Invite par: DOYERE Valerie Plus d'infos... Tags: Curves International, Franchises, Arrow Annonce publiée le 26-09-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Invite par: DOYERE Valerie Plus d'infos... Tags: Curves International, Franchises, Arrow Annonce publiée le 26-09-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Invite par: Aude Bernheim Seminar Maya Voichek: The twilight zone between transposons and endogenous retroviruses Endogenous retroviruses are abundantly embedded within host genomes and provide a unique snapshot of multiple past viral infections. They are thought to be ... Plus d'infos... Tags: Molecular biology, Non-coding DNA, Mobile genetic elements, Endogenous retrovirus, Retrovirus, Transposable element, Virus Annonce publiée le 26-09-2023 Tweet |
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Institut Pasteur Salle: Salle CFJ 28-01-01A - C. Francois Jacob 1er 01A |
Invited by the Prioleau Lab, Ana Rita Gomes (LPHI Laboratory of Pathogens and Host Immunity, Universite de Montpellier) will present an IJM seminar on the theme: The genetic landscape of origins of replication in P. falciparum A variety of origin mapping approaches have enabled genome-wide identification of origins of replication (ORI) in model organisms, but only a few of studies have focused on divergent organisms. By employing three complementary approaches we provide a high-resolution map of ORIs in Plasmodium falciparum, the deadliest human malaria parasite. We profiled the distribution of ORC binding sites by ChIP-seq of two subunits and mapped active ORIs using NFS and SNS-seq. We show that ORIs lack sequence specificity but are not randomly distributed, and group in clusters. Licensing is biased towards regions of higher GC content and associated with G-quadruplex forming sequences (G4FS). a product of evolutionary pressure imposed by the parasitic lifestyle. Plus d'infos... Tags: DNA replication, Malaria, Origin of replication, Plasmodium falciparum, G-quadruplex Annonce publiée le 25-09-2023 Tweet |
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Institut Jacques Monod Usually at 11.45 am in the Francois Jacob room |
Invited by the Wassmann Lab, Joao Matos (Max Perutz Labs, University of Vienna) will present an IJM seminar on the theme: Building, maintaining and discarding large macromolecular assemblies during gametogenesis The life cycle of sexually reproducing eukaryotes depends on two specialized chromosome segregation programs: mitosis and meiosis. Whereas mitosis drives cellular proliferation and the stable propagation of the genome, meiosis promotes genetic diversity and the formation of rejuvenated gametes, which combine at fertilization to restore the diploid state. I will discuss how meiotic cells build, maintain and disassemble/segregate/discard macromolecular assemblies during meiosis: i) the synaptonemal complex; ii)& novel filamentous structures that are important for cell viability after gametogenesis and for gamete rejuvenation. Plus d'infos... Tags: Cell cycle, Germ cells, Developmental biology, Cellular processes, Reproductive system, Gametogenesis, Meiosis, Biological life cycle, Chromosome segregation, Gamete, Synaptonemal complex, Eukaryote Annonce publiée le 25-09-2023 Tweet |
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Institut Jacques Monod Usually at 11.45 am in the Francois Jacob room |
Ineffective erythropoiesis (IE) is an important factor in many types of anemias. Recently, a study by El Hoss et al provided compelling evidence for IE being an important part of the pathophysiology of sickle cell anemia (SCA). Furthermore, we developed a clinical index to measure IE and showed that patients with the SS genotype had increased IE compared to healthy donors (HD). However, the molecular mechanisms of IE in SCA, its relationship todisease heterogeneity and its potential as a therapeutic target, remain unknown. Importantly, GATA1, an essential erythroid transcription factor known to be downregulated in haematological conditions presenting with IE, has not been previously investigated in SCA. Therefore, the aim of our work is to elucidate the role of GATA-1 in IE of SCA. By performing ex-vivo differentiation of primary human SS CD34+ cells we revealed (i) a significant delay in differentiation (ii) an elevated level of oxidative stress and a reduction in GATA-1 protein levels. In a parallel line of evidence, IE manifested in SS mice and was characterized by increased oxidative stress levels in both the