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Tuesday 03 November 2026    9:00
Invited by: Frederic LEMOINE The ShareFAIR days are a two-day gathering uniting our project partners and the broader scientific community to advancing the reproducibility of neuro-vascular research. As we navigate the complexities of massive, multi-scale health data, we ... More details...
Invited by: Camille Dos Santos-Toinet The STAPA International Network Congress (SINC) is an international scientific congress dedicated to host-pathogen interactions.Organized by the Young Researcher Association of Institut Pasteur of Paris (STAPA) and in collaboration with Institut Pasteur and the ... More details...
Tags: Grand Cross of the Legion of Honour, COVID-19 pandemic in France, Pasteur Institute, Louis Pasteur, Sinc function
Published on 17-07-2026
Institut Pasteur
Batiment CIS, salle ,
Monday 21 September 2026    11:00
Groups of migrating cells are usually guided by external cues, such as gradients of chemoattractant (chemotaxis), substrate stiffness (durotaxis), or electrostatic potential (electrotaxis). Here, I will show that cell groups can also be guided by internal cues, i.e., by gradients of their own properties. We found that, when moving from soft to stiff substrate, clusters of neural crest cells exhibit an opposite gradient in their own tissue stiffness, with soft cells at the front and stiff cells at the back. We predict that this internal stiffness gradient is enough to guide collective cell migration - a phenomenon that we call internal durotaxis. Moreover, these cell clusters are taller at the back than at the front. We explain this asymmetric height profile by modeling the cell cluster as an active liquid droplet driven by the motile cells at its base. We speculate that the emergence of internal guidance cues could provide robustness to the migration of cell clusters in noisy environments. More details...
Tags: Indian feudalism, Kulkarni, Surnames, Films, Saleel Kulkarni, Poshter Boyz
Published on 17-07-2026
Centre de Recherche des Cordeliers
Friday 18 September 2026    11:45
Invite par l'equipe Dumont, Prof. Omaya Dudin (Dpt. Biochemistry, University of Geneva) presentera un seminaire de l'Institut Jacques Monod sur le theme : Exploring multicellular developmental programs at the root of animals and beyond Resume : All animals develop from a single-celled zygote and undergo complex morphogenetic processes to form multicellular organisms. These processes are regulated by intrinsic and extrinsic factors that drive key developmental events, such as symmetry breaking, cell division, and differentiation. Despite the remarkable conservation of these pathways across species, the evolutionary origins of these morphogenetic mechanisms remain unclear. A major challenge in addressing this question is the limited availability of microscopy and cell biological data from key protists that occupy pivotal phylogenetic positions in the eukaryotic tree, including those identified as the closest unicellular relatives of animals. In this talk, I will present how our lab is utilizing Expansion Microscopy to capture novel ultrastructural details of microbial life cycles. I will also share recent insights into Ichthyosporeans, a lineage of protists closely related to animals, which exhibit diverse multicellular development strategies. These include species that undergo coenocytic development followed by cellularization, as well as others that develop through cleavage divisions to form spatially organized multicellular colonies. Our findings highlight the importance of studying diverse unicellular taxa to trace the origins of animal multicellularity, positioning Ichthyosporeans as a promising model for exploring the evolutionary roots of animal embryogenesis. More details...
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France
Thursday 30 July 2026    10:00
During development, organs acquire their function by assembling repeating structural units into coherent architectures. While the formation of individual units from cellular processes is increasingly well characterized, how neighbouring units coordinate their growth to achieve reproducible tissue organization remains unclear. Here, we focus on the mouse intestine, where thousands of stem-cell-rich crypts form postnatally with initially highly variable morphologies. Combining in vivo developmental time courses, organoids, and biophysical modelling, we find that crypts rapidly converge morphologically in response to tissue-scale mechanical changes in the surrounding villi. We show that transient swelling of villus enterocytes relaxes epithelial tension and increases crypt cell density. This density increase activates a mechanosensitive pathway in stem cells, in which the cytosolic calcium-dependent phospholipase cPLA2 promotes apical myosin relocalization. This process synchronizes apical contractility across neighbouring crypts, driving their morphological convergence. Disruption of either pathway instead leads to winner-takes-all dynamics, where only the initially more mature crypts close, at the expense of the others. Together, these findings identify a general principle of morphogenesis in which a global mechanical context, coupled with local cellular mechanosensation, prevents competitive amplification of variability and coordinates individual units to ensure reproducible tissue architecture. More details...
