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Invite par: 2025-2026 EEB Seminar series Plus d'infos... Tags: SARS-related coronavirus, SARS-CoV-2, Bat virome, Viral structural proteins, Zoonotic origins of COVID-19, SARS-CoV-1 Annonce publiée le 12-11-2025 |
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| IBENS salle Favard, IBENS 46 rue d'Ulm 75005 Paris |
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Vers une comprehension quantitative de la dynamique nucleaire au cours du developpement et des maladies Les objectifs de ce cours sont de fournir un apercu des mecanismes epigenetiques et de leurs liens avec la chromatine. Les differentes fonctions du noyau impliquant le genome et son organisation seront discutees en insistant sur les limites technologiques et les nouvelles approches experimentales developpees. Les liens entre la perte des fonctions du noyau et le developpement de pathologies humaines seront presentes. Cette annee ce cours abordera plus amplement les aspects physiologiques et pathologiques de l'epigenetique, en lien avec le metabolisme et la determination et maintien de l'identite cellulaire. Le succes de ce cours repose sur une forte contribution des participants qui doivent assister de facon tres proactive a l'ensemble des activites organises, tels que les sessions de presentations de posters, les analyses d'articles (Journal Club), et les ateliers. (voir section Travail personnel et le Programme pour plus d information). Une session speciale sera aussi dediee a aux presentations et echanges avec 1-2 alumni du cours qui ont poursuivi leur carriere dans le domaine de l'epigenetique.
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Annonce publiée le 11-11-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Invite par: Lisa Chakrabarti
The next GRS meeting will gather two speakers: Achille BROGGI Aix-Marseille Universite, CNRS, INSRM, Centre d’Immunologie de Marseille-Luminy (CIML) Type III interferons control of barrier function at mucosal sites Nathalie DEJUCQ-RAINSFORD Physiology and physiopathology ...
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Tags: Centre d'immunologie de Marseille-Luminy, Mucosal immunology, Sida, Aix-Marseille University Faculty of Sciences
Annonce publiée le 11-11-2025
Institut Pasteur
Batiment Fernbach, salle 68-rdc-03-05, -
Cette journee sera consacree aux recherches fondamentales et appliquees dans le domaine en pleine expansion des interactions entre cellules stromales (en particulier les fibroblastes et les cellules endotheliales) et cellules immunitaires au sein du microenvironnement tumoral (TME). Au cours de la derniere decennie, le stroma tumoral est devenu une cible therapeutique prometteuse dans le cancer, les fibroblastes associes au cancer (CAF) jouant un role cle dans la structuration du TME, la regulation de la croissance tumorale, l'evasion immunitaire et la resistance aux chimiotherapies et immunotherapies. Le nombre d'experts en France travaillant dans ce domaine ne cesse de croitre, et nous ressentons le besoin d'organiser un symposium qui reunisse des chercheurs experimentes et des debutants afin de favoriser la creation d'une communaute. Inspire par les initiatives fructueuses des dernieres decennies autour de la recherche sur les lymphocytes et les cellules myeloides, ce symposium vise a aider un cercle pluridisciplinaire d'experts interesses par les fibroblastes du TME a etablir des consensus sur les pratiques experimentales, proposer des nomenclatures unifiees, partager des resultats et echanger des modeles. L'objectif de ce symposium est de renforcer les collaborations naissantes et d'accroitre la visibilite internationale de l'Institut Curie et de la France dans le domaine de l'etude du stroma dans le cancer. Il s'adresse a des personnes disposant d'au moins des connaissances de base en biologie ou immunologie (niveau recommande : Master). Cet evenement sera egalement une opportunite pour faire progresser la recherche translationnelle et le developpement de traitements anticancereux ciblant specifiquement les composants stromaux. Le symposium se tiendra le mardi 23 juin 2026, de 8h30 a 20h, dans l'Amphitheatre Constant Burg (12 rue Lhomond, 75005 Paris, niveau -1), le plus spacieux et confortable de l'Institut Curie, avec ses 196 places. Nous esperons accueillir entre 120 et 150 participants. Les scientifiques que nous avons invites et qui ont confirme leur participation pour presenter leurs projets et leurs resultats les plus recents dans le domaine du stroma, de l'immunite et du cancer, sont listes ci-dessous par ordre alphabetique : CONFERENCIERS PRINCIPAUX (KEYNOTE SPEAKERS) Alexandra Naba - Etats-Unis Shannon Turley - Etats-Unis INTERVENANTS (SPEAKERS) Corinne Bousquet - France Cedric Gaggioli - France Fatima Mechta-Grigoriou - France Lucie Peduto - France Helene Salmon - France Karine Tarte - France Danijela Vignjevic - France En complement, trois jeunes postdocs/chercheurs (1 venant de l'UE, 1 hors Paris et 1 parisien) seront selectionnes pour des presentations courtes (10 minutes + 5 minutes de questions). La selection se fera sur la base des resumes des posters soumis lors de l'inscription. Nous veillerons autant que possible a respecter la parite hommes-femmes parmi les intervenants. L'inscription au symposium sera gratuite mais obligatoire. Nous diffuserons largement l'annonce afin de maximiser la visibilite et d'attirer des chercheurs, etudiants, medecins et ingenieurs internationaux, qui devront prendre en charge leurs frais de voyage et d'hebergement. Une session de posters accompagnee d'un « vin et fromage » sera organisee en fin de symposium, mais les posters pourront etre affiches des le matin a proximite de l'espace cafe/dejeuner pour favoriser les echanges tout au long des pauses. L'IHU Cancers de femmes de l'Institut Curie sponsorise cet evenement, dont la thematique correspond a l'un de ses axes de recherche.
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Annonce publiée le 08-11-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
Invite par: Anna-Bella Failloux
Grand challenges in vector-borne diseases Controlling vectors in the context of climate and environmental changes June 5th 2026 ? Institut Pasteur, Paris, France Registration is free but mandatory Registration form As part of the ...
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Tags: Infectious diseases, Epidemiology, Vector calculus, Disease transmission, Disease vector, Parasitology, Vector, Euclidean vector, Climate change and infectious diseases
Annonce publiée le 07-11-2025
Institut Pasteur
Batiment: Duclaux Salle: Amphitheatre Duclaux -
Implantation of the early embryo into the uterine wall is a key step in the mammalian reproductive cycle. This critical process mediates the connection between the embryo and the mother during the early stages of pregnancy. As the uterine tissues conceal the implanting embryo, the cellular interactions at the embryo-maternal interface are inaccessible for direct analysis and therefore poorly understood. Moreover, some mammalian species can pause the development of their embryos just before implantation. These embryos enter a reversible state of dormancy (diapause) for extended periods, delaying the time of birth. How the dormant embryos remain in suspended animation without compromising their developmental potential is still obscure. Using the mouse as a model system, our lab aims to decipher the cellular mechanisms of embryonic development and dormancy and the dynamic crosstalk between the implanting embryo and the mother.
