BRA-STRAP is performing targeted-sequencing of 24 genes commonly included on panel tests for breast cancer predisposition in 30,000 Australian women of all ages across the cancer risk spectrum, affected and unaffected with breast cancer, and their families. Contributing to BRA-STRAP are i) large research cohorts of aging populations and of women above population risk, and ii) the clinical genetics community and women found negative for BRCA1 and BRCA2 mutations following testing in a Familial Cancer Centre over the last 2 decades. BRA-STRAP is also engaged with the broader translational research community and other similarly designed studies set outside of Australia (e.g. BRIDGES and CARRIERS).
Data on this scale represents the spectrum of genetic variation observed in these genes and exemplifies the opportunities and challenges for realizing precision medicine and precision public health for breast cancer.
Dr Tu Nguyen-Dumont is a cancer geneticist and a bioinformatician. She is a Senior Research Fellow at Monash University, Australia. She obtained her PhD from Claude Bernard University, Lyon, France in 2010. During her undergrad and PhD studies, she trained at the International Agency for Research on Cancer (Lyon). In 2011, she was awarded a Komen Foundation Postdoctoral Fellowship, which allowed her to gain international research experience and move to Melbourne. In 2017, Tu was awarded a Career Development Fellowship by the National Breast Cancer Foundation.
Her research work is directed towards the identification and characterization of cancer susceptibility genes. Her primary area of interest is breast cancer, although she is also involved in the investigation of prostate and childhood cancers susceptibility. Tu applies cutting-edge technologies and computational approaches to conduct advanced genomics research. She has a strong commitment to translation of research and is currently leading research programs aiming at making fundamental -and much required- changes to breast cancer clinical genetics practice, for the benefit of all Australian women at genetic risk of breast cancer.
Annonce publiée le 12-06-2018