Friday 06 June 2025 11:00

Apprentissage de modeles a partir des donnees. Machine learning and stochastic optimization.
Sylvain Chevalier | Laboratoire Interdisciplinaire des Sciences du Numerique (LISN), Orsay


Invited by: HUETZ Chloe More details... Published on 29-05-2025

	NeuroPSI Salle de conference Albe-Fessard

Thursday 26 June 2025 12:00

Department of Parasites and Insect Vectors Seminar : Rob MOON Reassessing merozoite invasion processes and malaria vaccine development usingPlasmodium knowlesi?


Invited by: Chetan Chitnis More details... Tags: Malaria, Plasmodium knowlesi, Plasmodium, Parasitism, Apical membrane antigen 1 Published on 28-05-2025

	Institut Pasteur Batiment Lwoff, salle Retrovirus,

Wednesday 04 June 2025 11:30

Biological tissues as active amorphous solids
Marko Popoviamp;#263;


More details... Published on 28-05-2025

	Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie

Tuesday 10 June 2025 12:00

Uptake and recognition of naked extracellular RNAs
Juan Pablo TOSAR


Invited by: Lionel NAVARRO - EEB Seminar Series More details... Tags: Non-coding RNA, RNA, Molecular genetics, Uptake, Extracellular RNA Published on 28-05-2025

	IBENS salle Favard, IBENS 46 rue d'Ulm 75005 Paris

Thursday 19 June 2025 12:00

Department of Parasites and Insect Vectors Seminar : Professor Hedda Wardemann Rational design of a novel CSP-based Plasmodium falciparum malaria vaccine?


Invited by: Liliana Mancio Silva In this presentation, Professor Hedda Wardemann will describe how we study the clonal evolution of B and T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) at cellular and monoclonal antigen-receptor level to guide ... More details... Tags: Malaria, Plasmodium, Circumsporozoite protein, Isabella Akyinbah Quakyi, David A. Fidock Published on 27-05-2025

	Institut Pasteur Batiment Lwoff , salle Retrovirus,

Thursday 19 June 2025 11:00

Genomes and Genetique department seminar : Marco TRIZZINO Mechanisms of gene regulation in development and disease


Invited by: Camille Berthelot More details... Tags: Genomics, DNA, Genetic mapping, Genome, Methylation Published on 27-05-2025

	Institut Pasteur Batiment Duclaux , salle Duclaux amphitheater ,

Wednesday 18 June 2025 12:30

Joint seminar Departement des Parasites et Insectes Vecteurs - Departement Microbiologie : Mathilde GENDRIN Deciphering positive and negative impacts of bacteria on mosquito life cycle


Invited by: Lucy Glover More details... Tags: Ectoparasites, Mosquito Published on 27-05-2025

	Institut Pasteur Batiment Monod, salle Amphitheatre Agnes Ullmann ,

Thursday 05 June 2025 11:00

Genomes and Genetique department seminar : Susana COELHO The Curious World of Algae: Mating Rituals and Giant Viruses


Invited by: Martial Marbouty More details... Tags: Giant virus, Mating ritual, Virus, Sustainable Sanitation Alliance Published on 27-05-2025

	Institut Pasteur Batiment Fernbach, salle Jean-Paul Aubert ,

Monday 16 June 2025 11:00

Next generation pipeline for next generation spatial transcriptomic data
Pierre Bost


More details... Tags: Omics, Molecular biology, Transcriptomics technologies, Genomics, Deterministic Barcoding in Tissue for Spatial Omics Sequencing, Biotechnology Published on 27-05-2025

	Institut Curie Centre de recherche - Orsay - Amphitheatre du Batiment 111

Thursday 05 June 2025 11:00

The corrinoid model illuminates microbial community interactions across scales
Michi Taga


Invited by: Dr Olivier BERTEAU Nutritional interactions are widespread among microbes and are major drivers of microbial community structure. Among the many metabolites shared among microbes are corrinoids, the vitamin B12 family of cobalt-containing modified tetrapyrroles. Corrinoids are used as cofactors for diverse metabolic processes in prokaryotes including the catabolism of various carbon sources and biosynthesis of methionine, deoxynucleotides, and natural products. An unusual aspect of corrinoids is their structural variability: corrinoids produced by different microbes have variations in their structure, and each organism has distinct preferences for the ~20 structural variants. Furthermore, corrinoids are produced only by a fraction of prokaryotes. These features together make corrinoids a powerful model for understanding metabolite-sharing interactions in microbiomes. We have found that different corrinoids have distinct effects on growth in cultured bacteria, and recent results demonstrate that addition of certain corrinoids can shift bacterial composition, even in the complex microbiomes of soil and human gut-derived communities. Studies of bacterial co-cultures, tri-cultures, and higher-order consortia show that different microbes have distinct roles in producing and competing for corrinoids. A greater understanding of corrinoid metabolism and structural specificity may lead to improved strategies for manipulating the composition and function of microbiomes. More details... Tags: Microbiomes, Microorganisms, Microbiome, Microbial consortium, Plant microbiome Published on 26-05-2025

	Institut Micalis Auditorium 442 - Institut Micalis

Friday 06 June 2025 12:00

The lysosome: from trash can to signaling hub that controls cell metabolism
Andrea Ballabio | Telethon Institute of Genetics and Medicine, Naples, Italy


Invited by: Kristine Schauer Lysosomal function was long thought to be devoted exclusively to cellular degradation and recycling processes. A few years ago we showed that lysosomal biogenesis and autophagy are globally controlled by transcription factor EB (TFEB). The activity of TFEB is regulated by mTORC1 through a lysosomal signaling pathway that enables lysosomal function to adapt to environmental cues. mTORC1-mediated TFEB phosphorylation is dependent on the GTPase activity of folliculin (FLCN) but is insensitive to growth factor-induced Rheb activity, unlike the phosphorylation of other mTORC1 substrates such as S6K and 4E-BP1. This non-canonical, substrate-specific, mTORC1 signaling pathway plays a crucial role in Birt-Hogg-Dube (BHD) syndrome, a disorder caused by mutations of FLCN and characterized by benign skin tumors, lung and kidney cysts and renal cell carcinoma. We found that constitutive activation of TFEB, due FLCN loss of function, is the main driver of kidney cystogenesis and tumorigenesis observed in BHD syndrome. Remarkably, depletion of TFEB in a kidney-specific mouse model of BHD syndrome fully rescued the disease phenotype and associated lethality. In collaboration with the group of Lisa Henske at Harvard we demonstrated that TFEB also drives the kidney abnormalities found in Tuberous Sclerosis, another inherited cancer syndrome. More recently, in collaboration with James Hurley&'s and Lukas Huber&'s groups, we obtained structural evidence, using Cryo-EM, that the canonical and non-canonical branches of the mTORC1 pathway coexist in a 36 polypeptide mTORC1-TFEB-Rags-Ragulator megacomplex. Such regulatory machinery is located at the lysosomal surface and selectively controls cell metabolism in response to different stimuli. Dysregulation of this machinery leads to tumorigenesis. Together, these data have changed the view of the lysosome from a static station devoted to degradation and recycling processes to a dynamic and adaptive signaling hub that controls cell metabolism Tags: Lysosome Published on 25-05-2025

	Institut Gustave Roussy Gustave Roussy, salle Roger Monier du PR2

Monday 16 June 2025 11:00

The endovirome and its epigenetic controllers, or the species-specificity of human biology and of its pathological deviations
Didier TRONO


More details... Tags: Epigenetics, Genetic mapping, Lamarckism, Didier Trono, Specificity, Developmental biology, RNA Published on 24-05-2025

	Institut Curie Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e

Friday 04 July 2025 11:30

Soft dynamic channels in liquid ordered lipid membrane
Anand Srivastava


More details... Tags: Membrane biology, Lipid bilayer, Lamellar phase, Model lipid bilayer Published on 24-05-2025

	Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie

Thursday 19 June 2025 11:00

Synthetic biology tools for mammalian cell engineering
Francesca Ceroni


Invited by: Manish KUSHWAHA & Olivier BORKOWSKI Our lab at Imperial College is focused on the engineering of bacteria, mammalian and synthetic cells to advance the applications of synthetic biology. Resource competition between host cells and genetic constructs is one of our main research themes, for its impact on our ability to reliably engineer cellular hosts. In order to tackle resource competition and the cellular burden derived from it, we are currently developing novel tools to address measure and characterise competition in mammalian cells, building on our previous work in bacteria, but also exploring the design of novel gene expression control platforms for low-footprint genetic engineering. More details... Tags: Biotechnology, Appropriate technology, Biocybernetics, Bioinformatics, Synthetic biology, Systems biology, Christopher Voigt Published on 24-05-2025

	Institut Micalis Auditorium 442 - Institut Micalis

Thursday 19 June 2025 14:00

The growth-laws cookbook: Ingredients and recipes for mechanistic models of ribosome allocation in bacteria and beyond
Luca Ciandrini- 19/06/2025


Invited by: Manish KUSHWAHA Ribosomes in cells exist in multiple functional states: actively translating, hibernating, inhibited -when perturbed with sublethal doses of drugs. Current theoretical descriptions, based on steady-state growth models, fail to reconcile observed protein synthesis at negligible growth conditions-predicting paradoxically zero active ribosomes despite measurable translation. Here, we present a mechanistic framework that moves beyond the traditional ribosome-centric view by explicitly integrating transcription dynamics and quantifying ribosome usage, thus predicting the physiological costs-both transcriptional and translational-of expressing unnecessary proteins. This approach distinguishes active from inactive ribosome pools, revealing that even at slow growth, a significant fraction of ribosomes actively maintains protein levels against degradation. Our model predicts finely coordinated initiation and elongation rates, stabilizing ribosome densities across varying physiological states, and provides quantitative insights into ribosome sequestration by hibernation factors. More details... Tags: Protein biosynthesis, Molecular biology, Gene expression, Cellular processes, Hibernation factor, Metabolism, Ribosome, Translation Published on 24-05-2025

	Institut Micalis Auditorium 442 - Institut Micalis

Friday 04 July 2025 11:30

Contact-based transfer of thymidylate promotes collective tumor growth
Paolo CEPPI


More details... Tags: Thymidylate synthase, Antifolates Published on 23-05-2025

	Institut Curie Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)

Friday 04 July 2025 11:30

Tracking Reactive Microglia in Health and Disease
Dr Li Tristan Quingyun | Washington University School of Medicine


Invited by: CIRB - College de France More details... Tags: @cirbcdf.bsky.social Published on 23-05-2025

	College de France au College de France - Salle 2 11 place Marcelin Berthelot - 75005 Paris

Tuesday 26 August 2025 0:00

Checkpoint Molecules, Tregs and Induction of Anti-tumor Immunity
Vijay KUCHROO (Harvard Medical School, & Brigham and Women's Hospital, Boston, US)


Vijay KUCHROO's research mainly focuses on the regulation of T cell responses in the context of autoimmune disease, to elucidate the role of cytokines and transcription factors in the differentiation of CD4+ T helper subsets and the role of co-stimulatory and co-inhibitory receptors and their ligands in the regulation of autoreactive T cell responses. The team identified Tim-3 on CD4 + Th1 cells, leading to the discovery of the TIM molecule family. Tim-3 is now recognized as an important co-inhibitory receptor that dampens T cell responses in chronic viral diseases and cancer. Other key discoveries made in his lab include the elucidation of the differentiation factors for Th17, Th9 and Tr1 cells, all of which have a major influence on the development of autoimmunity and tissue inflammation. Vijay Kuchroo is invited by Armelle Blondel. More details... Tags: Immunology, Immune system, T cells, HAVCR2, Vijay Kuchroo, T helper 17 cell, Regulatory B cell, Immune checkpoint Published on 23-05-2025

	Institut Cochin Salle Rosalind Franklin

Monday 09 June 2025 0:00

Data Science approaches to GPCR signaling and implications for drug discovery
Madan Babu (St Jude Children’s Research Hospital, TN, USA)


G protein-coupled receptors (GPCRs) participate in diverse physiological processes, ranging from sensory responses such as vision, taste, and smell to those regulating behavior, the immune and the cardiac system among others. The ~800 human GPCRs sense diverse signaling molecules such as hormones and neurotransmitters to allosterically activate the associated G proteins, which in turn regulate diverse intracellular signaling pathways. In this manner, GPCRs regulate virtually every aspect of human physiology. Not surprisingly, GPCRs are the targets of over one-third of all prescribed human drugs. Our group develops data science approaches to investigate GPCR signaling at multiple levels of complexity, from the atomic-scale to tissue and population-scale. In this presentation, I will first discuss how one can leverage pharmacology and structural data to understand the origins of efficacy and potency. I will then focus on the chemokine-GPCR signaling system that governs cell movement to describe the molecular determinants of selectivity and promiscuity in this ligand-receptor system. Specifically, I will discuss how such insights can be used to design chemokine ligands for possible cell therapy applications. Finally, I will present ongoing work that utilize gene expression data during different stages of development to uncover principles of developmental dynamics of GPCRs. I will discuss the implications of the findings for drug development for the fetal, pediatric, pregnant and geriatric population. I will conclude by highlighting how studying GPCR signaling at all these scales can provide a rich source of new hypotheses with implications for personalized medicine, drug development and understanding basic receptor biology. Madan Babu is invited by Ralf Jockers. More details... Tags: Cell signaling, Signal transduction, Cell biology, G protein-coupled receptors, Molecular biology, G protein, Receptor, Adhesion G protein-coupled receptor, G protein-coupled receptors database Published on 23-05-2025

	Institut Cochin Salle Rosalind Franklin

Friday 27 June 2025 11:00

The catshark embryo as a model to study the origin and evolution of telencephalic cell types.
Idoia Quintana Urzainqui | EMBL Heidelberg Germany


Invited by: RETAUX Sylvie More details... Tags: Bioethics, Developmental biology, Embryo, Fertility medicine Published on 23-05-2025

	NeuroPSI Salle de conference Albe-Fessard

Thursday 19 June 2025 12:00

Seminaire Trans-Sciences - Comment se tisse la toile cosmique ?
Sandrine Codis (Institut d'Astrophysique de Paris)


Les galaxies ne voguent pas de façon désordonnée dans l’Univers mais forment un véritable réseau en bulles de savon que l’on appelle la toile cosmique. Cette toile est composée de grands vides entourés par des filaments le long desquels les galaxies se meuvent avant de terminer leur course aux noeuds où de gigantesques amas de galaxies se forment. A l'occasion de cette conférence, nous arpenterons l'Univers sur des milliards d'années lumière afin de comprendre comme se tisse cette toile cosmique, quelles sont ses origines, comment elle influence la naissance et l'évolution des galaxies et en quoi elle représente une sonde cosmologique formidable nous permettant de comprendre l'Histoire et la composition de l’Univers. More details... Published on 22-05-2025