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Tags: Developmental biology, Embryology, Midwifery, Ethology, Physiology, Implantation, Embryo, Dormancy, Diapause, Development of the human body, Uterus, Menstrual cycle
Annonce publiée le 07-11-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Invite par: Dr A. Teissier
Many animal societies rely on division of labor, but how such roles emerge and become stable is still poorly understood. In small groups of genetically identical mice living together in home-cage, individuals spontaneously adopt different rolessome work to access food, others rely on them to feed. These behavioral profiles are not fixed: they depend on the social context. Male groups tend to form competitive hierarchies, female groups behave more uniformly, and introducing trained or dopamine-modulated individuals into naive groups reshapes group organization. These roles are linked to activity in a key brain area for motivationthe ventral tegmental areaand modeled using reinforcement learning principles. Altogether, the results suggest a feedback loop where social interactions influence brain activity, which in turn stabilizes individual behaviors and group structure.
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Tags: Social behavior, microsociety, dopamine, specialization
Annonce publiée le 07-11-2025
Institut de Psychiatrie et Neurosciences de Paris
Room D Levy, Institut de Psychiatrie et Neurosciences de Paris (IPNP) UMR 1266 INSERM - Universite Paris Cite, 102-108 Rue de la Sante - 75014 Paris -
TBA
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Tags: Randlett, Draft:Poongodi, Draft:Punitha
Annonce publiée le 06-11-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407 -
À l'occasion de la Semaine europeenne pour l'emploi des personnes handicapees (SEEPH), l'Institut Curie vous propose un moment fort en emotion a travers une conference-temoignage d'Heloise Courvoisier , triathlete paralympique et ancienne patiente de l'Institut Curie: « De patiente a championne : le parcours inspirant d'Heloise Courvoisier » : Lundi 17 novembre 2025 ? de 12h15 a 13h ? en presentiel dans l'amphitheatre Helene-Martel-Massignac - 11 rue Pierre et Marie Curie, Paris 5e et egalement accessible a distance via ce lien Teams. Cet evenement interne sera anime par Anne-Claire de Reboul, directrice adjointe de l'Ensemble hospitalier, et sera suivi d'un temps de questions et d'echanges. Un parcours hors du commun Soignee des sa naissance a l'Institut Curie pour un retinoblastome, un cancer rare de la retine, Heloise Courvoisier a affronte 18 tumeurs et recidives avant ses 18 mois. Malgre une vision tres reduite, elle a transforme son handicap en force, devenant une athlete de haut niveau dans la categorie PTVI (deficience visuelle). Le 2 septembre 2024, elle a represente la France aux Jeux paralympiques de Paris dans l'epreuve exigeante du triathlon : 750 m de natation, 20 km a velo et 5 km de course a pied. Accompagnee de sa guide Anne Henriet, elle a incarne un message puissant d'espoir et de resilience. Aujourd'hui classee parmi les meilleures mondiales, Heloise est aussi kinesitherapeute, militante pour l'inclusion, et source d'inspiration pour les jeunes patients et leurs familles. Pourquoi venir ? Pour decouvrir un temoignage authentique et inspirant Pour echanger autour du handicap, du depassement de soi et de l'inclusion Pour celebrer les parcours de vie qui font la richesse de notre communaute Un rendez-vous a ne pas manquer !
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Annonce publiée le 06-11-2025
Institut Curie
Amphitheatre Helene Martel-Massignac (BDD) -
Aging is accompanied by striking changes across cell types, tissues and organs, with accumulating evidence supporting divergent trajectories of aging between females and males. Our lab studies drivers of such differences across several compartments, leveraging mouse models. First, a key compartment whose activity can be actively modulated by sex-dimorphic mechanisms throughout life is the immune system, whose function declines sharply with aging. Indeed, aspects of the immune responses differ between sexes, with a more robust immune response in females and an increased susceptibility to infection in males. One of our main cell models are macrophages, a core component of the innate immune system. Excitingly, we observed strong sex-differences in macrophage transcriptional and functional phenotypes, and as well as sex-dimorphic “omic” changes with aging, which show partial dependence on ovarian hormone exposures. Second, we have been taking advantage of a mouse model of adult somatic sex reprogramming to investigate the long-term impact of adult sex hormone exposure on shaping sex-differences with aging, with a focus on brain and cognition. Together, our data suggests that mechanisms involving both gonadal hormones and sex chromosomes fine-tune different aspects of mammalian aging and, thus, overall health and lifespan of males vs. females.
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Tags: Animal anatomy, Asymmetry, Polymorphism, Sexual dimorphism, Sexual selection, Macrophage
Annonce publiée le 06-11-2025
Institut Cochin
Salle Schapira -
Séminaire en français. L'écoute active : une technique de communication mais aussi une façon d'être pour mieux communiquer ! Est-ce une méthode, une philosophie ou un art ? En s'appuyant sur de nombreux exemples, Alexandre Philips nous présentera cette approche utile tant au niveau professionnel que personnel ! Alexandre Philips est invité par les CSCAs.
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Annonce publiée le 06-11-2025
Institut Cochin
Salle Rosalind Franklin -
Invite par: Philippe Bastin
The canonical genetic code contains 61 sense and 3 nonsense (stop) codons. Although it is almost universal, about 60 different genetic code variants have been described so far. Majority of these alterations evolved in ...
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Tags: Molecular biology, Molecular genetics, Genetics, Gene expression, Protein biosynthesis, Genetic code, Parasitism, Protist, Genetically modified organism
Annonce publiée le 06-11-2025
Institut Pasteur
Batiment Lwoff, salle Retrovirus, -
Du 17 au 21 novembre 2025, l'Institut Curie reaffirme son engagement pour l'inclusion des personnes en situation de handicap. Cette mobilisation s'inscrit dans l'ambition 5 du projet social Curie 2030 : favoriser l'integration, promouvoir l'inclusion et la diversite des parcours. À l'occasion de la Semaine europeenne pour l'emploi des personnes handicapees , la Cellule Handicap vous invite a participer a des evenements inspirants et interactifs qui visent a renforcer la culture de l'inclusion au sein de notre organisation. Conferences, ateliers, rencontres et animations vous permettront de mieux comprendre les enjeux du handicap au travail, de liberer la parole et d'agir ensemble pour un environnement professionnel inclusif. La participation en presentiel est vivement recommandee pour favoriser les echanges. Des liens Teams seront egalement disponibles pour permettre a chacun de suivre les evenements a distance. Programme ? Lundi 17 novembre 12h15 - 13h | Conference "De patiente a championne : le parcours inspirant d'Heloise Courvoisier" Nous aurons la grande fierte d'accueillir Heloise Courvoisier, triathlete paralympique et ancienne patiente de l'Institut Curie. Son temoignage puissant illustre comment la resilience et la determination peuvent transformer une epreuve en victoire. ? Lieu : amphitheatre Helene-Martel-Massignac - 11 rue Pierre et Marie Curie, Paris 5e Evenement diffuse en direct: via ce lien ? Mercredi 19 novembre Saynetes theatrales ? Une equipe de comediens formes a la diversite et au handicap (parfois eux-memes en situation de handicap) jouera des scenes de vie illustrant les consequences d'une situation de handicap au travail : Absence longue duree et reintegration dans l'equipe Trouble de l'apprentissage et adaptation au travail Neurodiversite : spectre autistique & TDAH Chaque session d'une duree d'1 heure comprend ces trois saynetes suivies d'un temps d'echange pour reflechir ensemble aux solutions. Sessions diffusees en direct Horaires : 12h - 13h (anglais) lien| 13h30 - 14h30 (francais) lien| 15h - 16h (francais) lien| 16h30 - 17h30 (francais) lien ? Jeudi 20 novembre DuoDay - Journee nationale dediee a l'inclusion ? Une opportunite unique pour creer des rencontres et lever les barrieres : une personne en situation de handicap decouvre un metier en binome avec un professionnel. ? Inscrivez-vous viace lien ? Toute la semaine Stands de sensibilisation : Orsay, Saint-Cloud et Paris ? Venez echanger, poser vos questions et decouvrir des ressources utiles pour mieux comprendre le handicap. Quiz Handicap : testez vos connaissances et tentez de gagner un brunch chez Cafe Joyeux ! ? Participez au quiz via ce lien Nous vous attendons nombreux a ces evenements ! Ensemble, faisons en sorte que le handicap ne soit plus un frein dans le monde du travail. Contribuons a batir un environnement inclusif où chacun a sa place.
