au College de France - Salle D2
11 place Marcelin Berthelot - 75005 Paris
Tuesday 10 September 2024    11:30
Although all biological systems must obey the laws of physics, specific examples of physical limitations on the performance of biological systems remain sparce. Bacterial motility is among the quantitatively best-understood biological behaviors, and it has long served as a model of how physics can help to understand bacterial ability to move and follow chemical gradients in the environment (chemotaxis). Using example of Escherichia coli, I will discuss how physical limits might have shaped the evolution of bacterial motility and of the chemotaxis system. Our recent work suggests that physical limitations on bacterial swimming, along with fitness tradeoffs associated with investment of limited cellular resources in motility, can be sufficient to quantitatively explain regulation of motility gene expression in both, laboratory model strains and natural isolates of E. coli. Moreover, hydrodynamics also determines performance of bacterial microswimmers that could be used for various biotherapeutic applications, and taking physics into account is important for their rational engineering.
Centre de recherche - Paris - Amphitheatre Marie Curie
Tuesday 10 September 2024    11:30
Although all biological systems must obey the laws of physics, specific examples of physical limitations on the performance of biological systems remain sparce. Bacterial motility is among the quantitatively best-understood biological behaviors, and it has long served as a model of how physics can help to understand bacterial ability to move and follow chemical gradients in the environment (chemotaxis). Using example of Escherichia coli, I will discuss how physical limits might have shaped the evolution of bacterial motility and of the chemotaxis system. Our recent work suggests that physical limitations on bacterial swimming, along with fitness tradeoffs associated with investment of limited cellular resources in motility, can be sufficient to quantitatively explain regulation of motility gene expression in both, laboratory model strains and natural isolates of E. coli. Moreover, hydrodynamics also determines performance of bacterial microswimmers that could be used for various biotherapeutic applications, and taking physics into account is important for their rational engineering.
Centre de recherche - Paris - Amphitheatre Marie Curie
Tuesday 10 September 2024    14:00
During infection, the immune system unleashes protective responses to fight against the pathogen while also establishes a memory compartment that will provide protection in case of a subsequent pathogen encounters. The B cell memory compartment is composed of two layers: long-lived plasma cells (LLPCs) and memory B cells (MBCs). LLPCs mainly migrate to the bone marrow, where they continuously secrete high-affinity antibodies and provide protection against re-infection with the same pathogen for years or even for lifetime. In contrast, MBCs remain in a quiescent state in secondary lymphoid organs (spleen and lymph nodes) until a future encounter with the same pathogen or a variant. Only then, MBCs will proliferate and differentiate into antibody-secreting plasma cells to provide a rapid and effective protective response, or re-enter germinal centre reactions, where they will diversify the memory repertoire. In the last years, it became evident than LLPCs and MBCs not only remain in lymphoid organs but further take residence in barrier tissues upon mucosal infections. During my talk, I will discuss how distinct barrier tissues, such as the lungs and the gut, use different B cell memory strategies to fight recurrent pathogens.
Cancer Immunotherapy has come of age in the last 15 years, with the success of checkpoint inhibitors, CAR-T cell therapy and adoptive T cell therapy. At Immunocore we develop soluble TCRs as therapeutics for cancer immunotherapy, autoimmune and infectious diseases. I will give an overview of the platform, the mechanism of action of TCR engagers and the challenges to develop new, HLA-unrestricted, therapeutics.
Tags: Achucarro Basque Center for Neuroscience, Devo, Evolutionary developmental biology, Achucarro, Evo
Published on 06-09-2024
College de France
au College de France - Salle D2
11 place Marcelin Berthelot - 75005 Paris
Thursday 12 September 2024    0:00
Nicolas Reynoird is invited by Frédéric Pendino. More details...
Tags: Dauphin, Grenoble
Published on 19-03-2024
Institut Cochin
Salle Rosalind Franklin
Thursday 12 September 2024    0:00
Malignant types of breast cancer that don't respond to current treatments remain a significant health challenge, largely because of their tendency to spread to other parts of the body. A deeper understanding of underlying mechanisms may offer valuable insights into alternative therapies aimed at stopping the dispersion of breast cancer cells.
Our lab recently identified the protein methyltransferase SMYD2 as a clinically actionable master regulator of breast cancer metastasis.
While SMYD2 is overexpressed in aggressive breast cancers, we noticed that it is not required for primary tumor growth. However, we found that specific SMYD2 ablation in mammary-epithelium increases mouse overall survival by blocking metastatic spread. Mechanistically, we identified that SMYD2 monomethylates a novel substrate, BCAR3, at lysine K334 in breast cancer cells. BCAR3 is a protein localized at focal adhesions and involved in cell migration and redistribution of actin fibers. Notably, we observed that methylated BCAR3 is specifically recognized by the FMNLs proteins. These actin cytoskeleton regulators are therefore recruited at the cell edges and modulate lamellipodia properties upon BCAR3 methylation. Remarkably, breast cancer cells with impaired BCAR3 methylation lose migration and invasiveness capacity in vitro and are ineffective in promoting metastases in vivo. SMYD2 pharmacologic inhibition efficiently impairs the metastatic spread of breast cancer cells, PDX and aggressive mammary tumors from genetically engineered mice. This study provides a rationale for innovative therapeutic prevention of malignant breast cancer metastatic progression by targeting the SMYD2-BCAR3-FMNL axis. Nicolas Reynoird is invited by Frédéric Pendino. More details...