	Institut Cochin Salle Rosalind Franklin

Tuesday 03 June 2025 11:45

Seminaire #8211; Irene Basili


Invite par l’Institut Jacques Monod, Irene Basili presentera un seminaire sur le theme : AMBRA1 controls the Sonic Hedgehog signaling pathway and SHH-medulloblastoma Resume : AMBRA1 (Autophagy and Beclin 1 Regulator 1) is primarily recognized as a tumor suppressor, however its role as a tumor promoter has garnered increasing attention. Here, leveraging clinical data of an international multi-omic medulloblastoma (MB) cohort, we identified that elevated AMBRA1 protein levels, independently of its mRNA expression, correlate with poor prognosis in the Sonic Hedgehog subgroup (MBSHH) compared to other MB variants. Mechanistically, AMBRA1 enhances SHH signaling by stabilizing GLI1, the pathway’s final effector, via inhibition of its ?TrCP-mediated degradation. Additionally, AMBRA1 protein stability is modulated by the REN E3 ubiquitin ligase, a tumor suppressor gene lost in MBSHH. Inhibition of AMBRA1 blocks MBSHH growth in murine and patient-derived pre-clinical models, highlighting its therapeutic potential. Moreover, combining AMBRA1 knockdown with FDA-approved SHH inhibitors enhances antitumor efficacy. These findings identify the AMBRA1/?TrCP/REN axis as a key regulatory mechanism in SHH signaling and discover an unrecognized function of AMBRA1 in MBSHH, providing actionable insights for innovative targeted therapies. Ce seminaire fait partie de la serie des Paris Postdoc Seminar. More details... Tags: Cell signaling, Proteins, Transcription factors, Morphogens, Sonic hedgehog protein, Sonic the Hedgehog, Hedgehog signaling pathway, Medulloblastoma, GLI1, Shh, Tumor suppressor gene, Hedgehog pathway inhibitor Published on 21-05-2025

	Institut Jacques Monod Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France

Monday 23 June 2025 9:00

VIP #038; DIF 2025


Les inscription pour le VIP & DIF Day #5 sont ouvertes! Où : Institut Jacques Monod (Amphi Buffon – 15 rue Helene Brion – 75013 Paris) Quand: Monday 23rd of June 2025. Cette annee, nous aurons le plaisir d’accueillir les deux orateurs principaux suivants : Maria-Cristina Gambetta, University of Lausanne Alper Akay, University of East Anglia Soumettez vos resumes d’affiches ou d’exposes. https://sites.google.com/view/vipdif/registration-2025 La participation est gratuite mais l’inscription est obligatoire pour tous. La date limite d’inscription est le 1er juin 2025. More details... Published on 20-05-2025

	Institut Jacques Monod Institut Jacques Monod Amphitheatre Buffon, 15 rue Helene Brion, Paris, France

Tuesday 03 June 2025 10:00

Biological tissues as materials: fluidity, rigidity and rheology
Cristina Marchetti


More details... Tags: Fluidity, M. Cristina Marchetti, Rheology, Rigidity, Tissue Published on 20-05-2025

	Institut Curie Centre de recherche - Orsay - Salle polyvalente du Batiment 111

Friday 13 June 2025 12:00

New tricks of an old dog: senescence induced-cellular plasticity in health amp; disease
Han Li | Institut Pasteur


Invited by: Mario Pende Han Li is a principle investigator at the Institut Pasteur, where she leads the cellular plasticity in age-related pathologies group in the department of developmental and stem cell biology. She studied genomic stability in cancer and aging under Dr. Paul Hasty's supervision at the University of Texas, health science center at San Antonio, and obtained PhD in 2007. Next, she performed her postdoc training in Dr. Manuel Serrano's lab at the Spanish National Cancer Research Centre, investigating the role of tumor suppressors in cellular reprogramming. In 2015, she established her own lab at the Institut Pasteur. Han Li has worked on various topics in the field of cancer and ageing, including genomic stability, cellular reprogramming, and cell senescence. Her group recently identified a novel role of senescence in regulating cellular plasticity in the context of in vivo reprogramming. Currently, her group is focused on understanding the functional relevance of senescence-modulated cellular plasticity in tissue regeneration, cancer, and aging-related pathologies. Seminar topic: New tricks of an old dog: senescence induced-cellular plasticity in health amp; disease More details... Tags: Cellular processes, Cell biology, Senescence, Old age, Stem cell, MTOR Published on 20-05-2025

	Institut Necker Enfants Malades Auditorium 4

Friday 13 June 2025 11:45

Genome wide data of a Penicillium roqueforti strain from Iron Age Austria: the oldest molecular evidence for fermented blue cheese.
Sabry Sarhan


Invites par l’equipe Grange/Geigl, Frank Maixner et Sabry Sarhan (Eurac Research – Institute for Mummy Studies, Bolzano, Italy) presenteront un seminaire de l’Institut Jacques Monod sur le theme : Genome wide data of a Penicillium roqueforti strain from Iron Age Austria: the oldest molecular evidence for fermented blue cheese. Resume : The application of metagenomic analysis on dated ancient human specimens opens a window into the past that enables scientists to address unique evolutionary research questions. Paleofeces are an important source of information to study the evolution of dietary habits and human health. The UNESCO World Heritage region of Hallstatt-Dachstein/Salzkammergut is one of Europe's oldest cultural and industrial landscapes; its underground salt mines dating back at least to the 14th century BC are one of the few archaeological sites where paleofeces are well preserved. Here we subjected human paleofeces dated from the Bronze Age to early Modern Times to an in-depth microscopic, metagenomic and proteomic analysis. This allowed us to reconstruct the diet of the former population and gain insights into their ancient gut microbiome composition. Dietary survey identified a highly fibrous, carbohydrate-rich diet supplemented with proteins from broad beans and occasionally with fruits, nuts, or animal food. Linked to these traditional dietary habits all ancient miners up to the early Modern times have gut microbiome structures akin to modern non-Westernized individuals which may indicate a shift in the gut community composition of modern Westernized populations due to quite recent dietary and lifestyle changes. When we extended our microbial survey to fungi present in the paleofeces, we observed in one of the Iron Age samples a high abundance of Penicillium roqueforti DNA. Genome-wide analysis placed the ancient P. roqueforti strain into the current non-Roquefort blue cheese diversity next to modern variants from different parts of the Alps (e.g. Termignon). Our findings present the earliest molecular evidence for blue cheese consumption during Iron Age Europe, which opens a new opportunity to better understand the domestication history of blue cheese fermentation. More details... Tags: Blue cheese, Blue cheeses, Penicillium, Paleofeces Published on 15-05-2025

	Institut Jacques Monod Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France

Wednesday 18 June 2025 14:00

Fundamental principles during the egg-to-embryo transition
Andrea PAULI


More details... Tags: Fertility medicine, Embryology, Developmental biology, Andrea Pauli, Embryo, Bird egg, Shengtai, Drosophila embryogenesis Published on 15-05-2025

	Institut Curie Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)

Thursday 19 June 2025 16:30

TBA and es 53BP1 bind to RNA-DNA primers to prevent the activation of innate immune response?
Loic BROIX and Patricia UGUEN


More details... Tags: Anonymous, Botnets, Denial-of-service attacks, Internet-based activism, Low Orbit Ion Cannon, Wakanumun, Loc Bouvard Published on 15-05-2025

	Paris RNA Club Auditorium Gallois - 45 rue d Ulm, 75005 Paris

Monday 16 June 2025 9:00

IBEID Labex Day 25


Invited by: Carla Saleh Annual Scientific Symposium of the Labex IBEID The upcoming Annual Scientific Symposium offers an opportunity to explore the research projects conducted by the IBEID members. Held this year at the ENVA (Ecole nationale veterinaire ... More details... Tags: Financial regulation, LabEx ReFi - European Laboratory on Financial Regulation, Systemic risk, French UMR, French National Centre for Scientific Research Published on 15-05-2025

	Institut Pasteur Salle ,

Thursday 05 June 2025 10:00

Neuroscience Dpt Seminar - Yamuna Krishnan (University of Chicago) - Intracellular Electrophysiology.


