbiology and emerging infectious diseases. Professor Sansonetti pioneered the field of Cellular Microbiology by deciphering the molecular and cellular mechanisms of Shigella pathogenesis. He more recently applied similar approaches to decipher the symbiotic mechanisms established between the host and his gut microbiota. His work on Shigella vaccine development and on pediatric malnutrition in relation with gut dysbiosis got him close to global health issues in low-income countries, particularly in Africa. Philippe Sansonetti received several prestigious awards including the Louis Jeantet Prize of Medicine and the Grand Prix de lAcademie des sciences, and a foreign member of the US National Academy of Sciences, the Royal Society and the German Academy of Sciences Leopldina.Seminar topic: Gut dysbiosis and colorectal cancer: from descriptomics to experimentomics Photo: Jerome Panconi
Plus d'infos...
Tags: Digestive system, Environmental microbiology, Microbiomes, Bacteriology, Pasteur Institute, Philippe Sansonetti, Dysbiosis, Gut microbiota, Gastrointestinal tract, Human microbiome, Sansonetti
Annonce publiée le 04-03-2025
Institut Necker Enfants Malades
Auditorium 3 -
Invited by Pascal Maire.
Plus d'infos...
Annonce publiée le 10-01-2025
Institut Cochin
Salle Rosalind Franklin -
Hematopoietic stem cells (HSCs) are multipotent, self-renewing cells responsible for the production of all blood cell types throughout the life of an individual. Despite their location within the adult bone marrow, HSCs are generated during development from specialized endothelial cells called hemogenic endothelial cells in the main embryonic arteries (dorsal aorta, umbilical and vitelline arteries), an evolutionary conserved mechanism within vertebrate species. HSCs arise through a process called endothelial-to-hematopoietic transition, a lineage switch which is tightly regulated in time and space and polarized to the ventral side of the embryonic aorta. In this respect, HSC production is also thought to rely on a specialized microenvironment localized underneath the aortic floor that would promote the lineage switch and constitute a niche for the first HSCs. Taken together, HSC formation encompasses intrinsic cues i.e., cell autonomous and extrinsic cues that constitute an unresolved paradigm for cell and developmental biology and a challenge for regenerative medicine, as clinical de novo formation of HSCs is an unmet goal. I investigate these intrinsic and extrinsic regulations using complementary in vitro and in vivo approaches in the avian embryo, which is a reliable and accessible vertebrate model, and using human iPSCs. On one hand, I am developing an in vitro system that allows mesodermal cells to differentiate into endothelial cells, then into hemogenic endothelial cells, and finally into hematopoietic cells. This system will be used to detect the discrete cellular differentiation steps leading to HSC formation using single cell RNA sequencing technology. The main goal is to elucidate the initial steps of HSC formation to eventually optimize in vitro culture systems for clinical grade HSC production. On the other hand, I use microsurgical techniques to alter the normal microenvironment of the aorta, the cradle of HSC formation, and evaluate the consequences for HSC development. Combining these ablation experiments with spatial transcriptomic approaches will decipher the role of the aortic environment in the formation of the first HSCs. Laurent Yvernogeau is invited by Pascal Maire.
Plus d'infos...
Tags: Stem cells, Developmental biology, Hematopoiesis, Hematopoietic stem cell, Biotechnology, Hematopoietic stem cell niche, Haematopoiesis, Cellular differentiation, Stem cell factor
Annonce publiée le 22-02-2025
Institut Cochin
Salle Rosalind Franklin -
Invite par: Gerald Spaeth
Plus d'infos...
Tags: Parasitology, Trypanosomatida, Infectious diseases, Leishmania, Disease ecology, Disease vector, Parasitism, Jeffares
Annonce publiée le 26-03-2025
Institut Pasteur
Batiment Lwoff, salle Retrovirus, -
Invite par: Théo Hirsch
Plus d'infos...
Tags: University of Leuven, In Belgium, Pierre-Joseph van Beneden
Annonce publiée le 22-12-2024
Centre de Recherche des Cordeliers
Amphi Gustave Roussy -
Plus d'infos...