bone marrow and spleen tissues. Moreover, both tissues showed a significant decline in GATA-1 levels. This research seeks to provide novel insights into the role of GATA-1 in sickle erythropoiesis, the latter could guide the development of potential therapeutic strategies targeting GATA-1 and thus improving the bone marrow niche and erythropoiesis in SCA. Invitation by Catherine Lavazec and Michaela Fontenay. Plus d'infos... Tags: Hematopoiesis, Transcription factors, Anemias, Erythropoiesis, Sickle cell disease, GATA1, Ineffective erythropoiesis, Red blood cell, Bone marrow Annonce publiée le 23-09-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Invite par: Marie-Eve Val Plus d'infos... Tags: Bacteria, Bacteriology, Domains, Immune system Annonce publiée le 23-09-2023 Tweet |
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Institut Pasteur Batiment: CFJ Salle: Auditorium Francois Jacob |
Invite par: Michael White Plus d'infos... Tags: Cholera, Diarrhea, Epidemics, Epidemiology Annonce publiée le 23-09-2023 Tweet |
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Institut Pasteur Batiment CFJ building, salle Auditorium F. Jacob, |
Invite par: Pierre Alexandr Kaminski ; Plus d'infos... Tags: Molecular biology, Biotechnology, Genome editing, Genetic engineering, Non-coding RNA, CRISPR, Pasteur Institute, Louis Pasteur, RNA, Sanne, Transposable element Annonce publiée le 23-09-2023 Tweet |
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Institut Pasteur Batiment: Duclaux building Salle: Amphitheater Duclaux |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 22-09-2023 Tweet |
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College de France au College de France - Amphitheatre Maurice Halbwachs 11 place Marcelin Berthelot - 75005 Paris |
Invite par: Vincent COLOT - Section Ecologie et Biologie de l’Evolution Plus d'infos... Tags: Epigenetics, Post-translational modification, Chromatin remodeling, Histone, H3R17me2, H3K36me Annonce publiée le 22-09-2023 Tweet |
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IBENS salle Favard, IBENS 46 rue d'Ulm 75005 Paris |
Invite par: Chetan Chitnis Plus d'infos... Tags: Disease ecology, Ecology, Parasitism, Parasitology, Virus-like particle, Virus, Zika virus vaccine, ATC code J07 Annonce publiée le 22-09-2023 Tweet |
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Institut Pasteur Batiment Lwoff, salle Retrovirus, |
Invite par: Jean-Christophe Poncer Plus d'infos... Tags: Perrin, lodie, Alain Decaux, Karel Elodie Ziketh Annonce publiée le 21-09-2023 Tweet |
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Insitut du Fer à Moulin 17 Rue du Fer a Moulin - 75005 Paris |
Invite par: Emmanuel Beaurepaire Integrating information over long-time scales is a critical component of most circuit computations in the brain across species. However, it remains poorly understood how such dynamics are implemented mechanistically. One idea is that slow time constants are implemented via recurrent connectivity of balanced excitation and inhibition. Dissecting such neural circuits requires precise knowledge of functional neural properties and correlating dynamics with the underlying wiring diagram, ideally, within the same individual animal (neurotransmitter identity, anatomy, and connectivity). To address this issue, we have developed a visual motion integration task in larval zebrafish and tools to combine functional calcium imaging with ultrastructural circuit reconstruction. We have recently complemented this approach involving an existing whole-brain connectomics resource as well as targeted fluorescent labeling of functionally identified neuronal response types. Our results will allow us to rapidly validate and constrain existing network models, and add resolution and confidence to previously proposed circuit arrangements at a reduced cost. Tags: Neuroscience, Connectomics, Omics, Brain, Computational neuroscience Annonce publiée le 19-09-2023 Tweet |
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Ecole Polytechnique Amphi Carnot |