Tags: Breast cancer, Cancer pathology, Oncology, Metastasis, BCAR3, Metastatic breast cancer, Cancer, Genes
Published on 31-05-2024
Institut Cochin
Salle Rosalind Franklin
Thursday 12 September 2024    11:00
Invited by: Jean-Louis Mergny RNA self-reproduction is central to origin-of-life scenarios. However, self-reproduction has been shown
in only a handful of systems. Using statistical covariation models and secondary structure prediction, we
populated a vast sequence space of ribozymes. Experimentally assayed sequences were found active
as far as 65 mutations from a reference natural sequence and computed that ~1039 such ribozymes could
be generated by the model, after correction by the experimental success rate. Randomly sampled artificial
ribozymes exhibited autocatalytic self-reproduction akin to the reference sequence, showing that selfreproduction
is a potentially wide-spread property of RNAs. Published on 02-09-2024
Ecole Polytechnique
Salle de conference du departement Batiment 84
Thursday 12 September 2024    11:30
au College de France - Salle 5
11 place Marcelin Berthelot - 75005 Paris
Thursday 12 September 2024    13:30
Objectifs pédagogiques de la formation
- Connaître les définitions légales des violences sexistes et sexuelles - Connaître les principales données chiffrées sur le sujet - Comprendre les conséquences des violences sexistes et sexuelles - Connaître les responsabilités et obligations de l’employeur, les sanctions encourues et les procédures - Savoir accueillir la parole et orienter
Aurore Vullien (equipe Gazave) va soutenir sa these : « Conservation evolutive et roles de la signalisation par les ROS durant l'initiation de la regeneration. Apport du cnidaire Nematostella vectensis et de l'annelide Platynereis dumerilii.» La soutenance se tiendra en francais le vendredi 13 septembre a 13h30 dans l'amphitheatre du Centre Antoine-Lacassagne (33, avenue de Valombrose) a Nice. Le jury est compose de : Lucas Leclere, CR, Sorbonne Universite (rapporteur) Morgane Locker, Pr, Universite Paris-Saclay (rapportrice) Hadi Boukhatmi, CR, Universite de Rennes 1 (examinateur) Nathalie Mazure, DR, Universite Cote d'Azur (examinatrice) Christine Rampon, MCU, Universite Paris Cite (examinatrice) Valerie Vouret, DR, Universite Cote d'Azur (examinatrice) Eve Gazave, CR, Universite Paris Cite (directrice de these) Eric Rottinger, DR, Universite Cote d'Azur (directeur de these) More details...
Published on 28-08-2024
Institut Jacques Monod
Universite Cote d#8217;Azur Amphitheatre du centre Antoine-Lacassagne, 33 avenue de valombrose, Nice, France
Monday 16 September 2024    11:00
The inhibitory immunoreceptor PD1 is a major cancer immunotherapy target. Anti-PD1 blockade antibodies have become the standard of care for cancer patients, but the low response rate and associated immune related side effects necessitate a better understanding of PD1 mechanism. Best known to be expressed by T cells, PD1 transduces inhibitory signals to attenuate T cell response upon binding to its ligand PDL1. In this seminar I will share our ongoing studies on the unexpected nuances in the signaling mechanism of PD1.
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e
Tuesday 17 September 2024
La seance est ouverte a un public general scientifique
Michael Hall est professeur au Biozentrum de Bale. La decouverte de Michael Hall qui lui vaut l'attribution de la grande Medaille de l'Academie des sciences consiste en la decouverte du mecanisme de la regulation de la croissance cellulaire. Il s'agit d'une avancee fondamentale de la biologie, la croissance cellulaire etant a c?te de la division et de la mort une des 3 fonctions essentielles de la biologie de toutes cellules . Ce regulateur denomme TOR (pour target of rapamycin) est present chez tous les eucaryotes (organismes constitues de cellules a noyau). C'est d'ailleurs chez la levure que Michael Hall l'a mis en evidence par une approche genetique particulierement elegante. Ce systeme agit sous la forme d'enzyme (de kinase) qui assure une fonction de tour de contr?le de la croissance et du volume cellulaire en couplant une serie d'informations (presence de nutriments) avec divers fonctions metaboliques comme la synthese de lipides, de proteines et des acides nucleiques.. Ce systeme est universel, de la levure a l'homme. Michael Hall en a decrypte les mecanismes d'action et a montre leurs implications dans nombre de processus pathologiques comme le cancer, l'obesite ou les maladies cardiovasculaires.
Michael Hall est un grand savant, unanimement respecte, il est laureat de nombreuses distinctions dont le prix Lasker. L'etendue de ses connaissances scientifiques et de leur histoire, et son inlassable curiosite sont particulierement impressionnantes. More details...