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Annonce publiée le 05-11-2025
Institut Curie
Saint-Cloud, Orsay et Paris -
Plus d'infos...
Tags: Fellows of the Royal Society, Raymond E. Goldstein, Faculty of Mathematics, University of Cambridge, Adriana Pesci
Annonce publiée le 04-11-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Ce seminaire est organise par l’Institut Jacques Monod et le laboratoire Epigenetique et Destin Cellulaire dans le cadre de l’inIdEx FORMULA, Raphael Guerois (Integrative Biology of the Cell (I2BC), CEA, CNRS, U P-Saclay, Gif-sur-Yvette) va presenter un seminaire de l’Institut Jacques Monod sur le theme : Decoding protein interaction networks with AI-driven evolutionary insights Resume : The rapid advancements in artificial intelligence have, within a few years, enabled the prediction of the three-dimensional structure of most proteins at atomic resolution [1]. These predictions critically depend on the evolutionary information available in the sequences of homologous proteins. Beyond modeling individual proteins, there is now a fundamental challenge to establish the most comprehensive mapping possible of macromolecular assemblies, which are central to cellular function. This goal faces several constraints, such as the combinatorial complexity of the interaction space and the type of evolutionary information needed to identify coevolution signals, which are much weaker at complex interfaces, especially in disordered regions of proteins. To achieve this goal, we are setting up computational pipelines [2, 3] with the aim of targeting the difficult task of predicting interactions mediated by disordered regions and pushing further the current boundaries to predict the structure of assemblies at large scale, addressing issues of conformational changes [4] and interaction specificities.
Plus d'infos...
Tags: Artificial intelligence, Computational neuroscience, Cybernetics, Data science, Jacques Monod, Gif-sur-Yvette, Saclay
Annonce publiée le 04-11-2025
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Ce seminaire est organise par l’Institut Jacques Monod et le laboratoire Epigenetique et Destin Cellulaire dans le cadre de l’inIdEx FORMULA, Raphael Guerrois (Integrative Biology of the Cell (I2BC), CEA, CNRS, U P-Saclay, Gif-sur-Yvette) va presenter un seminaire de l’Institut Jacques Monod sur le theme : Decoding protein interaction networks with AI-driven evolutionary insights Resume : The rapid advancements in artificial intelligence have, within a few years, enabled the prediction of the three-dimensional structure of most proteins at atomic resolution [1]. These predictions critically depend on the evolutionary information available in the sequences of homologous proteins. Beyond modeling individual proteins, there is now a fundamental challenge to establish the most comprehensive mapping possible of macromolecular assemblies, which are central to cellular function. This goal faces several constraints, such as the combinatorial complexity of the interaction space and the type of evolutionary information needed to identify coevolution signals, which are much weaker at complex interfaces, especially in disordered regions of proteins. To achieve this goal, we are setting up computational pipelines [2, 3] with the aim of targeting the difficult task of predicting interactions mediated by disordered regions and pushing further the current boundaries to predict the structure of assemblies at large scale, addressing issues of conformational changes [4] and interaction specificities.
Plus d'infos...
Tags: Artificial intelligence, Computational neuroscience, Cybernetics, Data science, Jacques Monod, Gif-sur-Yvette, Saclay
Annonce publiée le 03-11-2025
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Understanding and predicting biological complexity requires robust computational approaches. This presentation offers a concise overview of modelling strategies applied across diverse biological systems. We explore pathogen-host interactions at cellular and tissue levels to simulate infection and colonization dynamics. In human health, we focus on leukemic cell modelling to investigate mechanisms of treatment resistance. We also address host-microbiota interactions, with applications in gut and skin ecosystems. Finally, we provide insights into how modelling biological regulatory systems—combining mechanistic approaches and AI-driven methods—can pave the way for predictive immunology, grounded in the latest advances in immunological research. This work is carried out by iMEAN, a bioinformatics startup founded in 2018 and based in Toulouse within the Toulouse White Biotechnology (TWB) biofoundry.iMEAN specializes in predictive modelling of biological systems and offers innovative bioinformatics solutions to address the complexity of living systems by combining mathematical modeling, metabolic and regulatory network analysis, and multi-omics data integration. Our models simulate cellular behavior, predict metabolic fluxes, and help identify therapeutic solutions, supporting academic and industrial researchers in optimizing their Research & Development projects, particularly in health, agri-food, and environmental sectors.
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Tags: Bioinformatics, Systems biology, Modelling biological systems, Scientific modelling, Omics, Multiomics, Cancer systems biology
Annonce publiée le 01-11-2025
Institut Cochin
Salle Rosalind Franklin -
Invitee par l’equipe Duharcourt, Cecile Courret (Department of Genome Biology, I2BC – Institute for Integrative Biology of the Cell, Universite Paris-Saclay, CEA, CNRS UMR 9198, Gif sur Yvette, France) presentera un seminaire de l’Institut Jacques Monod sur le theme : Rapid turnover of centromeric DNA reveals signatures of genetic conflict in Drosophila Resume : Centromeres are essential chromosomal regions required for faithful chromosome segregation during cell division. They are defined epigenetically by the presence of the centromere-specific histone H3 variant, CENP-A, yet they are typically embedded in repeat-rich regions of the genome, making the role of underlying DNA sequences in centromere function and specification unclear. In Drosophila melanogaster, centromeres correspond to islands of retroelements flanked by tandem satellite repeats, but their evolutionary stability remains uncertain. We investigate centromere evolution and variation both within D. melanogaster and across its close relatives in the simulans clade (D. simulans, D. sechellia, and D. mauritiana). Using a combination of long- and short-read genomic sequencing, CUT&Tag mapping of CENP-A, and cytological validation with Fluorescence In Situ Hybridization (FISH), we characterize centromere organization, composition, and turnover. Within D. melanogaster, we find that centromere islands are polymorphic across strains from diverse geographic origins, with reference centromere islands absent in some genomes. We discover structural DNA variation that is associated with a shift in centromeric chromatin, suggesting that the organization of the reference centromere islands is not essential for centromere function. However, centromeres may still have conserved features even when their organization is variable, as we find that CENP-A enriched sequences are similar across strains, including those with polymorphic centromeres. Across species, we uncover dramatic centromere reorganization, including recurrent shifts between retroelements and satellite DNAs over short evolutionary timescales (<240 Kya). None of the D. melanogaster centromere islands are conserved in the simulans clade; instead, centromeres are largely composed of two clade-specific complex satellites (500 bp and 365 bp). Furthermore, in D. sechellia, the dot and X chromosome centromeres have relocated onto telomere-specific retroelements, creating true telocentric chromosomes. Interestingly, the G2/Jockey-3 retroelement, common to all D. melanogaster centromeres, shows variable enrichment across simulans clade species. Altogether, our findings demonstrate that centromeric DNA sequences are highly dynamic both within and between species, with recurrent turnover and structural polymorphisms shaping their evolution. These results highlight the plasticity of centromeric DNA and its role in chromosome function, consistent with ongoing genetic conflict driving rapid centromere evolution.