Invite par l'equipe Ladoux/Mege, Bram Hoogland (Vrije Universiteit, Amsterdam, Netherlands) presentera un seminaire de l'Institut Jacques Monod : Data-Driven Inference of Cell Migration and Polarity Dynamics Resume : Cell migration emerges from coupled processes including polarity, biochemical signaling, adhesion, and mechanical interactions. These processes govern how cells move, deform, and respond to one another, yet integrating them into a unified dynamical description remains a major challenge. Experiments typically capture only the resulting behaviors, such as cell shape and trajectories. Here, we present a data-driven framework to learn and disentangle underlying dynamics directly from observed cell behavior and apply it across scales from polarization dynamics of single cells to multicellular systems. In multicellular migration, our framework reveals distinct interaction rules across cell types. Non-cancerous epithelial cells exhibit reciprocal repulsion and velocity alignment, whereas cancerous mesenchymal cells additionally show nonreciprocal interactions that modulate self-propulsion. These nonreciprocal interactions shift the onset and speed of cellular flocks, linking microscopic interaction rules to collective behavior. Using experiments with a molecular polarity marker, (from the amazing Joseph), we uncover how cell motion, morphology, and polarity are coupled. We identify dynamical states associated with persistent migration in small cells but find that these states are absent in large cells, revealing a coupling between cell length and polarity-driven migration. Lastly, we have started making the first steps in learning a full 3D stochastic reaction diffusion model directly from experiments on budding yeast, capturing their symmetry breaking and finding active transport. Overall, our data-driven framework provides a principled route to learning interpretable dynamics from experiments, enabling comparison across cell types and linking cell-intrinsic dynamics and cell-cell interactions to emergent behavior. More details...
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France
Wednesday 30 September 2026    9:00
Invited by: Mallory Perrin-Wolff Stengthening Institut Pasteur's european partnerships, which can be a source of multiple scientific opportunities as well as new funding, is one of the key priorities of the Pasteur 2030 strategic plan.In this spirit, Institut ... More details...
Tags: Epidemiology, COVID-19 pandemic in France, Pasteur Institute, Louis Pasteur, Infection
Published on 08-07-2026
Institut Pasteur
Batiment: Duclaux Salle: Duclaux Lecture Hall
Tuesday 08 December 2026    0:00
This workshop aims to bridge this gap by giving a theoretical and practical training on functional ultrasound imaging (fUSi) from recognized leaders in the field. It is primarily intended to PhD students and postdocs aiming to use fUSi in their experiment, but we also welcome untrained scientists eager to discover its principle and applications. No prerequisite is necessary. Through six interactive modules, we will cover the theoretical bases of ultrafast imaging (Module #1), hands-on training on surgical design (Module #2), practical implementation of fUSi experiments in different contexts and species (Module #3), how to preprocess and analyze fUS data (Module #4). We will finally cover the specific developments of fUSi in clinical settings (Module #5) and ultrasound-based advances that offer promising avenues for neuroscience (Module #6) More details...
