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Jeudi 03 Avril 2025    11:00
Invite par: Pascale Serror Metazoans, including Drosophila and mammals, maintain complex interactions with their gut microorganisms, which play a crucial role in host physiology, particularly juvenile growth under chronic undernutrition. Nutrient deprivation often leads to stunted growth and disrupted gut microbiota maturation, but microbial interventions, including Lactiplantibacillus plantarum (Lp), can mitigate these effects. Lp promotes juvenile growth in Drosophila by stimulating protease expression in intestinal cells through bacterial cell envelope components, notably peptidoglycan and d-alanylated lipoteichoic acids (d-Ala-LTA), via an NF-?B-dependent pathway. Similar effects have been observed in undernourished mice, where Lp cell envelopes alone are sufficient to promote growth. Plus d'infos...
Tags: Bacteriology, Microbiomes, Digestive system, Microbiology, Environmental microbiology, Lipoteichoic acid, Microbiota, Drosophila, Peptidoglycan, Gut microbiota, NF-B, Lactiplantibacillus plantarum
Invite par: Marc Graille Life depends on extracellular energy to support growth, reproduction, and survival. However, the availability of energetic vectors (i.e., organic carbon, light, reductant) is variable in Nature, and the proper balance of dynamic energy fluxes is required to ensure cell health and organisms fitness. Yet how the balance between the cell energy supply and demand is achieved at the cellular level to survive and thrive in dynamic environments remains unclear.
Arguably, the most versatile cell bioenergetic network is the one of photosynthetic organisms since natural factors like canopy movement, clouds, or water mixing quickly and dynamically affect the amount of light energy available. In this talk, we will explore how photosynthetic cells maintain their energetic homeostasis in a dynamic environment using the model green microalgae Chlamydomonas reinhardtii. First, by developing an approach inspired by frequency-domain analysis, we show that various molecular players of the photosynthetic electron transport chain harbor a specific domain of energetic fluctuation frequency for which it can support the cell energetic needs, which we term bandwidth.
Our findings reveal how the flexibility of the electron transport chain maintains bioenergetic homeostasis at all timescales in dynamic light conditions. As the dynamic balance of the cell energy occurs at the cellular level, we further show how the development of systematic and genome-wide analyses of the response to light fluctuations allows us to describe the dynamic landscape of the bioenergetic network at the cellular level. We will further discuss the potential impacts of unravelling the dynamics of the cell bioenergetic network for improving energy systems, food production, and the health of plants and humans. Annonce publiée le 19-03-2025
Tags: Medical terminology, Neuron, Astrocyte, Synaptopathy
Annonce publiée le 04-03-2025
NeuroPSI
Salle de conference Albe-Fessard
Vendredi 04 Avril 2025    11:45
Invite par l’equipe Minc, Lionel Christiaen (Michael Sars Centre, University of Bergen, Bergen, Norway) va presenter un seminaire de l’Institut Jacques Monod sur le theme : Regulation of deterministic development Resume : Christiaen's research aims at understanding how tissue-specific regulatory programs and cell-cell communication coordinate cellular behavior in the context of animal development, regeneration and evolution. His laboratory focuses on mesodermal lineages that produce both heart and head muscles, using the ascidianCionaas model. His laboratory has contributed seminal findings in developmental and evolutionary biology, identifying key processes contributing to human congenital disorders. The Ciona model provides a unique opportunity to study the regulation of chordate development at single cell resolution, thanks to a highly deterministic (hard-wired?) mode of embryogenesis. However, recent attempts to uncover the impact of varying temperatures in a changing world are beginning to reveal regulative mechanisms of thermal adaptation. Plus d'infos...
Tags: Ascidiacea, Determinism
Annonce publiée le 25-03-2025
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France
Vendredi 04 Avril 2025    12:00
Invite par: Henrique TEOTÓNIO - 2024-2025 EEB external seminar Abstract : In many eukaryotes, meiotic recombination occurs preferentially at discrete sites, called recombination hotspots. In various lineages, recombination hotspots are located in regions with promoter-like features and are evolutionarily stable. Conversely, in some mammals, hotspots are driven by PRDM9 that targets recombination away from promoters. Paradoxically, PRDM9 induces the self-destruction of its targets and this triggers an ultra-fast evolution of mammalian hotspots. The reasons for the existence of these two categories of hotspots are unclear. PRDM9 is ancestral to all animals, suggesting a critical importance for the meiotic program, but has been lost in many lineages with surprisingly little effect on meiosis success. To try to understand the ?raison d'etre' of these different types of hotspots, we investigated the activity of Prdm9-dependent and Prdm9-independent recombination hotspots in several clades. I will present an overview of these analyses. Plus d'infos...