Plus d'infos...
Tags: Chromosomes, Animal models, DNA replication, Centromere, CENPA, Drosophila simulans, Drosophila, Satellite DNA, Neocentromere, Centromere protein B
Annonce publiée le 01-11-2025
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Oocytes are female germ cells that become eggs. They have the remarkable ability to survive for long periods of time, up to 50 years in humans, while retaining the potential to give rise to a new organism.We know surprisingly little about the molecular mechanisms that protect oocytes from cellular ageing, and why these mechanisms eventually fail with advanced age. In my talk, I will discussour recent discoveries thataddresstwo major challenges oocytes face during their long lifespan. First, I will show how oocyteslimitdamage caused by Reactive OxygenSpecies (ROS) by rewiring their metabolism. Second, I will describe how mouse and human oocytes manage protein aggregation and, more broadly, preserve protein homeostasis. Together, these discoveries highlight the remarkableadaptations of oocyte metabolism and proteostasis that support the long oocyte lifespan. http://www.crg.eu/en/elvan -boke
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Tags: Germ cells, Senescence, Oocyte, Ageing, Proteostasis, Reactive oxygen species, Metabolism
Annonce publiée le 30-10-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
https://www.mpinat.mpg.de/640165/jochen-rink
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Tags: Planarian, Rhabditophora
Annonce publiée le 29-10-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Invite par: Helene MORLON - Seminaire IBENS
Plus d'infos...
Tags: Draft:Center for Ethics and Law in Biomedicine
Annonce publiée le 29-10-2025
IBENS
salle Favard, IBENS 46 rue d'Ulm 75005 Paris -
Invite par: Drs D. Zala and R. de Santos
Microglia, the brain resident macrophages, are multifaceted cells that belong to the glial and immune systems. Beyond their role in immune defence, they are key actors of brain development, function, and homeostasis. Originating outside the central nervous system from yolk sac myeloid progenitors, microglia colonize the brain during early embryogenesis following a highly stereotypical spatiotemporal pattern. Along their brain colonization, they exhibit a remarkable cellular and transcriptional heterogeneity throughout development. Furthermore, by sensing a wide variety of local and systemic signals, microglia are positioned at a key interface between the brain and the environment. Our recent work explored how microglia develop and interact with their local environment during prenatal and early postnatal life. We specifically investigated the mechanisms guiding their colonization of the developing forebrain, focusing on how local and cell-type specific signals influence their distribution and proliferation. We also found that microglia impact key processes essential for proper brain development, highlighting their early and multifaceted roles in neural development. Altogether, our work reveals mechanisms orchestrating microglial colonization in the developing brain and sheds light on their key contribution to early brain development.
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Tags: Microglia, Development, Inflammation
Annonce publiée le 26-10-2025
Institut de Psychiatrie et Neurosciences de Paris
Room D Levy, Institut de Psychiatrie et Neurosciences de Paris (IPNP) UMR 1266 INSERM - Universite Paris Cite, 102-108 Rue de la Sante - 75014 Paris -
Invite par: Lionel NAVARRO - EEB Seminar Series
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Tags: Animal models, Bruno Lemaitre, Drosophila, Effector, Daisho
Annonce publiée le 24-10-2025
IBENS
salle Favard, IBENS 46 rue d'Ulm 75005 Paris -
Invite par: Philippe Bousso
The Immunology Department and Institut Imagine are organising a joint Immuno day? which will take place the Thursday, Dec 11th, 2025, 9:30 to 17:30, at Institut Pasteur, Duclaux Amphitheater. This event aims at foster ...
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Tags: COVID-19 pandemic in France, Pasteur Institute, Louis Pasteur, Yasmine Belkaid
Annonce publiée le 23-10-2025
Institut Pasteur
Batiment Duclaux Amphitheater, Institut Pasteur, salle , -
During the S-phase of the cell cycle, genetic material is replicated and packaged into chromatin. This requires the deposition of newly synthesized histones for the maintenance of the architecture. Using the unusual feature of incorporation of exogenous proteins within the naturally synchronous syncytial cell of Physarum polycephalum, tagged exogenous proteins can be tracked at specific stages of the cell cycle. Besides the introduction of the model system, we will examine the usage of H3 variants throughout the S-phase of Physarum and the effects of the incorporation of trace amounts of H3K27M on the epigenetic landscape.
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Tags: Epigenetics, Physaraceae, Post-translational modification, Physarum, Histone, Chromatin, S phase
Annonce publiée le 23-10-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Ce cours a pour but de rassembler les bases, les connaissances recentes et les perspectives therapeutiques autour de l'utilisation du systeme immunitaire de l'enfant pour cibler les cancers pediatriques, des particularites biologiques chez l'enfant aux innovations les plus poussees d'ingenierie cellulaire. Il se focalisera plus particulierement sur les tumeurs solides pediatriques, en tirant les enseignements des succes recents et defis restants dans les hemopathies malignes de l'enfant. Il rassemblera des acteurs nationaux et internationaux impliques dans ce domaine, dont les avancees precliniques et cliniques recentes permettent d'esperer des progres therapeutiques majeurs dans les annees a venir. Objectifs Exposer aux participants les recentes avancees en immunotherapie des cancers pediatriques. Mettre en valeur les specificites des cancers pediatriques et de l'immunite des enfants a prendre en compte pour les approches d'immunotherapie. Explorer leur developpement en recherche fondamentale, preclinique et clinique.
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Annonce publiée le 23-10-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Ce cours etudiera le spectre complet de la biologie du genome, de l'organisation et de l'imagerie de la chromatine a l'epigenetique, a l'ADN mobile et a la dynamique evolutive. Au cours de six sessions ciblees, des experts de renommee internationale presenteront leurs dernieres decouvertes liees a l'identification et a la caracterisation fonctionnelle du genome non codant et discuteront de nouveaux concepts de regulation et d'evolution du genome, en mettant l'accent sur les outils experimentaux et informatiques. Les sessions thematiques comprendront des approches unicellulaires et translationnelles de pointe pour demeler la plasticite et l'heterogeneite cellulaires, interroger la regulation des genes et suivre l'evolution du genome dans la physiologie et la maladie. Ce cours offrira aux jeunes etudiants et aux chercheurs l'occasion d'elargir leurs connaissances et de discuter de leurs travaux avec une communaute scientifique internationale dans un environnement chaleureux et stimulant a l'Institut Curie a Paris.
