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Invited by: Naima Belgareh-Touze Previous studies using ubiquitin traps combined with mass spectrometry revealed that in Bortezomib (BTZ) resistant Mantle Cell Lymphoma (MCL) cells, a selective autophagy mechanism, known as proteaphagy, was a main mechanism eliminating the proteasome and reducing the sensitivity to this treatment. In order to recover the sensitivity to BTZ we have tackled two main molecules that were found enriched in the ubiquitin proteome of those cells, the autophagy receptor p62 and the Tripartite Motif Containing protein 24 (TRIM24) ubiquitin ligase. To investigate how TRIM24 could contribute to this proteolytic crosstalk, dTRIM24, a proteolysis-targeting chimera (PROTAC), was employed. dTRIM24 treatment enhanced apoptosis in BTZ-resistant ZBR cells, but no significant difference was observed compared to the parental, BTZ-sensitive Z138 cells. However, the dTRIM24/BTZ combination significantly enhances cooperativity and drives an efficient apoptosis in ZBR cells. The use of a ZBRTRIM24 KO cell line further confirmed the important role of TRIM24 in the triggering of cell death in the context of BTZ resistance. Reducing the TRIM24 protein level in ZBR cells by dTRIM24 or in the context of the ZBRTRIM24 KO cell line allowed the recovery of proteasome activity and explained the apoptosis efficacy observed with the dTRIM24/BTZ treatment. Interestingly, proteaphagy is not significantly affected in the ZBRTRIM24 KO compared to the parental ZBR cell line, indicating that TRIM24 does not directly regulate proteaphagy. Instead, dTRIM24 treatment resulted in the remodeling of protein ubiquitination favoring the accumulation of K48 Ub chains and their interaction with proteasome subunits. A similar PROTAC strategy was used to tackle p62 and advances on this approach will be presented. Altogether, our data indicate that TRIM24 and p62 play an important role as a regulators of UPS/ALS crosstalk by distinct mechanisms, either by regulating the abundance of K63 vs K48 chains or directly blocking proteaphagy. Understanding the key molecular mechanisms underlying this process is crucial for the development of new combination therapies with the ability to overcome BTZ refractoriness or in general regulating selective autophagy events in distinct pathologies. More details... Published on 04-02-2025 |
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| IBPC Bibliotheque de l'Institut de Biologie Physico-Chimique |
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Invitee par l’equipe Greenberg, Maud Borensztein (Team Epigenetic Reprogramming and Mammalian Development, IGMM, CNRS, University of Montpellier) presentera un seminaire de l’Institut Jacques Monod sur le theme : Reprogramming the X chromosome: insights from mammalian development and germline Resume : Maud Borensztein team focuses on epigenetic mechanisms in mammalian development and reproduction, with a particular emphasis on X-chromosome dosage compensation. Since establishing her group at the Institut de Genetique Moleculaire de Montpellier (IGMM) in 2021, they have developed innovative tools to study gametogenesis and X-chromosome dynamics, both in vivo (using mouse models) and in vitro (using Primordial Germ Cell-like cells). Investigating the reactivation of the inactive X chromosome during germline specification in females-a unique epigenetic reprogramming process that highlights fine gene-regulation control-, they aim to uncover its timing, mechanisms, and biological implications.
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Tags: Developmental biology, Epigenetics, DNA, Genetics, Reprogramming, Sex-chromosome dosage compensation, Germ cell, Gametogenesis, Germline, X-chromosome reactivation
Published on 13-02-2025
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Invited by: Etienne Morel - Cedric Delevoye
Aurelien Roux studied biology at the Ecole Normale Superieure de Lyon, France (1997-1999), with a minor in Physics. He did a Master of Physics, University Denis Diderot, Paris (1999-2000). As a Ph.D student with Patricia Bassereau and Bruno Goud (Curie Institute, Paris, 2000-2004), he studied how lipids can be sorted by membrane curvature. He then did his post-doctoral work with Pietro de Camilli (2004-2007, Yale, USA), reconstituting in vitro dynamin mediated membrane fission, which he continued as a CNRS staff scientist (Institut Curie, Paris, 2007-2010). Appointed assistant professor of Biochemistry, Geneva (2010-2015), he expanded his work towards ESCRT-III, the most ancient and ubiquitous fission machinery in the cell. In 2016, he was tenured to associate professor at Unige, and then Full professor in 2020. During this period, he developed assays to reconstitute spontaneous morphogenesis of cellular assemblies in vitro.Seminar topic: Asgard archaea reveals the conserved principles of ESCRT-III membrane remodellingESCRT-III proteins assemble into composite polymers that undergo stepwise changes in composition and structure to deform membranes across the tree of life. Here, using a phylogenetic analysis we demonstrate that the two ESCRT-III proteins present in our closest archaeal relatives, Asgard, are evolutionarily related to B-type and A-type eukaryotic paralogues that initiate and execute membrane remodelling, respectively. We show how Asgard ESCRT-IIIB can assemble into parallel arrays on planar membranes to initiate membrane deformation and is required to recruit ESCRT-IIIA to generate composite polymers. Finally, Asgard ESCRT-IIIA is able to remodel membranes into tubes, as a likely prelude to scission. Taken together, our data reveal a set of conserved principles governing ESCRT-III-dependent membrane remodelling that first emerged in a two-component ESCRT-III system in archaea.