Ineffective erythropoiesis (IE) is an important factor in many types of anemias. Recently, a study by El Hoss et al provided compelling evidence for IE being an important part of the pathophysiology of sickle cell anemia (SCA). Furthermore, we developed a clinical index to measure IE and showed that patients with the SS genotype had increased IE compared to healthy donors (HD). However, the molecular mechanisms of IE in SCA, its relationship todisease heterogeneity and its potential as a therapeutic target, remain unknown. Importantly, GATA1, an essential erythroid transcription factor known to be downregulated in haematological conditions presenting with IE, has not been previously investigated in SCA. Therefore, the aim of our work is to elucidate the role of GATA-1 in IE of SCA. By performing ex-vivo differentiation of primary human SS CD34+ cells we revealed (i) a significant delay in differentiation (ii) an elevated level of oxidative stress and a reduction in GATA-1 protein levels. In a parallel line of evidence, IE manifested in SS mice and was characterized by increased oxidative stress levels in both the bone marrow and spleen tissues. Moreover, both tissues showed a significant decline in GATA-1 levels. This research seeks to provide novel insights into the role of GATA-1 in sickle erythropoiesis, the latter could guide the development of potential therapeutic strategies targeting GATA-1 and thus improving the bone marrow niche and erythropoiesis in SCA. Invitation by Catherine Lavazec. Plus d'infos... Tags: Hematopoiesis, Transcription factors, Anemias, Erythropoiesis, Sickle cell disease, GATA1, Ineffective erythropoiesis, Red blood cell, Bone marrow Annonce publiée le 19-09-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Invite par: Carmen Buchrieser Wenesday, September 27th, 2023, at 2.00pm Jules Bordet room Melanie Ott Senior Investigator, Gladstone Institute of Virology and Immunology at the UCSF (University of California San Francisco), Gladstone Institute of Virology and Immunology, ... Plus d'infos... Tags: University of California, San Francisco, Sunset District, San Francisco, Melanie Ott, Jules Bordet Annonce publiée le 19-09-2023 Tweet |
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Institut Pasteur Batiment: Metchnikoff building Salle: Jules Bordet room |
Invite par: Rendez-vous LORIER A loccasion de son webinaire, Brigitte exposera les elements contextuels actuels du debat sur le recours a l'animal en recherche biomedicale. Ils comprennent en particulier la question de la reproductibilite des resultats qui impose la mise en oeuvre de tous les moyens possibles pour assurer la robustesse scientifique des etudes et plus particulierement celles impliquant des animaux. LEDA (Experimental Design Assistant) est un de ces moyens recemment mis a disposition par le NC3R, organisation britannique dont la mission est de developper et promouvoir les 3R dans la recherche. Il permet d'accompagner et d'ameliorer la qualite du design experimental. Brigitte presentera les atouts de cet outil et surtout le dispositif mis en place au sein de lInserm pour faciliter sa prise en main et son utilisation par les chercheurs. Plus d'infos... Tags: ethics Annonce publiée le 17-09-2023 Tweet |
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Rendez-vous LORIER ONLINE |
Expression of the protein tyrosine kinase 7 (PTK7) receptor in tumoral epithelium has been associated with poor prognosis in colorectal cancer (CRC). Interestingly, an antibody-drug conjugate targeting PTK7 triggers tumor regression in ovarian, lung and breast cancer xenografts and has entered phase 2 clinical trials. We set out to better understand the role of PTK7 in CRC. In murine colon, we detected PTK7 expression in epithelial stem cells, as described in the literature. However, we also detected PTK7 expression in fibroblasts, which has been so far overlooked. Biopsies from CRC patients displayed distinct expression profiles for PTK7 in the epithelium and fibroblasts, suggesting a complex role for PTK7 in CRC.To explore the potential role of PTK7 in regulating the crosstalk between colonic epithelium and neighboring fibroblasts, we have generated cell type specific knock-out mice, by deleting Ptk7 in colonic epithelial cells upon tamoxifen injection(Ptk7fl/flVilCreERT2 mice) and a subpopulation of colonic fibroblasts (Ptk7fl/flColVICre mice), respectively. We started to analyze these mouse strains in homeostasis and colonic pathologies and I will present the results of these analyses. The data we obtained so far, suggest a disease suppressing role for a subset of PTK7 expressing colonic fibroblasts. Together, our findings suggest that PTK7 executes distinct roles in colon homeostasis and pathology. Plus d'infos... Tags: Tyrosine kinase receptors, PTK7, Digestive system, Tyrosine kinase, Large intestine Annonce publiée le 17-09-2023 Tweet |
