Histone variants are essential epigenetic players implicated in key nuclear events. However, their role in transcription regulation and genome organization is not clear and much remains to be done to understand their function in these processes. A key question for understanding their functional and structural involvement in all these roles is whether their location through chromatin is random or not, and if not, how are the specific sites of deposition determined and regulated ? The purpose of this presentation is to provide a comprehensive view about the genome-wide pattern of histone variants distribution in relation to DNA methylation and to their potential role in promoter architecture organization and transcription regulation.
Tags: Genetics, Biology, Epigenetics, Chromatin, DNA methylation, Histone, Transcriptional regulation, Epigenetics of plant growth and development, Epigenomics
Annonce publiée le 13-01-2018
|Institut de Biologie Integrative de la Cellule
salle de conference du Bat. 144