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Tags: ESCRT, Organelles, Domains, Archaea, Asgard, Fission
Published on 11-02-2025
Institut Necker Enfants Malades
Auditorium 1 -
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Published on 12-03-2025
NeuroPSI -
TBA
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Tags: Jami, Ludovic, Draft:Rincn Bomba massacre, Jami Masjid, Mangrol
Published on 23-01-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - Tours 22-32 - 4e etage - Piece 407 -
Invited by: Cristel Archambaud
Coxiella burnetii, the causal agent of the Q fever, is an obligate intracellular pathogen that replicates within host cells. This lifestyle relies on the formation of Coxiella-containing vacuoles (CCVs), specialized vacuoles that provide a shielded environment for bacterial replication, enabling C. burnetii to evade host immune defences and establish persistent infections. CCV development hinges on bacterial effector proteins translocated into host cells through a Type 4 Secretion System (T4SS), which interact with host proteins to subvert membrane trafficking. Expanding on the earlier identification of CvpB as a C. burnetii Lipid-Interacting Effector (LIE) that manipulates PI(3)P metabolism, we have conducted further investigations into the lipid composition of CCVs. Use of lipid binding probes revealed that PI(3)P, PI(4)P and LBPA were actively enriched at the CCV by T4SS effectors. We have identified the effector Vice as an additional LIE responsible for LPBA enrichment at the CCV. Vice interacts with phosphoinositides and late endosomal membranes, enriched in phosphatidylserine (PS) and lysobisphosphatidic acid (LBPA). CCVs generated by the vice::Tn mutants are negative for LBPA, showed a strong defect in size and an altered morphology as compared to wt CCVs. Strikingly, ectopic expression of Vice in eukaryotic cells leads to the formation of compartments reminiscent of early CCVs in both morphology, protein and lipid composition. The biogenesis of these Vice-induced compartments (VICs) is driven by an intriguing dual role of Vice. Initially, the effector localizes at the plasma membrane of eukaryotic cells, triggering the internalization of large vacuoles through the induction of macropinocytosis. Subsequently, Vice stabilizes VICs by disrupting the ESCRT machinery, impeding the formation of intraluminal vesicles (ILVs), with consequences on the release of extracellular vesicles (EVs). Taken together, our findings highlight Vice as a pivotal C. burnetii effector capable of exploiting two major cellular pathways to shape the bacterial replicative environment.
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Tags: Membrane biology, Organelles, Legionellales, Cell biology, Coxiella burnetii, Gram-negative bacteria, Intracellular parasite, Coxiella, Secretion, Effector, Endocytosis, Cellular compartment
Published on 07-02-2025
Institut Micalis
Auditorium 442 - Institut Micalis -
Tags: Hematology, Hematopoietic stem cell transplantation, Lymphology, Surgical oncology, Transplantation medicine, Gene therapy
Published on 08-03-2025
IMAGINE
IMAGINE, auditorium du 6eme etage, 24 boulevard du Montparnasse - 75015 -
La premiere reunion du cytoskeleton club de 2025 aura lieu ce mercredi a l’Institut Pasteur : – Charlotte Mallart (post-doc, Minc lab, Institute Jacques Monod) presentera : «Regulation of cytoplasm rheologyby bulk F-Actin networks». – Noemi Zollo (PhD student, Verlhac/ Terret lab, CIRB College de France) presentera : A novel RNP compartment allows mouse oocytes to adapt translational levels during late growth?.
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Published on 14-01-2025
Institut Jacques Monod
Institut Curie, 26 rue d#039;Ulm 75005 Paris, , France -
Tags: Neural coding, Immunity
Published on 08-03-2025
IMAGINE
IMAGINE, auditorium du 6eme etage, 24 boulevard du Montparnasse - 75015 -
Invited by Molly Ingersoll.
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Tags: NewYorkPresbyterian Healthcare System, Ingersoll, Ontario, Ingersoll, Donna Farber, Columbia University Irving Medical Center
Published on 19-12-2024
Institut Cochin
Salle Rosalind Franklin -
Invited by: Eduardo Rocha
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Tags: Bacteriophages, Phage therapy, Therapy, Bacteriophage, Antimicrobial resistance, Antibiotic, Drug resistance
Published on 11-03-2025
Institut Pasteur
Batiment Francois Jacob, salle Auditorium Francois Jacob, -
Tags: Neuroscience, Brain
Published on 13-03-2025
NeuroDiderot
salle de conferences 6eme etage du batiment Bingen, Point Rouge, Hopital Robert Debre, 48 boulevard Serurier - 75019 ou en visioconference : contact lien = sylvie.berrard at inserm.fr -
Seminar led by CELINE JAIMET (Single Cell Specialist at BD) AYMERIC SYLVIN (Institut Gustave Roussy) will also be attending and will present his work: “High-throughput scRNA-seq as a tool for better understanding immune cell heterogeneity and their contribution to diseases.” If you would like to connect with the speakers after the seminar, please contact: Valerie Chauffeton (CRC): valerie.chauffeton@crc.jussieu.fr or Céline Jaimet (BD): celine.jaimet@bd.com
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Tags: Molecular biology, RNA sequencing, Multiomics, RNA-Seq, Institut Gustave Roussy, Sylvin
Published on 27-02-2025
Centre de Recherche des Cordeliers -
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Published on 14-02-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Invited by: BONVENTO Gilles
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Tags: Motivation, Behavioral neuroscience, Addiction, Behavior modification, Cognitive neuroscience, Reward system, ESPCI Paris
Published on 18-02-2025
NeuroPSI
Salle de conference Albe-Fessard -
Invited by: Isabelle Sermet-Gaudelus
Dr. Olivier Tabary has been a researcher at Inserm at Institut Necker Enfants Malades since 2025. He began focusing on cystic fibrosis projects in 1996. Following his PhD in Reims and a post-doctoral fellowship at EMBL in Heidelberg, Germany, he spent a significant period at St Antoine Research Hospital in Paris. Throughout his career, he has advanced various techniques in microscopy, molecular and cell therapy, infection, and inflammation, consistently related to CF patient needs. In 2023, Dr. Tabary founded the startup Anoat Therapeutics to create a novel therapeutic approach for patients.Seminar topic: ANO1 a new approach for cystic fibrosis; from basic science to translational studies
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Tags: Channelopathies, Cystic fibrosis, Fibrosis
Published on 15-02-2025
Institut Necker Enfants Malades
Auditorium 1 -
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Tags: Malaria, Red blood cell, Malaria vaccine, Peter Preiser
Published on 06-03-2025
Institut Cochin
Salle Rosalind Franklin -
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Tags: J. William Harbour, Melanoma, Uveal melanoma, Uvea, DecisionDx-UM, Draft:Carlos Rogerio Figueiredo
Published on 14-01-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
Singing is a natural and universal human behavior uniquely processed by the brain. It offers a deeply enjoyable experience, particularly when per- formed in groups. As such, singing carries significant biological importance and holds great potential for promoting health and fostering social integration.