Invite par: Institut Necker Enfants Malades Meryem B. Baghdadi is a researcher in the field of stem cell and development biology and has made significant contributions to the understanding of stem cell niches and their regulation in both homeostasis and disease contexts.
Meryem's academic journey began at Universite Pierre et Marie Curie (UPMC), where she earned a Master's degree in Cellular and Molecular Biology, majoring in Stem Cell Biology. This was followed by a Ph.D. in Stem Cells and Development at Institut Pasteur. She then moved to Toronto, Canada for her postdoc at SickKids, exploring the role of enteric glial cells in stem cell niche regulation. In October 2022, she was awarded as a CNRS Research Associate position at the Institut Curie in Paris.
In January 2025, Meryem began a new role as a Junior Group Leader at the Institut Necker Enfant Malades in Paris, where she leads a team studying the regulation of the intestinal stem cell niche in development and disease.Meryem has an impressive list of publications, including co-corresponding author papers in prestigious journals such as Science, Cell Stem Cell, and Nature. Her work has been recognized with several awards, including, 2025 ATIP-Avenir program, ATIP award from the Fondation Bettencourt-Schueller, the Young Researcher Prize from the French Society of Cell Biology in 2024 and the Young Rising Talent France award from the Fondation L&'Oreal-UNESCO in 2022. Plus d'infos...
Tags: Delayed open access journals, Cell, Cell and molecular biology, Transfersome
Annonce publiée le 21-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)
Lundi 07 Avril 2025    0:00
Oscillations moleculaires et mecaniques L objectif general du 7e cours de biologie cellulaire et du cancer est de couvrir differents sujets en biologie cellulaire, biologie du developpement et physique, en mettant l accent sur les oscillations moleculaires et mecaniques dans les systemes biologiques. Keynote speaker Alexandre Aulehla - DE Intervenants Annabelle Ballesta - FR Thibaut Brunet, FR Clotilde Cadart- FR Mathieu Coppey - FR Stephanie Descroix - FR Silvia Fre - FR Martijn Gloerich - NL Hanspeter Herzel - DE Jean-Leon Maitre - FR Franck Perez - FR Francois Schweisguth - FR Katharina Sonnen - NL Xavier Trepat - ES Plus d'infos...
Annonce publiée le 15-01-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)
Lundi 07 Avril 2025    11:00
Invite par: Zehra Esra Ilhan Endometriosis and adenomyosis are debilitating gynecologic conditions that affect millions of women worldwide, yet their pathophysiology remains poorly understood, leading to delayed diagnoses and limited treatment options. Emerging evidence suggests that genetic, immune, and hormonal factors contribute to disease progression, while environmental exposures may further influence disease onset and severity. Despite their significant impact on reproductive health and quality of life, these conditions remain understudied, highlighting an urgent need for innovative research approaches. By leveraging integrated multi-omics analyses, including the microbiome, immunoproteomics, and metabolomics, we can unravel the complex interactions driving these diseases. A deeper understanding of these factors will pave the way for improved diagnostics, personalized therapeutic strategies, and targeted interventions, ultimately enhancing patient outcomes. Plus d'infos...
Invite par: Marianne de Paepe & Jeffrey Cornuault Mushuvirus mushu is a temperate bacteriophage linked to human gut bacteria. I identified its genome in 1,300-year-old paleofeces, revealing near-identical sequence to modern references, highlighting its remarkable conservation across human history. In follow-up work, I characterized the entire Mushuviridae family across tens of thousands of metagenomes, uncovering their interactions with gut-associated bacteria like Faecalibacterium, Roseburia, Blautia, and others. This study showcases how computational methods can reveal bacteriophage diversity on a global scale and expand our understanding of the human gut virome. Plus d'infos...