Published on 19-07-2024
Academie des Sciences
23 quai de Conti - 75006 Paris
Tuesday 17 September 2024
La seance est ouverte a un public general scientifique
La Grande medaille est une distinction attribuee chaque annee, en alternance, dans les disciplines relevant de chacune des divisions de l'Academie, a un savant francais ou etranger ayant contribue au developpement de la science de facon decisive, tant par l'originalite de ses recherches personnelles que par leur rayonnement international et l'influence stimulante qu'il aura eue en creant une veritable ecole de recherche. More details...
Published on 19-08-2024
Academie des Sciences
23 quai de Conti - 75006 Paris
Tuesday 17 September 2024    11:00
Thursday 19 September 2024    14:00
Raphael MANGIONE (equipe Palancade) va defendre sa these : Characterizing the Interplay Between DNA:RNAHybrids and Genome Stability Elle se tiendra le jeudi 19 septembre a 14h dans la salle Francois Jacob de l’Institut Jacques Monod(15 Rue Helene Brion, 75013 Paris),et sera en anglais. Les membres du jury sont : Dr. Valerie BORDE, Directrice de Recherche, Sorbonne Universite, Rapportrice Dr. Michael CHANG, Associate Professor, Universite de Groningen, Rapporteur Dr. Aline MARNEF, Chargee de Recherche, Universite Toulouse III, Examinatrice Dr. Jerome POLI, Maitre de Conferences, Universite de Montpellier, Examinateur Dr. Stephane MARCAND, Directeur de Recherche, Universite Paris-Saclay,Examinateur Dr. Benoit PALANCADE, Directeur de Recherche, Universite Paris Cite,Directeur de these More details...
Tags: Genetic mapping, Genomics, Genome
Published on 28-08-2024
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France
Invite par l'equipeGazave, Thibault Brunet (Evolutionary Cell Biology and Evolution of Morphogenesis team, Institut Pasteur, Paris) presentera un seminaire de l'Institut Jacques Monod sur le theme : The evolutionary origin of animal morphogenesis: insights from the closest living relatives of animals Resume : All animals are characterized by a recognizable, species-specific adult shape, which results from a controlled process of morphogenesis during embryonic development. Morphogenesis relies on a small core set of cellular mechanisms: cell adhesion, migration, division, deformation, and apoptosis. The mechanisms that shape animal embryos did not always exist, but gradually evolved as their single-celled ancestors successively acquired multicellularity, development, and cell differentiation more than 600 million years ago. While the origin of animals has only left few fossil traces, insights can be gained by the study of modern groups. In recent years, important concepts have emerged from the study of choanoflagellates, the closest living relatives of animals. Choanoflagellates are free-living aquatic protists that possess multiple features informative on the origin of animal development: they display a polarized cell architecture (with apical flagellum and microvilli) reminiscent of that of epithelial cells; their genome encodes an animal-like developmental molecular toolkit (including cadherins, integrins, collagens, actomyosin and its regulators); and they can facultatively develop into multicellular colonies that resemble early animal embryos. Our work combines functional genetics and high-resolution imaging to understand how choanoflagellate cell shape is generated, how shapes of individual cells underlie emerging multicellular shapes and behaviors, and how these findings inform our understanding of the origin of animal morphogenesis. More details...
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France
Friday 20 September 2024    12:00
Invited by: Peter van Endert In 2009, Oliver Bannard completed his PhD under the supervision of Professor Douglas Fearon at the University of Cambridge, UK, investigating the developmental pathway of memory CD8+ T cells. Subsequently, he joined Professor Jason Cyster's laboratory at the University of California, San Francisco (UCSF), supported by a Wellcome Trust-funded postdoctoral fellowship, where his focus shifted to B cell research. In 2015, Prof. Bannard returned to the UK to establish an independent research group at the Weatherall Institute of Molecular Medicine (WIMM) at the University of Oxford. His laboratory has received substantial funding from the Wellcome Trust, initially through a Sir Henry Dale Fellowship (20152021) and more recently a Senior Research Fellowship (2021present). The group's research aims to uncover the mechanisms governing humoral immune responses, with a particular focus on germinal centres.Seminar topic: Selection events that shape serum antibody responses to infection
More details...
Tags: Immunology, Glycoproteins, Antibody, Weatherall Institute of Molecular Medicine, Wellcome Trust, Humoral immunity
Published on 05-09-2024
Institut Necker Enfants Malades
Auditorium 3
Tuesday 24 September 2024    11:00
Plants, like all living organisms, are subject to mechanical forces either from their environment or from within their own bodies. For example, when the root encounters obstacles in the soil, or when rain, wind, and gravity exert mechanical stimuli on aerial parts. Endogenous forces result from the high osmotic pressure within the cell. To sense these forces, plants have evolved force microsensors embedded in their cell membrane that are mechanosensitive (MS) channels. Many MS channels belonging to five families (MSL, MCA, Piezo, OSCA and TPK) have been molecularly identified in plants. Some of them, such as Piezo, are found in animals and plants, while others, such as MCA, are restricted to plants. Only, few of these plant channels have been functionally characterized. I will present the basic properties of MSL10, which is predominantly expressed in aerial organs of Arabidopsis. I will then show that MSL10 activity is amplified by oscillatory stimulation at frequencies corresponding to wind-driven oscillations. Therefore, it is proposed that AtMSL10 represents a molecular component that allows plants to perceive oscillatory mechanical stimuli. Recently, we have also characterized a rapidly activated calcium MS channel (RMA) in Arabidopsis. We are currently investigating the role of this channel in root mechanosensing. Finally, I will stress the need to reintegrate plant MS channel in the cellular-context. Indeed, MS channels described with the patch-clamp technique are characterized in the absence of a cell wall. There is a need to map membrane tension at the cellular scale in order to specifying where, and under which conditions, plant MS channels operate. More details...