Invited by: Pierre-Jean Corringer Date : 5th June 2025 10am Speaker : Yamuna Krishnan (Department of Chemistry, University of Chicago) Title : Intracellular Electrophysiology Location : Room Jules Bordet (Metchnikoff) Abstract : The chemical milieu within an organelle ... More details... Tags: Yamuna Krishnan, Designer drugs, Yamuna, Dipropyltryptamine, DPT, Dermatopontin, Krishnan Published on 15-05-2025

	Institut Pasteur Batiment: Metchnikoff Salle: Jules Bordet

Thursday 05 June 2025 10:00

The expanding Roles of Autophagy in Epithelial Development: Mechanisms From Morphogenesis to Metabolic Programming and Tissue Adaptation
Fernando M. Belmonte


More details... Tags: Autophagy, Cell death, Immunology, Programmed cell death, Morphogenesis, FGF7, Madin-Darby canine kidney cells Published on 14-05-2025

	Institut Curie Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)

Friday 09 January 2026 11:00

Seminaire Scientifique | Sonia Garel | Informations a venir


More details... Published on 14-05-2025

	Inst. Bio. Paris Seine 7-9 quai Saint Bernard, 75005 Paris

Friday 12 December 2025 11:00

Seminaire decale | Julie Batut | Titre a venir


More details... Published on 14-05-2025

	Inst. Bio. Paris Seine 7-9 quai Saint Bernard, 75005 Paris

Friday 05 December 2025 11:00

Seminaire Scientifique | Raymond E. Goldstein (Churchill College, Cambridge) | Titre a venir


More details... Published on 14-05-2025

	Inst. Bio. Paris Seine 7-9 quai Saint Bernard, 75005 Paris

Friday 17 October 2025 11:00

Seminaire decale | Marie Legendre | Titre a venir


More details... Published on 14-05-2025

	Inst. Bio. Paris Seine 7-9 quai Saint Bernard, 75005 Paris

Friday 26 September 2025 11:00

Seminaire scientifique | Loic Broix (NeuroSU) | Titre a venir


More details... Published on 14-05-2025

	Inst. Bio. Paris Seine 7-9 quai Saint Bernard, 75005 Paris

Friday 19 September 2025 11:00

Seminaire decale | Raja Chatila | Titre a venir


More details... Published on 14-05-2025

	Inst. Bio. Paris Seine 7-9 quai Saint Bernard, 75005 Paris

Friday 20 June 2025 11:45

A cross talk between p53 and the cell cycle regulates apoptotic induction and tumor formation in Drosophila
Carlos Estella


Invite par l’equipe Konstantinides, Carlos Estella (Laboratory of stress response and morphogenesis. Centro de Biologia Molecular CSIC-UAM, Madrid, Spain) presentera un seminaire de l’Institut Jacques Monod sur le theme : A cross talk between p53 and the cell cycle regulates apoptotic induction and tumor formation in Drosophila Resume : Cell division is essential for tissue regeneration and organismal survival. However, errors in this process can lead to uncontrolled cell proliferation and cancer. The tumor suppressor gene p53 plays a critical role in maintaining genomic integrity by coordinating cellular responses to stress, such as DNA damage. These responses include cell cycle arrest, DNA repair, senescence, or apoptosis. Importantly, how these responses are precisely coordinated to maintain tissue homeostasis remains poorly understood. To address this challenge, simple genetic models are needed to study the precise regulation of cellular responses triggered by p53 and its role in tumorigenesis. To simplify the study of p53’s functions, we use Drosophila melanogaster, which has a single p53 homolog. Drosophila serves as a powerful genetic model due to its highly conserved pathways and sophisticated genetic tools. Notably, approximately 85% of human cancer-related genes have orthologs in flies. In this seminar I´ll discuss recent work from our laboratory that demonstrated how the cellular context and proliferative status of a cell significantly impact p53’s ability to regulate the various responses triggered by DNA damage. In addition, I´ll present the tumorigenic potential of p53 when its apoptotic role is inhibited. We find that cells with chronic p53 activity that have inhibited its apoptotic potential acquire a persistent activity of the JNK pathway, which drives them into a senescent-like status and induce the non-autonomous overgrowth of the surrounding tissue. These results lead us to propose a model in which cell cycle progression and p53 pro-apoptotic activity are molecularly connected to coordinate the appropriate response after DNA damage. More details... Tags: Programmed cell death, Proteins, Cellular senescence, Tumor suppressor genes, Apoptosis, P53, Tumor suppressor gene, Carcinogenesis, Cell cycle, Cell division, C-Jun N-terminal kinases, LRDD Published on 13-05-2025

	Institut Jacques Monod Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France

Friday 06 June 2025 11:45

Adjusting the timing of mammalian development
Aydan Karslioglu


Invitee par l’equipe Greenberg et par le laboratoire Epigenetique et Destin Cellulaire, Aydan Karslioglu (Group Leader, Max Planck Institute for Molecular Genetics) va presenter un seminaire de l’Institut Jacques Monod sur le theme : Adjusting the timing of mammalian development Resume : Our lab focuses on mechanisms regulating stem cell state transitions and fate commitment. Specifically, we study how cells communicate signals from their surroundings to the gene expression machinery, especially in the context of cell fate decisions in development and disease. To delineate principles of stemness, we use in vitro and in vivo models and probe molecular processes critical for the emergence, maintenance, and resolution of stem states in physiological and adverse conditions. More details... Tags: Education in Berlin, Max Planck Institute for Molecular Genetics Published on 13-05-2025

	Institut Jacques Monod Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France

Friday 04 July 2025 14:00

L#39;energie d#39;adhesion controle l#39;endocytose mediee par la liaison des lipides
Helge Ewers


More details... Published on 11-05-2025

	Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie

Tuesday 24 June 2025 11:00

Fueling macrophages with metabolic recycling of bacteria
Johan Garaude


More details... Tags: Cell biology, Immune system, Macrophages, Lymphatic system, Macrophage, Adipose tissue macrophages, White pulp Published on 06-05-2025

	Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie

Thursday 12 June 2025 11:00

#39;Adventures in Chemical Biology - From in vivo chemistry to real-time optical medical imaging#39;
Mark BRADLEY


More details... Tags: Chemical biology, Chemistry, In vivo, Medical imaging, Imaging, Laboratory equipment, Radiopharmaceutical, Molecular imaging Published on 03-05-2025

	Institut Curie Centre de recherche - Orsay - Amphitheatre du Batiment 111

Friday 20 June 2025 12:00

Mitohormesis and metabolic adaptations in response to therapeutic stress in acute myeloid leukemia
Jean-Emmanuel Sarry | Centre de recherches en cancerologie de Toulouse (CRCT)


Invited by: Elizabeth Macintyre amp; Vahid Asnafi Seminar Topic: Mitohormesis and metabolic adaptations in response to therapeutic stress in acute myeloid leukemia Photo credits: DDM-MICHEL VIALA More details... Tags: Leukemia, Myeloid leukemia, Myeloid tissue, Hormesis Published on 26-04-2025

	Institut Necker Enfants Malades Auditorium 3

Thursday 05 June 2025 11:00

Functional interplay between the chromatin assembly factor 1 (hCAF-1) and the BLM helicase in mammalian cells
Vincent PENNENEACH | Institut Curie, Orsay


Invited by: Jean-Louis Mergny Published on 25-04-2025

	Ecole Polytechnique Lecture room Building 84

Friday 13 June 2025 9:30

Molecular Mechanisms of Chromosome Folding and Enhancer Wiring
Elphege Nora


More details... Tags: Gene expression, Enhancer, Enhancer RNA, Chromosome conformation capture Published on 24-04-2025

	Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie

Wednesday 02 July 2025 11:30

Illuminating Compartmentalized Metabolic Regulation in Single Cells
Danielle L. Schmitt


More details... Tags: Cellular compartment, Metabolism, Cell biology, Organelles Published on 23-04-2025

	Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie

Tuesday 17 June 2025 11:30

The metabolic control of growth and senescence
Dr Mario Pende | Institut Necker Enfants Malades


Invited by: CIRB - College de France More details... Tags: @cirbcdf.bsky.social Published on 23-04-2025

	College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris

Tuesday 24 June 2025 11:30

Intravascular Cues Shape Tumor Metastasis
Dr Jacky Goetz | Centre de Recherche en Biomedecine de Strasbourg


Invited by: CIRB - College de France More details... Tags: @cirbcdf.bsky.social Published on 23-04-2025

	College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris

Friday 20 June 2025 14:00

Imagination and the neurophysiology of decision-making
Dr David Redish | Univ. Minnesota


Invited by: CIRB - College de France More details... Tags: @cirbcdf.bsky.social Published on 23-04-2025

	College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris

Thursday 05 June 2025 12:00

Department of Parasites and Insect Vectors Seminar : Professor Rita Tewari Unravelling atypical rapid mitosis inPlasmodium?