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Annonce publiée le 23-10-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
In every part of our bodies, cell types and anatomy are organized to carry out specialized functions, and the dorsal horn of the mammalian spinal cord serves as a beautiful example. It is characterized by a dazzling array of cell types arranged in a layered microcircuit architecture, with each layer receiving different sensory and descending neural inputs and contributing unique roles to animal behavior. In contrast with the ventral horn of the vertebrate spinal cord, which is a textbook example of morphogen signaling and discrete embryonic lineage domains, the development of the dorsal horn has remained an enigma. It is known that nearly the entire dorsal horn is formed from a common pool of seemingly homogenous progenitors during late spinal neurogenesis, but how? I will present my team&'s work on the developmental principles that shape the cell types and structure of the mouse spinal dorsal horn.
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Tags: Sensory systems, Motor system, Skeletal system, Spinal cord, Posterior horn, Peripheral nervous system, Neuromere, Spinothalamic tract
Annonce publiée le 22-10-2025
I. Cerveau et de la Moelle
Please join the conference in Paris Brain Institute auditorium. -
Submit your abstract providing a short summary (one page max) of your spatial research project including the use of our Xenium platform in the context of human or mouse brain research, and get the chance to be awarded a 50% discounted pilot experiment using our "Xenium Mouse/Human Brain Gene Expression Panel" ! Review all panel information on our website The winner will be announced at the end of the seminar. Projects need to be starting by the end of June 2026 at the latest, and priority will be given to abstracts that provide a full overview of the project (scientific objectives, sample types, total number of samples to be analysed, ...).
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Tags: Omics, Biotechnology, Spatial transcriptomics, 10x Genomics, Transcriptomics technologies
Annonce publiée le 22-10-2025
I. Cerveau et de la Moelle
Submit your abstract providing a short summary (one page max) of your spatial research project including the use of our Xenium platform in the context of human or mouse brain research, and get the chance to be awarded a 50% discounted pilot experiment using our "Xenium Mouse/Human Brain Gene Expression Panel" ! Review all panel information on our website The winner will be announced at the end of the seminar. Projects need to be starting by the end of June 2026 at the latest, and priority will be given to abstracts that provide a full overview of the project (scientific objectives, sample types, total number of samples to be analysed, ...). -
The stimulator of interferon genes (STING) pathway plays an important and conserved role in antiviral immunity. Human STING (hSTING) has been shown to mediate antiviral immunity by activating the transcription factors interferon regulatory factor 3 (IRF3) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B). The activation of IRF3 by hSTING involves the C-terminal tail (CTT) of hSTING and TANK-binding kinase 1 (TBK1), and this process is well-described. In contrast, the molecular mechanisms underlying NF-?B activation remain unclear. To elucidate this mechanism, we exploited the conserved Drosophila melanogaster STING (dSTING) pathway to uncover these mechanisms. Similar to the human pathway, dSTING confers antiviral immunity. However, dSTING lacks the CTT and drives the expression of antiviral genes via the NF-?B homolog Relish. Interestingly, there are features of dSTING and hSTING mediated NF-?B signaling which are conserved throughout evolution of animals. To elucidate how STING activate NF-?B signaling, we have developed a proximity labeling approach that enables the specific detection of activity-dependent STING interactors. We demonstrate that IKK? is recruited by STING upon activation and that the recruitment of IKK? is essential for STING-mediated activation of Relish. Moreover, studies in human cells indicate the pivotal role of linear ubiquitination in the interaction between IKK? and STING. Our findings suggest an evolutionarily conserved mechanism of STING-mediated NF-?B activation which existed prior to the evolution of the CTT and the IRF3 pathway. Keywords: NF-?B, STING, signaling mechanism, antiviral immunity, proximity labeling.
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Tags: Transcription factors, Immune system, TANK-binding kinase 1, NF-B, Stimulator of interferon genes, IRF3, CGASSTING cytosolic DNA sensing pathway, SNX8
Annonce publiée le 22-10-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Comprehension des bases moleculaires des tumeurs urotheliales pour ameliorer le diagnostic et les traitements Ce cours offre un apercu pratique et actualise des avancees dans la recherche, la biologie et le traitement des cancers urotheliaux. Il couvre les cancers de la vessie infiltrants et non infiltrants, les cancers des voies urinaires superieures ainsi que leurs metastases. Il met en lumiere de nouvelles connaissances sur les mecanismes de la maladie ainsi que des strategies diagnostiques et therapeutiques innovantes. Il est destine aux cliniciens et chercheurs engages dans le progres contre le cancer urothelial. L objectif de ce cours est de fournir une vue d ensemble precise et actualisee des dernieres recherches et des developpements cliniques dans le domaine du carcinome urothelial, qu'il s'agissedes cancers de la vessie invasifs et non invasifs du muscle, des cancers des voies excretrices superieures, et leurs metastases. Cela permettra a la fois de promouvoir une meilleure comprehension mecanistique de ces maladies, des methodologies utilisees pour les etudier et d'explorer de nouvelles strategies diagnostiques et therapeutiques.?
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Annonce publiée le 22-10-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Invite par: Yannick Allanore et Roberto Mallone
Developpement therapeutique chez la souris : Sylvaine You /// De la souris a l'Homme : les options therapeutiques aux stades precliniques du DT1 : Clementine Halliez /// Comprehension mecanistique et innovations therapeutiques des 20 dernieres annees : Jerome Avouac /// Resultats et lecons des approches de traitements dans la PR preclinique : Yannick Allanore /// Physiopathologie et depistage de la maladie coeliaque : chez qui, comment ? : Georgia Malamut
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Tags: Auto-immune diseases
Annonce publiée le 22-10-2025
Institut Cochin
amphitheatre Dausset de l'Hopital Cochin, 27 rue du Fg St Jacques 75014 -
Invite par: ESCHBACH Claire
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Tags: Nervous system, Neurology, Neurophysiology, Neuroscience, Brain
Annonce publiée le 22-10-2025
NeuroPSI
Salle de conference Albe-Fessard -
Invite par: EGO-STENGEL Valerie
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Tags: Memory, Memory consolidation, Consolidation
Annonce publiée le 22-10-2025
NeuroPSI
Salle de conference Albe-Fessard -
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Tags: Affect, Evolutionary psychology, Feeling, Neuropsychology, Leah Somerville, Jaak Panksepp
Annonce publiée le 22-10-2025
NeuroPSI
Salle de conference Albe-Fessard -
Invite par: Thomas Bourgeron
The INCEPTION aims to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in various health issues combining Integrative Biology, Social Science, and Data Science to understand the Emergence ...