Tags: Acoustics, Ultrasound, Medical imaging, Magnetic resonance imaging, Medical equipment, Functional ultrasound imaging, Medical ultrasound, Gravis UltraSound
Published on 02-07-2026
I. Cerveau et de la Moelle
Institut du cerveau
Thursday 03 September 2026    11:00
Invited by: Manish Kushwaha Information essential for life is encoded within DNA, yet this molecule is constantly challenged by diverse sources of damage. Our research program asks how microbial cells regulate DNA damage repair in space and time, using high-resolution imaging to track replication, recombination and repair inside individual cells. In this talk, I will focus on double-strand break repair by homologous recombination, centred on homology search, in which a RecA nucleoprotein filament must locate a matching sequence within a crowded genome. Our work shows that homology search is not a passive, diffusive scan but an actively organised process unfolding in two steps. First the filament must encounter its candidates, a problem of movement. We find that the SMC-like protein RecN acts as a DNA motor, driving filaments in long-range, back-and-forth sweeps across the cell, with a conserved DNA helicase an essential partner in this motion. A chance encounter must then become a commitment, and here the genome’s own topology supplies the selectivity. RecA filaments overwhelmingly favour negatively supercoiled targets, so that supercoiling, not mere proximity, finally licenses a faithful pairing. Together these pieces describe a coordinated apparatus for moving genetic information faithfully within a cell. Indeed, the same recombination machinery can move information between cells as well, and the very processes that protect genetic information are also the ones that move and reshape it. More details...
In animal development, timing matters. Phenomena operating within distinct levels-those of molecules, organelles, cells, or tissues, span the extremes of timescales and give rise to the clock work of development. Developmental programs are under genetic controf?however, the physical basis of these processes lie within the components that drive it - molecules, organelles, cells, supracellular assemblies. Capturing these mechanisms requires imaging approaches that can span different scales, molecular to tissue level processes demand both high spatial and temporal resolutions simultaneously. In the first part, I will introduce light-sheet microscopy and exemplify cell biological studies using endosomal timekeeping of biochemical reactions at single cell levels. However, these approaches are limited by the absence of physiological context as cells are investigated in isolation. In the second part, I will describe imaging approaches based on Airy beam-based light sheet microscopy of organelles in tens to hundreds of cells in a few hundred micrometre-wide tissue environments that will enable. This approach achieves a typical resolution of 320 nm over 266 × 266 × 100 ?m3 volumes at a temporal rate of 0.05 Hz that now allows tracking molecules and organelles in large living tissues. I will detail out how such imaging across scales allows discovering new phenomena in tissue morphogenesis using Drosophila as a model system, where we address how during germ band extension, the monolayer of cells from the central side wrap around the high curvature posterior pole onto the dorsal surface. We discover an interplay between curvature, waves of cell divisions within domains and tissue fluidization that work together to preserve segment boundaries. Finally, I will conclude by addressing data challenges, including visualization and analysis, and outlook on the future of biological problems that these approaches unravel. More details...
Centre de recherche - Paris - Amphitheatre Marie Curie
Thursday 24 September 2026    12:00
James H. Hurleyis a leading structural biologist ( https://vcresearch.berkeley.edu/faculty/james-hurley), whose work has transformed our understanding of the interplay between proteins and membrane lipids. He is especially known for seminal studies to uncover molecular mechanism ofthe ESCRTmachinery, HIVtrafficking, retrograde trafficking by retromer, and the autophagycore complexes, combining crystallography, cryo-EM, and reconstitution on model membranes to explain how cells sort cargo, remodel membranes, and initiate autophagy ( https://scholar.google.com/citations?user=SoNEZA8AAAAJ&hl=en). More details...
Tags: Cell biology, Protein structure, Organelles, Autophagy, Cell death, Immunology, Cryogenic electron microscopy, Structural biology, Lysosome
Published on 18-06-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie
amphitheatre Marguerite de Navarre du College de France
Tuesday 22 September 2026    9:00
The Postdoc Appreciation Week will be back for its second edition this September: the opportunity to celebrate the unique contribution of the postdoctoral community to science. Postdoc Appreciation Week (PAW) is a global tradition ... More details...
Tags: Academic administration, Postdoctoral researcher, National Postdoctoral Association
Published on 11-06-2026
Institut Pasteur
Batiment: Center Francois Jacob Salle: CFJ auditorium & Atrium
au College de France Salle D2
11 place Marcelin Berthelot - 75005 Paris
Friday 09 October 2026    0:00
Previous editions have explored topics ranging from mechanotransduction the mechanical forces that shape brain development to the physics of neurotransmission, spatial mechanotranscriptomics, and the emerging field of mechanomedicine. Building on these advances, this year&'s symposium will delve deeper into the physical principles that govern brain metabolism and function, continuing to expand the frontiers of neuroscience. More details...