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Tags: Animal anatomy, Brain, Organs, Isabelle Peretz, Cognitive musicology
Published on 25-01-2025
I. Cerveau et de la Moelle
Please join the conference in Paris Brain Institute auditorium. -
Invited by: IBENS Neuroscience seminar
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Published on 05-03-2025
IBENS
salle Favard, IBENS 46 rue d'Ulm 75005 Paris -
Ce cours explorera la polyvalence des elements d ADN non geniques et des ARN non codants dans un large eventail de processus cellulaires, chez l humain et les organismes modeles, ainsi que leur implication dans la physiologie et les maladies. Il elargira les sujets autour des domaines de la genomique, de l epigenetique et de la transcriptomique, y compris les technologies et analyses a cellule unique, la regulation de l'epigenome et de l expression des genes, l organisation du genome et la clonalite cellulaire. Des experts reconnus a l international presenteront leurs dernieres decouvertes concernant l identification et la caracterisation fonctionnelle du genome non codant, et discuteront des nouveaux concepts en matiere de regulation et d evolution du genome, avec un fort accent sur les outils experimentaux et informatiques. Les sessions thematiques incluront l analyse computationnelle de l heterogeneite cellulaire, les methodes d evaluation de l heterogeneite et de la plasticite cellulaire, l epigenome dans la regulation de l expression des genes, les retroelements dans la plasticite cellulaire, le genome "sombre" dans l identite et la clonalite cellulaire, ainsi que l organisation spatiale. Ce cours offrira aux jeunes etudiants et chercheurs l opportunite d elargir leurs connaissances et de discuter de leurs travaux avec une communaute scientifique internationale dans un environnement chaleureux et stimulant a l Institut Curie a Paris. Keynote speakers Stein AERTS - BE Maria Elena TORRES PADILLA - DE Intervenants Tugce AKTAS - DE Maria BRBIC - CH Chunlong CHEN - FR Bart DEPLANCKE - CH Dominic GRÜN- DE Amit IDO - IL Jop KIND - NL Gioele LA MANNO - CH Ana POMBO - DE Alex RADZISHEUSKAYA - UK Alejo RODRIGUEZ FRATICELLI - ES Arjun RAJ - USA Arnau SEBRE-PEDROS - ES Sydney SHAFFER - USA Angela TADDEI - FR Barbara TREUTLEIN - CH Didier TRONO - CH
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Published on 06-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Invited by: IBENS - Equipe Alice LEBRETON
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Published on 13-03-2025
IBENS
salle Favard, IBENS 46 rue d'Ulm 75005 Paris -
Invited by: Daniela POPA et Clement LENA, section Neurosciences
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Tags: Neurochemistry, Dopamine, Neurotransmitters, Adrenergic, Sympathetic nervous system, Sympathomimetics, Dopaminergic, Cerebellum, Alpha-1B adrenergic receptor, Incertohypothalamic pathway
Published on 15-02-2025
IBENS
salle Favard, IBENS 46 rue d'Ulm 75005 Paris -
Summury : Ultrasound is a widely used medical imaging technique that is sensitive to blood flow. However, it is limited by a classical trade-off between penetration and resolution. In particular, brain imaging and angiography using ultrasound are compromised by the skull, which attenuates acoustic waves, especially those that could provide submillimeter details. Ultrasound Localization Microscopy (ULM) is a novel technique that offers very high resolution deep within tissues. It relies on clinical contrast agents—specifically, intravascular microbubbles—that are isolated and localized at the micrometric scale in ultrasound images. Tracking their movement can yield blood velocities in the microvasculature. This technique has been demonstrated in various contexts, including the brain (Errico et al., Nature 2015), as well as in the kidney, tumors, peripheral vessels, lymph nodes, and more, both preclinically and clinically. In this presentation, we will describe recent advances in ULM, particularly focusing on 3D reconstruction of rat brain hemodynamics at the microvascular scale. We will also present angiography of the entire brain at this scale, highlighting its sensitivity to stroke models. Additionally, we will discuss the current results of clinical trials. Furthermore, we will introduce sensing-ULM, which provides access to the microvasculature of functional units, such as glomeruli, in both animals and humans. In our laboratory, these developments are aimed at creating a new imaging tool for stroke patients in critical care. In the future, ULM could indeed facilitate deep angiography, potentially reducing treatment time for ischemic patients. Bio : Olivier Couture was born in Quebec City (Canada) in 1978. He received his B.Sc degree in physics from McGill University, Montreal, Canada, in 2001, and his Ph.D degree from the department of Medical Biophysics, University of Toronto, Canada, in 2007. After a postdoctoral fellowship at ESPCI in Paris (France), he was hired as a research associate at CNRS, based within the Langevin Institute. In 2019, he moved to Laboratoire d’Imagerie Biomédicale (LIB, Sorbonne Université) as a research director to head the team Physiology and Pathology of Microcirculation and, later, co-supervise the Medical Ultrasound team of the LIB. He was awarded the CNRS Bronze Medal and the 2017 IEEE Ultrasonics Early Career Investigator Award for introducing super-resolution ultrasound through microbubble localization. He is the principal investigator of the ERC Consolidator Grant “ResolveStroke”, the ERC POC StrokeMonitor and the ERC POC KidneyScope. He is also the cofounder of the startup ResolveStroke.