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Tags: LGBTQ history in Greece, Symposium, Science, Social science
Annonce publiée le 21-10-2025
Institut Pasteur
Batiment: Auditorium & Atrium Francois Jacob -
Invite par: Reseau d Imagerie Cellulaire de Paris-Saclay
13h : Cafe d'accueil /// 13h30 Introduction : Pr Marc Humbert, Doyen Faculte de Medecine UPSaclay Mehran Mostafavi, Vice-President Recherche UPSaclay Frederic Pascal, Vice-President IA UPSaclay /// 13h45 AI in Correlative Microscopy: Unlocking the Potential of Multimodal Imaging Perrine Paul-Gilloteau, BioCore MicroPICell, Univ. Nantes /// 14h15 Life in motion - From AI-enhanced imaging to cellular processes simulations Olivier Schwartz, Institut Pasteur Mathieu Frechin, Nanolive SA /// 14h45 Flash Talk - Analyse cellulaire augmentee : apport de l'IA a l'Incucyte Mathias Lucas, Sartorius AG /// Pause cafe /// 15h30 Understanding complex tissues from microscopy images Anatole Chessel, LOB - Ecole Polytechnique /// 16h La pathologie computationnelle : du code au patient Catherine Guettier, UPSaclay Hopital Bicetre APHP /// 16h30 Conclusion Larbi Amazit, RIC UPSaclay
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Tags: AI, Imaging
Annonce publiée le 20-10-2025
RIC
Batiment Recherche de la Faculte de Medecine Paris-Saclay au Kremlin-Bicetre -
Invite par: DALLERAC Glenn
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Tags: Neuroimaging, Neurophysiology, Development of the nervous system, Electrophysiology, Neuroscience, Edward Ruthazer
Annonce publiée le 18-10-2025
NeuroPSI
Salle de conference Albe-Fessard -
TBA
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Tags: Recho Omondi, Draft:God Save The Tuches, Draft:Poongodi
Annonce publiée le 18-10-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407 -
TBA
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Tags: Draft:God Save The Tuches, Draft:Poongodi
Annonce publiée le 18-10-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407 -
TBA
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Tags: Thijs, Draft:God Save The Tuches, Draft:Poongodi
Annonce publiée le 18-10-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407 -
TBA
Plus d'infos...
Tags: Marbach, Caliciales, Draft:God Save The Tuches, Draft:Poongodi
Annonce publiée le 18-10-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407 -
TBA
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Tags: Dubreuil, Draft:God Save The Tuches, Draft:Poongodi
Annonce publiée le 18-10-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407 -
Invite par: H. de The
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Annonce publiée le 15-10-2025
College de France
au College de France - Amphitheatre Mireille Delmas-Marty, 11 place Marcelin Berthelot - 75005 Paris -
Invite par: H. de The
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Annonce publiée le 15-10-2025
College de France
au College de France - Amphitheatre Mireille Delmas-Marty, 11 place Marcelin Berthelot - 75005 Paris -
Invite par: Cirb
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Annonce publiée le 15-10-2025
College de France
au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris -
Invite par: Cirb
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Annonce publiée le 15-10-2025
College de France
au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris -
Plus d'infos...
Annonce publiée le 15-10-2025
College de France
au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris -
Invite par: Cirb
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Annonce publiée le 15-10-2025
College de France
au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris -
Invite par: Cirb
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Annonce publiée le 15-10-2025
College de France
au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris -
My research trajectory has focused on elucidating the role of tumor-derived Extracellular Vesicles (EVs) as key mediators of systemic immune responses. A core principle of my work is the study of native tumor EVs in physiologically relevant in vivo settings, facilitated by genetically engineering EV parental cells. This rigorous approach led to the discovery of a novel EV trafficking pathway in the lymph node, where tumor EVs are captured by subcapsular sinus (SCS) macrophages, a finding published in Science (2016). Building on this framework, our subsequent data uncovered a novel EV ? B cell axis. This work demonstrated that despite the potential for chronic immunosuppression, the antigens contained within these EVs are essential for generating potent, anti-tumor B cell responses. The emerging clinical significance of B cells as key prognostic and predictive indicators in cancer highlights B cell-mediated responses as a powerful, untapped pathway. Our data demonstrate that EV-mediated B cell activation suppresses tumor growth even in checkpoint-resistant models (under revision). Leveraging the same tools for studying native EVs, we also investigated the biology of Senescent Cell-Derived EVs (senEVs). This research demonstrated the unique immune-modulating capabilities of senEVs, distinct from other senescence-associated factors. By promoting senescent cell clearance, senEVs represent a novel therapeutic target to address cancer recurrence, thus showcasing the broad applicability of our in vivo EV methodology (Cancer Res 2025). Based on the evidence that B cell activation via EV-bound antigens is necessary to amplify anti-tumor responses, I now propose to translate this mechanistic insight into a tangible therapeutic reality. My strategy is to effectively convert the native antigenic payload of endogenous EVs into an in vivo cancer vaccine, offering a novel pathway to overcome primary resistance and drive durable, polyclonal T cell responses in solid tumors
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Tags: Cell biology, Vesicles, Cells, Immune system, Extracellular vesicle, Vesicle, Antigen, Immunotherapy, Cellular senescence, Exosome, Microvesicle
Annonce publiée le 15-10-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
Early human pregnancy has long been difficult to study due to limited accessibility. We recently developed stem cell-derived blastocyst models, or blastoids (Nature 2018; Nature 2021; Cell 2023), that mimic natural blastocysts in morphology, lineage composition, and transcriptional profiles. By combining human blastoids with endometrial organoids and deep learning models of chromatin accessibility and gene regulation, we uncovered molecular and evolutionary determinants of human blastocyst competence for implantation in utero. Blastoids provide a powerful platform to dissect mechanisms of human reproduction and trace their evolutionary origins, informing strategies to improve reproductive health.
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Tags: Embryology, Developmental biology, Stem cells, Blastoid, Tissue engineering, Human reproduction, Blastocyst, Implantation
Annonce publiée le 10-10-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Since 2015, the medical department organizes each year a Translational Research Day, which gathers a few hundred of basic researchers, clinicians and partners. EDITION 2025 : AXE SANTE ET MALADIE AUX ÂGES EXTRÊMES DE ...
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Tags: Exocrine system, Glands, Breast anatomy, Breastfeeding, Mammal anatomy, Mammary gland, Lactation
Annonce publiée le 09-10-2025
Institut Pasteur
Batiment: Duclaux Salle: Amphi Duclaux -
Invite par: Pierre Larraufie
Peer Community in (PCI) offers a free and transparent alternative to the traditional scientific publication system, by creating communities of researchers who evaluate and recommend preprints. Each PCI brings together ?recommenders' who act as editors, and recommend preprints which can then be submitted to journals or published directly in the ?Peer Community Journal'. Launched in 2017, the PCI initiative has expanded to 21 thematic communities (including PCI Microbiology), brings together more than 2,500 scientists and is supported by more than 200 institutions worldwide.