Exciting developments in quantum biology highlighted by an inaugural conference featuring Sonia Contera, Professor of Biological Physics at the University of Oxford.Physical approach to brain metabolism, incorporating thermodynamic principles and the emerging concept of photons as synaptic transmitters.A pioneering discipline at the intersection of biophysics, metabolism and medicine, focusing on mechanodiseases.A thought-provoking closing lecture on the relationship between metabolism and cognition.
Monday 30 November 2026    9:00
Invited by: Benoit Chassaing To officially launch this major programme, the Pasteur Institute invites you to a two-day series of talks featuring speakers from around the world as well as from the Pasteur Institute. Further details on the ... More details...
Tags: Microbiome, Pasteur Institute, Louis Pasteur, Bioinformatics, Human Microbiome Project
Published on 09-06-2026
Institut Pasteur
Batiment: CIS Salle: CIS
Monday 19 October 2026    0:00
From Stem Cells to Morphogenesis Ce cours intensif combine une formation theorique et pratique afin d'explorer les concepts fondamentaux, les defis et les technologies de la biologie du developpement moderne. Le programme couvre des sujets allant de la regulation de l'expression genique et des interactions cellulaires a la formation d'un embryon multicellulaire organise. Les participants sont inities a une variete de modeles embryonnaires, incluant des organismes modeles genetiques tels que Drosophila, C. elegans, la souris et le poisson zebre, ainsi que des modeles classiques d'embryologie experimentale tels que le Xenopeet le poulet. Ces modeles sont etudies a l'aide de methodologies et de technologies de pointe. Les etudiants peuvent beneficier a la fois d'un enseignement theorique (10 jours de cours magistraux) et d'une formation experimentale (3 semaines de travaux pratiques) portant sur les aspects normaux et pathologiques du developpement. À noter que le module de cours magistraux de 10 jours peut etre suivi seul ou en combinaison avec le module de travaux pratiques. Les cours magistraux sont dispenses par des chercheurs de renommee internationale et abordent des thematiques telles que la specification et la differenciation cellulaires, la biologie des cellules souches, la morphogenese et l'organogenese, la signalisation intracellulaire, ainsi que la regulation de l'expression genique au cours du developpement. Le cycle de conferences se conclut par un congres scientifique international de 1,5 jour consacre a la morphogenese, offrant a de nombreux participants l'opportunite d'assister a leur premiere conference scientifique. OBJECTIF(S) L'objectif est de familiariser les etudiants avec les concepts recents de la Biologie du developpement en soulignant plus particulierement leur importante contribution aux domaines des cellules souches et des sciences cliniques. Differents champs de la Biologie du developpement sont presentes en relation avec les cellules souches, non seulement a travers la diversite des modeles embryonnaires mais aussi a travers les approches recentes developpees dans ces domaines (approches a grande echelle, modelisation mathematique, approches biophysiques?). Plus d informations More details...
Published on 06-06-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)
Monday 05 October 2026    0:00
Founded by leading researchers, Professors Stephanie Debette and Sudha Seshadri, this annual event brings together a vibrant global community for an immersive, cross?disciplinary training experience. More details...
Tags: Institute of Science and Technology Austria, Ista, Lora, International Seed Testing Association
Published on 04-06-2026
NeuroPSI
Salle de conference Albe-Fessard
Thursday 03 September 2026    9:00
The first day will be devoted to presentations by international experts on methods, applications and issues related to longitudinal data. The second day will offer practical tutorials around open-source software in R and Python, including Leaspy, JMbayes2, lcmm and saemix. More details...
Tags: Social research, Design of experiments, Longitudinal study, Nursing research, Observational study
Published on 02-06-2026
I. Cerveau et de la Moelle
Day 1 - Thursday September 3, 2026
Friday 30 October 2026    9:00
Invited by: Darragh Duffy 30th OCTOBER 2026 | INSTITUT PASTEUR | FRANCE We are happy to announce the 2026 yearly meeting of Milieu Interieur LabEx Join un on the morning of the 30th of October at 9am at ... More details...
Tags: Corruption in France, Organized crime in France
Le 8e cours «?Biologie cellulaire et cancer»?explorera comment les formes biologiques emergent a differentes echelles, de l'organisation intracellulaire jusqu'aux tissus et aux organismes entiers. Il mettra l'accent sur des processus cellulaires cles tels que la dynamique du cytosquelette et le trafic intracellulaire, et sur la maniere dont ces processus faconnent des structures cellulaires complexes. Le cours abordera egalement la formation de patterns, la morphogenese et les comportements collectifs des cellules a l'echelle des tissus, dans le contexte de la mecanobiologie et de la biologie du developpement. More details...
Published on 07-05-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)
Tags: Medical imaging, Tomography, Crista, Volumetric Electron Microscopy
Published on 29-04-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie
Monday 21 September 2026    0:00
L heterogeneite observee entre les tumeurs de differents patients, et meme entre les cellules cancereuses d'un meme patient, complique considerablement le developpement de traitements. La medecine « personnalisee » ou « de precision » vise a surmonter ce probleme en proposant un traitement adapte a chaque patient, en fonction de son profil genetique individuel et de la signature moleculaire de sa tumeur. Cet objectif ambitieux necessite une caracterisation moleculaire approfondie du cancer chez le patient, a l'aide de technologies a haut debit et de techniques d'imagerie avancees. Beaucoup de donnees multi-echelles sur le cancer deviennent disponibles, mais elles restent encore largement sous-exploitees pour elucider les mecanismes sous-jacents et ainsi guider la stratification des patients et le choix des traitements. L'analyse integrative multimodale des donnees omiques et cliniques offre un fort potentiel pour elucider les bases moleculaires des differents types de cancer. L'integration multimodale des donnees sur la maladie est particulierement prometteuse pour mettre en evidence les relations complexes entre les mecanismes moleculaires qui contribuent collectivement a la maladie. More details...
Published on 18-04-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)
Monday 28 September 2026    0:00
Le cours est dedie aux connaissances les plus actuelles articulant la biologie du developpement et l etude cellulaire et moleculaire des cancers. Les cretes neurales et les melanomes, depuis leur formation jusqu a leur migration (metastases), ainsi que les cancers pediatriques d'origine embryonnaires tels que les medulloblastomes et neuroblastomes sont pris comme exemples. Le cours beneficie d une approche multidisciplinaire a multiples echelles (embryologie sur des modeles varies, biophysique, biologie cellulaire, transcriptomique, imagerie...). Il aborde egalement des approches therapeutiques et ainsi que la prise en compte des 3R en recherche avec l'invitation des chercheurs developpant des organoides et des modeles animaux alternatifs. Le cours est ponctue par des tables rondes sur les carrieres dans le milieu academique ou dans l industrie,sur la publication d articles scientifiques ainsi que sur l ethique en experimentation animale.Des sessions posters de doctorants sont egalement organises et des prix pour les meilleurs posters seront decernes par les participants aux cours. More details...
Published on 10-04-2026
Institut Curie
Centre de recherche - Orsay - Amphitheatre du Batiment 111
Monday 21 September 2026    0:00
The Conference Jacques Monod » The mechanistic and evolutionary basis of programmed DNA elimination» will take place fromMonday, September 21, 2026 toFriday, September 25, 2026 in Roscoff (Bretagne, France). Abstracts submission deadline :Tuesday, May 5, 2026 Deadline for payment of registration fees :July 2, 2026 Deadline for return of completed forms :July 2, 2026 Registration and abstract submission website Beyond mutations, the genetic content of an organism is generally constant across cells throughout development. Programmed DNA elimination (PDE) - a process in which specific cell lineages lose DNA segments or whole chromosomes - represents is a striking deviation to this principle. PDE is widespread in eukaryotes and plays roles in a variety of cellular processes, including gene silencing, germline differentiation, genome defence, and non-Mendelian inheritance. It manifests in diverse biological contexts, including the formation of germline-limited genomes, meiotic elimination of parental chromosomes, and sex determination via X-chromosome loss. In recent years, it has become increasingly clear that PDE occurs across a wide range of phylogenetic groups, and involves diverse mechanisms. These findings underscore the overlooked plasticity of genome integrity, and reveal significant gaps in our understanding of why PDE has evolved repeatedly and is maintained across the Tree of Life. This conference is designed to present the latest research on the mechanisms and evolution of PDE - from the molecular pathways that control genome stability and chromosome segregation, to genomic conflictsand the long-term evolutionary consequences of PDE on population dynamics and species diversification.We also welcome researchers studying related phenomena, such as meiotic drive, B chromosomes, and those that work on the mechanisms and regulation of genome stability, chromosome segregation and germline development. The meeting will address the following key topics: Mechanisms and regulation of genome stability and instability Mechanisms of chromosome segregation and missegregation Genomic conflicts Evolutionary dynamics of programmed DNA elimination More details...
Epigenome editing is a rapidly emerging field that has the potential to revolutionise genomic medicine by offering new ways to precisely program gene expression and treat a range of diseases. Precision control of the epigenome and gene activity is further unlocking key mechanistic insights into a wide variety of molecular and cellular processes. The potential of epigenome editing technologies for both research and therapeutic applications has thus led to widespread excitement over the last five years, in areas ranging from neurobiology, to high-throughput (epi)genomics to agriculture. As the technologies continue to emerge and the epigenome editing field begins to coalesce, we feel now is the time to bring interdisciplinary experts and leaders in the field together. This will enable, for the first time, epigenome editors and related disciplines to collectively discuss the technology, its applications and ethics, and the exciting scientific insights being generated. Such a symposium will help to accelerate progress in this field by facilitating collaborations between researchers and providing a platform for the dissemination of new discoveries and techniques. It will also help to raise broader awareness of this exciting emerging science and its potential to transform precision medicine. Time and Place The meeting will take place fromNovember 16-17atInstitut Jacques Monodin the heart of Paris, France We will have two half day sessions, and a poster session over cocktails and light bites Key Dates Abstract Submission:October 1, 2026 Registration:November 9, 2026 Invited Speakers ? Gabriella Ficz (QMUL, UK) ? Charles Gersbach (Duke University, USA) ? Jamie Hackett (EMBL Rome, Italy) ? Jake Harris (Cambridge University, UK) ?Angelo Lombardo (San Raffaele University, Italy) ? Reini Luco (Institut Curie, France) ?Mariane Rots (UMCG, Netherlands) ?Edda Schulz (MPI Berlin, Germany) ?Stefan Stricker (Helmholtz Munich, Germany) More speakers will be selected from abstracts! You can find all the informations regarding the symposium, the registration and abstract submission here Flyer of the event: here More details...
Tags: Pasteur Institute, Yasmine Belkaid, Yasmin, Aboubakr Belkaid, Lurie Prize in Biomedical Sciences
Published on 04-03-2026
Centre de Recherche des Cordeliers
Thursday 24 September 2026    9:00
Every year, the Centre de Recherche des Cordeliers organises a scientific day where its young researchers, students and post-docs present their work.Prestigious speakers are also invited to take part.This year, we will be welcoming:This event is open to the entire scientific community. More details...
Tags: Inquiry, Observation, Science, European Research Council
Published on 27-02-2026
Centre de Recherche des Cordeliers
Monday 14 September 2026    14:00
Invited by: Giulia Manina Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains one of the deadliest infectious diseases worldwide. Meanwhile, non-tuberculous mycobacteria (NTM) are an increasing global health concern. NTM infections often resemble TB clinically, which can lead to ... More details...
Invited by: Darragh Duffy Thursday 29th Oct 26 | Institut Pasteur KEYNOTE SPEAKERS ? Prof. Yasmine Belkaid President of the Institut Pasteur (Paris), Professor Yasmine Belkaid is an internationally recognized immunologist specializing in host-microbiota interactions and tissue immunity. ... More details...
Tags: Pasteur Institute, Yasmine Belkaid, Microbiology, Microbiomes, Bacteriology, Louis Pasteur, Variability, Human microbiome