Annonce publiée le 20-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Invited by Anne Hosmalin.
Plus d'infos...
Tags: Dudziak, Diana
Annonce publiée le 16-01-2025
Institut Cochin
Salle Rosalind Franklin -
Invite par: ROUYER Francois
Plus d'infos...
Tags: Vision scientists, Vision, Perception, Visual perception, Ophthalmology, Jennifer S. Lund, Ruxandra Sireteanu
Annonce publiée le 26-03-2025
NeuroPSI
Salle de conference Albe-Fessard -
Invite par: Mario Pende
Brendan Manning, Ph.D. is a Professor and Acting Chair in the Department of Molecular Metabolism at the Harvard T.H. Chan School of Public Health. He received his PhD from Yale University in 2000 and was a postdoctoral fellow at Harvard Medical School. In 2004, Dr. Manning became the first faculty member hired in the then newly established Department of Genetics and Complex Diseases (later changed to Molecular Metabolism) at Harvard-Chan. Dr. Manning was an inaugural recipient of the National Cancer Institute&'s Outstanding Investigator Award.Research in the Manning lab is defining the molecular interface between cellular signaling networks and metabolic networks, as it relates to both normal physiology and diseases with metabolic dysregulation as a key feature, including cancer, diabetes, and aging-related diseases. Research efforts are focused in part on defining the regulatory mechanisms and functions of a signaling network converging on the tuberous sclerosis complex (TSC) protein complex and the mammalian target of rapamycin (mTOR), which relay an array of extracellular and intracellular growth signals to control the balance between anabolic and catabolic metabolism in cells, tissues, and tumors.
Plus d'infos...
Tags: Signal transduction, MTOR, Immunosuppressants, MTOR inhibitors, Macrolides, Polyenes, Metabolism, Sirolimus, Harvard T.H. Chan School of Public Health
Annonce publiée le 11-03-2025
Institut Necker Enfants Malades
Auditorium 3 -
Invite par: Matthieu Mahevas - Pascal Chappert
Christopher Goodnow holds The Bill and Patricia Ritchie Foundation Chair as Head of the Immunogenomics Laboratory, a NHMRC Senior Principal Research Fellow, and is Professor and Chair of the Cellular Genomics Futures Institute at UNSW Sydney. Professor Goodnow obtained his medical degree from the University of Sydney and a PhD from the Walter and Eliza Hall Institute. His pioneering work in the field of immunology has significantly advanced our understanding of the immune system, particularly in areas such as immune tolerance and autoimmunity. Goodnow's research has been instrumental in uncovering the genetic basis of immune disorders, leading to the development of new therapeutic approaches. Throughout his career, he has held numerous prestigious positions, including Professor of Immunology at the Australian National University and Executive Director of the Garvan Institute of Medical Research.In addition to his academic and research accomplishments, Professor Goodnow has received numerous accolades, reflecting his contributions to science and medicine. He was elected as a Fellow of the Australian Academy of Science and has been recognised with several awards for his groundbreaking research. At the Garvan Institute, he continues to lead cutting-edge research efforts aimed at unravelling the complexities of the immune system and translating these findings into clinical applications. His work not only enhances our scientific knowledge but also has a profound impact on the development of treatments for immune-related diseases.Photo credits: Garvan Institute of Medical Research
Plus d'infos...
Tags: Chris Goodnow, Garvan Institute of Medical Research, Garvan, Goodnow, Draft:Greg Neely, Leslie Lazarus
Annonce publiée le 11-03-2025
Institut Necker Enfants Malades
Auditorium 3 -
Plus d'infos...
Annonce publiée le 20-03-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Plus d'infos...
Tags: Ens, Provincial road N765
Annonce publiée le 13-11-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
Invite par: Romain Briandet
Information obtained through detail analysis of microbial function leads to the finding of unexpected enzymes, metabolisms, and communities useful as novel biotechnological tools in food, medical, and chemical industries. Examples of bioprocess development by applying unique tools found through functional analysis of microbial metabolisms will be introduced.
Plus d'infos...