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Tags: Academic publishing, Open science, Peer Community in, Digital libraries, Preprint, Open access, EPrints, Open peer review, Research Square
Annonce publiée le 02-10-2025
Institut Micalis
Auditorium 442 - Institut Micalis -
Extracellular vesicles (EVs) are increasingly recognized as critical mediators in the pathogenesis of fungal infections, particularly those caused by Cryptococcus species—opportunistic pathogens responsible for life-threatening diseases in immunocompromised individuals. While structural models of fungal EVs have been proposed, they often overlook the natural heterogeneity within EV populations. Although the identification and functional analysis of EV subpopulations have been well explored in mammalian systems—and to a lesser extent in plants—this area remains underexplored in fungi. In this study, we isolated and characterized EVs from Cryptococcus using a combination of size-, weight-, and density-based separation techniques, allowing us to resolve distinct EV subpopulations. Importantly, we identified a previously uncharacterized small EV population, currently undergoing functional investigation. Preliminary data suggest this subpopulation may carry unique molecular signatures, with several candidates showing promise as biomarkers. Given the established roles of Cryptococcus-derived EVs in host–pathogen interactions, immune modulation, and the dissemination of virulence factors, these findings could significantly enhance our understanding of fungal pathogenesis. Ultimately, by revealing new layers of EV diversity, our work aims to facilitate the development of targeted biomarkers for early detection and to support novel therapeutic strategies focused on EV-mediated processes. Paris postdoc seminar series
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Tags: Tremellomycetes, Yeasts, Vesicles, Cell biology, Zoonoses, Extracellular vesicle, Cryptococcus, Vesicle, Pathogenic fungus, EV, Arturo Casadevall, Thomas G. Mitchell
Annonce publiée le 01-10-2025
Institut Cochin
Salle Rosalind Franklin -
Invite par: Thomas Bourgeron
The INCEPTION aims to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in various health issues. The inception program uses Integrative Biology, Social Science, and Data Science to ...
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Tags: Genetic epidemiology, Personalized medicine, Genome-wide association study
Annonce publiée le 01-10-2025
Institut Pasteur
Batiment: Auditorium & Atrium Francois Jacob -
Despite major advances in systemic therapies, outcomes for patients with metastatic uveal melanoma remain poor. Since up to 90% of patients develop liver metastases, the liver has become the primary target for locoregional treatment strategies. This lecture will review the evolution and future of these approaches, focusing on isolated hepatic perfusion (IHP) and percutaneous hepatic perfusion (PHP). Data from registry studies, randomized controlled trials such as SCANDIUM, and the recent FOCUS trial highlight the capacity of locoregional therapy to provide meaningful benefits. Emerging evidence also indicates that regional treatments may trigger immunogenic cell death, creating opportunities for rational combinations with systemic immunotherapy. Recent trials, including CHOPIN and SCANDIUM III, are evaluating the safety and efficacy of combining PHP with immune checkpoint inhibitors, with endpoints spanning survival, progression, quality of life, and biomarker discovery. Together, these efforts are redefining the role of locoregional therapy from liver-directed palliation toward integrated multimodal treatment, with the potential to extend survival in patients beyond what is achievable with systemic therapy alone. Teams link: https://teams.microsoft.com/l/meetup-join/19%3ameeting_YTE3NWRmNjktMjFkOC00NjBkLWE2ZGMtNWEzMmQ4NmNhYTA1%40thread.v2/0?context=%7b%22Tid%22%3a%22183ad437-6002-48ad-8886-c5885ce9be1a%22%2c%22Oid%22%3a%221ed1e97e-4bdf-4145-b23a-9858c31bd9e7%22%7d
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Tags: Hepatology, Uveal melanoma, Percutaneous hepatic perfusion, Melanoma, Liver metastasis, DecisionDx-UM
Annonce publiée le 26-09-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
Invite par: Francois Bontems
ReCombinaisons se veut un espace de rencontre et de discussion entre chercheuses et chercheurs (biologie-sante, sciences humaines et sociales, philosophie), autrices, auteurs et artistes de science-fiction, et public le plus large possible, pour reflechir ...
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Annonce publiée le 26-09-2025
Institut Pasteur
Batiment: CIS Salle: Auditorium -
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Tags: Bregaglia, ItalySwitzerland border, Pizz Gallagiun
Annonce publiée le 23-09-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Escherichia coli is an important opportunistic bacterial pathogen and one of the most frequent causes of Urinary Tract Infections (UTIs). One of the key survival strategies of E. coli is its ability to form “biofilm”, in which the bacteria are encased in extracellular polymeric substances. This makes them highly resistant to standard antibiotics treatment and also frequently lead to chronic or relapsing infections. Therefore, there is a dire need for novel alternative therapeutics to treat such bacterial infections. In my research work, I have shown that the FDA-approved antifungal drug, 5-fluorocytosine (5-FC), can effectively disarm E. coli, stripping off the virulence factors essential for its pathogenesis and hamper biofilm formation. Most importantly, I identified that when 5-FC is combined with common penicillin-like antibiotics (beta-lactams), it creates a powerful synergy that can kill even the highly protected bacteria residing within the biofilm shield. This novel "Sabotage and Strike" strategy—dismantling the bacteria's defenses and striking with antibiotics—represents a promising approach to combat persistent infections and tackle the global challenge of antibiotic resistance. Paris postdoc seminar series
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Tags: Bacteriology, Biological matter, Environmental soil science, Membrane biology, Environmental microbiology, Biofilm, Antivirulence, Antimicrobial resistance, Escherichia coli, Extracellular polymeric substance, Biofilm prevention, Dispersin B
Annonce publiée le 20-09-2025
Institut Cochin
Salle Rosalind Franklin -
Invite par: Paola Arimondo
Plus d'infos...
Tags: Screening, Drug discovery, Society for Biomolecular Sciences, Draft:Vipergen
Annonce publiée le 16-09-2025
Institut Pasteur
Batiment Duclaux, salle Duclaux amphitheater, -
Invite par: Maria Teresa Teixeira
The DNA Damage Response (DDR) is a complex signaling cascade elicited in the cell by damaged DNA, orchestrated by apical protein kinases, assisted by sensors and effectors. The two master kinases upstream of the DDR, ATR and ATM, are thought to mainly respond to single-stranded DNA and double strand breaks, respectively. However, non-canonical types of DDR have been reported (compact chromatin, mechanical or oxidative stress, among others), meaning that there exist stimuli equally capable of launching the DDR, yet in the absence of actual DNA damage. Overall, it remains poorly understood which is the actual signal, or signals, engaging these kinases. Building on the knowledge that ATM and ATR belong to the phosphatidyl-inositol-3-phosphate (PI3P)-kinase-related kinase family, we interrogated in the past if ATM and / or ATR can bind to, or be influenced by, phosphoinositides or other types of lipids. Of note, ATR has been found, in at least four previous studies, to sense the physico-chemical properties of phospholipids. We have discovered that ATM binds phosphatidyl-inositol-4-phosphate (PI4P) at the Trans Golgi, which allows it to remain anchored in an inactive (and non-phosphorylated) status. Activated ATM working in the nucleus can be titrated by the Golgi if PI4P levels at this location increase. Reciprocally, if PI4P levels decrease at the Golgi, ATM becomes more available to readily respond to DNA lesions inside the nucleus. Concerning ATR, we found thatATR combines its ability to sense DNA damage and phospholipid profiles to finetune the response to DNA lesions in a manner dependent on metabolic cues. We are confronting at present an even more surprising (yet simple) rule: DNA damage can be felt by membranes without the intermediate action of a DDR protein cascade. Inspired by compelling examples occurring in the mitochondria during the quality control of mitochondrial DNA, we are defining now general principles of this DNA-membrane signaling axis in the nucleus. Overall, I will discuss how the lipid profile of the nuclear envelope and other cellular membranes, which evolve in time and space, exerts a control over the response to DNA damage.