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Centre de Recherche des Cordeliers Pavillon 4 du batiment de la Surelevation (Campus des Cordeliers) |
Invitée par Ludivine Doridot. Plus d'infos... Tags: Dobbs Annonce publiée le 15-09-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Understanding the mechanisms by which a genetic variation contributes to diseases is a central aim of human genetics and should greatly facilitate the development of preventive strategies and treatments. Implementing this approach to understand the cellular and molecular basis of neuromuscular disorders (NMDs) is particularly challenging due to the inherent inaccessibility of the affected cell types from patients. Despite the wealth of existing cellular and animal models, progresses towards identification of new treatments have been hampered by the incomplete understanding of the pathogenic mechanisms involved in these diseases as well as the availability of relevant screening tools. The development of convenient Human models that even more closely replicate the disease will undoubtedly improve pathological modeling of neuromuscular disorders as well as more adapted therapeutics. In this context, my group is interesting in developing an in vitro human “tool box” to establish pathological models of representative NMDs based on the use of human pluripotent stem cells. While developing these models, our proposal has several objectives: (1) deciphering the pathophysiological mechanisms of different NMDs (2) to use biomarkers revealed by the mechanistic approach as readouts for drug screening and (3) validate these developments by a proof-of-concept high-throughput screening (4) to convert these models into therapeutic products. [Invitation de Latif Rachdi] Plus d'infos... Tags: Stem cells, Induced stem cells, Biotechnology, Cloning, Developmental biology, Neuromuscular junction Annonce publiée le 15-09-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Plus d'infos... Annonce publiée le 15-09-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Invitation de Latif Rachdi. Plus d'infos... Tags: Evry, Martinat, Ccile, vry, Essonne, Latif Annonce publiée le 13-09-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Invite par: IBENS - Equipe Herve LE HIR Plus d'infos... Tags: RNA, Spliceosome, Exon junction complex, Molecular biology, EJC, Transcriptomics technologies, Gene expression, CASC3 Annonce publiée le 13-09-2023 Tweet |
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IBENS salle Favard, IBENS 46 rue d'Ulm 75005 Paris |
Invite par: Vincent COLOT - Section Ecologie et Biologie de l’Evolution Plus d'infos... Tags: Mobile genetic elements, Molecular biology, DNA, Genetic mapping, Transposable element, Epigenetics, Regulation of gene expression, Epigenetic regulation of transposable elements in the plant kingdom, DNA transposon Annonce publiée le 13-09-2023 Tweet |
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IBENS salle Favard, IBENS 46 rue d'Ulm 75005 Paris |
TBA Plus d'infos... Tags: Sorbonne University, Perrin, Lobato Annonce publiée le 08-09-2023 Tweet |
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Laboratoire Jean Perrin Salle de seminaires 5eme etage - LJP - Tours 32-33 |
Invite par: Mael Bessaud Plus d'infos... Annonce publiée le 05-09-2023 Tweet |
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Institut Pasteur Batiment Lwoff, salle Salle Retrovirus (22-00-14), |
Internal seminar Plus d'infos... Annonce publiée le 05-09-2023 Tweet |
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Laboratoire Jean Perrin Salle de seminaires 5eme etage - LJP |
The nematode Caenorhabditis elegans is an excellent experimental system for studying how cell division and differentiation events are orchestrated in the context of a developing animal. A set of master regulatory genes, so calle ‘heterochronic genes’, have been identified in C. elegans whose activity changes as the worm progresses through larval development. The various heterochronic genes encode transcription factors, microRNAs, RNA binding proteins, and other proteins and noncoding RNAs that comprise a developmentally dynamic regulatory network that controls the timing of cell fate transitions throughout the animal. Many of the C. elegans heterochronic genes, and in some cases the regulatory interactions amongst them, are conserved in mammals, including humans. Mutations in C. elegans heterochronic genes cause stage-specific developmental events to be expressed with incorrect timing. We are particularly intrigued by the robustness with which this