Tags: Biotechnology, Microorganism
Annonce publiée le 18-03-2025
Institut Micalis
Auditorium 442 - Institut Micalis -
Invite par: EGO-STENGEL Valerie
Plus d'infos...
Tags: Augmented reality, Braincomputer interface, Humancomputer interaction, Spatial computing, Virtual reality
Annonce publiée le 20-03-2025
NeuroPSI
Salle de conference Albe-Fessard -
Plus d'infos...
Annonce publiée le 28-11-2024
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
ldquo;The origin of animals from unicellular ancestors has been a key step in our evolutionary origins. However, the cellular and molecular basis of this transition remain incompletely understood. In the past few years, key insights have emerged from the study of choanoflagellates: the closest living relatives of animals. I will summarize some of our recent research showing how choanoflagellate biology informs our understanding of several pivotal features of animal complexity, including multicellular development, morphogenesis, cell differentiation, and cell-cell communication.rdquo;
Plus d'infos...
Tags: Developmental biology, Evolutionary biology, Choanoflagellate, Cellular differentiation, Multicellular organism, Morphogenesis, Biology, Holozoa, Capsaspora
Annonce publiée le 04-03-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407 -
Invite par: axe transversal, Claire JANOIR and Thomas CANDELA
La presentation explorera des developpements de pointe en chimie des substances naturelles, abordant les defis lies a la comprehension de leurs fascinantes diversite et complexite a travers des perspectives (bio)chimiques et evolutives. Elle mettra en lumiere des approches innovantes en fouille profonde de donnees et en metabolomique pour decoder, par exemple, des voies biosynthetiques complexes. Nous discuterons de la maniere dont ces outils comblent des lacunes dans la comprehension d'aspects moleculaires des espaces chimiques des substances naturelles, qu'elles proviennent de micro-organismes, de plantes ou d'animaux tels que des invertebres marins.
Plus d'infos...
Annonce publiée le 20-03-2025
Institut Micalis
Auditorium 442 - Institut Micalis -
Plus d'infos...
Tags: Joseph Babinski
Annonce publiée le 01-04-2025
Centre de Recherche en Myologie -
Invite par: CIRB - College de France
Plus d'infos...
Tags: @cirbcdf.bsky.social
Annonce publiée le 11-12-2024
College de France
au College de France - Salle D2 acces restreint, merci de passer par l'accueil du CDF : 11 place Marcelin Berthelot - 75005 Paris -
Invite par: Rencontre Clinico-Biologique Institut Cochin Hopital Cochin
Accueil : Florence Niedergang Yannick Allanore --- Introduction : Camille Tlemsani --- Diagnostic anatomopathologique des sarcomes : Frederique Larousserie --- Radiomique dans le diagnostic des sarcomes : Marie-Pauline Talabard --- Transcriptomique pour l aide au diagnostic : Albain Chansavang --- Epigenomique et IA pour classer les sarcomes : Djihad Hadjadj --- Point de vue chirurgical : l impact du diagnostic sur la chirurgie : David Biau --- Transcriptomique spatiale dans l os (problematique des marges) : Diana Passaro --- Point de vue de l oncologue sur l impact du diagnostic : Camille Tlemsani --- Caracterisation des cellules immunitaires des tumeurs : Julie Helft
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Tags: Sarcoma, Personalized medicine
Annonce publiée le 13-03-2025
Institut Cochin
salle Rosalind Franklin au 2eme etage, 22 rue Mechain 75014 -
Invited by Katia Ancelin and Julie Chaumeil.
Plus d'infos...
Tags: Chaumeil
Annonce publiée le 24-01-2025
Institut Cochin
Salle Rosalind Franklin -
Invite par: Rogerio Amino
Plus d'infos...
Tags: Malaria, Renia
Annonce publiée le 26-03-2025
Institut Pasteur
Batiment Lwoff, salle Retrovirus, -
Plus d'infos...
Annonce publiée le 20-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
L'instabilite genetique est une caracteristique des cellules cancereuses mais aussi une cause de maladies genetiques chez l'homme. Notre apprehension des relations causales entre instabilite genetique et le developpement de pathologies humaines repose sur nos connaissances des mecanismes fondamentaux du metabolisme de l'ADN et de l'ARN, depuis l'organisation spatial et chromatinien des genomes, leur expression et regulation au cours du developpement ou en reponse a des stress environnementaux. La deregulation de ces mecanismes fondamentaux lies au metabolisme des genomes peut etre a l'origine de pathologies humaines, incluant le cancer, le vieillissement, des maladies neurologiques et des deficits immunitaires. Organisation: Des seminaires donnes par des orateurs specialistes du domaine couvrant les mecanismes fondamentaux qui gouvernent la stabilite des genomes, aux approches grandes echelles (signatures moleculaires, proteomique, NGS) et les pathologies associees. Il s'agit de valoriser comment un continuum de recherche, allant de la recherche fondamentale a la recherche clinique et translationnelle, permet de repondre a des questions de sante humaine. Des ateliers: Developpement de carriere, communication scientifique, Workshop technologique, session poster, «Elevator Pitch», presentation et moderation des orateurs par les participants. Prix Poster Visite du musee Curie
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Annonce publiée le 20-02-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Plus d'infos...
Tags: Fellows of the American Association for the Advancement of Science, Chen Tianqiao, Chen Wei
Annonce publiée le 22-02-2025
NeuroPSI
Salle de conference Albe-Fessard -
Invite par: CIRB - College de France
Plus d'infos...
Tags: @cirbcdf.bsky.social
Annonce publiée le 21-10-2024
College de France
au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris -
Invited by Sophie Vaulont.
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Tags: Universities UK, Russell Group, University of Birmingham, Sophie
Annonce publiée le 20-12-2024
Institut Cochin
Salle Rosalind Franklin -
Invite par: Claire Deligne
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Tags: Midwood Books, Midwood, Brooklyn
Annonce publiée le 22-12-2024
Centre de Recherche des Cordeliers
Amphi Gustave Roussy -
Plus d'infos...
Tags: Ardem Patapoutian, Piezo, Scripps, E. W. Scripps Company, Nobel Prize in Physiology or Medicine
Annonce publiée le 12-03-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Invite par: ROUYER Francois
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Tags: Scout leader, Leadership, Rapid Results, World Summit of Religious Leaders
Annonce publiée le 18-03-2025
NeuroPSI
Visio -
Invite par: SHULZ Daniel
Plus d'infos...
Tags: Integral membrane proteins, Signal transduction, Biochemistry, G protein-coupled receptor, Molecular biology
Annonce publiée le 27-03-2025
NeuroPSI
Salle de conference Albe-Fessard -
Invite par: CIRB - College de France
Plus d'infos...
Tags: @cirbcdf.bsky.social
Annonce publiée le 12-02-2025
College de France
au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris -
The escalating spread and density of tick populations underscore the urgent need for enhanced surveillance and risk assessment strategies for tick-borne diseases (TBD). Biomarkers derived from the antibody response to tick saliva can be used to facilitate the surveillance of vector establishment in novel regions, assess anti-vector interventions and diagnose TBD through documentation of antecedent tick bites in suspected cases. Here, we derived short peptides from previously identified immunogenic proteins—namely IrCRT, IrSPI, and IrLIP—through bioinformatic predictive analysis using the Immune Epitope Database. ELISAs performed with experimentally controlled sheep sera infested with Ixodes ricinus were used to assess the level of antibody response of IgM and IgG to the peptides derived from these three proteins. Next, we tested the candidates on sera derived from both field and clinical isolates of tick-exposed individuals. For all sera, we obtained different IgM and IgG responses with varying degrees of immunogenicity detected per peptide. Further, through use of an exploratory microarray assay (PepperPrint™), we selected new peptides based on their ability to be recognized using serum from experimentally infested sheep. Amongst the top randomly generated peptides, we found a more specific immunogenic response against the IgG antibodies when compared to IgM. Selected candidates were further tested against experimentally-controlled infested sheep sera, as well as field and clinical isolates. Finally, candidates were cross-validated against mosquito-exposed sera to ensure vector specificity. This study offers the potential for developing new effective strategies for the surveillance and diagnosis of tick-related risks as well as the control and prevention of TBD. Paris Post-docs seminar series.
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Tags: Tick-borne diseases, Tick-borne disease, Ixodidae, Ixodes ricinus, Ixodes, Tick, Biomarker, Zoonoses, Deer tick, Lyme disease
Annonce publiée le 01-02-2025
Institut Cochin
Salle Rosalind Franklin -
Invite par: Fawaz Alzaid
Mohammed Al-Onaizi is an Assistant Professor at the Faculty of Medicine, Kuwait University. His research focuses on the intersection of neurodegeneration and metabolic diseases, particularly diabetes and obesity. He holds a Bachelor of Science in Physiotherapy from Kuwait University, a Master's of Science in Human Anatomy from the University of Dundee, and a PhD in Anatomy and Cell Biology from the University of Western Ontario. Dr. Al-Onaizi has held academic positions as an Assistant Professor at Kuwait University and a Visiting Scientist at the University of Laval. His research, supported by grants from Kuwait University and the Dasman Diabetes Institute, explores the molecular and cellular mechanisms underlying diabetes-associated neurodegeneration.Beyond research, he is dedicated to education, mentoring students, and serving on academic committees. He is an active member of the Kuwait University Faculty Members Association and regularly contributes to the scientific community through publications, conference presentations, and outreach initiatives.Seminar topic: The inflammatory IRF5-TNF axis contributes to cognitive and behavioral effects of type 2 diabetes
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Tags: Cytokines, Endocrine diseases, Metabolic disorders, Tumor necrosis factor, Diabetes
Annonce publiée le 15-02-2025
Institut Necker Enfants Malades
Auditorium 3 -
Invited by Pascal Maire.
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Tags: Maire, Fallon, The Roots, The Tonight Show, Jimmy Fallon
Annonce publiée le 07-02-2025
Institut Cochin
Salle Rosalind Franklin -
Plus d'infos...
Annonce publiée le 07-02-2025
Institut Curie
Centre de recherche - Paris - Webinar -
Invite par: Guido Kroemer and PIO 2025 Organizing Committee
Day 1 : Tumor immunology immunotherapy Day 2 : Microbiota-immune interface
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Tags: Immunology, Oncology, Immunotherapy, Microbiota
Annonce publiée le 27-03-2025
Centre de Recherche des Cordeliers
Amphitheatre Farabeuf, Campus des Cordeliers, 15 rue de l Ecole de Medecine 75006 -
Plus d'infos...
Tags: Bacteriophages, Bacteriophage, Motility, Phage ecology, Phage display
Annonce publiée le 28-02-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Plus d'infos...
Tags: Anonymous, Botnets, Denial-of-service attacks, Internet-based activism, Low Orbit Ion Cannon, Wakanumun, Loc Bouvard
Annonce publiée le 06-02-2025
Paris RNA Club
Auditorium Gallois - 45 rue d Ulm, 75005 Paris -
Invités par Djihad Hadjadj et Benjamin Saint-Pierre.
Plus d'infos...
Annonce publiée le 27-03-2025
Institut Cochin
Salle Rosalind Franklin -
Plus d'infos...
Annonce publiée le 05-03-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Plus d'infos...
Annonce publiée le 05-03-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Plus d'infos...
Tags: Pediatric cancers, Adrenal gland disorders, Adrenaline, Brain tumor, Neuroblastoma, Blastoma, Adrenal gland, Malia Jusczyk
Annonce publiée le 01-02-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Clear cell renal cell carcinoma (ccRCC) is a prevalent and aggressive subtype of kidney cancer. Immunotherapies that boost the ability of CD8+ T cells to eliminate cancer cells have become a standard of care for ccRCC. However, tumor infiltration of CD8+ T cells can result in contradicting clinical outcomes, potentially due to the functional heterogeneity among tumor-specific CD8+ T cells. In this study, we observed that ccRCC tumors are infiltrated by circulating (Tcirc) and tissue-resident (Trm) memory CD8+ T cells that specifically recognize autologous RCC cells in an HLA class I-dependent manner. Trm cells exhibited higher tumor reactivity but reduced stemness potential and a more exhausted state, whereas Tcirc cells retained higher stemness and cytotoxic potential. Single-cell transcriptomics revealed a rather heterogenous composition of memory populations, including cytotoxic and progenitor Tcirc subsets, as well as multiple Trm subsets, including exhausted Trm cells. TCR and trajectory analyses indicate that circulating progenitors lose their circulation, cytotoxicity and stemness potential within the tumor microenvironment while progressively acquiring a tissue-resident differentiation program followed by a terminal differentiation state. Interestingly, tumor enrichment of Trm and cytotoxic Tcirc cells predicts better survival, while exhausted Trm and total CD8+ T cells predict worse survival in RCC patients. Our findings provide new insights into the differentiation pathways and clinical impact of tumor-specific memory CD8+ T cells infiltrating human RCC tumors. Adoptive T cell therapy (ACT) has demonstrated remarkable efficacy in treating hematological cancers. However, its efficacy against solid tumors remains limited and the emergence of cancer cells that lose expression of targeted antigens promotes resistance to ACT. The mechanisms underlying effective and durable ACT-mediated tumor control are incompletely understood. Here, we show that adoptive transfer of TCR-transgenic CD8+ T cells that efficiently eliminates established murine tumors induces tumor accumulation of CD8+ T cells exhibiting tumor-reactive phenotypes. Interestingly, host CD8+ T cells contributed to ACT-mediated elimination of primary tumors and rejected ACT-resistant melanoma cells lacking the targeted antigen. Mechanistically, ACT induced TNF-?- and dendritic cell-dependent tumor accumulation of endogenous CD8+ T cells and effective tumor elimination. Importantly, although lymphodepleting preconditioning enhanced expansion of transferred cells and ACT-mediated tumor elimination, it impaired host antitumor immunity and abrogated protection against ACT-resistant tumors. Tumor enrichment of transcriptional signatures associated with TNF-? signaling, cross-presenting dendritic cells and tumor-specific CD8+ T cells in correlated with favorable responses to ACT and increased survival in human cancers. Our findings reveal that long-term efficacy of ACT is determined by the interplay between transferred and endogenous CD8+ T cells and is undermined by lymphodepleting preconditioning, which ultimately favors ACT resistance.
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Tags: Immunology, Immune system, T cells, Adoptive cell transfer, Tumor microenvironment, Dendritic cell, Lymphocyte, Immunotherapy, Immunoediting, Natural killer cell
Annonce publiée le 14-03-2025
Institut Cochin
Salle Rosalind Franklin -
Plus d'infos...
Annonce publiée le 05-02-2025
Institut Curie
Centre de recherche - Paris - Webinar -
Analyse de donnees multimodales et modelisation de reseaux pour maitriser les capacites distinctives des cancers Le cours reunira des intervenants de premier plan issus de differents domaines de la biologie des systemes cancereux, de la recherche sur le cancer et de la clinique. Les orateurs invites exposeront diverses approches pour l analyse et l interpretation des donnees omiques, d imagerie et cliniques, en combinant les reseaux de signalisation avec des donnees moleculaires multi-echelles, et en les associant a des donnees cliniques. Les themes abordes comprennent l integration et l analyse de donnees genomiques multimodales, les algorithmes de prediction de la sensibilite aux medicaments, l identification de biomarqueurs et de facteurs de cancer, la stratification des patients, et les applications de la modelisation mathematique et de l analyse d images dans le domaine du cancer. Cette edition comprendra egalement de nouvelles sessions consacrees aux applications actuelles du traitement du langage naturel dans la biologie des systemes computationnels du cancer, a l integration des donnees epigenomiques, ainsi qu aux approches de pharmacologie systemique et de metabolomique. Enfin, un moment fort de la rencontre sera la celebration du 25e anniversaire de la publication de l article fondamental "The hallmarks of cancer" (les capacites distinctives des cancers) de Hanahan et Weinberg (Cell 2000).
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Annonce publiée le 18-03-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Invitation de Sophie Vaulont.
Plus d'infos...
Annonce publiée le 29-03-2025
Institut Cochin
Salle Rosalind Franklin