Invited by: Rogerio Amino More details... Tags: Rita Tewari, Disease vector, Rita, Mitosis Published on 16-04-2025

	Institut Pasteur Batiment Lwoff, salle Retrovirus,

Friday 04 July 2025 11:00

Paris Post-Doc Seminar | Maria Christina Capizzi (ICM)


More details... Published on 15-04-2025

	Inst. Bio. Paris Seine 7-9 quai Saint Bernard, 75005 Paris

Friday 06 June 2025 12:00

Developmental Programming of Tissue-Resident Macrophages
Elvira Mass | LIMES Institute - University of Bonn


Invited by: Nicolas Venteclef Elvira Mass studied biology at the University of Bonn and did her PhD thesis at the Life and Medical Sciences Institute (LIMES) in Bonn. In 2014, she moved to Frederic Geissmann's laboratory at King's College in London and followed him a few months later to the Memorial Sloan-Kettering Cancer Center in New York. From there she returned to the LIMES Institute in Bonn in 2017 as a group leader. In 2019, she became Associate Professor for "Integrated Immunology" at the University of Erlangen-Nurnberg. In 2020, she switched to back to the LIMES Institute, and was tenured as a full professor in 2022. In 2019 Elvira was awarded an ERC Starting Grant to work on the impact of micro- and nanoplastics on macrophage functions. She has also received several awards, including the Paul Ehrlich and Ludwig Darmstaedter Prize for Young Researchers in 2021 and the EMBO YIP award in 2022 for her work on macrophage biology.Seminar topic: Developmental Programming of Tissue-Resident Macrophages More details... Tags: Immune system, Cell biology, Lymphatic system, Macrophage, Phagocytes Published on 14-04-2025

	Institut Necker Enfants Malades Auditorium 2

Thursday 26 June 2025 11:00

Discovery of Potential Anti-tuberculosis Agents
Jichan Jang


Invited by: research axis and Marie-Agnes Petit Tuberculosis(TB), driven primarily by Mycobacterium tuberculosis, continues to pose a severe global health challenge, especially with the rise of multidrug-resistant (MDR) strains. Current treatments are insufficient, creating an urgent demand for new therapeutic options. In our study, we introduce compound X that demonstrates potent efficacy against both actively replicating and dormant M. tuberculosis, including MDR strains. In animal models, compound X exhibits strong in vivo activity, effectively combating both acute and chronic MDR infections. These results highlight compound X as a compelling candidate for advancing the treatment of MDR-TB. More details... Tags: Tuberculosis, Multidrug-resistant tuberculosis, Management of tuberculosis, Mycobacterium tuberculosis, Multiple drug resistance, Extensively drug-resistant tuberculosis, Tuberculosis in Nigeria Published on 11-04-2025

	Institut Micalis Auditorium 442 - Institut Micalis

Friday 06 June 2025 11:30

La mecanobiologie des fuseaux mitotiques revele une loi d#39;echelle universelle regie par l#39;encombrement des chromosomes
Nenad Pavin


More details... Published on 06-04-2025

	Institut Curie Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e

Thursday 16 October 2025 0:00

Title to be announced
Jamie Hackett (EMBL Roma)


Invited by Julie Cocquet and Alberto de la Iglesia. More details... Tags: European Molecular Biology Laboratory, Heidelberg Published on 04-04-2025

	Institut Cochin Salle Rosalind Franklin

Tuesday 24 June 2025 11:00

TBA
Hamid Kellay | LOMA


TBA More details... Tags: Loma, Draft:Rincn Bomba massacre, La Loma Published on 02-04-2025

	Laboratoire Jean Perrin Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407

Tuesday 03 June 2025 11:00

Plant root growth in mechanically heterogeneous substrates
Evelyne Kolb


TBA More details... Tags: Kolb, Draft:Rincn Bomba massacre, Draft:Evelyn Lenton Published on 02-04-2025

	Laboratoire Jean Perrin Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407

Thursday 25 September 2025 0:00

Retour d#039;experience sur la creation de start-up
Stefano Marullo, Raphaël Scharfmann (Institut Cochin)


Invitation de Sophie Vaulont. More details... Published on 29-03-2025

	Institut Cochin Salle Rosalind Franklin

Monday 16 June 2025 9:00

Immuno-Oncology (PIO) Conference 2025
Bart Lambrecht, Jerome Galon, Remy Nicolle, Bana Jabri, Elodie Segura, Julie Helft, Chrysothemis Brown, Ignacio Melero, Jennifer Wargo, Ivo Gomperts Boneca, Janne Lehtio, Guido Kroemer, Dan Littman, Tim Greten, Gianluca Ianiro, Francesca Gazzaniga, Benoit Chassaing, Johannes R Bjork, Marlies Meisel, Giorgio Trinchieri, Bertrand Routy, Jean Jacques Trochon, Laurence Albiges, Laurence Zitvogel


Invited by: Guido Kroemer and PIO 2025 Organizing Committee Day 1 : Tumor immunology immunotherapy Day 2 : Microbiota-immune interface More details... Tags: Immunology, Oncology, Immunotherapy, Microbiota Published on 27-03-2025

	Centre de Recherche des Cordeliers Amphitheatre Farabeuf, Campus des Cordeliers, 15 rue de l Ecole de Medecine 75006

Thursday 26 June 2025 0:00

Bonnes pratiques en bioinfo _ principes FAIR (Findable, Accessible, Interoperable, Reusable)
Thomas Denecker, Imane Messak, Baptiste Rousseau (Institut Français de Bioinformatique)


Invités par Djihad Hadjadj et Benjamin Saint-Pierre. More details... Published on 27-03-2025

	Institut Cochin Salle Rosalind Franklin

Monday 02 June 2025 11:00

A paradigm shift in GPCR recruitment and activity: GPCR Voltage Dependence Controls Neuronal Plasticity and Behavior.
Pr. Moshe Parnas


Invited by: SHULZ Daniel More details... Tags: Integral membrane proteins, Signal transduction, Biochemistry, G protein-coupled receptor, Molecular biology Published on 27-03-2025

	NeuroPSI Salle de conference Albe-Fessard

Monday 22 September 2025 0:00

8e edition - Biologie des Systemes du Cancer - 2025


Analyse de donnees multimodales et modelisation de reseaux pour maitriser les capacites distinctives des cancers Le cours reunira des intervenants de premier plan issus de differents domaines de la biologie des systemes cancereux, de la recherche sur le cancer et de la clinique. Les orateurs invites exposeront diverses approches pour l analyse et l interpretation des donnees omiques, d imagerie et cliniques, en combinant les reseaux de signalisation avec des donnees moleculaires multi-echelles, et en les associant a des donnees cliniques. Les themes abordes comprennent l integration et l analyse de donnees genomiques multimodales, les algorithmes de prediction de la sensibilite aux medicaments, l identification de biomarqueurs et de facteurs de cancer, la stratification des patients, et les applications de la modelisation mathematique et de l analyse d images dans le domaine du cancer. Cette edition comprendra egalement de nouvelles sessions consacrees aux applications actuelles du traitement du langage naturel dans la biologie des systemes computationnels du cancer, a l integration des donnees epigenomiques, ainsi qu aux approches de pharmacologie systemique et de metabolomique. Enfin, un moment fort de la rencontre sera la celebration du 25e anniversaire de la publication de l article fondamental "The hallmarks of cancer" (les capacites distinctives des cancers) de Hanahan et Weinberg (Cell 2000). More details... Published on 18-03-2025

	Institut Curie Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)

Thursday 11 September 2025 0:00

Dissecting the crossroads of circulating and tissue-resident T cells in solid tumors
Alvaro Lladser (Fundacion Ciencia & Vida, Universidad San Sebastián)


Clear cell renal cell carcinoma (ccRCC) is a prevalent and aggressive subtype of kidney cancer. Immunotherapies that boost the ability of CD8+ T cells to eliminate cancer cells have become a standard of care for ccRCC. However, tumor infiltration of CD8+ T cells can result in contradicting clinical outcomes, potentially due to the functional heterogeneity among tumor-specific CD8+ T cells. In this study, we observed that ccRCC tumors are infiltrated by circulating (Tcirc) and tissue-resident (Trm) memory CD8+ T cells that specifically recognize autologous RCC cells in an HLA class I-dependent manner. Trm cells exhibited higher tumor reactivity but reduced stemness potential and a more exhausted state, whereas Tcirc cells retained higher stemness and cytotoxic potential. Single-cell transcriptomics revealed a rather heterogenous composition of memory populations, including cytotoxic and progenitor Tcirc subsets, as well as multiple Trm subsets, including exhausted Trm cells. TCR and trajectory analyses indicate that circulating progenitors lose their circulation, cytotoxicity and stemness potential within the tumor microenvironment while progressively acquiring a tissue-resident differentiation program followed by a terminal differentiation state. Interestingly, tumor enrichment of Trm and cytotoxic Tcirc cells predicts better survival, while exhausted Trm and total CD8+ T cells predict worse survival in RCC patients. Our findings provide new insights into the differentiation pathways and clinical impact of tumor-specific memory CD8+ T cells infiltrating human RCC tumors. Adoptive T cell therapy (ACT) has demonstrated remarkable efficacy in treating hematological cancers. However, its efficacy against solid tumors remains limited and the emergence of cancer cells that lose expression of targeted antigens promotes resistance to ACT. The mechanisms underlying effective and durable ACT-mediated tumor control are incompletely understood. Here, we show that adoptive transfer of TCR-transgenic CD8+ T cells that efficiently eliminates established murine tumors induces tumor accumulation of CD8+ T cells exhibiting tumor-reactive phenotypes. Interestingly, host CD8+ T cells contributed to ACT-mediated elimination of primary tumors and rejected ACT-resistant melanoma cells lacking the targeted antigen. Mechanistically, ACT induced TNF-?- and dendritic cell-dependent tumor accumulation of endogenous CD8+ T cells and effective tumor elimination. Importantly, although lymphodepleting preconditioning enhanced expansion of transferred cells and ACT-mediated tumor elimination, it impaired host antitumor immunity and abrogated protection against ACT-resistant tumors. Tumor enrichment of transcriptional signatures associated with TNF-? signaling, cross-presenting dendritic cells and tumor-specific CD8+ T cells in correlated with favorable responses to ACT and increased survival in human cancers. Our findings reveal that long-term efficacy of ACT is determined by the interplay between transferred and endogenous CD8+ T cells and is undermined by lymphodepleting preconditioning, which ultimately favors ACT resistance. More details... Tags: Immunology, Immune system, T cells, Adoptive cell transfer, Tumor microenvironment, Dendritic cell, Lymphocyte, Immunotherapy, Immunoediting, Natural killer cell Published on 14-03-2025

	Institut Cochin Salle Rosalind Franklin

Friday 04 July 2025 11:00

Paris Post-Doc Seminar | Maria Christina Capizzi


More details... Published on 05-03-2025

	Inst. Bio. Paris Seine 7-9 quai Saint Bernard, 75005 Paris

Friday 27 June 2025 11:00

Seminaire Scientifique | Matthieu Montes (Cnam)


More details... Published on 05-03-2025

	Inst. Bio. Paris Seine 7-9 quai Saint Bernard, 75005 Paris

Wednesday 18 June 2025 11:30

5:2& molecular& motors: from bacterial motility to anti-phage defense
Nicholas Taylor


More details... Tags: Bacteriophages, Bacteriophage, Motility, Phage ecology, Phage display Published on 28-02-2025

	Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie

Tuesday 10 June 2025 12:00

The inflammatory IRF5-TNF axis contributes to cognitive and behavioral effects of type 2 diabetes
Mohammed Al-Onaizi | Kuwait University


Invited by: Fawaz Alzaid Mohammed Al-Onaizi is an Assistant Professor at the Faculty of Medicine, Kuwait University. His research focuses on the intersection of neurodegeneration and metabolic diseases, particularly diabetes and obesity. He holds a Bachelor of Science in Physiotherapy from Kuwait University, a Master's of Science in Human Anatomy from the University of Dundee, and a PhD in Anatomy and Cell Biology from the University of Western Ontario. Dr. Al-Onaizi has held academic positions as an Assistant Professor at Kuwait University and a Visiting Scientist at the University of Laval. His research, supported by grants from Kuwait University and the Dasman Diabetes Institute, explores the molecular and cellular mechanisms underlying diabetes-associated neurodegeneration.Beyond research, he is dedicated to education, mentoring students, and serving on academic committees. He is an active member of the Kuwait University Faculty Members Association and regularly contributes to the scientific community through publications, conference presentations, and outreach initiatives.Seminar topic: The inflammatory IRF5-TNF axis contributes to cognitive and behavioral effects of type 2 diabetes More details... Tags: Cytokines, Endocrine diseases, Metabolic disorders, Tumor necrosis factor, Diabetes Published on 15-02-2025

	Institut Necker Enfants Malades Auditorium 3

Tuesday 03 June 2025 11:30

Perivascular macrophages : key players of the blood-brain neuroimmune interactions
Dr Marina Rubio | Univ. de Caen


Invited by: CIRB - College de France More details... Tags: @cirbcdf.bsky.social Published on 12-02-2025

	College de France au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris

Thursday 12 June 2025 0:00

Targeting neural and muscle stem cells to promote adult hippocampal neurogenesis and muscle growth
Justin Fallon


Invited by Pascal Maire. More details... Tags: Maire, Fallon, The Roots, The Tonight Show, Jimmy Fallon Published on 07-02-2025

	Institut Cochin Salle Rosalind Franklin

Thursday 19 June 2025 16:30

Titre à venir
Loic BROIX


More details... Tags: Anonymous, Botnets, Denial-of-service attacks, Internet-based activism, Low Orbit Ion Cannon, Wakanumun, Loc Bouvard Published on 06-02-2025

	Paris RNA Club Auditorium Gallois - 45 rue d Ulm, 75005 Paris

Tuesday 08 July 2025 9:30

Why neuroblastoma occurs in the adrenal gland? Cell fate decision implication in pediatric cancer
Kameneva Polina


More details... Tags: Pediatric cancers, Adrenal gland disorders, Adrenaline, Brain tumor, Neuroblastoma, Blastoma, Adrenal gland, Malia Jusczyk Published on 01-02-2025

	Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie

Thursday 05 June 2025 0:00

CANCELLED - Identification of biomarkers after Ixodes ricinus tick bite exposure as a diagnostic and surveillance tool
Alexis Dziedziech (EEAP/Bonnet group, Institut Pasteur, Paris)


The escalating spread and density of tick populations underscore the urgent need for enhanced surveillance and risk assessment strategies for tick-borne diseases (TBD). Biomarkers derived from the antibody response to tick saliva can be used to facilitate the surveillance of vector establishment in novel regions, assess anti-vector interventions and diagnose TBD through documentation of antecedent tick bites in suspected cases. Here, we derived short peptides from previously identified immunogenic proteins—namely IrCRT, IrSPI, and IrLIP—through bioinformatic predictive analysis using the Immune Epitope Database. ELISAs performed with experimentally controlled sheep sera infested with Ixodes ricinus were used to assess the level of antibody response of IgM and IgG to the peptides derived from these three proteins. Next, we tested the candidates on sera derived from both field and clinical isolates of tick-exposed individuals. For all sera, we obtained different IgM and IgG responses with varying degrees of immunogenicity detected per peptide. Further, through use of an exploratory microarray assay (PepperPrint™), we selected new peptides based on their ability to be recognized using serum from experimentally infested sheep. Amongst the top randomly generated peptides, we found a more specific immunogenic response against the IgG antibodies when compared to IgM. Selected candidates were further tested against experimentally-controlled infested sheep sera, as well as field and clinical isolates. Finally, candidates were cross-validated against mosquito-exposed sera to ensure vector specificity. This study offers the potential for developing new effective strategies for the surveillance and diagnosis of tick-related risks as well as the control and prevention of TBD. Paris Post-docs seminar series. More details... Tags: Tick-borne diseases, Tick-borne disease, Ixodidae, Ixodes ricinus, Ixodes, Tick, Biomarker, Zoonoses, Deer tick, Lyme disease Published on 01-02-2025