network normally operates, since developmental events occur with precise and invariant timing in the wild type, regardless of environmental and physiological stresses experienced by the free-living larva. By contrast, the developmental timing phenotypes of heterochronic mutants are often dramatically modified by those same everyday stresses, indicating roles for the corresponding genes in conferring developmental robustness. I will report on recent findings from our explorations of the regulatory mechanisms underlying the robust control of developmental timing by heterochronic genes. Plus d'infos... Tags: Caenorhabditis elegans, Ambros, Howard Hughes Medical Investigators, MicroRNA, Gary Ruvkun, Victor Ambros Annonce publiée le 31-08-2023 Tweet |
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Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie |
Invite par: ROUYER Francois Plus d'infos... Tags: Padmanabhan, Kiran, T Padmanabhan Annonce publiée le 29-08-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Invite par: Christophe D’Enfert Mycology department seminar Thursday October, 5th @ 1.00pm Jules Bordet room, Metchnikoff building Yue Wang IDLabs, A*Star (Singapore) Mechanistic understanding of the yeast-to-hyphae transition of Candida albicans Abstract: Candida albicansis the most prevalent fungal ... Plus d'infos... Tags: Yeasts, Gut flora, Pathogenic microbes, Candida albicans, Candida Annonce publiée le 28-08-2023 Tweet |
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Institut Pasteur Batiment: Metchnikoff building Salle: Jules Bordet room |
Invite par: Richard Belvindrah Plus d'infos... Tags: Cerebral cortex, Cortex, Morphogenesis, Cerebral Annonce publiée le 24-08-2023 Tweet |
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Insitut du Fer à Moulin 17 Rue du Fer a Moulin - 75005 Paris |
Dans le cadre de l'action commune des instituts Carnot Pasteur Microbes et Sante et France Futur Elevage (porte par l'Inrae), ils vous proposent un seminaire qui sera l’occasion du lancement du nouvel AAP Inter-Carnot ... Plus d'infos... Annonce publiée le 17-08-2023 Tweet |
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Institut Pasteur |
Invite par: Gerald Spaeth Seminaire extraordinaire du Departement des Parasites et Insectes Vecteurs Maria Adelaida GOMEZ Coordinator of the Molecular Biology and Biochemistry lab CIDEIM (Centro Internacional de Entrenamiento e Investigaciones Medicas) - Cali-Colombia Treatment failure and persistent ... Plus d'infos... Tags: Parasitology, Epidemiology, Trypanosomatida, Infectious diseases, Disease ecology, Leishmania, Parasitism, Disease vector, Infection Annonce publiée le 02-08-2023 Tweet |
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Institut Pasteur Batiment Monod, salle Amphitheatre Ullmann, |
Invite par: Philippe Bastin Seminaire extraordinaire du Departement des Parasites et Insectes Vecteurs Professor Vyacheslav YURCHENKO Professor of Molecular and Cellular Biology and Genetics; Lab Head Laboratory of Trypanosomatid Biology - Life Science Research Center University of Ostrava ... Plus d'infos... Tags: Parasitology, Trypanosomatida, Molecular biology, Gene delivery, Infectious diseases, Vector, Trypanosoma, Parasitism, Disease vector, Endosymbiont, Vyacheslav Annonce publiée le 02-08-2023 Tweet |
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Institut Pasteur Batiment Retrovirus, salle Lwoff, |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 26-07-2023 Tweet |
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College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 26-07-2023 Tweet |
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College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 26-07-2023 Tweet |
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College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Invite par: CREUZET Sophie Plus d'infos... Tags: Martine Annonce publiée le 25-07-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 17-07-2023 Tweet |
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College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 17-07-2023 Tweet |
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College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris |
Invite par: ROUYER Francois Plus d'infos... Tags: Helfrich, Forster Annonce publiée le 08-07-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Invite par: SHULZ Daniel Plus d'infos... Tags: Slimane, Abdelhalim Bensmaia Annonce publiée le 08-07-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
Invite par: RETAUX Sylvie Plus d'infos... Annonce publiée le 05-07-2023 Tweet |
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NeuroPSI Salle de conference Albe-Fessard |
TBA Plus d'infos... Tags: Grandes coles, Ens, cole normale suprieure, Draft:202526 Indian Super League, cole normale suprieure de Rennes Annonce publiée le 02-07-2023 Tweet |
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Laboratoire Jean Perrin Salle de seminaires 5eme etage - LJP - Tours 32-33 |
TBA Plus d'infos... Tags: Grandes coles, Ens, Barbosa, cole normale suprieure, Draft:202526 Indian Super League, Joo Salla Annonce publiée le 30-06-2023 Tweet |
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Laboratoire Jean Perrin Salle de seminaires 5eme etage - LJP - Tours 32-33 |
TBA Plus d'infos... Annonce publiée le 29-06-2023 Tweet |
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Laboratoire Jean Perrin Salle de seminaires 5eme etage - LJP - Tours 32-33 |
L'objectif de ce cours est de fournir une vue d'ensemble pratique et actualisée des dernières recherches et des développements cliniques dans le domaine du cancer urothélial, y compris les cancers de la vessie invasifs et non invasifs sur le plan musculaire, les carcinomes urothéliaux des voies urinaires supérieures et leurs métastases. Ce faisant, nous visons à : a) promouvoir une compréhension consensuelle des stratégies optimales actuelles de traitement de ces maladies, b) fournir des connaissances pratiques et une perspective clinique des maladies et de leur traitement, c) promouvoir une meilleure compréhension mécaniste des maladies et des méthodologies utilisées pour les étudier, et d) fournir une perspective industrielle pour partager la façon dont les nouveaux traitements sont développés. Plus d'infos... Annonce publiée le 12-06-2023 Tweet |
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Institut Curie Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) |
Institut Curie and Sorbonne Université organize their 14th International Developmental Biology course. The aim of the program is to provide the participants a comprehensive coverage of the paradigms, problems and technologies of modern Developmental Biology paying particular attention to stem cells. Training in theoretical and experimental aspects of normal and abnormal development is developed through a variety of embryonic systems using state-of-the-art instrumentation and methodology. The program is proposed in two versions (more information available soon) so there will be two registration deadlines: Long version (3,5 weeks, w/ practicals at Sorbonne University & Seminars at Institut Curie) : July 15th Important information: people who need a visa have to apply by June 15th Plus d'infos... Tags: Biology, Branches of biology, Life sciences, Developmental biology, Biotechnology, Induced stem cells, Evolutionary developmental biology, Morphogenesis, Morphology, Morphogen, Stem cell Annonce publiée le 12-06-2023 Tweet |
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Institut Curie Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) |
Invited by Pascal Maire. Plus d'infos... Tags: Illkirch-Graffenstaden, Maire Annonce publiée le 10-06-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Christine Goffinet is a Prof., leader of the team "Innate Immunity and Viral Evasion" at the Institute of Virology from the Berlin Institute of Health. She is since many years an expert in the HIV-1 field, and now also intensively working on SARS-CoV-2, interested in gaining a better understanding of the interplay between host cells and viruses at the cellular and molecular level. She is invited by Serge Benichou. Plus d'infos... Annonce publiée le 10-06-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
TBA Plus d'infos... Tags: Alexis, Draft:Valley Vista Elementary School, Undichna britannica Annonce publiée le 03-06-2023 Tweet |
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Laboratoire Jean Perrin salle de seminaires 5eme etage - LJP - Tour 32-33 |
Plus d'infos... Annonce publiée le 30-05-2023 Tweet |
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Inst. Bio. Paris Seine 7-9 quai Saint Bernard, 75005 Paris |
Plus d'infos... Annonce publiée le 30-05-2023 Tweet |
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Inst. Bio. Paris Seine 7-9 quai Saint Bernard, 75005 Paris |
Hematopoietic stem cells (HSCs) are the rare cells responsible for the lifelong curative effects of hematopoietic cell transplantation. The demand for clinical-grade HSCs has increased significantly in recent decades, leading to major difficulties in treating patients. A promising but not yet achieved goal is the generation of HSCs from pluripotent stem cells. Here, we have obtained vector- and stroma-free transplantable HSCs by differentiating human induced pluripotent stem cells (hiPSCs) using an original one-step culture system. After injection into immunocompromised mice, cells derived from hiPSCs settle in the bone marrow and form a robust multilineage, hematopoietic population that can be serially transplanted. Single cell RNA sequencing shows that this repopulating activity is due to a hematopoietic population that is transcriptionally similar to human embryonic aorta-derived HSCs. Overall, our results demonstrate the generation of HSCs from hiPSC and will help identify key regulators of HSC production during human ontogeny. Thierry Jaffredo is invited by Pascal Maire. Plus d'infos... Tags: Branches of biology, Biology, Life sciences, Stem cells, Hematopoietic stem cell, Haematopoiesis, Induced pluripotent stem cell, Hematopoietic stem cell niche, Stemcell Technologies Annonce publiée le 25-05-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Cell plasticity plays an essential role in chronic pancreatitis, human pancreatic cancer (PDAC) and development of diabetes. The morphological processes are closely related to molecular programs known from early embryonic development of the pancreas. Based on these analogies, we have developed new disease models to decipher the causes of the aforementioned pathophysiologies and to design innovative, personalized therapies. One of the core areas in the lab is pancreatic differentiation of human pluripotent stem cells (hPSC). Here , we have differentiated hPSCs into pancreatic duct-like organoids (PDLOs) with morphological, transcriptional, proteomic, and functional characteristics of human pancreatic ducts, further maturing upon transplantation into mice. This model enabled in vitro and in vivo studies of pancreatic plasticity, dysplasia, and cancer formation from a genetically defined background. Using similar models, we also approached the endocrine lineage and revealed that loss of ONECUT1 impairs pancreatic progenitor formation and a subsequent endocrine program. Loss of ONECUT1 altered transcription factor binding and enhancer activity and NKX2.2/NKX6.1 expression in pancreatic progenitor cells. Collectively, we demonstrate that ONECUT1 controls a transcriptional and epigenetic machinery regulating endocrine development, involved in a spectrum of diabetes, encompassing monogenic (recessive and dominant) as well as multifactorial inheritance. In this seminar, I will summarize these seminal papers and give an overview about our unpublished efforts to model pancreatic disorders. Invited by Cécile Julier Plus d'infos... Tags: Branches of biology, Biology, Life sciences, Stem cells, Developmental biology, Biotechnology, Induced stem cells, Cell biology, Organoid, Pancreatic progenitor cell, Pancreas, Progenitor cell Annonce publiée le 15-05-2023 Tweet |
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Institut Cochin Salle Rosalind Franklin |
Invite par: Yannick Allanore, Julie Chaumeil, Molly Ingersoll, Catherine Postic, Carina Prip-buus, Dominique Zeliszewski Many recent works demonstrate that biological sex - or whether it is female or male - as well as the number of sex chromosomes carried by an individual, can have a profound impact on various aspects of biology, in homeostasis and in many diseases. The influence of biological sex is still poorly understood and too often ignored both in basic research practices and by the medical profession. The French High Council for Equality between Women and Men noted, in its 2020 report, the importance of taking sex and gender into account to provide better care, as a public health issue. The Institut Cochin symposium Why sex matters in health and disease will highlight the impact of sex on gene regulation, cancer, immunology and metabolism. In these areas, both the physiological mechanisms involved and the development of chronic diseases such as cancer, autoimmune diseases, diabetes, chronic liver diseases will be addressed. Plus d'infos... Tags: Gender in Health Annonce publiée le 14-05-2023 Tweet |
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Institut Cochin amphitheatre Luton, UFR de Medecine site Cochin, 24 rue du Fg St Jacques 75014 |