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Tags: Ultrasound, Medical ultrasonography, Acoustics, Medical equipment, Ultrasound Localization Microscopy, Medical ultrasound, Microbubble, Angiography, Neuroimaging, Focused ultrasound-mediated diagnostics, Acoustic angiography
Published on 27-02-2025
Centre de Recherche des Cordeliers
Amphi Gustave Roussy -
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Published on 14-02-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Invited by: Etienne Morel
Jacky Goetz graduated in Pharmacology and Cell Biology from University of Strasbourg (France) in the laboratory of K.TAKEDA. He then moved to the laboratory of I.R. NABI in Montreal (University of Montreal, Canada), and later in Vancouver (University of British Columbia, Canada), where he obtained his PhD in 2007. He performed two postdoctoral stays, one at the CNIC in Madrid (Spain) in the laboratory of M.A. DEL POZO, and one in the lab of J.VERMOT at the IGBMC in Strasbourg (France). Fascinated by tumor metastasis, its mechanical aspects and the use of state-of-the-art microscopy approaches in several animal models, he created the TUMOR BIOMECHANICS LAB in 2013. Quickly joined by a team of experts in imaging, mechanobiology, extracellular vesicles, he built a task force aiming at further dissecting the mechanisms and mechanics of tumor dissemination. The team made several exciting discoveries around tumor metastasis that were acknowledged by several prizes (SBCF, Ruban Rose, Academy of Sciences, Fondation de France). When he is not in the lab, Jacky is either running, swimming or biking and loves competing during half IronMan triathlons (70.3). You can also find him traveling with his family, during sabbaticals (Australia, South Africa), always thinking about the next trip. Fascinated by Japan but also by Alsace, where he grew up, he could kill for sushi and loves the alsatian architecture.Seminar topic: Multi-modal tracking of metastasis : from priming to inhibitory targets
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Tags: Cancer pathology, Metastasis, Oncology
Published on 11-02-2025
Institut Necker Enfants Malades
Auditorium 1 -
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Published on 28-11-2024
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Invited by: CIRB - College de France
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Tags: @cirbcdf.bsky.social
Published on 11-12-2024
College de France
au College de France - Salle D2 acces restreint, merci de passer par l'accueil du CDF : 11 place Marcelin Berthelot - 75005 Paris -
Invited by: Pascale Serror
Metazoans, including Drosophila and mammals, maintain complex interactions with their gut microorganisms, which play a crucial role in host physiology, particularly juvenile growth under chronic undernutrition. Nutrient deprivation often leads to stunted growth and disrupted gut microbiota maturation, but microbial interventions, including Lactiplantibacillus plantarum (Lp), can mitigate these effects. Lp promotes juvenile growth in Drosophila by stimulating protease expression in intestinal cells through bacterial cell envelope components, notably peptidoglycan and d-alanylated lipoteichoic acids (d-Ala-LTA), via an NF-?B-dependent pathway. Similar effects have been observed in undernourished mice, where Lp cell envelopes alone are sufficient to promote growth.
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Tags: Bacteriology, Microbiomes, Digestive system, Microbiology, Environmental microbiology, Lipoteichoic acid, Microbiota, Drosophila, Peptidoglycan, Gut microbiota, NF-B, Lactiplantibacillus plantarum
Published on 07-02-2025
Institut Micalis
Auditorium 442 - Institut Micalis -
Invited by: MARTIN Jean-Rene
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Tags: Medical terminology, Neuron, Astrocyte, Synaptopathy
Published on 04-03-2025
NeuroPSI
Salle de conference Albe-Fessard -
Invited by: Institut Necker Enfants Malades
Meryem B. Baghdadi is a researcher in the field of stem cell and development biology and has made significant contributions to the understanding of stem cell niches and their regulation in both homeostasis and disease contexts. Meryem's academic journey began at Universite Pierre et Marie Curie (UPMC), where she earned a Master's degree in Cellular and Molecular Biology, majoring in Stem Cell Biology. This was followed by a Ph.D. in Stem Cells and Development at Institut Pasteur. She then moved to Toronto, Canada for her postdoc at SickKids, exploring the role of enteric glial cells in stem cell niche regulation. In October 2022, she was awarded as a CNRS Research Associate position at the Institut Curie in Paris. In January 2025, Meryem began a new role as a Junior Group Leader at the Institut Necker Enfant Malades in Paris, where she leads a team studying the regulation of the intestinal stem cell niche in development and disease.Meryem has an impressive list of publications, including co-corresponding author papers in prestigious journals such as Science, Cell Stem Cell, and Nature. Her work has been recognized with several awards, including, 2025 ATIP-Avenir program, ATIP award from the Fondation Bettencourt-Schueller, the Young Researcher Prize from the French Society of Cell Biology in 2024 and the Young Rising Talent France award from the Fondation L&'Oreal-UNESCO in 2022.