Tags: Transmembrane proteins, Membrane biology, Ion channels, Integral membrane proteins, Protein families, Mechanosensitive channels, Root, Cell membrane, Piezo, Small-conductance mechanosensitive channel
Published on 26-08-2024
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407
Tuesday 24 September 2024    11:30
Invited by: Lida Katsimpardi Hospital Bonn. His career includes clinical and research stays at the Psychiatric University Clinic Zurich, the National Institute on Aging in Bethesda, USA, and the Translational Genomics Research Institute in Phoenix, USA. In 2003, he was awarded a research professorship by the Swiss National Science Foundation. By 2007, he had become a full professor of Molecular Neuroscience, and in 2010, he was appointed director of the Research Cluster for Cognitive and Molecular Neuroscience at the University of Basel. Andreas has received numerous prestigious awards, including the Robert Bing Prize, the Weizmann Lecture, and the Cloetta Prize. He is also an elected member of the Senate of the Swiss Academy of Medical Sciences.Seminar topic: Human genetic signatures of remembering and forgetting as a basis for drug discovery
More details...
Le cours réunira des intervenants de premier plan issus de différents domaines de la biologie des systèmes cancéreux, de la recherche sur le cancer et de la clinique. Les orateurs invités exposeront diverses approches pour l'analyse et l'interprétation des données omiques, d'imagerie et cliniques, en combinant les réseaux de signalisation avec des données moléculaires multi-échelles, et en les associant à des données cliniques.
Les thèmes abordés comprennent l'intégration et l'analyse de données génomiques multimodales, les algorithmes de prédiction de la sensibilité aux médicaments, l'identification de biomarqueurs et de facteurs de cancer, la stratification des patients, et les applications de la modélisation mathématique et de l'analyse d'images dans le domaine du cancer.
L'objectif du cours est de promouvoir une meilleure intégration des approches informatiques dans les laboratoires biologiques et cliniques et dans les cliniques. Nous voulons aider les participants à comprendre et à utiliser les approches d'intégration multimodale pour exploiter efficacement les différents types de données qui s'accumulent dans la plupart des laboratoires biologiques ou médicaux.
Le cours passera en revue les méthodes et outils actuels pour l'analyse et l'interprétation des données génomiques multimodales, en mettant l'accent sur la transcriptomique et la protéomique spatiales récentes, ainsi que sur des applications concrètes liées au cancer.
En particulier, le cours présentera des méthodes informatiques nous permettant d'approfondir notre compréhension de l'hétérogénéité des tumeurs, de tirer parti de l'intégration multimodale des données cliniques et omiques, et de concevoir des schémas de traitement personnalisés.
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)
Tuesday 01 October 2024
Les remarquables performances sportives des athletes en situation de handicap sont un exemple de la capacite humaine a s'adapter et a compenser des deficits perceptifs, moteurs et mentaux. L'usage efficace et encadre de technologies de substitution, comme les protheses, ortheses, equipements adaptes, ou interfaces robotisees, suppose que ces athletes aient pu s'approprier ces artefacts en les integrant a leur corps et a leur fonctionnement cerebral. Enfin, le succes des methodes specifiques d'entrainement et l'exceptionnelle motivation de ces athletes suggerent, qu'au-dela des bases physiologiques et neurales, des dimensions psycho-sociales contribuent a la realisation de performances etonnantes.
A l'occasion des Jeux paralympiques de Paris 2024 qui se tiendront au mois de septembre, l'Academie des Sciences organise, le 1er octobre 2024, un colloque interdisciplinaire de reflexion sur ? Handicap, Sport, et Sciences du Mouvement ? en collaboration avec l'Academie Nationale de Medecine, l'Academie des Technologies, et l'Institut National du Sport, de l'Expertise et de la Performance (INSEP). Ce colloque aura pour ambition de faire le point sur les connaissances scientifiques, de recueillir les temoignages d'athletes handisports et de degager des pistes et themes de recherche meritant d'etre approfondis a l'avenir.