	Institut Cochin Salle Rosalind Franklin

Friday 20 June 2025 11:00

When the non-coding codes: Mining the microproteome for novel regulators of cancer cell plasticity
Maria Abad


My group is focused on the discovery of microproteins relevant for cellular plasticity and cancer. Using a computational method for phylogenetic analysis, we have identified 5 novel and evolutionary conserved microproteins dysregulated in cancer and in cellular differentiation/de-differentiation processes. We have experimentally validated their translation and characterized their molecular functions in vitro and in vivo. Our results demonstrate that our newly identified microproteins are novel regulators of cell identity that play important roles in diverse functions such as induction of cellular differentiation, inhibition of EMT and mitochondrial metabolism, all of them under the umbrella of tumor suppression. Our group also hypothesized that the microproteins' small size makes them ideal candidates to be shed by the cell and act as extracellular messengers. We have mined the pancreatic cancer-secreted microproteome for novel regulators of tumor progression and metastasis. Using proteogenomics in patient-derived samples, we have identified hundreds of microproteins secreted -soluble or coated in exosomes- by pancreatic tumors. The characterisation of our top candidates so far has shown that they can extrinsically promote tumor growth and metastasis. Altogether, our data advances our knowledge on the underexplored microproteome and provides pioneering evidence of its role in cancer cell plasticity and tumor communication. More details... Tags: Oncology, Exosome, Vesicles, Metastasis, Pancreatic cancer, NOV, Cancer, Carcinogenesis, Tumor microenvironment Published on 06-12-2024

	Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie

Apprentissage de modeles a partir des donnees. Machine learning and stochastic optimization. Sylvain Chevalier | Laboratoire Interdisciplinaire des Sciences du Numerique (LISN), Orsay

Department of Parasites and Insect Vectors Seminar : Rob MOON Reassessing merozoite invasion processes and malaria vaccine development usingPlasmodium knowlesi?

Biological tissues as active amorphous solids Marko Popoviamp;#263;

Uptake and recognition of naked extracellular RNAs Juan Pablo TOSAR

Department of Parasites and Insect Vectors Seminar : Professor Hedda Wardemann Rational design of a novel CSP-based Plasmodium falciparum malaria vaccine?

Genomes and Genetique department seminar : Marco TRIZZINO Mechanisms of gene regulation in development and disease

Joint seminar Departement des Parasites et Insectes Vecteurs - Departement Microbiologie : Mathilde GENDRIN Deciphering positive and negative impacts of bacteria on mosquito life cycle

Genomes and Genetique department seminar : Susana COELHO The Curious World of Algae: Mating Rituals and Giant Viruses

Next generation pipeline for next generation spatial transcriptomic data Pierre Bost

The corrinoid model illuminates microbial community interactions across scales Michi Taga

The lysosome: from trash can to signaling hub that controls cell metabolism Andrea Ballabio | Telethon Institute of Genetics and Medicine, Naples, Italy

The endovirome and its epigenetic controllers, or the species-specificity of human biology and of its pathological deviations Didier TRONO

Soft dynamic channels in liquid ordered lipid membrane Anand Srivastava

Synthetic biology tools for mammalian cell engineering Francesca Ceroni

The growth-laws cookbook: Ingredients and recipes for mechanistic models of ribosome allocation in bacteria and beyond Luca Ciandrini- 19/06/2025

Contact-based transfer of thymidylate promotes collective tumor growth Paolo CEPPI

Tracking Reactive Microglia in Health and Disease Dr Li Tristan Quingyun | Washington University School of Medicine

Checkpoint Molecules, Tregs and Induction of Anti-tumor Immunity Vijay KUCHROO (Harvard Medical School, & Brigham and Women's Hospital, Boston, US)

Data Science approaches to GPCR signaling and implications for drug discovery Madan Babu (St Jude Children’s Research Hospital, TN, USA)

The catshark embryo as a model to study the origin and evolution of telencephalic cell types. Idoia Quintana Urzainqui | EMBL Heidelberg Germany

Seminaire Trans-Sciences - Comment se tisse la toile cosmique ? Sandrine Codis (Institut d'Astrophysique de Paris)

Seminaire #8211; Irene Basili

VIP #038; DIF 2025

Biological tissues as materials: fluidity, rigidity and rheology Cristina Marchetti

New tricks of an old dog: senescence induced-cellular plasticity in health amp; disease Han Li | Institut Pasteur

Genome wide data of a Penicillium roqueforti strain from Iron Age Austria: the oldest molecular evidence for fermented blue cheese. Sabry Sarhan

Fundamental principles during the egg-to-embryo transition Andrea PAULI

TBA and es 53BP1 bind to RNA-DNA primers to prevent the activation of innate immune response? Loic BROIX and Patricia UGUEN

IBEID Labex Day 25

Neuroscience Dpt Seminar - Yamuna Krishnan (University of Chicago) - Intracellular Electrophysiology.

The expanding Roles of Autophagy in Epithelial Development: Mechanisms From Morphogenesis to Metabolic Programming and Tissue Adaptation Fernando M. Belmonte

Seminaire Scientifique | Sonia Garel | Informations a venir

Seminaire decale | Julie Batut | Titre a venir

Seminaire Scientifique | Raymond E. Goldstein (Churchill College, Cambridge) | Titre a venir

Seminaire decale | Marie Legendre | Titre a venir

Seminaire scientifique | Loic Broix (NeuroSU) | Titre a venir

Seminaire decale | Raja Chatila | Titre a venir

A cross talk between p53 and the cell cycle regulates apoptotic induction and tumor formation in Drosophila Carlos Estella

Adjusting the timing of mammalian development Aydan Karslioglu

L#39;energie d#39;adhesion controle l#39;endocytose mediee par la liaison des lipides Helge Ewers

Fueling macrophages with metabolic recycling of bacteria Johan Garaude

#39;Adventures in Chemical Biology - From in vivo chemistry to real-time optical medical imaging#39; Mark BRADLEY

Mitohormesis and metabolic adaptations in response to therapeutic stress in acute myeloid leukemia Jean-Emmanuel Sarry | Centre de recherches en cancerologie de Toulouse (CRCT)

Functional interplay between the chromatin assembly factor 1 (hCAF-1) and the BLM helicase in mammalian cells Vincent PENNENEACH | Institut Curie, Orsay

Molecular Mechanisms of Chromosome Folding and Enhancer Wiring Elphege Nora

Illuminating Compartmentalized Metabolic Regulation in Single Cells Danielle L. Schmitt

The metabolic control of growth and senescence Dr Mario Pende | Institut Necker Enfants Malades

Intravascular Cues Shape Tumor Metastasis Dr Jacky Goetz | Centre de Recherche en Biomedecine de Strasbourg

Imagination and the neurophysiology of decision-making Dr David Redish | Univ. Minnesota

Department of Parasites and Insect Vectors Seminar : Professor Rita Tewari Unravelling atypical rapid mitosis inPlasmodium?