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Tags: Stem cells, Biotechnology, Cell biology, Cloning, Developmental biology, Stem-cell niche
Published on 11-03-2025
Institut Necker Enfants Malades
Auditorium 1 -
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Tags: Koukouli, Pierrette Gaudreau, Jean Garrab
Published on 13-11-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
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Tags: Barbosa
Published on 19-11-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
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Tags: Delayed open access journals, Cell, Cell and molecular biology, Transfersome
Published on 21-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Oscillations moleculaires et mecaniques L objectif general du 7e cours de biologie cellulaire et du cancer est de couvrir differents sujets en biologie cellulaire, biologie du developpement et physique, en mettant l accent sur les oscillations moleculaires et mecaniques dans les systemes biologiques. Keynote speaker Alexandre Aulehla - DE Intervenants Annabelle Ballesta - FR Thibaut Brunet, FR Clotilde Cadart- FR Mathieu Coppey - FR Stephanie Descroix - FR Silvia Fre - FR Martijn Gloerich - NL Hanspeter Herzel - DE Jean-Leon Maitre - FR Franck Perez - FR Francois Schweisguth - FR Katharina Sonnen - NL Xavier Trepat - ES
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Published on 15-01-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Invited by: Zehra Esra Ilhan
Endometriosis and adenomyosis are debilitating gynecologic conditions that affect millions of women worldwide, yet their pathophysiology remains poorly understood, leading to delayed diagnoses and limited treatment options. Emerging evidence suggests that genetic, immune, and hormonal factors contribute to disease progression, while environmental exposures may further influence disease onset and severity. Despite their significant impact on reproductive health and quality of life, these conditions remain understudied, highlighting an urgent need for innovative research approaches. By leveraging integrated multi-omics analyses, including the microbiome, immunoproteomics, and metabolomics, we can unravel the complex interactions driving these diseases. A deeper understanding of these factors will pave the way for improved diagnostics, personalized therapeutic strategies, and targeted interventions, ultimately enhancing patient outcomes.
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Tags: Gynaecologic disorders, Adenomyosis, Endometriosis, Omics, Multiomics, Microbiome
Published on 04-03-2025
Institut Micalis
Auditorium 442 - Institut Micalis -
Invited by: Marianne de Paepe & Jeffrey Cornuault
Mushuvirus mushu is a temperate bacteriophage linked to human gut bacteria. I identified its genome in 1,300-year-old paleofeces, revealing near-identical sequence to modern references, highlighting its remarkable conservation across human history. In follow-up work, I characterized the entire Mushuviridae family across tens of thousands of metagenomes, uncovering their interactions with gut-associated bacteria like Faecalibacterium, Roseburia, Blautia, and others. This study showcases how computational methods can reveal bacteriophage diversity on a global scale and expand our understanding of the human gut virome.
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Tags: Bacteriophages, Virology, Microbiomes, Bacteriology, Environmental microbiology, Bacteriophage, Gut microbiota, Virome, Temperateness, Faecalibacterium, Phageome
Published on 06-03-2025
Institut Micalis
Auditorium 442 - Institut Micalis -
The development of complex in vitro models, such as organoids, gastruloids and organ-on-chips systems, will allow the better understanding of human biological processes that are otherwise difficult to address with classical in vitro 2D culture and/or with animal models. Elucidating how pathogens, such as the SARS-CoV-2, invade human cells by evading the immune system and how this could be modulated by the host microbiota has been greatly facilitated by the advancement of 3D cell culture techniques. For example, mimicking the gut peristalsis in gut-on-a-chip device improves the maturation of colon epithelial cells and aid to unveil the role of mechanical stress in accelerating enteropathogen invasion. Our lab is working on establishing unique advanced microphysiological systems that can mimic the interaction between human epithelial barriers with the surrounding tissues, such as blood vessels, mesenchyme and immune cells. My scientific project is focused on the establishment of lung-on-chip devices that cover the entire respiratory tract (from the nasopharynx to the alveoli) as a platform to understand airborne infections and tropism of respiratory viruses. There we relay both on the use of lung multipotent stem cells grown as organoids, in order to produce the different cell population of the respiratory tract, and on microfluidic chips. Paris Post-docs seminar series.
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Tags: Tissue engineering, Biotechnology, Stem cells, Microfluidics, Nanotechnology, Organoid, Organ-on-a-chip, Respiratory tract, 3D cell culture, Lung, Organ, Intestine-on-a-chip
Published on 08-01-2025
Institut Cochin
Salle Rosalind Franklin -
Invited by: Manish KUSHWAHA
Therapeutic phages used alongside antibiotics show potential for combating antibiotic-resistant bacteria. Some antibiotics induce physiological changes in bacteria, such as filamentation, which enhances phage infection and replication, a phenomenom known as Phage-Antibiotic Synergy (PAS).
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Tags: Bacteriology, Bacteriophages, Filamentation, Microbiology, Antimicrobial resistance, Bacteriophage, Antibiotic, Bacteria, Phage therapy, Bacterial morphological plasticity
Published on 12-02-2025
Institut Micalis
Auditorium 442 - Institut Micalis -
Invited by: Laurence Arbibe
Philippe Sansonetti, MD, trained in infectious diseases in Paris and in bacterial genetics at Institut Pasteur, Paris, then at the Walter Reed Army Institute of Research as a post-doctoral scientist. He is currently Emeritus Professor at Institut Pasteur and at the College de France where he has been lecturing for 12 years at the interface between basic microbiology and emerging infectious diseases. Professor Sansonetti pioneered the field of Cellular Microbiology by deciphering the molecular and cellular mechanisms of Shigella pathogenesis. He more recently applied similar approaches to decipher the symbiotic mechanisms established between the host and his gut microbiota. His work on Shigella vaccine development and on pediatric malnutrition in relation with gut dysbiosis got him close to global health issues in low-income countries, particularly in Africa. Philippe Sansonetti received several prestigious awards including the Louis Jeantet Prize of Medicine and the Grand Prix de lAcademie des sciences, and a foreign member of the US National Academy of Sciences, the Royal Society and the German Academy of Sciences Leopldina.Seminar topic: Gut dysbiosis and colorectal cancer: from descriptomics to experimentomics Photo: Jerome Panconi
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Tags: Digestive system, Environmental microbiology, Microbiomes, Bacteriology, Pasteur Institute, Philippe Sansonetti, Dysbiosis, Gut microbiota, Gastrointestinal tract, Human microbiome, Sansonetti
Published on 04-03-2025
Institut Necker Enfants Malades
Auditorium 3 -
Invited by Pascal Maire.
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Published on 10-01-2025
Institut Cochin
Salle Rosalind Franklin -
Hematopoietic stem cells (HSCs) are multipotent, self-renewing cells responsible for the production of all blood cell types throughout the life of an individual. Despite their location within the adult bone marrow, HSCs are generated during development from specialized endothelial cells called hemogenic endothelial cells in the main embryonic arteries (dorsal aorta, umbilical and vitelline arteries), an evolutionary conserved mechanism within vertebrate species. HSCs arise through a process called endothelial-to-hematopoietic transition, a lineage switch which is tightly regulated in time and space and polarized to the ventral side of the embryonic aorta. In this respect, HSC production is also thought to rely on a specialized microenvironment localized underneath the aortic floor that would promote the lineage switch and constitute a niche for the first HSCs. Taken together, HSC formation encompasses intrinsic cues i.e., cell autonomous and extrinsic cues that constitute an unresolved paradigm for cell and developmental biology and a challenge for regenerative medicine, as clinical de novo formation of HSCs is an unmet goal. I investigate these intrinsic and extrinsic regulations using complementary in vitro and in vivo approaches in the avian embryo, which is a reliable and accessible vertebrate model, and using human iPSCs. On one hand, I am developing an in vitro system that allows mesodermal cells to differentiate into endothelial cells, then into hemogenic endothelial cells, and finally into hematopoietic cells. This system will be used to detect the discrete cellular differentiation steps leading to HSC formation using single cell RNA sequencing technology. The main goal is to elucidate the initial steps of HSC formation to eventually optimize in vitro culture systems for clinical grade HSC production. On the other hand, I use microsurgical techniques to alter the normal microenvironment of the aorta, the cradle of HSC formation, and evaluate the consequences for HSC development. Combining these ablation experiments with spatial transcriptomic approaches will decipher the role of the aortic environment in the formation of the first HSCs. Laurent Yvernogeau is invited by Pascal Maire.
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Tags: Stem cells, Developmental biology, Hematopoiesis, Hematopoietic stem cell, Biotechnology, Hematopoietic stem cell niche, Haematopoiesis, Cellular differentiation, Stem cell factor
Published on 22-02-2025
Institut Cochin
Salle Rosalind Franklin -
Invited by: Théo Hirsch
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Tags: University of Leuven, In Belgium, Pierre-Joseph van Beneden
Published on 22-12-2024
Centre de Recherche des Cordeliers
Amphi Gustave Roussy -
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Published on 20-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Invited by Anne Hosmalin.
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Tags: Dudziak, Diana
Published on 16-01-2025
Institut Cochin
Salle Rosalind Franklin -
Invited by: Mario Pende
Brendan Manning, Ph.D. is a Professor and Acting Chair in the Department of Molecular Metabolism at the Harvard T.H. Chan School of Public Health. He received his PhD from Yale University in 2000 and was a postdoctoral fellow at Harvard Medical School. In 2004, Dr. Manning became the first faculty member hired in the then newly established Department of Genetics and Complex Diseases (later changed to Molecular Metabolism) at Harvard-Chan. Dr. Manning was an inaugural recipient of the National Cancer Institute&'s Outstanding Investigator Award.Research in the Manning lab is defining the molecular interface between cellular signaling networks and metabolic networks, as it relates to both normal physiology and diseases with metabolic dysregulation as a key feature, including cancer, diabetes, and aging-related diseases. Research efforts are focused in part on defining the regulatory mechanisms and functions of a signaling network converging on the tuberous sclerosis complex (TSC) protein complex and the mammalian target of rapamycin (mTOR), which relay an array of extracellular and intracellular growth signals to control the balance between anabolic and catabolic metabolism in cells, tissues, and tumors.
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Tags: Signal transduction, MTOR, Immunosuppressants, MTOR inhibitors, Macrolides, Polyenes, Metabolism, Sirolimus, Harvard T.H. Chan School of Public Health
Published on 11-03-2025
Institut Necker Enfants Malades
Auditorium 3 -
Invited by: Matthieu Mahevas - Pascal Chappert
Christopher Goodnow holds The Bill and Patricia Ritchie Foundation Chair as Head of the Immunogenomics Laboratory, a NHMRC Senior Principal Research Fellow, and is Professor and Chair of the Cellular Genomics Futures Institute at UNSW Sydney. Professor Goodnow obtained his medical degree from the University of Sydney and a PhD from the Walter and Eliza Hall Institute. His pioneering work in the field of immunology has significantly advanced our understanding of the immune system, particularly in areas such as immune tolerance and autoimmunity. Goodnow's research has been instrumental in uncovering the genetic basis of immune disorders, leading to the development of new therapeutic approaches. Throughout his career, he has held numerous prestigious positions, including Professor of Immunology at the Australian National University and Executive Director of the Garvan Institute of Medical Research.In addition to his academic and research accomplishments, Professor Goodnow has received numerous accolades, reflecting his contributions to science and medicine. He was elected as a Fellow of the Australian Academy of Science and has been recognised with several awards for his groundbreaking research. At the Garvan Institute, he continues to lead cutting-edge research efforts aimed at unravelling the complexities of the immune system and translating these findings into clinical applications. His work not only enhances our scientific knowledge but also has a profound impact on the development of treatments for immune-related diseases.Photo credits: Garvan Institute of Medical Research
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Tags: Chris Goodnow, Garvan Institute of Medical Research, Garvan, Goodnow, Draft:Greg Neely, Leslie Lazarus
Published on 11-03-2025
Institut Necker Enfants Malades
Auditorium 3 -
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Tags: Ens, Provincial road N765
Published on 13-11-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
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Published on 28-11-2024
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
ldquo;The origin of animals from unicellular ancestors has been a key step in our evolutionary origins. However, the cellular and molecular basis of this transition remain incompletely understood. In the past few years, key insights have emerged from the study of choanoflagellates: the closest living relatives of animals. I will summarize some of our recent research showing how choanoflagellate biology informs our understanding of several pivotal features of animal complexity, including multicellular development, morphogenesis, cell differentiation, and cell-cell communication.rdquo;
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Tags: Developmental biology, Evolutionary biology, Choanoflagellate, Cellular differentiation, Multicellular organism, Morphogenesis, Biology, Holozoa, Capsaspora
Published on 04-03-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407 -
Invited by: CIRB - College de France
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Tags: @cirbcdf.bsky.social
Published on 11-12-2024
College de France
au College de France - Salle D2 acces restreint, merci de passer par l'accueil du CDF : 11 place Marcelin Berthelot - 75005 Paris -
Invited by: Rencontre Clinico-Biologique Institut Cochin Hopital Cochin
Accueil : Florence Niedergang Yannick Allanore --- Introduction : Camille Tlemsani --- Diagnostic anatomopathologique des sarcomes : Frederique Larousserie --- Radiomique dans le diagnostic des sarcomes : Marie-Pauline Talabard --- Transcriptomique pour l aide au diagnostic : Albain Chansavang --- Epigenomique et IA pour classer les sarcomes : Djihad Hadjadj --- Point de vue chirurgical : l impact du diagnostic sur la chirurgie : David Biau --- Transcriptomique spatiale dans l os (problematique des marges) : Diana Passaro --- Point de vue de l oncologue sur l impact du diagnostic : Camille Tlemsani --- Caracterisation des cellules immunitaires des tumeurs : Julie Helft
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Tags: Sarcoma, Personalized medicine
Published on 13-03-2025
Institut Cochin
salle Rosalind Franklin au 2eme etage, 22 rue Mechain 75014 -
Invited by Katia Ancelin and Julie Chaumeil.
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Tags: Chaumeil
Published on 24-01-2025
Institut Cochin
Salle Rosalind Franklin -
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Published on 20-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
L'instabilite genetique est une caracteristique des cellules cancereuses mais aussi une cause de maladies genetiques chez l'homme. Notre apprehension des relations causales entre instabilite genetique et le developpement de pathologies humaines repose sur nos connaissances des mecanismes fondamentaux du metabolisme de l'ADN et de l'ARN, depuis l'organisation spatial et chromatinien des genomes, leur expression et regulation au cours du developpement ou en reponse a des stress environnementaux. La deregulation de ces mecanismes fondamentaux lies au metabolisme des genomes peut etre a l'origine de pathologies humaines, incluant le cancer, le vieillissement, des maladies neurologiques et des deficits immunitaires. Organisation: Des seminaires donnes par des orateurs specialistes du domaine couvrant les mecanismes fondamentaux qui gouvernent la stabilite des genomes, aux approches grandes echelles (signatures moleculaires, proteomique, NGS) et les pathologies associees. Il s'agit de valoriser comment un continuum de recherche, allant de la recherche fondamentale a la recherche clinique et translationnelle, permet de repondre a des questions de sante humaine. Des ateliers: Developpement de carriere, communication scientifique, Workshop technologique, session poster, «Elevator Pitch», presentation et moderation des orateurs par les participants. Prix Poster Visite du musee Curie
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Published on 20-02-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
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Tags: Fellows of the American Association for the Advancement of Science, Chen Tianqiao, Chen Wei
Published on 22-02-2025
NeuroPSI
Salle de conference Albe-Fessard -
Invited by: CIRB - College de France
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Tags: @cirbcdf.bsky.social
Published on 21-10-2024
College de France
au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris -
Invited by Sophie Vaulont.