Ce colloque est organise par et Alain Berthoz, Professeur au College de France ?merite, membre de l'Academie des Sciences et de l'Academie des Technologies, et Antoine Triller, Directeur de Recherche ?merite Ecole Normale Superieure-Inserm, Secretaire Perpetuel de l'Academie des Sciences, avec un Comite de Programme compose de Yves Agid, Marie-Paule Cani, Claude Debru, Jocelyne Troccaz, Membres de l'Academie des Sciences, Catherine Barthelemy et Xavier Bigard, Membres de l'Academie Nationale de Medecine, Stephane Andrieux, Membre de Academie des technologies, Vincent Nougier, ancien directeur du GDR sport-CNRS, Patrick Roult, chef du P?le Haut niveau, INSEP.
Le programme sera tres prochainement mis en ligne.
Credits photo : ?ginettigino More details...
Tags: Peter Doherty, Doherty Institute, Laura Mackay
Published on 13-07-2024
Institut Cochin
Salle Rosalind Franklin
Friday 04 October 2024    9:30
Invited by: Laura Cantini The Targeted Technological Action on Artificial Intelligence (ATC-IA) is organizing the second edition of its Symposium Artificial Intelligence in Biology and Health. It will be held on 4th October 2024 in the Emile ... More details...
Tags: IA, Artificial intelligence
Published on 04-03-2024
Institut Pasteur
Batiment: Emile Duclaux Salle: Lecture Hall
Friday 04 October 2024    11:00
Invited by: Michel Sliwa Archaerhodopsin-3 (AR-3) is a light-driven transmembrane proton pump found in Halorubrum sodomense, that has emerged as an interesting platform for optogenetics [1], since the wild-type form and a large variety of mutants [2] display good fluorescence levels, depending on the cellular transmembrane voltage. Multiple mutants were reported over the years, with fluorescence quantum yields (FQY) reaching up to 1.2%, in the best cases, which is still low as compared to the most fluorescent natural NeoRh [3]. Experimental and theoretical studies aiming at a rational understanding of the mutation-induced 100-fold increase of FQY, as compared to wild-type (wt) AR-3, were disclosed recently for the so-called Quasar and Archon families. In the our ongoing project, we focus on the double mutant DETC and the quintuple mutant Arch-5 [2]. A combination of different spectroscopic techniques (fluorescence, transient absorption and Raman scattering), either steady-state or with time resolution down to the 50 fs, allow us to establish that the long-lived fluorescence in the mutant comes from a one-photon excitation process, unlike wt AR-3. Both all-trans/15-anti and 13-cis/15-syn isomers of the protonated Schiff base retinal (PSBR) cation contribute to the fluorescence in the mutants with slightly different excited state lifetimes (ESL). The temperature-dependence of the ESL 15 times smaller for DETC, and close to zero for Arch-5.
In this talk, I95.
[2] R. Scott McIsaac et al PNAS, 2014, 111, 36, 13034-13039.
[3] L. Barneschi et al, Nat. Communication, 2022, 13, 6432. Published on 02-09-2024
Ecole Polytechnique
Amphitheatre POISSON, Ecole Polytechnique
Friday 04 October 2024    12:00
Invited by: Peter van Endert After completing his M.D. and Ph.D. at the University of Pisa, Gennaro De Libero joined the Max Planck Institute for Immunobiology in 1984 as a postdoctoral fellow in Professor Stefan Kaufman's laboratory, supported by a long-term EMBO fellowship. In 1988, he moved to the Basel Institute of Immunology and, in 1990, to the Faculty of Medicine at the University of Basel, where he took responsibility for the Experimental Immunology Group. From 2010 to 2016, he served as Director of the Tuberculosis Unit at the Singapore Immunology Network. Upon returning to Basel, he resumed his research as a Group Leader at the Department of Biomedicine at the University of Basel. He is also a co-founder of the Upper Rhine Immunology Society.
His primary scientific focus is on the antigen specificities of non-MHC-restricted T cells and their role in physiology and disease.Seminar topic: Carbonyl adducts of nucleases are new antigens stimulating T cells More details...
Tags: Antigen, Biomolecules, Immune system
Published on 05-09-2024
Institut Necker Enfants Malades
Auditorium 3
Friday 04 October 2024    17:00
The agility of humans and other animals relies on their ability to maintain balance during movement. This is a complex task requiring the integration of neurophysiology and biomechanics. In this talk, I show that young healthy adults use simple control strategies to maintain balance during standing and walking. Moreover, when standing and walking on the hands, gymnasts employ the same biomechanical strategies for balance. This however requires the nervous system to adapt both sensory integration and motor coordination. An inability to adjust the sensorimotor coordination may lead to the balance impairments seen in a variety of neurological conditions. More details...
Tags: Physical fitness, Balance, Motor coordination, Agility, Sensorimotor
Published on 31-08-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris
Monday 07 October 2024    10:30
Luca Magnani graduated from his bachelor’s and master’s degree at the University of Bologna. During an exchange visit to Purdue University, he discovered his interest in early embryogenesis. Dr. Magnani’s work took him to Michigan State University, where he continued his research on mouse embryogenesis and more specifically on chromatin remodelling ATPases. In 2009, he made a significant shift in his research focus and began to investigate how cancer cells leverage the same processes that drive development to evolve drug resistance. Working with Professor Mathieu Lupien at Dartmouth College and the University of Toronto, he unearthed new insights into epigenetic reprogramming during tumour evolution. He started his laboratory at Imperial College London in 2013 as an Imperial College Research Fellow before becoming a CRUK fellow and the Imperial Chair in Cancer Adaptation and Evolution. His laboratory is interested in hormone dependent breast cancer and the use of genomics and epigenomics paradigms as well as convergent science approaches to understand how the tumour starts and evolve. Their goal is to develop novel strategies to target dormant cells as they believe this could dramatically improve the outcome for hormone dependent breast cancer patients.
Tags: Cancer dormancy, Carcinogenesis, Dormancy, Breast cancer, Robert C. Bast Jr.
Published on 07-06-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)
Tuesday 08 October 2024    8:30
The Epigenetics and Cell Fate Center celebrates its fifteen years of existence on October 8, 2024. Come, and join us for this special day!
This conference will look back on 15 years of scientific advances in the fields of epigenetics and cellular differentiation in normal or pathological conditions.
We will gather renowned international speakers, the Parisian scientific community, and alumni for a day of scientific conferences, followed by a career round table.
Keynote speaker:
Edith Heard, Director General of EMBL, member of the French Academy of Sciences.
Invited speakers:
Julie Chaumeil, Institut Cochin, Paris
Jerome Dejardin, Institut de Genetique Humaine, Montpellier
Rachid El Fatimy, Mohammed VI Polytechnic University, Ben Guerir
Justine Marsolier, Institut Curie, Paris
Antonin Morillon, Institut Curie, Paris
Chiara Mozzetta, Institute of Molecular Biology and Pathology, Rome
Rebecca Oakey, Kings College, London
Beatrice Rondinelli, Institut Gustave Roussy, Paris More details...
Tags: Epigenetics
Published on 28-08-2024
Epigenetique et Destin Cellulaire
Buffon auditorium 15 rue Helene Brion, 75013 Paris
Invited by: Marco Pontoglio Melissa Little, AC, is CEO of the Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), Chief Scientist at the Murdoch Children More details...
This 6th edition of the international breast cancer course organized by the Institut Curie offers a comprehensive overview of current topics on clinical and biological aspects of breast cancer. This course brings together internationally renowned experts who will present the latest innovations in the clinical management of breast cancer, on both diagnostic and therapeutic aspects, as well as the latest advances in the understanding of biological mechanisms such as plasticity, tumor heterogeneity or genomics of breast cancer. The focus will be on the latest cutting-edge technologies and innovative approaches, including artificial intelligence and single cell analysis.
The format of the course is designed to encourage exchanges and to allow students to interact with researchers from the Institut Curie and from several international institutes.
Tags: Breast cancer, Hereditary cancers, Medical signs, Kefah Mokbel, Dennis Slamon
Published on 24-05-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)
Tuesday 15 October 2024    11:30
Over the past two decades, there has been a significant shift in our understanding of the role of endocytosis and trafficking of signaling receptors. It has evolved from being viewed simply as a signal extinguisher (resulting in long-term attenuation) to being recognized as a sophisticated mechanism capable of delivering signals to specific cellular locations with precise timing. Therefore, endocytosis functions as a regulatory program that impacts various aspects of cell physiology, and we have evidence suggesting that alterations in this program may be causal and targetable in cancer. On the one hand, by exploiting the EGFR model system, we obtained confirmation that the integration of the two functions of endocytosis (sustainment and attenuation of signals) might be achieved, at least in part, at the plasma membrane (PM) by activation of different endocytic routes. Disruption of this balance appears to contribute significantly to cancer cell proliferation, invasion, and metastasis. On the other hand, our research has demonstrated the causal role of an endocytic protein, Epsin3 (EPN3), in breast cancer development, particularly in association with the emergence of partial epithelial-to-mesenchymal transition (pEMT), cancer stem cells, and invasive phenotypes. Increased E-cadherin endocytosis is the initial event driving EPN3-induced pEMT, that render cells more plastic and prone to metastatic dissemination. Importantly, inhibition of increased E-Cadherin endocytosis is capable of reversing EPN3-dependent invasiveness. The restricted expression of EPN3 in adult tissues, along with its overexpression in breast cancer, positions EPN3-drived endocytosis as a promising target for therapeutic intervention.
Ana-Maria Lennon Duménil is invited by Fatah Ouaaz. More details...
Tags: Carnot label, Curie Institute, Curie
Published on 05-06-2024
Institut Cochin
Salle Rosalind Franklin
Monday 21 October 2024    0:00
Long version (3,5 weeks, w/ practicals at Sorbonne University & Seminars at Institut Curie) : July 20th Short Version (10 days, Seminars at Institut Curie) : September 1st
Institut Curie and Sorbonne Université organize their 15th International Developmental Biology course.
The aim of the program is to provide the participants a comprehensive coverage of the paradigms, problems and technologies of modern Developmental Biology paying particular attention to stem cells.
Training in theoretical and experimental aspects of normal and abnormal development is developed through a variety of embryonic systems using state-of-the-art instrumentation and methodology.
The program is proposed in two versions (more information available soon) so there will be two registration deadlines:
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)
Tuesday 22 October 2024    11:00
The size of the nucleus scales robustly with cell size so that the nuclear-to-cell volume ratio (N/C ratio) is typically maintained as a constant in many cell types. Previous studies show that the N/C ratio is not determined merely by the amount of DNA but is influenced by nuclear envelope transport and mechanics. We and other groups have recently developed a quantitative model for nuclear size control based upon a balance of colloid osmotic pressures in the nucleoplasm and cytoplasm. This model posits that the N/C ratio is determined by the numbers of macromolecules in the nucleoplasm and cytoplasm as well as the nuclear envelope membrane tension. In the fission yeast S. pombe, osmotic shift experiments demonstrate that the nucleus behaves as an ideal osmometer whose volume is primarily dictated by osmotic forces, with no detectable contribution of membrane tension. Thus, we predict that the key determinants of nuclear size in fission yeast are simply the numbers of macromolecules in the nucleoplasm and cytoplasm that produce colloid osmotic pressure. Here, to test this model, we quantified the effects of massive overexpression (~107 molecules) of exogenous proteins targeted to either the nucleus or the cytoplasm. In both cases, the resulting N/C ratio quantitatively aligned with our model's prediction. We have thus developed a tunable system for altering the N/C ratio by overexpression of a single exogenous protein. These data provide critical quantitative support for the osmotic model for nuclear size control More details...
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407
Thursday 24 October 2024    0:00
During a viral infection, a multitude of cellular factors come into play. The initial challenge that viruses must overcome is gaining access to the intracellular compartment. The infection process starts when viral particles contact the host cell surface. A complex sequence of events ensues, with the diffusion at the cell surface, receptor binding, signaling, internalization, and ultimately, the delivery of the genetic material. In this seminar, we will delve into the mechanisms of virus entry into host cells. Our exploration will be grounded in an analysis of early virus-host cell interactions using the bunyaviruses Rift Valley fever, Toscana, Uukuniemi, and Germiston viruses. Bunyavirales is the largest order of RNA viruses, with over 400 members worldwide which infect a large range of hosts, including vertebrates, invertebrates, and plants. Several cause severe diseases in both livestock and humans. The discussion will involve state-of-the-art fluorescence detection-based methodologies in both fixed and live cells, encompassing microscopy, flow cytometry, and fluorimetry. Pierre-Yves Lozach is invited by Florence Niedergang. More details...
Gou Young Koh is invited by Sandrine Bourdoulous. More details...
Tags: Koh, Ko, Daejeon, Institute for Basic Science, Koh Gou Young, Top Scientist and Technologist Award of Korea
Published on 07-09-2024
Institut Cochin
Salle Rosalind Franklin
Tuesday 29 October 2024
Les mysteres de la turbulence ou comment un papillon peut faire trembler les avions et les mathematiciens...
Attachez vos ceintures et embarquez a bord d'un voyage pour percer les mysteres de la turbulence ! La turbulence est-elle seulement dans l'atmosphere ? La turbulence est-elle utile? Pourquoi la tete de la turbulence est-elle mise a prix ? Quelle est la difference entre le chaos et la turbulence ? Un papillon peut-il engendrer des turbulences ? Des avions aux canards en plastique, en passant par les tornades et les ouragans, venez decouvrir les coulisses d'un phenomene universel, qui defie depuis plus de 500 ans les physiciens et mathematiciens. More details...
au College de France - Salle D2
11 place Marcelin Berthelot - 75005 Paris
Thursday 07 November 2024    0:00
Mosquitoes transmit arthropod-borne viruses (arboviruses), which are responsible for 17% of the global burden of infectious diseases in humans. Recent metagenomics studies have revealed that the mosquito viral microbiota also includes mosquito-specific viruses, which do not infect vertebrate cells. Taxonomically diverse and incredibly prevalent, these viruses are poised to shift our understanding of how mosquito antiviral immunity works. In addition, certain mosquito-specific viruses enhance or suppress the replication and dissemination of arboviruses in mosquitoes. They could thus serve as the basis for innovations in arboviral disease management, vaccine development, and vector control interventions. This seminar will present mosquito-specific viruses as a nascent intersection between virology, immunology, and ecology. I will share novel insights from our ongoing efforts to understand the factors shaping mosquito virome diversity through a longitudinal metagenomics study of 21 mosquito species from Cambodia, Madagascar, the Central African Republic, and French Guiana. Our extensive dataset revealed virus distribution patterns that bring further insights into species-specific ‘core’ viromes. Notably, we found ‘super host’ mosquito species and viruses with broad mosquito host ranges, reshaping our view of virus-host interactions. This also highlights the mosquito-specific viruses deserving further research attention for improved mosquito-borne disease management through a One Health perspective. Paris Post-docs seminar series. More details...
Thursday 07 November 2024    11:00
Invited by: Marc Graille Published on 03-09-2024
Ecole Polytechnique
Seminar Room (Building 84)
Ecole Polytechnique
Friday 08 November 2024    17:00
How spikes propagate along multiple layer networks has been extensively studied with computational models. Feedforward networks are a prominent model able to transmit information rapidly, but these networks have been difficult to isolate in the intact mammalian brain. Here, we focus on the auditory network which is characterized by multiple connected relays. We used sound and optogenetic stimulations to drive the auditory periphery and monitored neuronal activity at two locations along the auditory pathway simultaneously, using large-scale electrophysiological recordings. We observed fast and efficient propagation of pulse packets, in agreement with a feedforward description of the auditory network. We further determined the state-phase diagram of spike propagation and demonstrated the presence of an attractor fixpoint that enables robust and quick transfer of information. However, propagation was not limited to only synchronized events. Prolonged firing was also evoked and necessary to promote an efficient transfer of graded inputs and subsequent readout in downstream structures. Taken together, the auditory network combines both temporal and firing rate modes of propagation to reliably encode the different dimensions of sound features. More details...
María Soledad Matus (USS-Fundación Ciencia & Vida, CL)
Mario Rosemblatt (USS-Fundación Ciencia & Vida, CL)
Álvaro Lladser (USS-Fundación Ciencia & Vida, CL)
Mariana Maccioni (National University of Córdoba, CIBICI-CCT-CONICET, AR)
Nathalie Amzallag (Institut Curie, FR)
Inês Pires Pinheiro (Institut Curie, FR)
The Immunity and Cancer Unit of Institut Curie (INSERM U932) is organizing the 7th edition of the Advanced Course on Immunity and Cancer Immunotherapy.
In the context of ongoing cooperation projects with research teams in Chile and Argentina that have resulted in the prior organization of workshops in cell biology and immunology, this year’s edition is jointly organized with the Fundación Ciencia & Vida (Chile) and will be dedicated to multiple aspects of fundamental immunology and possible applications in cancer immunotherapy. The course will offer 4 days of lectures and discussions centered on the latest developments in innate immunity, myeloid and lymphoid cell biology, tissue immunity and the role of the microenvironment in immune activation, cancer immunity, as well as state-of-the-art cell therapy and cancer immunotherapy. Besides attending the lectures, the participants will have the opportunity to present their projects during two poster sessions, discuss with the speakers, attend workshops on open science and scientific integrity, and participate in a round table on career opportunities.
Expanding the links with Latin American research institutions, the Advanced course on Immunity and Cancer Immunotherapy is jointly organized with the 3rd Franco-Austral Course on BioinformaticsApplied to Immunology, taking place in Buenos Aires, Argentina, from October 30th to November 2nd, just before the 2024 meeting of the Latin American and Caribbean Association for Immunology.
The Advanced Course on Immunity and Cancer Immunotherapyis exclusively destined to Master students, PhD students and postdoctoral researchers from Latin American universities and/or research institutions.
The course is organized and funded by the LabEx DCBIOL, Institut Curie’s Advanced Training Office, Institut Curie’s Medico-Scientific Program in Immunotherapy, the Inserm CIC-1428, PSL University, Universidad San Sebastián, Centro BASAL Ciencia & Vida (ANID-FB210008) and Fundación Ciencia & Vida. The cell therapy session is organized and funded by the RHU EpCART, a structuring project funded by the French National Research Agency (ANR) in the framework of the France 2030 program.
Tags: Paris-Saclay, Saclay, Essonne, French Alternative Energies and Atomic Energy Commission
Published on 20-06-2024
NeuroPSI
Salle de conference Albe-Fessard
Tuesday 19 November 2024    9:00
Since 2014, the medical department organizes each year an International Day for Translational Science, which gathers a few hundred of basic researchers, clinicians and industrial partners. For the 2024 edition, we have chosen to ... More details...
Tags: Research, Medical research, Nursing research, Translational research, Translational medicine
au College de France - Salle D2
11 place Marcelin Berthelot - 75005 Paris
Thursday 12 December 2024    0:00
Malaria still poses a threat to public health in tropical and sub-tropical countries with 250 million cases and 608 thousands deaths reported in year 2022 (1). The first generation of malaria vaccines, RTS,S and R21, are based on virus-like particles (VLPs) consisting of the Plasmodium falciparum (Pf) cirmcumsporozoite protein (PfCSP) fused to the surface antigen of Hepatitis B virus (HBsAg). RTS,S and Rv21 have recently being licensed and showed an efficacy of 40% (2) and 70% (3), respectively. Even though these studies have validated PfCSP as a vaccine candidate for malaria, there is a need for more effective vaccines (4). In addition, P. vivax (Pv) infection is more prevalent in the world outside Africa (5) and yet, there is no licensed vaccine for P. vivax. In this study, we have shown that PfCSP or PvCSP fused with HBsAg and delivered by mRNA secretes chimeric VLPs in HEK293 cells. Importantly, immunization with mRNA encoding these PfCSP or PvCSP fusions elicits protent antibody responses that protects mice against infection of transgenic P. berghei sporozoites expressing PfCSP or PvCSP. Therefore, these studies demonstrated it is possible to use mRNA constructs based on HBsAg fusions with malaria parasite antigens to develop vaccines for P. vivax and P. falciparum malaria. Paris Post-docs seminar series. More details...