Paris Post-Doc Seminar | Maria Christina Capizzi (ICM)

Developmental Programming of Tissue-Resident Macrophages Elvira Mass | LIMES Institute - University of Bonn

Discovery of Potential Anti-tuberculosis Agents Jichan Jang

La mecanobiologie des fuseaux mitotiques revele une loi d#39;echelle universelle regie par l#39;encombrement des chromosomes Nenad Pavin

Title to be announced Jamie Hackett (EMBL Roma)

TBA Hamid Kellay | LOMA

Plant root growth in mechanically heterogeneous substrates Evelyne Kolb

Retour d#039;experience sur la creation de start-up Stefano Marullo, Raphaël Scharfmann (Institut Cochin)

Bonnes pratiques en bioinfo _ principes FAIR (Findable, Accessible, Interoperable, Reusable) Thomas Denecker, Imane Messak, Baptiste Rousseau (Institut Français de Bioinformatique)

A paradigm shift in GPCR recruitment and activity: GPCR Voltage Dependence Controls Neuronal Plasticity and Behavior. Pr. Moshe Parnas

8e edition - Biologie des Systemes du Cancer - 2025

Dissecting the crossroads of circulating and tissue-resident T cells in solid tumors Alvaro Lladser (Fundacion Ciencia & Vida, Universidad San Sebastián)

Paris Post-Doc Seminar | Maria Christina Capizzi

Seminaire Scientifique | Matthieu Montes (Cnam)

5:2& molecular& motors: from bacterial motility to anti-phage defense Nicholas Taylor

The inflammatory IRF5-TNF axis contributes to cognitive and behavioral effects of type 2 diabetes Mohammed Al-Onaizi | Kuwait University

Perivascular macrophages : key players of the blood-brain neuroimmune interactions Dr Marina Rubio | Univ. de Caen

Targeting neural and muscle stem cells to promote adult hippocampal neurogenesis and muscle growth Justin Fallon

Titre à venir Loic BROIX

Why neuroblastoma occurs in the adrenal gland? Cell fate decision implication in pediatric cancer Kameneva Polina

CANCELLED - Identification of biomarkers after Ixodes ricinus tick bite exposure as a diagnostic and surveillance tool Alexis Dziedziech (EEAP/Bonnet group, Institut Pasteur, Paris)

When the non-coding codes: Mining the microproteome for novel regulators of cancer cell plasticity Maria Abad

Apprentissage de modeles a partir des donnees. Machine learning and stochastic optimization.
Sylvain Chevalier | Laboratoire Interdisciplinaire des Sciences du Numerique (LISN), Orsay

Biological tissues as active amorphous solids
Marko Popoviamp;#263;

Uptake and recognition of naked extracellular RNAs
Juan Pablo TOSAR

Next generation pipeline for next generation spatial transcriptomic data
Pierre Bost

The corrinoid model illuminates microbial community interactions across scales
Michi Taga

The lysosome: from trash can to signaling hub that controls cell metabolism
Andrea Ballabio | Telethon Institute of Genetics and Medicine, Naples, Italy

The endovirome and its epigenetic controllers, or the species-specificity of human biology and of its pathological deviations
Didier TRONO

Soft dynamic channels in liquid ordered lipid membrane
Anand Srivastava

Synthetic biology tools for mammalian cell engineering
Francesca Ceroni

The growth-laws cookbook: Ingredients and recipes for mechanistic models of ribosome allocation in bacteria and beyond
Luca Ciandrini- 19/06/2025

Contact-based transfer of thymidylate promotes collective tumor growth
Paolo CEPPI

Tracking Reactive Microglia in Health and Disease
Dr Li Tristan Quingyun | Washington University School of Medicine

Checkpoint Molecules, Tregs and Induction of Anti-tumor Immunity
Vijay KUCHROO (Harvard Medical School, & Brigham and Women's Hospital, Boston, US)

Data Science approaches to GPCR signaling and implications for drug discovery
Madan Babu (St Jude Children’s Research Hospital, TN, USA)

The catshark embryo as a model to study the origin and evolution of telencephalic cell types.
Idoia Quintana Urzainqui | EMBL Heidelberg Germany

Seminaire Trans-Sciences - Comment se tisse la toile cosmique ?
Sandrine Codis (Institut d'Astrophysique de Paris)

Biological tissues as materials: fluidity, rigidity and rheology
Cristina Marchetti

New tricks of an old dog: senescence induced-cellular plasticity in health amp; disease
Han Li | Institut Pasteur

Genome wide data of a Penicillium roqueforti strain from Iron Age Austria: the oldest molecular evidence for fermented blue cheese.
Sabry Sarhan

Fundamental principles during the egg-to-embryo transition
Andrea PAULI

TBA and es 53BP1 bind to RNA-DNA primers to prevent the activation of innate immune response?
Loic BROIX and Patricia UGUEN

The expanding Roles of Autophagy in Epithelial Development: Mechanisms From Morphogenesis to Metabolic Programming and Tissue Adaptation
Fernando M. Belmonte

A cross talk between p53 and the cell cycle regulates apoptotic induction and tumor formation in Drosophila
Carlos Estella

Adjusting the timing of mammalian development
Aydan Karslioglu

L#39;energie d#39;adhesion controle l#39;endocytose mediee par la liaison des lipides
Helge Ewers

Fueling macrophages with metabolic recycling of bacteria
Johan Garaude

#39;Adventures in Chemical Biology - From in vivo chemistry to real-time optical medical imaging#39;
Mark BRADLEY

Mitohormesis and metabolic adaptations in response to therapeutic stress in acute myeloid leukemia
Jean-Emmanuel Sarry | Centre de recherches en cancerologie de Toulouse (CRCT)

Functional interplay between the chromatin assembly factor 1 (hCAF-1) and the BLM helicase in mammalian cells
Vincent PENNENEACH | Institut Curie, Orsay

Molecular Mechanisms of Chromosome Folding and Enhancer Wiring
Elphege Nora

Illuminating Compartmentalized Metabolic Regulation in Single Cells
Danielle L. Schmitt

The metabolic control of growth and senescence
Dr Mario Pende | Institut Necker Enfants Malades

Intravascular Cues Shape Tumor Metastasis
Dr Jacky Goetz | Centre de Recherche en Biomedecine de Strasbourg

Imagination and the neurophysiology of decision-making
Dr David Redish | Univ. Minnesota

Developmental Programming of Tissue-Resident Macrophages
Elvira Mass | LIMES Institute - University of Bonn

Discovery of Potential Anti-tuberculosis Agents
Jichan Jang

La mecanobiologie des fuseaux mitotiques revele une loi d#39;echelle universelle regie par l#39;encombrement des chromosomes
Nenad Pavin

Title to be announced
Jamie Hackett (EMBL Roma)

TBA
Hamid Kellay | LOMA

Plant root growth in mechanically heterogeneous substrates
Evelyne Kolb

Retour d#039;experience sur la creation de start-up
Stefano Marullo, Raphaël Scharfmann (Institut Cochin)

Bonnes pratiques en bioinfo _ principes FAIR (Findable, Accessible, Interoperable, Reusable)
Thomas Denecker, Imane Messak, Baptiste Rousseau (Institut Français de Bioinformatique)

A paradigm shift in GPCR recruitment and activity: GPCR Voltage Dependence Controls Neuronal Plasticity and Behavior.
Pr. Moshe Parnas

Dissecting the crossroads of circulating and tissue-resident T cells in solid tumors
Alvaro Lladser (Fundacion Ciencia & Vida, Universidad San Sebastián)

5:2& molecular& motors: from bacterial motility to anti-phage defense
Nicholas Taylor

The inflammatory IRF5-TNF axis contributes to cognitive and behavioral effects of type 2 diabetes
Mohammed Al-Onaizi | Kuwait University

Perivascular macrophages : key players of the blood-brain neuroimmune interactions
Dr Marina Rubio | Univ. de Caen

Targeting neural and muscle stem cells to promote adult hippocampal neurogenesis and muscle growth
Justin Fallon

Titre à venir
Loic BROIX

Why neuroblastoma occurs in the adrenal gland? Cell fate decision implication in pediatric cancer
Kameneva Polina

CANCELLED - Identification of biomarkers after Ixodes ricinus tick bite exposure as a diagnostic and surveillance tool
Alexis Dziedziech (EEAP/Bonnet group, Institut Pasteur, Paris)

When the non-coding codes: Mining the microproteome for novel regulators of cancer cell plasticity
Maria Abad