Invite par: Anne-Gaelle Planson Understanding bacterial adaptation is key to both fundamental biology and strain engineering. In this talk, I will present my work on deep mutational scanning (DMS) to explore adaptation mediated by mutations in essential genes-critical yet underexplored drivers of bacterial evolution. To overcome limitations in mutational library diversity and editing efficiency, I developed CRISPR/Cas9-mediated error-prone editing (CREPE), achieving mutation efficiencies of 70-80%. Using CREPE, I mapped the adaptive landscape of RNA polymerase, uncovering modular domains that control global traits of growth and maintenance, with implications for optimizing engineered strains. Beyond individual gene adaptations, tracking beneficial mutations in evolving bacterial populations remains a major challenge due to low detection limits in conventional sequencing. To address this, I developed a CRISPR/Cas9-based molecular barcoding system capable of tracking over 100,000 bacterial lineages at ultra-low frequencies (10??). Applying this system to a 20,000-generation evolution experiment, I identified 250 fitness-enhancing mutations in ~30 genes-dramatically improving upon traditional approaches. These insights demonstrate how a priori knowledge of adaptation mechanisms can enable knowledge-driven microbial engineering, accelerating the development of robust industrial strains. Plus d'infos...
Tags: Moreau, Draft:Rincn Bomba massacre, Moreau River
Annonce publiée le 28-03-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407
Mardi 08 Avril 2025    11:45
Invitee par l’Institut Jacques Monod, Suzette Lust (Postdoctoral researcher in Danijela Matic Vignjevic’s team – Cell migration and invasion Laboratory at Institut Curie) va presenter le seminaire sur le theme : Understanding the role of interstitial flow in vascular smooth muscle cell phenotype in the context of aortic aneurysms Ce seminaire se deroule dans le cadre des Paris Postdocs Seminars. Resume : Aortic aneurysms are abnormal enlargements of blood vessel diameter caused by aberrant extra-cellular matrix (ECM) remodelling. As the tissue dilates, it loses its mechanical integrity, exposing patients to risk of highly fatal aortic dissections or ruptures. This is mediated in part by phenotypic switching and or apoptosis of the intima-resident vascular smooth muscles (VSMCs). What drives this pathology is not well understood, particularly in the case of aneurysms in Bicuspid Aortic Valve disease (BAV) patients, a congenital condition characterised by the malformation of the aortic valve resulting in only 2 leaflets. Improvements in imaging techniques have now allowed pathological blood flow patterns to be correlated to aneurysm morphology and indeed there is increasing evidence that mechanotransduction from flow may be a driver of aneurysm development. Blood flow imparts mechanical forces to cells through stretching and frictional shear forces and we are focused here on the interstitial flow driven into the wall by differential pressure gradients within the aorta. We hypothesise that interstitial flow plays a crucial role in regulating VSMC phenotype and ECM interactions and that this may be used to correlate disrupted flow patterns seen in BAV patients to the morphology changes in their aortas. To test this hypothesis, we created a reductionist in-vitro model culturing VSMCs in 3D under interstitial flow. We combined a synthetic PEG based ECM mimicking hydrogel with primary cultures of VSCMs with a microfluidics setup. We showed hydrogels doctored with degradable bioactive peptides could be broken down by exogenous and cell derived MMPs. We measured hydrogel permeability using 2 separate techniques which confirmed the material to have a low permeability compared to other standard hydrogels, on the order of 10?16 m2. Furthermore, we characterised mass transport of solutes within hydrogels and were able to demonstrate a negligible impact of changing polymer solid content on diffusivity in hydrogels of up to 5% weight/volume for molecules up to 40 kDa in size. Via production of MMPs, VSMCs break down the hydrogel and importantly by day 7 of culture, we detected newly synthesised fibronectin, collagen 1 and 4 proteins. We stimulated encapsulated cells with interstitial flows demonstrating that cells align to the flow direction. Finally, we performed RNA sequencing on 3 human patient samples comparing standard culture conditions, non-flow stimulated encapsulated cells and interstitial-flow stimulated cells. The data set reveals significant upregulation of genes in multiple pathways associated with cyclic AMP production, which plays a crucial role in regulating VSMC contractility and calcium signalling and hence phenotype. The data suggests that this is mediated via activation of G-protein receptors leading to increased expression of adenylyl cyclase but this remains to be confirmed. In conclusion, we developed a novel in-vitro platform to study the impact of interstitial flow on VSMC behaviour. Our data suggests that interstitial flow may play a regulating role in determining VSMC phenotype with potential consequences for matrix remodelling in disease. Plus d'infos...
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France
Mardi 08 Avril 2025    13:30
Invite par: Judith Halewa Tags: Genetics
Annonce publiée le 28-03-2025
IMAGINE
auditorium du 6eme etage, 24 boulevard du Montparnasse - 75015
Mercredi 09 Avril 2025    9:30
La premiere reunion du cytoskeleton club de 2025 aura lieu ce mercredi a l’Institut Pasteur : – Charlotte Mallart (post-doc, Minc lab, Institute Jacques Monod) presentera : «Regulation of cytoplasm rheologyby bulk F-Actin networks». – Noemi Zollo (PhD student, Verlhac/ Terret lab, CIRB College de France) presentera : A novel RNP compartment allows mouse oocytes to adapt translational levels during late growth?. Plus d'infos...
Annonce publiée le 14-01-2025
Institut Jacques Monod
Institut Pasteur, 28 rue du dr roux, 75015 Paris, France
Jeudi 10 Avril 2025    0:00
The development of complex in vitro models, such as organoids, gastruloids and organ-on-chips systems, will allow the better understanding of human biological processes that are otherwise difficult to address with classical in vitro 2D culture and/or with animal models. Elucidating how pathogens, such as the SARS-CoV-2, invade human cells by evading the immune system and how this could be modulated by the host microbiota has been greatly facilitated by the advancement of 3D cell culture techniques. For example, mimicking the gut peristalsis in gut-on-a-chip device improves the maturation of colon epithelial cells and aid to unveil the role of mechanical stress in accelerating enteropathogen invasion. Our lab is working on establishing unique advanced microphysiological systems that can mimic the interaction between human epithelial barriers with the surrounding tissues, such as blood vessels, mesenchyme and immune cells. My scientific project is focused on the establishment of lung-on-chip devices that cover the entire respiratory tract (from the nasopharynx to the alveoli) as a platform to understand airborne infections and tropism of respiratory viruses. There we relay both on the use of lung multipotent stem cells grown as organoids, in order to produce the different cell population of the respiratory tract, and on microfluidic chips. Paris Post-docs seminar series. Plus d'infos...
Batiment Francois Jacob , salle Auditorium Francois Jacob ,
Vendredi 11 Avril 2025    11:00
Invite par: Manish KUSHWAHA Therapeutic phages used alongside antibiotics show potential for combating antibiotic-resistant bacteria. Some antibiotics induce physiological changes in bacteria, such as filamentation, which enhances phage infection and replication, a phenomenom known as Phage-Antibiotic Synergy (PAS). Plus d'infos...
Invitee par l’equipe Konstantinides, Dr. Marion Silies (Johannes-Gutenberg-University Mainz, Germany) presentera un seminaire de l’Institut Jacques Monod sur le theme : Heterogeneity of connectivity and function in the fly visual system Resume : Visual systems are considered homogeneous structures where repeating visual units contain the same circuit motifs that fulfil the same functional role, leading to translation invariance. However, our recent work, analyzing full fly brain connectomes, revealed remarkable heterogeneity, even within anatomically and genetically identifiable cell types. I will describe this heterogeneity in synaptic connectivity, and address where it arises developmentally. Furthermore, I will discuss how heterogeneous circuit motifs can lead to degeneracy of neuronal function, and thus to both, reliablility and flexiblity of neuronal information processing in the visual system. Plus d'infos...
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France
Vendredi 11 Avril 2025    12:00
Invite par: Laurence Arbibe Philippe Sansonetti, MD, trained in infectious diseases in Paris and in bacterial genetics at Institut Pasteur, Paris, then at the Walter Reed Army Institute of Research as a post-doctoral scientist. He is currently Emeritus Professor at Institut Pasteur and at the College de France where he has been lecturing for 12 years at the interface between basic microbiology and emerging infectious diseases.
Professor Sansonetti pioneered the field of Cellular Microbiology by deciphering the molecular and cellular mechanisms of Shigella pathogenesis. He more recently applied similar approaches to decipher the symbiotic mechanisms established between the host and his gut microbiota. His work on Shigella vaccine development and on pediatric malnutrition in relation with gut dysbiosis got him close to global health issues in low-income countries, particularly in Africa.
Philippe Sansonetti received several prestigious awards including the Louis Jeantet Prize of Medicine and the Grand Prix de lAcademie des sciences, and a foreign member of the US National Academy of Sciences, the Royal Society and the German Academy of Sciences Leopldina.Seminar topic: Gut dysbiosis and colorectal cancer: from descriptomics to experimentomics Photo: Jerome Panconi Plus d'infos...
Tags: Digestive system, Environmental microbiology, Microbiomes, Bacteriology, Pasteur Institute, Philippe Sansonetti, Dysbiosis, Gut microbiota, Gastrointestinal tract, Human microbiome, Sansonetti
Hematopoietic stem cells (HSCs) are multipotent, self-renewing cells responsible for the production of all blood cell types throughout the life of an individual. Despite their location within the adult bone marrow, HSCs are generated during development from specialized endothelial cells called hemogenic endothelial cells in the main embryonic arteries (dorsal aorta, umbilical and vitelline arteries), an evolutionary conserved mechanism within vertebrate species. HSCs arise through a process called endothelial-to-hematopoietic transition, a lineage switch which is tightly regulated in time and space and polarized to the ventral side of the embryonic aorta. In this respect, HSC production is also thought to rely on a specialized microenvironment localized underneath the aortic floor that would promote the lineage switch and constitute a niche for the first HSCs. Taken together, HSC formation encompasses intrinsic cues i.e., cell autonomous and extrinsic cues that constitute an unresolved paradigm for cell and developmental biology and a challenge for regenerative medicine, as clinical de novo formation of HSCs is an unmet goal.
I investigate these intrinsic and extrinsic regulations using complementary in vitro and in vivo approaches in the avian embryo, which is a reliable and accessible vertebrate model, and using human iPSCs.
On one hand, I am developing an in vitro system that allows mesodermal cells to differentiate into endothelial cells, then into hemogenic endothelial cells, and finally into hematopoietic cells. This system will be used to detect the discrete cellular differentiation steps leading to HSC formation using single cell RNA sequencing technology. The main goal is to elucidate the initial steps of HSC formation to eventually optimize in vitro culture systems for clinical grade HSC production.
On the other hand, I use microsurgical techniques to alter the normal microenvironment of the aorta, the cradle of HSC formation, and evaluate the consequences for HSC development. Combining these ablation experiments with spatial transcriptomic approaches will decipher the role of the aortic environment in the formation of the first HSCs. Laurent Yvernogeau is invited by Pascal Maire. Plus d'infos...
Tags: University of Leuven, In Belgium, Pierre-Joseph van Beneden
Annonce publiée le 22-12-2024
Centre de Recherche des Cordeliers
Amphi Gustave Roussy
Vendredi 18 Avril 2025    12:00
Invite par: Petra BULANKOVA - EEB Seminar Series One of the most dramatic transitions in eukaryotic cell evolution is that from being a non-photosynthetic protozoan, to a photosynthetic alga, via the acquisition of chloroplasts. This process has happened many times in eukaryotic evolution, but most of the photosynthetic eukaryotes that exist today, including plants, are too ancient to give us clues into how this cellular merger occurs. Plus d'infos...
Tags: Vision scientists, Vision, Perception, Visual perception, Ophthalmology, Jennifer S. Lund, Ruxandra Sireteanu
Annonce publiée le 26-03-2025
NeuroPSI
Salle de conference Albe-Fessard
Vendredi 25 Avril 2025    12:00
Invite par: Mario Pende Brendan Manning, Ph.D. is a Professor and Acting Chair in the Department of Molecular Metabolism at the Harvard T.H. Chan School of Public Health. He received his PhD from Yale University in 2000 and was a postdoctoral fellow at Harvard Medical School. In 2004, Dr. Manning became the first faculty member hired in the then newly established Department of Genetics and Complex Diseases (later changed to Molecular Metabolism) at Harvard-Chan. Dr. Manning was an inaugural recipient of the National Cancer Institute&'s Outstanding Investigator Award.Research in the Manning lab is defining the molecular interface between cellular signaling networks and metabolic networks, as it relates to both normal physiology and diseases with metabolic dysregulation as a key feature, including cancer, diabetes, and aging-related diseases. Research efforts are focused in part on defining the regulatory mechanisms and functions of a signaling network converging on the tuberous sclerosis complex (TSC) protein complex and the mammalian target of rapamycin (mTOR), which relay an array of extracellular and intracellular growth signals to control the balance between anabolic and catabolic metabolism in cells, tissues, and tumors. Plus d'infos...
Tags: Signal transduction, MTOR, Immunosuppressants, MTOR inhibitors, Macrolides, Polyenes, Metabolism, Sirolimus, Harvard T.H. Chan School of Public Health
Annonce publiée le 11-03-2025
Institut Necker Enfants Malades
Auditorium 3
Lundi 28 Avril 2025    12:00
Invite par: Matthieu Mahevas - Pascal Chappert Christopher Goodnow holds The Bill and Patricia Ritchie Foundation Chair as Head of the Immunogenomics Laboratory, a NHMRC Senior Principal Research Fellow, and is Professor and Chair of the Cellular Genomics Futures Institute at UNSW Sydney. Professor Goodnow obtained his medical degree from the University of Sydney and a PhD from the Walter and Eliza Hall Institute. His pioneering work in the field of immunology has significantly advanced our understanding of the immune system, particularly in areas such as immune tolerance and autoimmunity. Goodnow's research has been instrumental in uncovering the genetic basis of immune disorders, leading to the development of new therapeutic approaches. Throughout his career, he has held numerous prestigious positions, including Professor of Immunology at the Australian National University and Executive Director of the Garvan Institute of Medical Research.In addition to his academic and research accomplishments, Professor Goodnow has received numerous accolades, reflecting his contributions to science and medicine. He was elected as a Fellow of the Australian Academy of Science and has been recognised with several awards for his groundbreaking research. At the Garvan Institute, he continues to lead cutting-edge research efforts aimed at unravelling the complexities of the immune system and translating these findings into clinical applications. His work not only enhances our scientific knowledge but also has a profound impact on the development of treatments for immune-related diseases.Photo credits: Garvan Institute of Medical Research Plus d'infos...
Tags: Chris Goodnow, Garvan Institute of Medical Research, Garvan, Goodnow, Draft:Greg Neely, Leslie Lazarus
Invite par: Romain Briandet Information obtained through detail analysis of microbial function leads to the finding of unexpected enzymes, metabolisms, and communities useful as novel biotechnological tools in food, medical, and chemical industries. Examples of bioprocess development by applying unique tools found through functional analysis of microbial metabolisms will be introduced. Plus d'infos...
ldquo;The origin of animals from unicellular ancestors has been a key step in our evolutionary origins. However, the cellular and molecular basis of this transition remain incompletely understood. In the past few years, key insights have emerged from the study of choanoflagellates: the closest living relatives of animals. I will summarize some of our recent research showing how choanoflagellate biology informs our understanding of several pivotal features of animal complexity, including multicellular development, morphogenesis, cell differentiation, and cell-cell communication.rdquo; Plus d'infos...
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407
Mercredi 07 Mai 2025    14:00
Invite par: axe transversal, Claire JANOIR and Thomas CANDELA La presentation explorera des developpements de pointe en chimie des substances naturelles, abordant les defis lies a la comprehension de leurs fascinantes diversite et complexite a travers des perspectives (bio)chimiques et evolutives. Elle mettra en lumiere des approches innovantes en fouille profonde de donnees et en metabolomique pour decoder, par exemple, des voies biosynthetiques complexes. Nous discuterons de la maniere dont ces outils comblent des lacunes dans la comprehension d'aspects moleculaires des espaces chimiques des substances naturelles, qu'elles proviennent de micro-organismes, de plantes ou d'animaux tels que des invertebres marins. Plus d'infos...
au College de France - Salle D2 acces restreint, merci de passer par l'accueil du CDF : 11 place Marcelin Berthelot - 75005 Paris
Mercredi 14 Mai 2025    15:00
Invite par: Rencontre Clinico-Biologique Institut Cochin Hopital Cochin Accueil : Florence Niedergang Yannick Allanore ---
Introduction : Camille Tlemsani ---
Diagnostic anatomopathologique des sarcomes : Frederique Larousserie ---
Radiomique dans le diagnostic des sarcomes : Marie-Pauline Talabard ---
Transcriptomique pour l aide au diagnostic : Albain Chansavang ---
Epigenomique et IA pour classer les sarcomes : Djihad Hadjadj ---
Point de vue chirurgical : l impact du diagnostic sur la chirurgie : David Biau ---
Transcriptomique spatiale dans l os (problematique des marges) : Diana Passaro ---
Point de vue de l oncologue sur l impact du diagnostic : Camille Tlemsani ---
Caracterisation des cellules immunitaires des tumeurs : Julie Helft
Plus d'infos...
Tags: Sarcoma, Personalized medicine
Annonce publiée le 13-03-2025
Institut Cochin
salle Rosalind Franklin au 2eme etage, 22 rue Mechain 75014
Jeudi 15 Mai 2025    0:00
Invited by Katia Ancelin and Julie Chaumeil. Plus d'infos...
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)
Lundi 19 Mai 2025    0:00
L'instabilite genetique est une caracteristique des cellules cancereuses mais aussi une cause de maladies genetiques chez l'homme. Notre apprehension des relations causales entre instabilite genetique et le developpement de pathologies humaines repose sur nos connaissances des mecanismes fondamentaux du metabolisme de l'ADN et de l'ARN, depuis l'organisation spatial et chromatinien des genomes, leur expression et regulation au cours du developpement ou en reponse a des stress environnementaux. La deregulation de ces mecanismes fondamentaux lies au metabolisme des genomes peut etre a l'origine de pathologies humaines, incluant le cancer, le vieillissement, des maladies neurologiques et des deficits immunitaires. Organisation: Des seminaires donnes par des orateurs specialistes du domaine couvrant les mecanismes fondamentaux qui gouvernent la stabilite des genomes, aux approches grandes echelles (signatures moleculaires, proteomique, NGS) et les pathologies associees. Il s'agit de valoriser comment un continuum de recherche, allant de la recherche fondamentale a la recherche clinique et translationnelle, permet de repondre a des questions de sante humaine. Des ateliers: Developpement de carriere, communication scientifique, Workshop technologique, session poster, «Elevator Pitch», presentation et moderation des orateurs par les participants. Prix Poster Visite du musee Curie Plus d'infos...
Annonce publiée le 20-02-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)
au College de France - Salle D2
11 place Marcelin Berthelot - 75005 Paris
Jeudi 05 Juin 2025    0:00
The escalating spread and density of tick populations underscore the urgent need for enhanced surveillance and risk assessment strategies for tick-borne diseases (TBD). Biomarkers derived from the antibody response to tick saliva can be used to facilitate the surveillance of vector establishment in novel regions, assess anti-vector interventions and diagnose TBD through documentation of antecedent tick bites in suspected cases. Here, we derived short peptides from previously identified immunogenic proteins—namely IrCRT, IrSPI, and IrLIP—through bioinformatic predictive analysis using the Immune Epitope Database. ELISAs performed with experimentally controlled sheep sera infested with Ixodes ricinus were used to assess the level of antibody response of IgM and IgG to the peptides derived from these three proteins. Next, we tested the candidates on sera derived from both field and clinical isolates of tick-exposed individuals. For all sera, we obtained different IgM and IgG responses with varying degrees of immunogenicity detected per peptide. Further, through use of an exploratory microarray assay (PepperPrint™), we selected new peptides based on their ability to be recognized using serum from experimentally infested sheep. Amongst the top randomly generated peptides, we found a more specific immunogenic response against the IgG antibodies when compared to IgM. Selected candidates were further tested against experimentally-controlled infested sheep sera, as well as field and clinical isolates. Finally, candidates were cross-validated against mosquito-exposed sera to ensure vector specificity. This study offers the potential for developing new effective strategies for the surveillance and diagnosis of tick-related risks as well as the control and prevention of TBD. Paris Post-docs seminar series. Plus d'infos...
Invite par: Fawaz Alzaid Mohammed Al-Onaizi is an Assistant Professor at the Faculty of Medicine, Kuwait University. His research focuses on the intersection of neurodegeneration and metabolic diseases, particularly diabetes and obesity. He holds a Bachelor of Science in Physiotherapy from Kuwait University, a Master's of Science in Human Anatomy from the University of Dundee, and a PhD in Anatomy and Cell Biology from the University of Western Ontario. Dr. Al-Onaizi has held academic positions as an Assistant Professor at Kuwait University and a Visiting Scientist at the University of Laval. His research, supported by grants from Kuwait University and the Dasman Diabetes Institute, explores the molecular and cellular mechanisms underlying diabetes-associated neurodegeneration.Beyond research, he is dedicated to education, mentoring students, and serving on academic committees. He is an active member of the Kuwait University Faculty Members Association and regularly contributes to the scientific community through publications, conference presentations, and outreach initiatives.Seminar topic: The inflammatory IRF5-TNF axis contributes to cognitive and behavioral effects of type 2 diabetes Plus d'infos...
Centre de recherche - Paris - Amphitheatre Marie Curie
Jeudi 11 Septembre 2025    0:00
Clear cell renal cell carcinoma (ccRCC) is a prevalent and aggressive subtype of kidney cancer. Immunotherapies that boost the ability of CD8+ T cells to eliminate cancer cells have become a standard of care for ccRCC. However, tumor infiltration of CD8+ T cells can result in contradicting clinical outcomes, potentially due to the functional heterogeneity among tumor-specific CD8+ T cells. In this study, we observed that ccRCC tumors are infiltrated by circulating (Tcirc) and tissue-resident (Trm) memory CD8+ T cells that specifically recognize autologous RCC cells in an HLA class I-dependent manner. Trm cells exhibited higher tumor reactivity but reduced stemness potential and a more exhausted state, whereas Tcirc cells retained higher stemness and cytotoxic potential. Single-cell transcriptomics revealed a rather heterogenous composition of memory populations, including cytotoxic and progenitor Tcirc subsets, as well as multiple Trm subsets, including exhausted Trm cells. TCR and trajectory analyses indicate that circulating progenitors lose their circulation, cytotoxicity and stemness potential within the tumor microenvironment while progressively acquiring a tissue-resident differentiation program followed by a terminal differentiation state. Interestingly, tumor enrichment of Trm and cytotoxic Tcirc cells predicts better survival, while exhausted Trm and total CD8+ T cells predict worse survival in RCC patients. Our findings provide new insights into the differentiation pathways and clinical impact of tumor-specific memory CD8+ T cells infiltrating human RCC tumors. Adoptive T cell therapy (ACT) has demonstrated remarkable efficacy in treating hematological cancers. However, its efficacy against solid tumors remains limited and the emergence of cancer cells that lose expression of targeted antigens promotes resistance to ACT. The mechanisms underlying effective and durable ACT-mediated tumor control are incompletely understood. Here, we show that adoptive transfer of TCR-transgenic CD8+ T cells that efficiently eliminates established murine tumors induces tumor accumulation of CD8+ T cells exhibiting tumor-reactive phenotypes. Interestingly, host CD8+ T cells contributed to ACT-mediated elimination of primary tumors and rejected ACT-resistant melanoma cells lacking the targeted antigen. Mechanistically, ACT induced TNF-?- and dendritic cell-dependent tumor accumulation of endogenous CD8+ T cells and effective tumor elimination. Importantly, although lymphodepleting preconditioning enhanced expansion of transferred cells and ACT-mediated tumor elimination, it impaired host antitumor immunity and abrogated protection against ACT-resistant tumors. Tumor enrichment of transcriptional signatures associated with TNF-? signaling, cross-presenting dendritic cells and tumor-specific CD8+ T cells in correlated with favorable responses to ACT and increased survival in human cancers. Our findings reveal that long-term efficacy of ACT is determined by the interplay between transferred and endogenous CD8+ T cells and is undermined by lymphodepleting preconditioning, which ultimately favors ACT resistance. Plus d'infos...
Analyse de donnees multimodales et modelisation de reseaux pour maitriser les capacites distinctives des cancers Le cours reunira des intervenants de premier plan issus de differents domaines de la biologie des systemes cancereux, de la recherche sur le cancer et de la clinique. Les orateurs invites exposeront diverses approches pour l analyse et l interpretation des donnees omiques, d imagerie et cliniques, en combinant les reseaux de signalisation avec des donnees moleculaires multi-echelles, et en les associant a des donnees cliniques. Les themes abordes comprennent l integration et l analyse de donnees genomiques multimodales, les algorithmes de prediction de la sensibilite aux medicaments, l identification de biomarqueurs et de facteurs de cancer, la stratification des patients, et les applications de la modelisation mathematique et de l analyse d images dans le domaine du cancer. Cette edition comprendra egalement de nouvelles sessions consacrees aux applications actuelles du traitement du langage naturel dans la biologie des systemes computationnels du cancer, a l integration des donnees epigenomiques, ainsi qu aux approches de pharmacologie systemique et de metabolomique. Enfin, un moment fort de la rencontre sera la celebration du 25e anniversaire de la publication de l article fondamental "The hallmarks of cancer" (les capacites distinctives des cancers) de Hanahan et Weinberg (Cell 2000). Plus d'infos...
Annonce publiée le 18-03-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)