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Tags: Universities UK, Russell Group, University of Birmingham, Sophie
Published on 20-12-2024
Institut Cochin
Salle Rosalind Franklin -
Invited by: Claire Deligne
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Tags: Midwood Books, Midwood, Brooklyn
Published on 22-12-2024
Centre de Recherche des Cordeliers
Amphi Gustave Roussy -
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Published on 20-02-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
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Tags: Ardem Patapoutian, Piezo, Scripps, E. W. Scripps Company, Nobel Prize in Physiology or Medicine
Published on 12-03-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Invited by: CIRB - College de France
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Tags: @cirbcdf.bsky.social
Published on 12-02-2025
College de France
au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris -
The escalating spread and density of tick populations underscore the urgent need for enhanced surveillance and risk assessment strategies for tick-borne diseases (TBD). Biomarkers derived from the antibody response to tick saliva can be used to facilitate the surveillance of vector establishment in novel regions, assess anti-vector interventions and diagnose TBD through documentation of antecedent tick bites in suspected cases. Here, we derived short peptides from previously identified immunogenic proteins—namely IrCRT, IrSPI, and IrLIP—through bioinformatic predictive analysis using the Immune Epitope Database. ELISAs performed with experimentally controlled sheep sera infested with Ixodes ricinus were used to assess the level of antibody response of IgM and IgG to the peptides derived from these three proteins. Next, we tested the candidates on sera derived from both field and clinical isolates of tick-exposed individuals. For all sera, we obtained different IgM and IgG responses with varying degrees of immunogenicity detected per peptide. Further, through use of an exploratory microarray assay (PepperPrint™), we selected new peptides based on their ability to be recognized using serum from experimentally infested sheep. Amongst the top randomly generated peptides, we found a more specific immunogenic response against the IgG antibodies when compared to IgM. Selected candidates were further tested against experimentally-controlled infested sheep sera, as well as field and clinical isolates. Finally, candidates were cross-validated against mosquito-exposed sera to ensure vector specificity. This study offers the potential for developing new effective strategies for the surveillance and diagnosis of tick-related risks as well as the control and prevention of TBD. Paris Post-docs seminar series.
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Tags: Tick-borne diseases, Tick-borne disease, Ixodidae, Ixodes ricinus, Ixodes, Tick, Biomarker, Zoonoses, Deer tick, Lyme disease
Published on 01-02-2025
Institut Cochin
Salle Rosalind Franklin -
Invited by: Fawaz Alzaid
Mohammed Al-Onaizi is an Assistant Professor at the Faculty of Medicine, Kuwait University. His research focuses on the intersection of neurodegeneration and metabolic diseases, particularly diabetes and obesity. He holds a Bachelor of Science in Physiotherapy from Kuwait University, a Master's of Science in Human Anatomy from the University of Dundee, and a PhD in Anatomy and Cell Biology from the University of Western Ontario. Dr. Al-Onaizi has held academic positions as an Assistant Professor at Kuwait University and a Visiting Scientist at the University of Laval. His research, supported by grants from Kuwait University and the Dasman Diabetes Institute, explores the molecular and cellular mechanisms underlying diabetes-associated neurodegeneration.Beyond research, he is dedicated to education, mentoring students, and serving on academic committees. He is an active member of the Kuwait University Faculty Members Association and regularly contributes to the scientific community through publications, conference presentations, and outreach initiatives.Seminar topic: The inflammatory IRF5-TNF axis contributes to cognitive and behavioral effects of type 2 diabetes
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Tags: Cytokines, Endocrine diseases, Metabolic disorders, Tumor necrosis factor, Diabetes
Published on 15-02-2025
Institut Necker Enfants Malades
Auditorium 3 -
Invited by Pascal Maire.
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Tags: Maire, Fallon, The Roots, The Tonight Show, Jimmy Fallon
Published on 07-02-2025
Institut Cochin
Salle Rosalind Franklin -
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Published on 07-02-2025
Institut Curie
Centre de recherche - Paris - Webinar -
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Tags: Bacteriophages, Bacteriophage, Motility, Phage ecology, Phage display
Published on 28-02-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
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Tags: Anonymous, Botnets, Denial-of-service attacks, Internet-based activism, Low Orbit Ion Cannon, Wakanumun, Loc Bouvard
Published on 06-02-2025
Paris RNA Club
Auditorium Gallois - 45 rue d Ulm, 75005 Paris -
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Published on 05-03-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
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Published on 05-03-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
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Tags: Pediatric cancers, Adrenal gland disorders, Adrenaline, Brain tumor, Neuroblastoma, Blastoma, Adrenal gland, Malia Jusczyk
Published on 01-02-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
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Published on 05-02-2025
Institut Curie
Centre de recherche - Paris - Webinar