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Annonce publiée le 10-09-2025
IBPC
Conference room IBPC, 13 rue Pierre et Marie Curie 75005 Paris -
Invite par: Maria Teresa Teixeira
Plus d'infos...
Annonce publiée le 10-09-2025
IBPC
Conference room IBPC, 13 rue Pierre et Marie Curie 75005 Paris, Ile de France -
CpG dinucleotides are hotspots for mutagenesis by spontaneous deamination of 5-methylcytosine (5mC) into thymine, resulting in T:G mismatches that can lead to C>T transitions. These mutations are not only a hallmark of aging and cancer but also a major force shaping the evolution of vertebrate genomes. We have previously uncovered MBD4 as the primary base excision repair (BER) glycosylase responsible for 5mC deamination repair in both CpG and non-CpG contexts, with a striking preference for guarding active chromatin and early-replicating DNA. In this study, we employ a targeted base-editing system—comprising an APOBEC1 deaminase fused to a catalytically dead Cas9—to induce precise and strand-specific cytosine deamination and track its repair. This approach allows us to systematically investigate the cellular components required for efficient 5mC deamination repair in human cells. Our data reveal that MBD4 cooperates with the mismatch repair (MMR) pathway outside of S-phase, implicating non-canonical MMR in the repair of this form of DNA damage. Using AI-based structural predictions alongside biochemical validation, we identify a previously unrecognized complex including MBD4 and MMR components, positioning them as key players in a coordinated repair response. Finally, we analyze thousands of tumor whole-genomes to show that MMR deficiency leads to CpG hypermutagenesis lacking replication strand asymmetry, further supporting a role for replication-independent MMR activity in 5mC deamination repair. Altogether, we uncover a novel function of non-canonical MMR that underscores its interplay with BER in safeguarding genomic integrity in mammalian cells. Paris postdoc seminar series
Plus d'infos...
Tags: DNA, Mutation, Molecular genetics, Senescence, Base excision repair, CpG site, Deamination, 5-Methylcytosine, MBD4, DNA repair, DNA damage, Transition
Annonce publiée le 06-09-2025
Institut Cochin
Salle Rosalind Franklin -
Invite par: Michaela Muller-Trutwin
As part of the annual meetings of the Coordinated Action on Host-Virus Interactions: Basic and Translational HIV Research, the TheGeVec Group is hosting its first symposium on November 28th 2025: Shaping the Future of ...
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Tags: Gene delivery, Biotechnology, Molecular biology, Applied genetics, Bioethics, Gene therapy, Pasteur Institute, Therapy
Annonce publiée le 05-09-2025
Institut Pasteur
Batiment: Centre Francois Jacob Salle: Auditorium Francois Jacob -
Invite par: Philippe Sansonetti
Human milk lives at the very intersection of maternal and infant health. Yet, it remains poorly understood and highly understudied. The presentation outlines the many benefits of breastfeeding and human milk for both the ...
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Tags: Breastfeeding, Breast milk, Milk, Oligosaccharide, Infant
Annonce publiée le 05-09-2025
Institut Pasteur
Batiment: Duclaux Building Salle: Duclaux Amphitheater -
Invite par: Morgane Bomsel - Frederic Bouillaud - Sandrine Bourdoulous - Catherine Postic - Dominique Salmon - Dominique Zeliszewski
Plus d'infos...
Tags: Long COVID, Post-acute infections
Annonce publiée le 05-09-2025
Institut Cochin
Amphitheatre Luton de la Faculte de Medecine, 24 rue du Fg St Jacques - 75014 -
Le cours est dedie aux connaissances les plus actuelles articulant la biologie du developpement et l etude cellulaire et moleculaire des cancers. Les cretes neurales et les melanomes, depuis leur formation jusqu a leur migration (metastases), ainsi que les cancers pediatriques d'origine embryonnaires tels que les medulloblastomes et neuroblastomes sont pris comme exemples. Le cours beneficie d une approche multidisciplinaire a multiples echelles (embryologie sur des modeles varies, biophysique, biologie cellulaire, transcriptomique, imagerie...). Il aborde egalement des approches therapeutiques. Le cours est ponctue par des tables rondes sur les carrieres dans le milieu academique ou dans l industrie,sur la publication d articles scientifiques ainsi que sur l ethique en experimentation animale.Des sessions posters de doctorants sont egalement organises et des prix pour les meilleurs posters seront decernes par les participants aux cours.
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Annonce publiée le 04-09-2025
Institut Curie
Centre de recherche - Orsay - Amphitheatre du Batiment 111 -
Plus d'infos...
Annonce publiée le 02-09-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Plus d'infos...
Tags: Digital violence, Moral law
Annonce publiée le 02-09-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Plus d'infos...
Tags: Ens, cole normale suprieure
Annonce publiée le 30-08-2025
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
Invite par: Sylvie Rabot
How the gut microbiota and its host communicate and react together to environmental stimuli is essential to understand a mammalian holobiont. In a biomedical context, such communication might be a reason for staying healthy, if it is balanced, or associated with diseases when the communication is disrupted. Microbiota and host produce metabolites that can regulate and limit epigenetic enzymes, controlling epigenetic marks in the host. Using a germ-free mouse model, including males and females, we investigated how biological sex and microbiota status influenced the microbiota-nutrient metabolism-host epigenetic? axis of communication. We studied microbes, metabolism, epigenetic marks and gene expression in the host, focusing on the liver as target tissue, through a multi-omics and correlational analysis approach. Our results show the interaction of biological sex and microbiota in controlling the levels of DNA methylation in an additive manner. Where males are hypomethylated compared to females, and where the presence of microbiota accentuates this pattern in both sexes, being more pronounced in males. Males without microbiota present a feminised pattern of gene DNA methylation and expression. We have also observed a strong positive correlation between the levels of host DNA methylation in genes involved in testosterone degradation, and the Ruminococcaceae family, more abundant in males than females. Altogether, we propose Ruminococcaceae as a key ecological player in the holobiont ecosystem, influencing host gene regulation in a sex-dependent manner, through the modulation of DNA methylation levels of steroids degradation genes.
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Tags: Epigenetics, DNA, Bacteriology, Microbiomes, Post-translational modification, DNA methylation, Microbiota, Methylation, Gut microbiota, Regulation of gene expression, Ecological evolutionary developmental biology, Cancer epigenetics
Annonce publiée le 22-08-2025
Institut Micalis
Auditorium 442 - Institut Micalis -
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Tags: Fricker, Desdemona
Annonce publiée le 19-08-2025
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
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Tags: Saclay, Paris-Saclay University
Annonce publiée le 19-08-2025
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
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Tags: Ranft, Ens
Annonce publiée le 19-08-2025
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
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Tags: Operas, Ulisse, Flavio Manzoni, Ulisse Cantagalli
Annonce publiée le 19-08-2025
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
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Tags: Ens, Carlos Costa
Annonce publiée le 19-08-2025
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
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Tags: Sergent, Enea Benedetto
Annonce publiée le 19-08-2025
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
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Tags: Villette, Ens
Annonce publiée le 19-08-2025
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
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Annonce publiée le 14-05-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
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Annonce publiée le 14-05-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
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Annonce publiée le 14-05-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris