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More details... Published on 05-02-2025 |
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| Institut Curie Centre de recherche - Paris - Webinar |
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Published on 05-02-2025
Institut Curie
Centre de recherche - Paris - Webinar -
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Tags: Behavioral neuroscience, Neurology
Published on 05-02-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
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Tags: Max Planck Institute for Multidisciplinary Sciences, Meiosis, Max Planck Society, Starfish, Lenart, Oocyte
Published on 05-02-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
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Published on 05-02-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Invited by: Rozenn Gardan
Gram-positive Bacillota bacteria and their mobile genetic elements (e.g., plasmids or bacteriophages) encode peptide-based quorum-sensing systems (QSSs) that orchestrate behavioral transitions as a function of population densities. Among these, the RRNPP family represents the simplest form, consisting of two adjacent genes encoding a signaling peptide and its cognate intracellular receptor. RRNPP QSSs shape the social dynamics of microbial communities by regulating processes such as virulence or biofilm formation in bacteria, conjugation in plasmids, or lysogeny in temperate bacteriophages.
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Tags: Bacteriology, Plasmid, Bacteria, Quorum sensing, Bacteriophage, Biofilm, Gram-positive bacteria, Virulence, Gram-negative bacteria, Mobile genetic elements, Autoinducer, Integrative and conjugative element
Published on 04-02-2025
Institut Micalis
Auditorium 442 - Institut Micalis -
Invited by: Naima Belgareh-Touze
Previous studies using ubiquitin traps combined with mass spectrometry revealed that in Bortezomib (BTZ) resistant Mantle Cell Lymphoma (MCL) cells, a selective autophagy mechanism, known as proteaphagy, was a main mechanism eliminating the proteasome and reducing the sensitivity to this treatment. In order to recover the sensitivity to BTZ we have tackled two main molecules that were found enriched in the ubiquitin proteome of those cells, the autophagy receptor p62 and the Tripartite Motif Containing protein 24 (TRIM24) ubiquitin ligase. To investigate how TRIM24 could contribute to this proteolytic crosstalk, dTRIM24, a proteolysis-targeting chimera (PROTAC), was employed. dTRIM24 treatment enhanced apoptosis in BTZ-resistant ZBR cells, but no significant difference was observed compared to the parental, BTZ-sensitive Z138 cells. However, the dTRIM24/BTZ combination significantly enhances cooperativity and drives an efficient apoptosis in ZBR cells. The use of a ZBRTRIM24 KO cell line further confirmed the important role of TRIM24 in the triggering of cell death in the context of BTZ resistance. Reducing the TRIM24 protein level in ZBR cells by dTRIM24 or in the context of the ZBRTRIM24 KO cell line allowed the recovery of proteasome activity and explained the apoptosis efficacy observed with the dTRIM24/BTZ treatment. Interestingly, proteaphagy is not significantly affected in the ZBRTRIM24 KO compared to the parental ZBR cell line, indicating that TRIM24 does not directly regulate proteaphagy. Instead, dTRIM24 treatment resulted in the remodeling of protein ubiquitination favoring the accumulation of K48 Ub chains and their interaction with proteasome subunits. A similar PROTAC strategy was used to tackle p62 and advances on this approach will be presented. Altogether, our data indicate that TRIM24 and p62 play an important role as a regulators of UPS/ALS crosstalk by distinct mechanisms, either by regulating the abundance of K63 vs K48 chains or directly blocking proteaphagy. Understanding the key molecular mechanisms underlying this process is crucial for the development of new combination therapies with the ability to overcome BTZ refractoriness or in general regulating selective autophagy events in distinct pathologies.
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Published on 04-02-2025
IBPC
Bibliotheque de l'Institut de Biologie Physico-Chimique -
Invited by: Pierre BADUEL - Section Ecologie et Biologie de l’Evolution
Summary : Detlef’s group is addressing fundamental questions in evolutionary biology, using both genome-first and phenotype-first approaches. A particular interest is in how organisms solve the problems associated with fluctuating selection pressures. He will discuss how their work has led to the discovery of new biology, and how their studies of genetic conflicts inform our knowledge of constraints in plant immunity. Detlef will emphasize that an understanding of what is relevant in the real world requires the integration of detecting footprints of past selection in genomes, performing lab experiments to gain insight into molecular mechanisms, and observing how plants behave in the field.
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Tags: Evolutionary biology, Selection, Detlef, Fluctuating selection, Evolution, Phenotype, Plant
Published on 04-02-2025
IBENS
salle Favard, IBENS 46 rue d'Ulm 75005 Paris -
Invited by: Kristine Schauer
Cancer cells are regulated by oncogenic mutations and microenvironmental signals, yet these processes are often studied separately. To functionally map how cell-intrinsic and cell-extrinsic cues co-regulate cell-fate, we performed a systematic single-cell analysis of 1,000 colonic organoid cultures regulated by: 1) colorectal cancer (CRC) oncogenic mutations, 2) fibroblasts and macrophages, 3) stromal ligands, and 4) signaling inhibitors. We discovered a stepwise epithelial differentiation phenoscape dictated by combinations of oncogenes and stromal ligands, spanning from fibroblast-induced revival colonic stem cells (revCSC) to oncogene-driven hyper-proliferative CSC (proCSC). To explore the role of stem cell polarisation in CRC therapy response, we measured post translational modification (PTM) signalling, DNA-damage, cell-cycle activity, and apoptosis in 2,500 CRC patient-derived organoid (PDO) and cancer associated fibroblast (CAF) cultures in response to clinical therapies at single-cell resolution. This analysis revealed that on-target cell-cycle blockage and DNA- damage drug effects are common, even in chemorefractory PDOs. However, drug-induced apoptosis is rarer, patient-specific, and aligns with a proCSC PTM signalling state. We find that CAFs can regulate PDO plasticity shifting mitotic proCSC to slow-cycling revCSC to protect cancer cells from chemotherapy and radiotherapy.
Tags: Stem cells, Developmental biology, Tissue engineering, Tumor, Biotechnology, Organoid, Tumor microenvironment, Carcinogenesis, Oncogene, Cellular differentiation, Apoptosis, Stem-cell niche
Published on 02-02-2025
Institut Gustave Roussy
salle Pierre Denoix, etage 15 - ascenseur C du batiment principal, 114 rue Edouard-Vaillant, 94 800 Villejuif -
Invited by: David Castel
Diffuse midline glioma (DMG) is a very aggressive pediatric brain cancer. This glioma is driven by heterozygous mutations in histone 3 that reprogram the epigenome and block terminal differentiation. Single cell transcriptomics revealed that DMG is mainly constituted by highly proliferative stem-like cell states that fuel tumor growth. However, the concomitant presence of more mature and less tumorigenic cancer cells suggests potential for differentiation therapies. Interestingly, we can modulate cancer cell state in vitro, from more stem-like to more differentiated cell states, by supplementing the media with serum. To understand how we can promote differentiation in DMG, we assessed for changes in the epigenome upon serum-induced differentiation and observed that differentiated cells lose H3K27 acetylation. Hence, we questioned whether loss of H3K27ac would reciprocally provoke differentiation. Pharmacological inhibition of EP300/CBP, the histone acetyltransferases responsible for H3K27 acetylation, drastically decreased DMG cell proliferation leading to cell cycle arrest. Besides loss of H3K27ac, H3K27me3 is rescued upon EP300/CBP inhibition suggesting that targeting these acetyltransferases can revert the epigenetic reprograming caused by the histone mutation. ATAC sequencing revealed that the epigenetic changes caused by EP300/CBP inhibition mimic the ones obtained upon serum-induced differentiation. Moreover, similarly to serum treatment, EP300/CBP targeting shifts DMG cells towards a more differentiated astrocyte-like cell state. In contrast, H3G34R/V gliomas and non-malignant cells lines responded less to EP300/CBP inhibition, indicating a selective sensitivity of H3K27M gliomas. In summary, our findings suggest that targeting H3K27 acetylation is a promising strategy to revert the activity of the histone mutation and unblock cell differentiation
Tags: Epigenetics, H3K27me3, H3K27, Diffuse midline glioma, Glioma, Cellular differentiation, Epigenome, Histone acetyltransferase, Epigenetics in stem-cell differentiation
Published on 02-02-2025
Institut Gustave Roussy
Espace Maurice Tubiana (amphitheatre EMT) -
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Tags: Pediatric cancers, Adrenal gland disorders, Adrenaline, Brain tumor, Neuroblastoma, Blastoma, Adrenal gland, Malia Jusczyk
Published on 01-02-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
The escalating spread and density of tick populations underscore the urgent need for enhanced surveillance and risk assessment strategies for tick-borne diseases (TBD). Biomarkers derived from the antibody response to tick saliva can be used to facilitate the surveillance of vector establishment in novel regions, assess anti-vector interventions and diagnose TBD through documentation of antecedent tick bites in suspected cases. Here, we derived short peptides from previously identified immunogenic proteins—namely IrCRT, IrSPI, and IrLIP—through bioinformatic predictive analysis using the Immune Epitope Database. ELISAs performed with experimentally controlled sheep sera infested with Ixodes ricinus were used to assess the level of antibody response of IgM and IgG to the peptides derived from these three proteins. Next, we tested the candidates on sera derived from both field and clinical isolates of tick-exposed individuals. For all sera, we obtained different IgM and IgG responses with varying degrees of immunogenicity detected per peptide. Further, through use of an exploratory microarray assay (PepperPrint™), we selected new peptides based on their ability to be recognized using serum from experimentally infested sheep. Amongst the top randomly generated peptides, we found a more specific immunogenic response against the IgG antibodies when compared to IgM. Selected candidates were further tested against experimentally-controlled infested sheep sera, as well as field and clinical isolates. Finally, candidates were cross-validated against mosquito-exposed sera to ensure vector specificity. This study offers the potential for developing new effective strategies for the surveillance and diagnosis of tick-related risks as well as the control and prevention of TBD. Paris Post-docs seminar series.
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Tags: Tick-borne diseases, Tick-borne disease, Ixodidae, Ixodes ricinus, Ixodes, Tick, Biomarker, Zoonoses, Deer tick, Lyme disease
Published on 01-02-2025
Institut Cochin
Salle Rosalind Franklin -
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Tags: Deep learning, Natural language processing, Computational linguistics, Artificial intelligence, Cybernetics, Data science, Foundation model, Neural scaling law
Published on 31-01-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Biosketch: Corinne Albiges-Rizo received a PhD in Cellular and Molecular biology from the University of Grenoble in 1990. She worked as a PhD student at EMBL in Grenoble and completed her post-doctoral research as a fellow in HHMI in Chicago. She moved back to Grenoble as a CNRS Scientist. Her team is based within the Institute for Advanced Biosciences (Institut Albert Bonniot) and she also heads the department of microenvironment and cell plasticity. She was President of the French Society for Cell Biology (SBCF). Using transdisciplinary approach, her team is investigating how adhesion sites sense varied external cues to modulate downstream signaling networks and force transmission to elucidate the sensory mechanisms underlying invasion and tissue architecture. The team is specifically exploring the biological and physiological relevance of integrin activation. The question is to know how cells integrate physical and biochemical cues of their environment and intertwine signaling networks that ultimately control their shape, their contractile state, their communication capacity and their migratory behavior. To address how cells detect temporally close but spatially distant signals, such as growth factors and extracellular matrix components to control multi-decisional signaling, the team combines biomaterials, optogenetics, advanced live cell imaging including single-particle-tracking localization microscopy (SPT-PALM) along with morphometric and dynamic measurements. The team has shown the property of BMP2 signal to override the effects of soft biomaterial-induced signaling through an integrin-dependent biomechanical response and a segregation of BMP2 receptor subpopulation in adhesion sites to couple cell differentiation and cell migration. 3 integrin-mediated spreading induced by matrix-bound BMP-2 controls Smad signaling in a stiffness-independent manner. J Cell Biol. 2016 Mar 14;212(6):693-706. doi: 10.1083/jcb.201508018. Epub 2016 Mar 7. PMID: 26953352; PMCID: PMC4792076. Guevara-Garcia A, Fourel L, Bourrin-Reynard I, Sales A, Oddou C, Pezet M, Rossier O, Machillot P, Chaar L, Bouin AP, Giannone G, Destaing O, Picart C, Albiges-Rizo C. Integrin-based adhesion compartmentalizes ALK3 of the BMPRII to control cell adhesion and migration. J Cell Biol. 2022 Dec 5;221(12):e202107110. doi: 10.1083/jcb.202107110. Epub 2022 Oct 7. PMID: 36205720; PMCID: PMC9552562. Kyumurkov A, Bouin AP, Boissan M, Manet S, Baschieri F, Proponnet-Guerault M, Balland M, Destaing O, Regent-Kloeckner M, Calmel C, Nicolas A, Waharte F, Chavrier P, Montagnac G, Planus E, Albiges-Rizo C. Force tuning through regulation of clathrin-dependent integrin endocytosis. J Cell Biol. 2023 Jan 2;222(1):e202004025. doi: 10.1083/jcb.202004025. Epub 2022 Oct 17. PMID: 36250940; PMCID: PMC9579986
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Tags: Integrin
Published on 31-01-2025
Centre de Recherche en Myologie -
Antimicrobial resistance develops as a major problem in infectious diseases treatment. Starting with a high-density Transposon insertion library in Vibrio cholerae and following its evolution by TN-seq in the presence of antibiotics, we have linked 23 tRNA and rRNA modification enzymes with specific responses to various antibiotics. In particular, deletion of tRNA guanine transglycosylase tgt leads to strong aminoglycoside sensitivity. Tgt is responsible for the queuosine (Q) modification of tRNA-tyrosine at the anti-codon loop wobble position. We used molecular reporters for translation fidelity and efficiency as well as a proteomics analysis to further characterize molecular mechanisms behind the aminoglycoside sensitive phenotype in the absence of tgt/Q modification.
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Tags: Vibrionales, Protein biosynthesis, Food microbiology, RNA, Nucleic acids, Vibrio cholerae, Transfer RNA, Wobble base pair, Vibrio, Antimicrobial resistance, Drug resistance, TGT
Published on 30-01-2025
Institut Micalis
Auditorium 442 - Institut Micalis -
Abstract : In the visual system, the signals available to the brain are limited to the two-dimensional images formed on the retinae. To reconstruct the three-dimensional location of objects in the environment, visual circuits must infer the missing depth information. This ability is innate in most mammals, not requiring visual experience, and involves the neocortex. While animals take advantage of both monocular and binocular signals to estimate depth, binocular vision is not necessary for depth perception. Animals' innate capacity for depth perception is thought to rely on motion parallax - visual motion resulting from animals movements. I will show that neurons in the mouse primary visual cortex are selective for depth from motion parallax as a result of integration of visual and locomotion-related signals. Consequently, V1 neurons have three-dimensional receptive fields - they are selective for both retinotopic location and depth of visual stimuli. I will also present our unpublished work exploring the circuits supporting such computations.
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Tags: Vision, Visual perception, Stereoscopy, Perception, Sensory systems, Visual cortex, Depth perception, Retinotopy, Visual system, Cerebral cortex, Binocular vision, Binocular neurons
Published on 30-01-2025
IBENS
salle Favard, IBENS 46 rue d'Ulm 75005 Paris -
Invited by: Benoit Chassaing
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Tags: Microbiomes, Microbiology, Bacteriology, Childbirth, Bacteria, Human microbiome, Microbiota, Caesarean section, Vaginal seeding, Vaginal delivery
Published on 29-01-2025
Institut Pasteur
Batiment Duclaux , salle Duclaux amphitheater , -
Invite par l’equipe Courtier, Marla Sokolowski (Department of Ecology and Evolutionary Biology, University of Toronto) va presenter un seminaire de l’Institut Jacques Monod sur le theme : The foraging gene: will that be for here or to go? Resume : The Drosophila melanogaster foraging (for) gene, with its rover and sitter larval foraging variants, is an established behaviour genetics model. Orthologues of the foraging gene also modulate the individual and social behaviour of a wide range of species including the regulation of behaviour in eusocial insects. In Drosophila, foraging modifies the expression of multiple traits, including feeding and foraging, stress tolerance, sleep, metabolism, dispersal, escape responses, social behaviour, and learning and memory. From a social context perspective, Drosophila foraging affects larval clustering during foraging under high larval densities, adult social behaviour and social networks, and social learning. We wondered how foraging accomplishes its behavioural pleiotropy at the molecular level. We found that D. melanogaster foraging has a complex modular genomic structure with four promoters, 21 transcripts, and eight protein isoforms. The four promoter modules are differentially regulated during development and in a timescale, tissue, and cell-type dependent manner. Two examples illustrate these findings: the epigenetic regulation of the adult rover-sitter foraging-related phenotypes by G9a, a histone methyltransferase, and the regulation of differences in the latency of rover compared to sitter larval escape responses to noxious stimuli such as parasitoid wasps. Our work provides a nuanced picture of the molecular basis of foraging's pleiotropy.
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Tags: Animal models, Foraging, Behavioral ecology, Marla Sokolowski, Drosophila melanogaster, Drosophila, Eusociality, Period
Published on 29-01-2025
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Le vendredi 7 mars, Andrea Musacchio (Max Planck Institute of Molecular physiology) presentera une Conference de l'Institut Jacques Monod sur le theme : Feedback control of mitosis in the context of the kinetochore Resume : Kinetochores provide chromosomes with points of attachment to spindle microtubules during cell division, and are therefore essential for genome inheritance and the propagation of life. In addition to binding microtubules, kinetochores control mitotic surveillance mechanisms that promote chromosome bi-orientation (the error correction mechanism) and prevent premature mitotic exit in presence of incomplete or incorrect microtubule attachments (spindle assembly checkpoint, SAC). Elimination of the NDC80 complex, the main microtubule receptor of kinetochores, causes a SAC deficiency, identifying this complex as a crucial regulatory focus for checkpoint function. In recent years, there has been considerable progress in understanding how the SAC effector, known as the mitotic checkpoint complex (MCC), assembles from its individual components to inhibit its target, the anaphase promoting complex/cyclosome (APC/C). Conversely, how microtubule attachment to kinetochores regulates the SAC remains incompletely understood. From a molecular perspective, answering this question implies investigating the mechanisms that promote targeting of the SAC proteins to unattached kinetochores, and suppress it upon microtubule binding and biorientation. In our recent work, we have combined biochemical reconstitutions, structural biology/modelling, and cell biology to gain insights into this fundamental biological question.
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Tags: Mitosis, Cell cycle, Organelles, Cell biology, Kinetochore, Meiosis, Spindle checkpoint, Spindle apparatus, Biorientation, Microtubule, Cell division, Mad1
Published on 28-01-2025
Institut Jacques Monod
Institut Jacques Monod Amphitheatre Buffon, 15 rue Helene Brion, Paris, France -
Invite par le Centre for Genomic Regulation, Felix Ruhnow va presenter un seminaire sur le theme : NuMA is a mitotic adaptor protein that activates dynein and connects it to microtubule minus ends Resume : Nuclear mitotic apparatus protein (NuMA) is indispensable for the mitotic functions of the major microtubule minus-end directed motor cytoplasmic dynein 1. NuMA and dynein are both essential for correct spindle pole organization. How these proteins cooperate to gather microtubule minus ends at spindle poles remains unclear. Here we use microscopy-based in vitro reconstitutions to demonstrate that NuMA is a dynein adaptor, activating processive dynein motility together with dynein’s cofactors dynactin and Lissencephaly-1 (Lis1). Additionally, we find that NuMA binds and stabilizes microtubule minus ends, allowing dynein/dynactin/NuMA. to transport microtubule minus ends as cargo to other minus ends. We further show that the microtubule-nucleating ?-tubulin ring complex (?TuRC) hinders NuMA binding and that NuMA can only cap minus ends of ?TuRC-nucleated microtubules after ?TuRC release. These results provide new mechanistic insight into how dynein, dynactin, NuMA, Lis1 together with ?TuRC and uncapping proteins cooperate to organize spindle poles in cells.
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Tags: Motor proteins, Mitosis, Cytoskeleton, Dynein, Dynactin, Microtubule, Spindle apparatus, Tubulin, Cell biology, Microtubule plus-end tracking protein, MAPRE1
Published on 28-01-2025
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Invited by: Xavier Nassif
Peter Sebo got a PhD. (CSc.) in microbiology in 1990 in Prague and did his postdoc at Institut Pasteur in Paris (1990-95). Since 1995, he heads a lab at the Institute of Microbiology of the Czech Academy of Sciences (CAS) in Prague. He also founded the Institute of Biotechnology of the CAS and designed the BIOCEV research center in Vestec and also serves as professor of microbiology at the University of Chemistry and Technology in Prague. Peter Sebo's research focuses on bacterial pathogenesis and the mechanisms of Bordetella pertussis virulence and toxin action. Prof. Sebo is involved in therapeutic and prophylactic vaccine development, published over 165 papers (H=43) and was elected to EMBO and the European Academy of Microbiology. Seminar topic: Why is whooping cough a problem again and how it works
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Tags: Burkholderiales, Whooping cough, Vaccine-preventable diseases, Pediatrics, Bordetella, Jules Bordet, Cough, BIOCEV, Whooping
Published on 27-01-2025
Institut Necker Enfants Malades
Auditorium 1 -
Invited by: CIRB - College de France
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Tags: @cirbcdf.bsky.social
Published on 27-01-2025
College de France
College de France au College de France - Salle D2 acces restreint, merci de passer par l'accueil du CDF : 11 place Marcelin Berthelot - 75005 Paris -
Invited by: Kevin JEAN - Section Ecologie et Biologie de l’Evolution
Antimicrobial resistance is undeniably a global public health threat. But how does it spread ? At the human level, we can sometimes observe transmission events where individuals acquire bacteria from someone else. However, there are multiple instances where we simply can't find a good explanation for the origin of a resistant bacteria. To solve this mystery, we need to go one step further : at the bacterial level. In this seminar, I will present our work on the invisible dynamics of horizontal gene transfer in S. aureus bacterial populations, which dictate the prevalence of antimicrobial resistance at the human level. Through an interdisciplinary approach combining lab work and mathematical modelling, we explored the strange interactions between bacteria and their viral predators (bacteriophage), and the conditions under which these interactions can lead to evolution of antimicrobial resistance? or total bacterial eradication !
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Tags: Evolutionary biology, Pharmaceuticals policy, Veterinary medicine, Immunology, Antimicrobial resistance, Antimicrobial, Bacteriophage, Drug resistance, Staphylococcus aureus, Antimicrobial peptides, Multiple drug resistance
Published on 26-01-2025
IBENS
salle Favard, IBENS 46 rue d'Ulm 75005 Paris -
Singing is a natural and universal human behavior uniquely processed by the brain. It offers a deeply enjoyable experience, particularly when per- formed in groups. As such, singing carries significant biological importance and holds great potential for promoting health and fostering social integration.
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Tags: Animal anatomy, Brain, Organs, Isabelle Peretz, Cognitive musicology
Published on 25-01-2025
I. Cerveau et de la Moelle
Please join the conference in Paris Brain Institute auditorium. -
Our daily life is a succession of cognitive actions influenced by our emotions. Emotions, often referred to as feelings, are necessary to maintain a balance throughout the life of an individual, if not his survival: love, anger, pain and fear are the most common examples. While neuronal networks sustaining emotions are well studied, a tremendous question persists: how does our brain cellular networks supports the enduring effects of emotions?
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Tags: Interpersonal attraction, Glial cells, Central nervous system, Antidiuretics, Neurotransmitters, Oxytocin, Astrocyte, Amygdala, Biology of romantic love, Emotion
Published on 25-01-2025
I. Cerveau et de la Moelle
Please join the conference in Paris Brain Institute auditorium. -
Invited by: Wilfried Le Goff and Anatol Kontush
The remarkable energy burning capacity of thermogenic brown adipocytes represents a valuable therapeutic target for the treatment of obesity, dyslipidemia and atherosclerosis. The Heeren group demonstrated that activated brown and beige adipocytes have profound metabolic effects and can lower blood triglyceride and atherogenic lipoprotein levels. Using state-of-the-art technologies to visualize and quantify metabolite flux, systemic and local mechanisms controlling energy and lipid metabolism in adipose tissue under conditions of adaptive thermogenesis will be shown. Furthermore, the molecular and cellular mechanisms that initiate inflammatory degeneration of the BAT, as observed in obesity and ageing, and their relevance to systemic energy metabolism will be presented. The background, concepts and original findings of the Heeren group can be found in Siracusa et al (Nat Immunol 2023), Niemann et al (Nature 2022), Fischer et al (Cell Metab 2021), Scheja and Heeren (Nat Rev Endocrinol 2019), Heine et al (Cell Metab 2018), Worthmann et al (Nat Med 2017).
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Tags: Connective tissue, Obesity, Adipocyte, Adipose tissue, Brown adipose tissue, Thermogenesis
Published on 25-01-2025
Umrs 1166 - IHU-ICAN
salle bordeaux au 5eme etage de la Faculte de Medecine Sorbonne Universite, 105 boulevard de l'Hopital 75013 -
Invited by: Marie-Odile Krebs, Gwenaelle Le Pen
During his PhD in robotics, Dr de Chaumont designed an autonomous robot to help people with motor disabilities (paraplegics, hemiplegics). In 2007 at Institut Pasteur, he created a 3D engine based on the OpenGL library to represent biological samples and image analysis results in the unit's internal software. He then created a new image analysis software, Icy. He was working on tracking C. elegans in a screen analysis context. To achieve this, he created a tracking method based on a physical engine. An object is represented by primitives (rectangles, squares, circles) connected to each other via joints (piston, axis of rotation, rope, elastic). The whole is animated by a set of forces applied to each element, and calculated from the video. This system was finally applied to mouse tracking. It is with Sylvie Granon who works on mouse behavior that he applies this system to track mice with precision. It allows a finer understanding of the interaction of mice: it provides new details during animal contacts that were impossible to detect before. In addition, this system allows to follow the temporal evolution of social contact between individuals, which did not exist either. Finally, this method allows to obtain a considerable amount of information for each animal observed and thus contributes to limiting the number of animals used in experiments. This work was published in 2012 in Nature methods.
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Tags: Behaviour, Environment, Cognition
Published on 24-01-2025
Institut de Psychiatrie et Neurosciences de Paris
salle Deborah Levy, 102-108 rue de la Sante 75014 -
Invited by Katia Ancelin and Julie Chaumeil.
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Tags: Chaumeil
Published on 24-01-2025
Institut Cochin
Salle Rosalind Franklin -
Invite par l’Institut Jacques Monod, Nathaniel Henneman (team of Ganna Panasyuk at Institut Necker Enfants Malades (INEM)) va presenter un Paris Postdoc Seminar sur le theme : Nuclear functions of nutrient sensing signaling for metabolic adaptation Presentation et resume : I am a Postdoc in the team of Ganna Panasyuk at Institut Necker Enfants Malades (INEM). I graduated from Bates College (USA) in 2016, majoring in Biology. I then spent two years working on retinal degeneration at Emory University beforeobtaining my master's degree at University of Paris Descartes in 2019 and defended my PhD in December 2023. One of the key questions I am to address in my work is how cellular metabolism, gene expression and transcription, are all coordinated. Energy stress in fasting is managed by activating autophagy and promoting the transcriptional remodeling of metabolism. Cytosolic nutrient sensors coordinate extracellular nutrient availability with intracellular metabolic processes to allow for cell survival. Class 3 PI3K is a highly conserved nutrient sensor known to regulate autophagy and endocytosis in response to varying nutrient conditions. It's direct role in transcription, however, was only suggested in few studies in yeast and plants. However, we believe there is a nuclear pool of class 3 PI3K that directly regulates gene expression for metabolic adaptation. My work aims to address this unmet burden in the field. We find that nuclear class 3 PI3K regulates the transcriptional response to nutrient stress by controlling RNA Polymerase II, the Set1/COMPASS methyltransferase, and nuclear methionine to SAM flux. I aim to understand how these players are needed for our fasting adaptation and how these mechanisms could affect our metabolic resilience.
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Tags: Metabolism, Nutrient sensing, Nutrition, Receptors, Necker, Autophagy, Starvation response, Fasting
Published on 24-01-2025
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Invited by: MARTIN Jean-Rene
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Tags: Glial cells, Glia
Published on 23-01-2025
NeuroPSI
Salle de conference Albe-Fessard -
TBA
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Tags: Jami, Ludovic, Draft:Rincn Bomba massacre, Jami Masjid, Mangrol
Published on 23-01-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - Tours 22-32 - 4e etage - Piece 407 -
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Tags: Physiology
Published on 23-01-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
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Tags: Germ cells, Cell cycle, Meiosis, Plant sexuality, Starfish, Oocyte, Melina Schuh
Published on 23-01-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
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Published on 23-01-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Invited by: Lubka Roumenina
Joshua M. Thurman, MD is the Temple Hoyne Buell Professor of Medicine in the Division of Nephrology and Hypertension at the University of Colorado. His laboratory studies the underlying causes of autoimmunity and inflammation of the kidney. Dr. Thurman has developed several novel anti-inflammatory therapeutic agents. His laboratory has also created new methods for monitoring tissue inflammation, including magnetic resonance imaging (MRI) and positron emission tomography (PET) based probes.
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Tags: Animal physiology, Human physiology, Immunology, Inflammation, Nephrology, Magnetic resonance imaging, Systemic inflammation
Published on 22-01-2025
Centre de Recherche des Cordeliers
Amphi Gustave Roussy -
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Tags: Intravital microscopy, Microscopy, Carcinogenesis, Tumor initiation
Published on 22-01-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Invited by: Fabiola Terzi
After completing a PhD in immuno-oncology in 2001 at GIMAP (INSERM), Jean-Philippe Herbeuval was awarded a 5-year Fogarty Fellowship at the NIH (USA) in Dr. G. Shearer's lab to work on the antiviral response to HIV. His work earned him the Norman P. Salzman Award (NIH, FDA, CDC) and the NIH Cash Award in 2005. He was recruited as a CR1 researcher by the CNRS in 2001 at Necker Hospital (UMR8147), where he established a research group. In 2012, Jean-Philippe Herbeuval founded the interdisciplinary team CBMIT at the Saints-Peres Biomedical Faculty to develop interdisciplinary and translational projects integrating immunology, virology, chemistry, and in silico modeling. In 2019, he founded the start-up Ermium Therapeutics with the investment fund Kurma Partners and Domain Therapeutics. He was awarded the national i-Lab Innovation Prize (BPI, Ministry of Research), and named Ambassadeur innovation du CNRS.Seminar topic: Control of type I interferon production by CXCR4 minor pocket agonists (MiPAs): from HIV sexual transmission to novel therapeutic strategies for interferonopathies
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Tags: Sexually transmitted diseases and infections, HIV, Lentiviruses, CXCR4, Interferon
Published on 22-01-2025
Institut Necker Enfants Malades
Auditorium 1 -
Invited by: Peter van Endert
Prof. L. Zitvogel, MD (Clinical Oncology), PhD (Tumor Immunology), full professor at the University Paris Saclay, graduated in Medical Oncology in 1992. Scientific career first at the University of Pittsburgh, US. Became Research Director at Institut National de la Sante et Recherche Medicale U1015, and Scientific Director of the Clinicobiome program at Gustave Roussy, the largest cancer Center in Europe in 1998. Actively contributed to the field of cancer immunology and immunotherapy. Pionneer of the concepts of immunogenic cell death and gut microbiota in cancer immunosurveillance and therapies. Recipient of many awards: Translation Research INSERM Prize, the ASCO-SITC, Brupbacher Awards 2017, ESMO Immuno-Oncology Award 2017, Baillet Latour Prize 2019, the Griffuel Prize 2019, the Duquesne Ligue Prize, and ITOC9 german award. Knighted Officer of Legion dgt;500 publications on PubMed, 108 265 citations in Clarivate analytics (highly cited researchers 2021, 2020, 2019, 2018, 2017, 2016). Scientific founder of everImmune. Seminar topic: The dirty secrets of cancer immunotherapy
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Tags: Immunotherapy, Laurence Zitvogel, Women in medicine, Guido Kroemer
Published on 22-01-2025
Institut Necker Enfants Malades
Auditorium 3 -
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Published on 21-01-2025
NeuroPSI
Salle de conference Albe-Fessard -
Invited by: Benoit Arcangioli
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Tags: Mutation, Cellular processes, Genetic mapping, Genome, Genomics, DNA repair, Poly (ADP-ribose) polymerase, PARP inhibitor
Published on 21-01-2025
Institut Pasteur
Batiment Metchnikoff , salle Jules Bordet, -
Invited by: Marie-Agnes Petit
Evolution is an inexorable force that hinders our best efforts to control infectious diseases. When it comes to pathogenic bacteria, the conventional approach shoot antibiotics first, ask questions later? has undoubtedly saved many lives but has led to widespread resistance. To effectively address the challenges of the looming post-antibiotic era, we must seek solutions based on a comprehensive understanding of pathogen evolution in relevant ecological contexts. A crucial aspect of bacterial infections is that pathogens rarely exist in isolation within their respective niches. The host harbors diverse microbial communities that compete with invading pathogens, and mutants from pathogenic strains compete with each other during infections. Our work focuses on the key role of competitive exclusion in pathogen evolution. I will present recent findings that illustrate how this fundamental ecological concept can lead to evolutionary robust solutions to combat bacterial infections.
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Tags: Microbiology, Bacteriology, Pathogenic bacteria, Bacteria, Pathogen, Antimicrobial resistance, Infection, Pathogenomics, Hostpathogen interaction
Published on 20-01-2025
Institut Micalis
Auditorium 442 - Institut Micalis -
Invited by: Marc Graille
Published on 20-01-2025
Ecole Polytechnique
Amphi 1021004 BEM - Institut Polytechnique de Paris -
TBA
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Tags: Cantini, Draft:Rincn Bomba massacre, Trees in L'Estaque
Published on 17-01-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - Tours 22-32 - 4e etage - Piece 407 -
TBA
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Tags: Mathieu, Rivire, Draft:Rincn Bomba massacre, Daniel Riviere
Published on 17-01-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - Tours 22-32 - 4e etage - Piece 407 -
Invited by Anne Hosmalin.
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Tags: Dudziak, Diana
Published on 16-01-2025
Institut Cochin
Salle Rosalind Franklin -
Conference dansee : MOVE YOUR SCIENCE Jeudi 6 fevrier a 19h | Hall Buffon, Institut Jacques Monod Gratuit sur inscription Creation collective avec les doctorant.esKenzaAlaoui Sosse,AmandineAlbizzati,MariamBougma,StephanieBrunot, Mert Can, JohannaExenberger, AudreyGosset,CapucineGros,EmileLe LievreetJosephineSchelle Choregraphie etrecherche danse/sciences: Cosetta Graffione et Namiko Gahier-Ogawa Coordination scientifiqueet recherche danse/sciences : Melina Heuze,enseignante-chercheuse Depuis septembre, dixdoctorant·es de l'Universite Paris Cite toutes disciplinesconfondues,travaillent avec les choregraphesCosetta GraffioneetNamiko Gahier-Ogawa ainsi quel'enseignante-chercheuse Melina Heuze pour partager leur projet scientifique dans un esprit de mediation vers le grand public. Dans undialogue art et sciences, le public pourraeprouverles principes scientifiques de leur travail de these a travers des sequences dansees faisant emerger une poesie des corps. Cette conference dansee en quatre tableaux sera suivie d'un echange avec le public autour d'un verre de l'amitie.
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Published on 15-01-2025
Institut Jacques Monod
Institut Jacques Monod Amphitheatre Buffon, 15 rue Helene Brion, Paris, France -
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Tags: DNA repair, DNA, DNA damage, Mutation, Postreplication checkpoint, DNA-SCARS
Published on 15-01-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Oscillations moleculaires et mecaniques L objectif general du 7e cours de biologie cellulaire et du cancer est de couvrir differents sujets en biologie cellulaire, biologie du developpement et physique, en mettant l accent sur les oscillations moleculaires et mecaniques dans les systemes biologiques. Keynote speaker Alexandre Aulehla - DE Intervenants Annabelle Ballesta - FR Thibaut Brunet, FR Clotilde Cadart- FR Mathieu Coppey - FR Stephanie Descroix - FR Silvia Fre - FR Martijn Gloerich - NL Hanspeter Herzel - DE Jean-Leon Maitre - FR Franck Perez - FR Francois Schweisguth - FR Katharina Sonnen - NL Xavier Trepat - ES
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Published on 15-01-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
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Tags: J. William Harbour, Melanoma, Uveal melanoma, Uvea, DecisionDx-UM, Draft:Carlos Rogerio Figueiredo
Published on 14-01-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
The swimming motion of bacteria has recently seen an increasing interest from physicists, utilizing the recent progresses in microscopy and the development of microfluidics to study this interdisciplinary subject. In this seminar, I will present our two main experimental findings on the motile soil bacteria Burkholderia contaminans : its reaction to oxygen and its ability to gather micron-sized beads in clusters. First, we quantitatively studied its aerotaxis, i.e. its behaviour in an oxygen gradient. We notably characterized the aerotactic coefficient dependency on the oxygen concentration, with both a macroscopic (population scale analysis) and microscopic approaches (bacterial scale analysis), and compared it to the literature. Second, we uncovered a rich clustering phenomena happening when some micron-sized passive beads ( 2 - 40 mu; m ) are added to the bacterial suspension. Besides the enhanced bead diffusivity, the swimming bacteria are also responsible for a short-range attractive force between the beads. This results in a dynamical clustering of the beads, with a dynamics similar to Ostwald ripening and a characteristic cluster size slowly growing in t 1 / 3 without any apparent saturation.
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Tags: Bacteriology, Biotechnology, Microfluidics, Nanotechnology, Aerotaxis, Motility, Bacteria
Published on 14-01-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - Tours 22-32 - 4e etage - Piece 407 -
La premiere reunion du cytoskeleton club de 2025 aura lieu ce mercredi a l’Institut Pasteur : – Charlotte Mallart (post-doc, Minc lab, Institute Jacques Monod) presentera : «Regulation of cytoplasm rheologyby bulk F-Actin networks». – Noemi Zollo (PhD student, Verlhac/ Terret lab, CIRB College de France) presentera : A novel RNP compartment allows mouse oocytes to adapt translational levels during late growth?.
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Published on 14-01-2025
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Invited by Pascal Maire.
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Published on 10-01-2025
Institut Cochin
Salle Rosalind Franklin -
The development of complex in vitro models, such as organoids, gastruloids and organ-on-chips systems, will allow the better understanding of human biological processes that are otherwise difficult to address with classical in vitro 2D culture and/or with animal models. Elucidating how pathogens, such as the SARS-CoV-2, invade human cells by evading the immune system and how this could be modulated by the host microbiota has been greatly facilitated by the advancement of 3D cell culture techniques. For example, mimicking the gut peristalsis in gut-on-a-chip device improves the maturation of colon epithelial cells and aid to unveil the role of mechanical stress in accelerating enteropathogen invasion. Our lab is working on establishing unique advanced microphysiological systems that can mimic the interaction between human epithelial barriers with the surrounding tissues, such as blood vessels, mesenchyme and immune cells. My scientific project is focused on the establishment of lung-on-chip devices that cover the entire respiratory tract (from the nasopharynx to the alveoli) as a platform to understand airborne infections and tropism of respiratory viruses. There we relay both on the use of lung multipotent stem cells grown as organoids, in order to produce the different cell population of the respiratory tract, and on microfluidic chips. Paris Post-docs seminar series.
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Tags: Tissue engineering, Biotechnology, Stem cells, Microfluidics, Nanotechnology, Organoid, Organ-on-a-chip, Respiratory tract, 3D cell culture, Lung, Organ, Intestine-on-a-chip
Published on 08-01-2025
Institut Cochin
Salle Rosalind Franklin -
Invite par l’equipe Courtier, Peter Andolfatto (Professor, Dept. of Biological Sciences, Columbia University) presentera un seminaire de l’Institut Jacques Monod sur le theme : The evolution of toxin-resistant Na+,K+-ATPases: new insights from frogs and fireflies We study the process of adaptive evolution through the lens of repeated adaptation of many distantly species to a similar selection pressure (i.e. «parallel evolution»). Over the past decade, we have explored patterns of adaptation in the context of animals that have specialized in eating plants, or other animals, that contain toxic cardiotonic steroids (CTS). CTS are toxic to animals because they inhibit sodium-potassium ATPase, a key enzyme in animals needed in everything from maintaining cell homeostasis, muscle contraction to neuron activity. Here I review our most recent work combining comparative molecular evolution, molecular and biochemical assays andin vivoengineering of Drosophila to deduce the rules governing the adaptive evolution of CTS resistance in animals. Together, our results have interesting implications for how epistasis and pleiotropy both limit the rate of adaptive protein evolution and increase its predictability.
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Published on 04-01-2025
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Le mardi 11 fevrier, Richard Benton (Center for Integrative Genomics, University of Lausanne) presentera une Conference de l’Institut Jacques Monod sur le theme : Fatal chemosensation, and how insects fight back Resume : Insecticide resistance is a widespread challenge for the management of vectors transmitting pathogens and agricultural pests, requiring a better understanding of the genetic mechanisms underlying the evolution of resistance. Drosophila sechellia is a compelling model for such studies as it naturally evolved resistance to octanoic acid, an abundant chemical of its noni fruit host that is toxic for other insects, including close relatives D. simulans and D. melanogaster. We have used a multi-pronged strategy to identify genes contributing to octanoic acid resistance. We began by experimentally-evolving D. simulans strains with higher tolerance to octanoic acid and determined the resulting genetic architecture. To identify specific candidate genes, we integrated this analysis with a genome-wide association study of octanoic acid resistance in D. simulans and a genome-wide CRISPR selection screen upon octanoic acid exposure in D. melanogaster S2R+ cultured cells. We identified four candidates, with diverse predicted molecular and expression properties, and validated their relevance using genetic analyses in D. melanogaster. Two of these genes displayed an increased expression in the experimentally-evolved strains, paralleling their higher levels of expression in D. sechellia. Our results suggest an adaptive role of these genes in shaping toxin resistance both under laboratory conditions and during D. sechellia's evolutionary history.
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Published on 04-01-2025
Institut Jacques Monod
Batiment Condorcet Amphitheatre Pierre Gilles de Gennes, 4 rue Elsa Morante, Paris, France -
Levendredi 7 fevrier 2025, Sophie G. Martin (Department of Molecular and Cellular Biology, University of Geneva, Switzerland) presentera une Conference de l'Institut Jacques Monod sur le theme : Signaling and actin focus architecture for cell-cell fusion Resume : Sexual reproduction is ubiquitous amongst eukaryotes. This requires alternation of cell-cell (gamete) fusion and genome reduction through meiosis. My lab has been using the yeast sexual reproduction pathway to study how cells polarize to find a mate and mount a fusion reaction. In the fission yeast Schizosaccharomyces pombe, sexual reproduction occurs between P and M cells, which communicate through pheromone-GPCR-MAPK signaling, driving the formation of cell pairs. Transition from gametes to zygote involves local cell wall digestion at the point of gamete contact, while preserving cell integrity. We have shown that cell-cell fusion requires the actin fusion focus, an aster-like assembly of linear actin filaments assembled by the formin Fus1, which concentrates both signaling molecules and secretory vesicles carrying cell wall digestion enyzmes. I will present our recent work on the molecular mechanisms of formation of the actin fusion focus, which require both formation of a formin biomolecular condensate and cytoskeletal focusing through formin-myosin feedback. I will also describe our progress in understanding the roles of local MAPK and PAK signaling for cells to pierce their cell wall once and only once.
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Published on 04-01-2025
Institut Jacques Monod
Institut Jacques Monod Amphitheatre Buffon, 15 rue Helene Brion, Paris, France -
Invited by: Claire Deligne
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Tags: Midwood Books, Midwood, Brooklyn
Published on 22-12-2024
Centre de Recherche des Cordeliers
Amphi Gustave Roussy -
Invited by: Théo Hirsch
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Tags: University of Leuven, In Belgium, Pierre-Joseph van Beneden
Published on 22-12-2024
Centre de Recherche des Cordeliers
Amphi Gustave Roussy -
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Tags: Cancer
Published on 22-12-2024
Centre de Recherche des Cordeliers
Amphi Gustave Roussy -
Invited by: Gilles Crambert
Summary: Solid tumors are heterogeneous environments, containing niches of varying hypoxia, acidosis, and nutrient deprivation. Evidence from us and others shows that such hostile conditions can endow cancer cells with highly aggressive traits, including increased growth, invasiveness, and rewired metabolism. Such niches can also support cancer stem cells and protect cancer cells against chemotherapeutic and immune-oncological therapies. Accordingly, we recently demonstrated that acid-adapted pancreatic cancer cells give rise to highly aggressive tumors with increased metastatic potential in vivo. Understanding these niches and their impact can uncover new targets for improving treatment of aggressive cancers. I will present our recent work in which we combine in vitro and in vivo cancer models, microfluidics, and spatial transcriptomics to study the mechanisms through which tumor acidosis may drive cancer aggressiveness.
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Tags: Oncology, Tumor, Tumor microenvironment, Cancer stem cell, Metastasis, Patient derived xenograft, Oncometabolism
Published on 22-12-2024
Centre de Recherche des Cordeliers
Amphi Gustave Roussy -
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Tags: Delayed open access journals, Cell, Cell and molecular biology, Transfersome
Published on 21-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Invited by: YAMAMOTO Kei
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Tags: 5th arrondissement of Paris, National Museum of Natural History, France, Triune brain
Published on 21-12-2024
NeuroPSI
Salle de conference Albe-Fessard -
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Published on 20-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
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Published on 20-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
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Published on 20-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Invited by Sophie Vaulont.
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Tags: Universities UK, Russell Group, University of Birmingham, Sophie
Published on 20-12-2024
Institut Cochin
Salle Rosalind Franklin -
Invited by Molly Ingersoll.
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Tags: NewYorkPresbyterian Healthcare System, Ingersoll, Ontario, Ingersoll, Donna Farber, Columbia University Irving Medical Center
Published on 19-12-2024
Institut Cochin
Salle Rosalind Franklin -
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Tags: Epigenetics, Genetic mapping, Lamarckism, Edith Heard, Genevive Almouzni
Published on 13-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
Invited by: CIRB - College de France
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Tags: @cirbcdf.bsky.social
Published on 11-12-2024
College de France
au College de France - Salle D2 acces restreint, merci de passer par l'accueil du CDF : 11 place Marcelin Berthelot - 75005 Paris -
Invited by: CIRB - College de France
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Tags: @cirbcdf.bsky.social
Published on 11-12-2024
College de France
au College de France - Salle D2 acces restreint, merci de passer par l'accueil du CDF : 11 place Marcelin Berthelot - 75005 Paris -
Invited by: CIRB - College de France
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Tags: @cirbcdf.bsky.social
Published on 11-12-2024
College de France
au College de France - Salle D2 acces restreint, merci de passer par l'accueil du CDF : 11 place Marcelin Berthelot - 75005 Paris -
Save the date! The Single Cell Initiative, the Cell and Tissue Imaging Platform (PICT) and the Experimental Pathology (PATHEX) core facilities co-organise an afternoon dedicated to spatial omics at Institut Curie. Meet the core facilities and discover how your colleagues apply spatial omics technologies in their research! Agenda, registration link and more information to come soon.
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Tags: Genomics, Omics, OMICS Publishing Group
Published on 06-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Ce cours explorera la polyvalence des elements d ADN non geniques et des ARN non codants dans un large eventail de processus cellulaires, chez l humain et les organismes modeles, ainsi que leur implication dans la physiologie et les maladies. Il elargira les sujets autour des domaines de la genomique, de l epigenetique et de la transcriptomique, y compris les technologies et analyses a cellule unique, la regulation de l'epigenome et de l expression des genes, l organisation du genome et la clonalite cellulaire. Des experts reconnus a l international presenteront leurs dernieres decouvertes concernant l identification et la caracterisation fonctionnelle du genome non codant, et discuteront des nouveaux concepts en matiere de regulation et d evolution du genome, avec un fort accent sur les outils experimentaux et informatiques. Les sessions thematiques incluront l analyse computationnelle de l heterogeneite cellulaire, les methodes d evaluation de l heterogeneite et de la plasticite cellulaire, l epigenome dans la regulation de l expression des genes, les retroelements dans la plasticite cellulaire, le genome "sombre" dans l identite et la clonalite cellulaire, ainsi que l organisation spatiale. Ce cours offrira aux jeunes etudiants et chercheurs l opportunite d elargir leurs connaissances et de discuter de leurs travaux avec une communaute scientifique internationale dans un environnement chaleureux et stimulant a l Institut Curie a Paris. Keynote speakers Stein AERTS - BE Maria Elena TORRES PADILLA - DE Intervenants Tugce AKTAS - DE Maria BRBIC - CH Chunlong CHEN - FR Bart DEPLANCKE - CH Dominic GRÜN- DE Amit IDO - IL Jop KIND - NL Gioele LA MANNO - CH Ana POMBO - DE Alex RADZISHEUSKAYA - UK Alejo RODRIGUEZ FRATICELLI - ES Arjun RAJ - USA Arnau SEBRE-PEDROS - ES Sydney SHAFFER - USA Angela TADDEI - FR Barbara TREUTLEIN - CH Didier TRONO - CH
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Published on 06-12-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Invited by Pascal Maire.
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Tags: Maire, Municipal governments in Saint Pierre and Miquelon, When Do You Commit Suicide?
Published on 04-12-2024
Institut Cochin
Salle Rosalind Franklin -
Invited by Anne Hosmalin.
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Tags: Karolinska Institute, Solna
Published on 30-11-2024
Institut Cochin
Salle Rosalind Franklin -
Mitochondria are double membrane-bound organelles that perform biosynthetic and signaling roles to control the life and death of the cell. Mitochondria are paramount to the metabolism and survival of cardiomyocytes, which have the most densely packed inner mitochondrial membrane of all cells. Cardiomyocytes are exquisitely sensitive to perturbations of mitochondrial structure, which can lead trigger downstream maladaptive and compensatory responses. In my talk, I will share our latest, unpublished findings using mouse models we have developed that have revealed the importance of inner mitochondrial membrane integrity in restraining cardiac inflammation and the emerging effects that biological sex can have on these phenomena. Timothy Wai is invited by Molly Ingersoll and Catherine Postic.
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Tags: Membrane biology, Mitochondria, Cellular respiration, Mitochondrion, Inner mitochondrial membrane, Cell membrane, Cell biology, MFN2
Published on 29-11-2024
Institut Cochin
Salle Rosalind Franklin -
Anti-PD-1 therapy targets intratumoral CD8+ T cells to promote clinical responses in cancer patients. Recent evidence has suggested that anti-PD-1 also act in the periphery. In particular, new T cell clonotypes emerge during anti-PD-1 therapy within the tumor microenvironment, suggesting de novo priming in the periphery. However, the underlying mechanism remains incompletely understood. In this presentation, I will show the importance of TDLN during anti-PD-1 therapy and discuss unexpected mechanisms for the peripheral activity of anti-PD-1 antibodies Paris Post-docs seminar series.
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Tags: Immune system, Immunology, Clusters of differentiation, Programmed cell death protein 1, Tumor microenvironment, T cell, Pd1, Antibody, Cancer immunotherapy, Dario Angelo Alberto Vignali
Published on 29-11-2024
Institut Cochin
Salle Rosalind Franklin -
Invited by Florence Margottin-Goguet
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Tags: Lentiviruses, Antiviral protein, HIV, Virus, Zinc finger, Antiviral drug, Virology, Simian immunodeficiency virus
Published on 28-11-2024
Institut Cochin
Salle Rosalind Franklin -
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Published on 28-11-2024
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
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Published on 28-11-2024
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
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Published on 28-11-2024
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
TBA
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Tags: Morvan, Ghislain
Published on 23-11-2024
Laboratoire Jean Perrin
Salle de seminaires 4eme etage - LJP - Tours 22-23 -
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Tags: Barbosa
Published on 19-11-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
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Tags: Ens, Provincial road N765
Published on 13-11-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
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Tags: Koukouli, Pierrette Gaudreau, Jean Garrab
Published on 13-11-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
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Tags: ICM, Piti-Salptrire Hospital
Published on 13-11-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
Invited by Anne Hosmalin.
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Tags: Solan, Karolinska Institute
Published on 25-10-2024
Institut Cochin
Salle Rosalind Franklin -
Invited by: CIRB - College de France
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Tags: @cirbcdf.bsky.social
Published on 21-10-2024
College de France
au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris -
Proteins in cells are not homogeneously distributed, but often localized to specific compartments, which may or may not be enclosed by membranes.
Here I will first discuss the dynamic formation of membraneless compartments in the non-equilibrium environment of living cells and how this formation can be regulated, e.g. by kinases [1]. Then I will show how single-molecule FRET (smFRET) and tracking of biomolecules can be used to study conformational dynamics and time-resolved cellular localization in living cells [2]. Results with the transcription initiation factor TAF2 show that the same protein can be in different compartments and thereby have different functions [3]. For the heat shock protein Hsp90 we will determine how proteins may be recruited to different compartments and have different conformational dynamics.
Altogether, smFRET has the potential to change our view on compartment-specific protein dynamics and therefore signalling within living cells.
[1] C. Lan, J. Kim, S. Ulferts, F. Aprile-Garcia, A. Anandamurugan, R. Grosse, R. Sawarkar, A. Reinhardt and T. Hugel, Nat. Commun., 14:4831 2023 (https://doi.org/10.1038/s41467-023-40540-2)
[2] A. Anandamurugan, A. Eidloth, P. Wortmann, L. Schrangl, F. Aprile-Garcia, C. Lan, R. Sawarkar, G. J. Schütz, T. Hugel, bioRxiv 2023 (https://doi.org/10.1101/2023.09.15.557875)
[3] T. Bhuiyan, P. K. Mendoza Sanchez, N. Arecco, J. Kim, S. Nizamuddin, A. Prunotto, M. Tekman, M. L. Biniossek, S. Koidl, T. Hugel, S. J. Arnold, bioRxiv 2024, (https://doi.org/10.1101/2024.02.05.578926)
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Tags: Single-molecule FRET, Live single-cell imaging, DEP domain
Published on 12-09-2024
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Abstract will appear here.
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Tags: Boisbriand
Published on 10-09-2024
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris