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TBA Plus d'infos... Tags: Besse, Autonomism, Guillaume Besse, Eugne Besse Annonce publiée le 02-09-2025 |
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| Laboratoire Jean Perrin Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407 |
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Active systems, such as living cells, are traditionally modelled via self-propelled particles driven by internal forces. It is however often assumed that these internal forces do not depend on the environment which is questionable from a biological perspective. Here we use the framework of Generalized Langevin Equations (GLE) to go beyond this paradigm by incorporating internal state dynamics and environmental sensing into active particle models. We show that when the self-propulsion of a particle depends on internal variables themselves depending on the environment, qualitatively new behaviours emerge. These include memory-induced responses, controllable localization in complex landscapes, and suppression of motility-induced phase separation or enhanced jamming transitions. Our results demonstrate how minimal information processing capabilities, intrinsic to nonequilibrium systems like living cells, can profoundly influence both individual and collective behaviours. This framework bridges cell-scale activity and large-scale intelligent motion of active agents and offers insights relevant to systems ranging from synthetic colloids to biological collectives or robotic swarms.
Plus d'infos...
Tags: Zoology, Complex systems theory, Multi-agent systems, Biophysics, Ethology, Self-propelled particles, Swarm behaviour, Jamming, Colloid
Annonce publiée le 10-09-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407 -
Invite par: CIRB
Plus d'infos...
Tags: Protein structure, Bioinformatics, Biotechnology, Protein methods, Proteomics
Annonce publiée le 08-08-2025
College de France
au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris -
From a scientific concept to an innovative cell &gene therapy product
Plus d'infos...
Tags: Amigorena, Zelia, Claude Vivier, Menegatti, Eyquem, Puisieux, Vivier, Paoletti, Tovar
Annonce publiée le 12-09-2025
Institut Curie -
Invite par: Emmanuel Beaurepaire
Blood cell / vessel wall interactions are critical both for the flow of red blood cells, and for the control of white blood cell adhesion to the walls (e.g. at a site of inflammation). However, the biochemical and mechanical cues governing their tight regulation are still poorly understood, in particular because of the challenge of non-invasive investigation of cell-wall short-range interactions under flow in a complex environment. Using a home-built platform combining advanced biochemical surface functionalization, microfluidics and high-speed interferometric imaging, we have investigated experimentally the role of the softness of the vessel wall outer layer in the regulation of blood cell homing under flow. This brush, named glycocalyx and mainly composed of polysaccharides, is both thick (up to 1m) and extremely soft (down to a few Pa in compression modulus). In this presentation, I will illustrate with experimental data and modelling how the glycocalyx acts as a gatekeeper for the adhesion to the blood vessel wall, and discuss the importance of soft adhesion in biology and its underlying soft matter concepts.
Tags: Cell biology, Glycobiology, Glycocalyx, Polymers, Polysaccharides, Red blood cell, Microfluidics, Cell adhesion
Annonce publiée le 29-08-2025
Ecole Polytechnique
PC44 -
Invite par: Marie-Anne FELIX - Section Ecologie et Biologie de l’Evolution
Plus d'infos...
Tags: Microbiomes, Bacteriology, Microbiology, Environmental microbiology, Bacteria, Microbiota, Gut microbiota, Human microbiome, Flora, Microbiome in the Drosophila gut
Annonce publiée le 23-09-2025
IBENS
salle Favard, IBENS 46 rue d'Ulm 75005 Paris -
The opportunistic human fungal pathogen Candida albicans displays a high degree of morphological plasticity, with the ability to switch between at least 7 different forms, depending on its environment. Of these, the hyphal form is able to penetrate host mucosal surfaces and therefore plays an important role in the dissemination and development of disease. Under certain conditions, including physical confinement and nutrient restriction, hyphae grow helically- a little-studied morphology which may afford the cell both increased virulence and drug resistance. This study investigates the molecular basis behind helical growth via both a large-scale screen and targeted analysis, through which we have uncovered the cooperation of diverse cellular processes, including cell wall and plasma membrane dynamics, whole-cell polarisation and calcium homeostasis. Furthermore, we have used a colon-on-chip model, which replicates the peristaltic stretch found in the human gut, to trigger 3D epithelial architecture, allowing the imaging and study of C. albicans hyphal invasion in situ. We have observed helical hyphal growth through gut epithelial layers, causing increased tissue damage in comparison with non-helical strains. This indicates for the first time that this morphology likely plays a role in tissue invasion. This model also sheds light on the involvement of gut peristalsis with prevention of systemic fungal infection. This work details a collaboration between diverse processes across the cell to produce a helical hypha morphology, which together aid human gut epithelial invasion. Paris postdoc seminar series
Plus d'infos...
Tags: Yeasts, Gut flora, Pathogenic microbes, Candida albicans, Candida, Epithelium, Hypha, Gastrointestinal tract, Hwp1, Candidalysin
Annonce publiée le 06-09-2025
Institut Cochin
Salle Rosalind Franklin -
Invite par: Yasmine Belkaid
Annual Retreat of Cancer Grand Challenges Team PROSPECT Thursday, October 2 Friday, October 3 If you would like to attend these two sessions, please email Emilie Gehin at emilie.gehin@pasteur.fr before Friday, September 26, including ...
Plus d'infos...
Tags: Cancer, Colorectal cancer
Annonce publiée le 17-09-2025
Institut Pasteur
Batiment: Monod Salle: Agnes Ullmann amphitheater -
Invite par: Emmanuel Beaurepaire
In a microscope, the back-focal plane (BFP) of the objective lens is where light rays are sorted by angle rather than position. The BFP contains the average fluorophore radiation pattern of all excited fluorophores within the field-of-view (FOV). This radiation pattern encodes information about the fluorophore orientation, nanometric axial distance from the surface and the local refractive index (RI) of the the fluorophore-embedding medium, information that is complementary to what can be retrieved from a sample plane (SP) image. However, when imaging the BFP spatial (x,y) information is generally lost, or it can only be obtained indirectly - either by reducing the FOV to a tiny excitation spot and implementing stage scanning, or in biological experiments by genetically addressing the fluorophore to defined sub-cellular targets. Applied to wide-field fluorescence microscopy, SAF is the optical reciprocal and experimental twin of objective-type TIRF. With their large collection numerical aperture (NA refractive index, RI), highly corrected oil-immersion objectives capture both under- and supercritical fluorescence components. Supercritical fluorescence (SAF), which is forbidden by Snell&'s law for most dipoles, occurs when fluorophores are very close to the dielectric interface, producing high-angle emission. The SAF/UAF ratio can provide a nanometric height map of fluorophores over the entire FOV, allowing axial fluorophore localisation with unprecedented precision on a standard inverted microscope. BFP images also aid in optical metrology, helping with aberration correction and optical misalignment detection. They provide a simple way to measure the effective numerical aperture (NAeff) of high-NA objectives and it can improve TIRF penetration-depth calibration and quantify optical sectioning in super-resolution microscopies. In my talk, I will present recent and ongoing work using combinatorial front- and BFP imaging for biological fluorescence. I will argue that this approach not only offers advantages compared to TIRF microscopy, but offers completely new experimental paradigms that result from the unique physical properties of near-interface fluorophores.
Annonce publiée le 29-08-2025
Ecole Polytechnique
Amphi Becquerel -
Annonce publiée le 04-09-2025
Ecole Polytechnique
Amphi To be announced (BEM) -
mRNA vaccines proved to be very successful during the COVID-19 pandemic. The most advanced platform uses nucleoside-modified mRNA formulated in lipid nanoparticles (LNPs). Both the mRNA and LNP design and chemistry contribute to the immunostimulatory properties of mRNA vaccines. Dr. Pardi s seminar will discuss how the composition of LNPs can be tailored to induce more cellular- or humoral-focused immune responses based on the vaccine application.
Plus d'infos...
Tags: RNA, MRNA vaccine, Lipid-based nanoparticle, Nucleoside-modified messenger RNA, Norbert Pardi, Vaccine, Messenger RNA, RNA therapeutics, Self-amplifying RNA
Annonce publiée le 12-09-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
Melanoma is known for its heterogeneity and plasticity, yet the origins and extent of its cell state diversity are unclear. It remains uncertain whether melanoma growth, metastasis, and therapy resistance arise from overlapping or distinct subpopulations. By utilizing mouse genetics, lineage tracing, and single-cell spatial transcriptomics, we have mapped the diversity and trajectories of cancer cell states within the melanoma ecosystem. Our findings indicate that distinct pools of melanoma cells support growth, metastasis, and drug resistance, and that these capabilities can be dynamically acquired through specific extrinsic niche signals. To explore therapeutic strategies that disrupt this reprogramming, comprehensive methods for monitoring intratumor heterogeneity (ITH) and cell state dynamics at the single-cell level are essential. Although single-cell transcriptomics is the standard, it has limitations such as high costs and long analysis times. We discovered that distinct morphological features characterize canonical melanoma transcriptional states, leading to the development of SHAPE, a simple, cost-effective FACS-based method for quantifying morphometric parameters. Leveraging SHAPE, we analyzed escape trajectories from therapies and identified a drug combination that effectively targets melanoma cells regardless of genetic background, enhancing sensitivity to standard treatments in preclinical models. This approach is also applicable to other tumor types. Overall, these findings create a geometry-based framework for monitoring ITH and propose a universal combination strategy that addresses genetic diversity and non-genetic adaptive resistance. Few Refs: Karras P, Bordeu I, Pozniak J, Pedri D, Landeloos E, Van Raemdonck N, et al, Marine JC. A cellular hierarchy in melanoma uncouples growth and metastasis. Nature, 2022 Oct; 610(7930): 190-198. Karras P, Black JRM, McGranahan N, Marine JC. Decoding the interplay between genetic and non-genetic drivers of metastasis. Nature. 2024 May;629(8012):543-554. Pozniak J, Pedri D, Landeloos E, Van Herck Y, Antoranz A, Karras P, et al, Marine JC. A TCF4/BRD4-dependent regulatory network confers cross-resistance to targeted and immune checkpoint therapy in melanoma. Cell 2024, 187, 166-183. Pozniak J, Roda N, Landeloos E, Antoranz A, Van Herck Y, De Visscher A, et al, Marine JC. Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype. Cancer Discov. 2025 Jun 18:OF1-OF16.
Plus d'infos...
Tags: Cancer pathology, Skin cancer, Carcinogenesis, Immune system, Cancer immunotherapy, Metastasis, Melanoma, Checkpoint inhibitor, Cancer, Tumour heterogeneity
Annonce publiée le 13-09-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
Plus d'infos...
Annonce publiée le 19-08-2025
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
Brown algae (seaweeds) are remarkable organisms that independently evolved complex multicellularity, making them an invaluable window into how development can arise in very different evolutionary contexts. In this talk, I will explore the biology of these seaweeds, from themolecular mechanisms governing their mating rituals, including sex determination, pheromone signaling, cell-cell recognition and gamete fusion, andthe surprising ways in which viruses shape their life cycles. I will highlight our recent discovery of a giant virus that integrates into the genome of the model alga Ectocarpus, reactivating during reproduction and influencing both host development and evolution. Together, these stories reveal brown algae as a powerful system for uncovering fundamental principles of multicellularity, reproduction, and host-virus interactions across the tree of life.
Plus d'infos...
Tags: Evolutionary biology, Ectocarpales, Ectocarpus, Biological oceanography, Multicellular organism, Virus, Algae, Brown algae, Sex, Mating
Annonce publiée le 13-09-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Invite par: Eugenia Soledad Bardossy
Title Hacking bacterial growth: genomic strategies to reprogram generation time. Abstract Bacterial growth rate (GR) determines how quickly microbes spread, compete, or produce valuable products. Yet the genetic and genomic factors encoding it remain ...
Plus d'infos...
Tags: Bacteriology, Bacteria, Domains
Annonce publiée le 26-09-2025
Institut Pasteur
Batiment: Monod Salle: Amphitheater Agnes Ullmann -
TBA
Plus d'infos...
Tags: Jean-Charles, Draft:The walk (2015 tv series(, Draft:
Annonce publiée le 10-09-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407 -
Invite par l’equipe Gazave, Can Aztekin (Friedrich Miescher Laboratory of the Max Planck Society) presentera un seminaire de l’Institut Jacques Monod : Signaling centers of appendage regeneration: from single cells to species Resume : Unlike mammals,Xenopus laevistadpoles possess a remarkable ability to regenerate lost appendages. In our previous work (Aztekin et al., 2019, 2021), we identified key signaling center cell types that form during tail and limb regeneration. Through cross-species comparisons (Zhong et al., 2023), we have identified equivalent cell populations in mammals, and developed simplified stem cell-based models to investigate the properties of these regenerative cells (Skoufa et al., 2024). In this talk, I will present our findings on the critical genetic and environmental factors that influence signaling center formation inXenopustadpole and mouse embryonic limbs (Tsissios et al., 2024). These results shed light on the mechanisms underlying limb regeneration competence and provide insights into the divergent regenerative capabilities between species.
Plus d'infos...
Tags: Developmental biology, Healing, Regeneration, Senescence, Animal models, Animal anatomy, Xenopus, Appendage
Annonce publiée le 25-08-2025
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Plus d'infos...
Annonce publiée le 23-09-2025
NeuroPSI
Salle de conference Albe-Fessard -
Invite par: SHULZ Daniel
Plus d'infos...
Tags: Sensory systems, Cerebral cortex, Sensory cortex, Somatosensory system, Proprioception, Somatosensory disorder, Tactile hallucination
Annonce publiée le 09-09-2025
NeuroPSI
Salle de conference Albe-Fessard -
Invite par: Chiara STRINGARI
Custom-Access Serial Holography (CASH) is a high-speed 3D random-access two-photon imaging technique for recording neuronal activity in behaving animals. Using acousto-optic deflectors synchronized with a 40 kHz regenerative amplifier, CASH enables ultrafast phase and amplitude modulation of each laser pulse for digital holography over extended volumes. This allows calcium imaging at 200 Hz in 50100 neurons, and voltage recordings at 410 kHz in up to 10 neurons in head-fixed mice on a treadmill. Aberration and scattering correction extend transcranial imaging beyond the scattering memory effect. Finally, we combine temporal focusing with CASH to improve the signal-to-noise ratio and optical sectioning, thus extending the use of CASH to densely labelled samples.
Tags: Digital holography, Holography, Cerebral cortex, Neurophysiology, Neuroimaging
Annonce publiée le 16-09-2025
Ecole Polytechnique
Amphi Carnot -
The development of the human central nervous system starts by the closure of the neural tube between day 23 to 30 of gestation. This event leads to the formation of two important regions: the brain in the rostral part and the spinal cord in the caudal part. The brain is a complex organ that control and process thought, memory, emotion, sensation, movement etc. and the spinal cord is the relay between the body and the brain and conduct sensory and motor information. During my PhD and my first postdoc, I tried to understand how newborn neurons migrate to settle in the appropriate region of the brain in mice and why their migration is affected in some diseases such as ciliopathies or prenatal alcohol exposure. However, animal models present significant limitations in the understanding of human development. Therefore, to fully understand the human central nervous system development and recapitulate human diseases, new experimental models need to be developed. The use of organ-on-chip permit the development of new human models allowing to better understand how the organ of interest is generated. By using microfluidic devices, we are setting up a new model of human spinal cord to study the acquisition of cellular diversity during the development of this structure. In the developing spinal cord, 11 molecularly distinct progenitor territories give rise to the full neural populations necessary for a functional spinal cord. By using these innovative microfluidic devices, we can further assess the specificity of human spinal cord development and study cell-cell communication and morphogens gradient involved in progenitor cell fate acquisition.
Plus d'infos...
Tags: Skeletal system, Motor system, Spinal cord, Central nervous system, Spinal column, Neuromere, Spinal cord injury research
Annonce publiée le 25-09-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Invite par: Imge Ozugergin
Our next Qbio lunch/minisymposium, organized by Imge Ozugergin, will take place on Wednesday 08/10/25, Monod 7th floor (12:00 to 14:30). This time, we'll lure around the notion of timescale in biology trying to address ...
Plus d'infos...
Tags: Metronome, Music education, Pendulums, Timekeeping
Annonce publiée le 13-09-2025
Institut Pasteur
Batiment: Monod/66 Salle: 03, 7th floor -
Grégory Verdeil is invited by Laurie Choux.
Plus d'infos...
Annonce publiée le 11-09-2025
Institut Cochin
Salle Rosalind Franklin -
Invite par: Dr A. Pierani
The developing hippocampus undergoes profound structural and functional changes that are critical for the establishment of functional networks. Disruptions in these processes are implicated in a range of neurological and psychiatric disorders. Particular attention is given to CajalRetzius cells, an early-born neuronal population with strong synaptic integration into the hippocampus, whose dysfunction can be linked to impaired memory and increased innate anxiety. The perspective then shifts to the maturation of synaptic networks in the dentate gyrus, with a focus on granule cells and their perforant path synapses as a key model of connectivity development. A multimodal approach combining 3D electron microscopy, patch-clamp electrophysiology, and computational simulations is used to uncover cellular and synaptic principles that shape hippocampal development. During this period, synapses undergo profound structural changes that may contribute to synaptic plasticity and enable memory formation within a functional, mature hippocampal neural circuit.
Plus d'infos...
Tags: Hippocampus, Neural Networks, Synapse, Cajal-Retzius cells, Granule Cells
Annonce publiée le 17-09-2025
Institut de Psychiatrie et Neurosciences de Paris
Room D Levy, Institut de Psychiatrie et Neurosciences de Paris (IPNP) UMR 1266 INSERM - Universite Paris Cite, 102-108 Rue de la Sante - 75014 Paris -
Invite par: Dr A. Pierani
There is now long-lasting evidence that the construction and maturation of cortical networks during development is activity dependent. In the developing hippocampus, such activity consists of intermittent busts of activity called early sharp waves (eSPWs) that are spontaneously triggered in the periphery. With age, eSPWs leave place to a continuous activity regimen dominated by rhythmic activity. Pioneering ex-vivo experiments suggest that GABAergic interneurons control and orchestrate immature network activity. In-vivo, however, this role is less clear. While there is evidence for the recruitment of GABAergic neurons during eSPWs, the precise timing of their activation in unknown. Furthermore, there are still uncertainties on how GABAergic cells impact the excitability of the immature hippocampal networks in-vivo. To address these issues, we developed a combined electrophysiological and optogenetic method allowing us to identify and manipulate GABAergic neuron activity in neonatal mice. Our results show that GABAergic neurons were more active than the rest of the recorded population and participated in more eSPWs. We also found evidence of both spontaneous and GABA-driven inhibition as early as post-natal day (P) 3. This inhibitory effect increased with age and reached plateau at P9-P10. Putative excitatory effect of GABAergic firing was negligible. We propose that rather than being caused by a switch in the polarity of GABA action, such rise of inhibition is due to the rapid growth of peri-somatic GABAergic inputs to pyramidal cells. The resulting development of feed-back inhibition within hippocampal networks would allow for the apparition of continuous network dynamics, ultimately supporting the emergence of cognitive processes.
Plus d'infos...
Tags: development, hippocampus, GABAergic, electrophysiological and optogenetic
Annonce publiée le 17-09-2025
Institut de Psychiatrie et Neurosciences de Paris
Room D Levy, Institut de Psychiatrie et Neurosciences de Paris (IPNP) UMR 1266 INSERM - Universite Paris Cite, 102-108 Rue de la Sante - 75014 Paris -
Invite par: Nicolas Rascovan
Un modelo organico como alteridad de lo biologico Por Miguel Benasayag Argentino, vive en Paris hace casi cuatro decadas y es un pensador de la modernidad, a la cual problematiza tomando e integrando hereticamente ...
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Annonce publiée le 26-09-2025
Institut Pasteur
Batiment: Yersin (24) Salle: Agora -
Invite par: Jessica Bryant
Join us in celebrating the distinguished career, invaluable mentorship, and scientific legacy of Prof. Artur Scherf. This symposium will celebrate the immense impact of Artur Scherf’s research and activism on the parasitology community through ...
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Tags: Ecology, Parasitology, Disease ecology, Parasitism
Annonce publiée le 05-09-2025
Institut Pasteur
Batiment CFJ, salle CFJ Auditorium , -
Invite par: PERRON Muriel
Plus d'infos...
Tags: Developmental neuroscience, Cajal, Retzius, Santiago Ramn y Cajal, Gustaf Retzius
Annonce publiée le 01-07-2025
NeuroPSI
Salle de conference Albe-Fessard -
Invite par l’equipe Courtier, Nicolas Rode, (Centre de Biologie pour la Gestion des Populations, INRAE, Montpellier) va presenter un seminaire de l’Institut Jacques Monod sur le theme : Investigating microbiota-induced plastic tracking of seasonal host fruits in the invasive pest, Drosophila suzukii Resume : Elucidating the genetic and plastic mechanisms by which insect populations can track seasonal variation in their host plants is a long-standing central goal of evolutionary ecology and has major applied implications in agriculture. By sampling natural populations of Drosophila suzukii on different fruits and doing reciprocal transplant experiments, we found that both oviposition preference and offspring performance were higher on original fruits from which populations originated than on alternative fruits. We are currently investigating the role of a flexible and fruit-specific microbiota in driving this pattern. I will present recent data showing that (1) the fungal communities of D. suzukii are more strongly structured among different host fruits than bacterial communities, (2) differences in fungal communities among fruits are maintained over time in the laboratory whereas bacterial communities change over time due to different life stages of D. suzukii preferentially selecting for some bacterial taxa and that (3) different fungal and bacterial communities induce strong plastic responses in both oviposition preference and offspring performance across host fruits. These results help us better understand how the gut microbiota allow D. suzukii to track seasonal changes in host fruits.
Plus d'infos...
Tags: Microbiomes, Bacteriology, Microbiology, Environmental microbiology, Drosophila suzukii, Drosophila, Microbiota, Human microbiome, Gut microbiota
Annonce publiée le 18-09-2025
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Gastrulation is a hallmark event in embryonic development, resulting in germ layer specification and formation of the body axes. While the role of diffusible morphogen signals (e.g. BMP, Wnt, Nodal) in gastrulation is well-established, recent studies increasingly implicate mechanical forces as an additional source of morphogenetic information. Taking advantage of a minimal pluripotent stem cell (PSC)-based model of human gastrulation, we are investigating the interplay between cell fate and mechanics during gastruloid disc self-organization. These are micropatterned PSC colonies, which self-organize into concentric rings of the three germ layers and the extraembryonic amnion upon BM4 stimulation. Taking advantage of their simplified geometry, we established a computational image analysis pipeline to project, segment and automatically extract key morphometric parameters (e.g. cell shape, tissue stress) during gastruloid self-organization. We found that extraembryonic amnion cells, induced at the gastruloid edge, adopt a squamous organization while the differentiated epiblast remains columnar, consistent with their in vivo counterparts. This differential cell shape pattern arises due to gastruloid specification rather than to purely geometrical constrains, as edge cells remain columnar in confined pluripotent gastruloids. Our ongoing work supports that the squamous organization of the amnion is cell-autonomous, since it is observed even colonies homogeneously induced to amnion identity. We are now investigating the mechanical forces driving these shape changes, as well as how this biophysical mechanism is linked to amnion specification. Overall, this multiscale approach is allowing us to quantitatively characterize the mechanical forces arising during cell fate acquisition and gastruloid patterning, opening the door for a mechanistic understanding of the regulation and functional role of mechanical forces in human gastrulation.
Plus d'infos...
Tags: Embryology, Developmental biology, Gastrulation, Stem cells, Gastruloid, Tissue engineering, Epiblast, Germ layer, Cellular differentiation, Amnion, Morphogenesis
Annonce publiée le 05-09-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Genetic perturbation is a powerful way to analyze the function of proteins in living cells. Specifically, when investigating proteins important for cell viability, conditional perturbation offers a significant opportunity. For this purpose, we pioneered the auxin-inducible degron (AID) technology, enabling rapid degradation of a degron-fused protein upon the introduction of the plant hormone auxin. We have refined this system, named AID2, by taking advantage of chemical biology. Through integration with CRISPR-based genome editing, it has become feasible to generate conditional mutants of mammalian cells and mice. We are employing AID2 to elucidate the mechanism governing genomic DNA replication and maintenance in human cells. Replication initiation in human cells occurs in a stochastic manner, but certain regions exhibit higher frequencies of initiation. These regions, known as initiation zones (IZs), are often found in proximity to open-chromatic active genes, showing a stark difference from yeast, which has sequence-defined replication origins. Importantly, the mechanism that defines IZs in human cells has been elusive. In this seminar, I will introduce a new technique for detecting IZs and present the key mechanism that define and control them in human cells.
Plus d'infos...
Tags: DNA replication, Molecular biology, Cellular processes, Senescence, Genome editing, Auxin, Degron, CRISPR, Origin of replication
Annonce publiée le 23-08-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Morphogenesis is the process in which cells, tissues, organs and embryos acquire orderedness, patterns, shapes and higher order organizations. Studies in the last decades began to reveal that morphogenetic processes depend not only on deterministic genetic programs, but also mechanical/physical mechanisms that show hallmarks of stochasticity and self-organization. The involvement of physical mechanisms raises intriguing questions as to how they might influence the evolutionary dynamics of morphogenesis, in conjunction with the well-established evolutionary pathways of descent with genetic modifications. Using early embryonic morphogenesis in the Drosophila as a model system, recent work in my lab shows that: 1) the build-up of compressive stresses during axial elongation and tissue expansion is averted by divergent strategies that act as ?mechanical sink' to pre-empt tissue ?tectonic' collision; 2) tensile stresses generated during invagination and convergent extension require a cell-intrinsic compliance program to prevent tissue rupture; and 3) efficient yolk compaction via colloidal forces safeguards cell formation and tissue invagination to prevent mechanical instabilities that could arise due to physical impediment of the yolk compartment. These data suggests that physical factors and mechanics might be more than a contributor of morphogenesis, but a facilitator of evolutionary transition and innovation
Plus d'infos...
Tags: Developmental biology, Cellular processes, Morphology, Invagination, Morphogenesis
Annonce publiée le 16-09-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Invite par: Cirb
Despite the incredible diversity of total vertebral number seen across species in nature, a major roadblock in the field has been the inability to experimentally increase total vertebral number in a model organism such as the mouse, with original views suggesting a progenitor exhaustion&' that could not be overcome. Work from several groups, including ours, has now revealed the molecular logic constraining each region of the vertebral column, from cervical through to tail. We show that region-specific expansions in vertebral number correlated with coordinated changes in the timing of Hox cluster progression and, using mouse genetics, we provide evidence reinforcing the view that Hox genes do indeed control progenitor proliferation and axial elongation, not solely patterning. We have gone on to reveal a single integrating factor, Nr6a1, whose precise expression level was able to increase or decrease murine vertebral number in vivo. Combining this knowledge with an AI-assisted imaging pipeline to extract vertebral count data from the large-scale human biomedical database UK Biobank, we have identified a genome variant at a splice acceptor site of the Nr6a1 gene locus that is likely causative in controlling differences in vertebral number across the human population.
Plus d'infos...
Tags: Irregular bones, Skeletal system, Vertebrate anatomy, Spinal column, Vertebra, Hox gene
Annonce publiée le 23-09-2025
College de France
au College de France - Salle D2 11 place Marcelin Berthelot - 75005 Paris -
Invite par: Gerald Spaeth
Plus d'infos...
Tags: Leishmaniasis, Parasitology, Trypanosomatida, Zoonoses, Leishmania, Visceral leishmaniasis, Disease vector, Parasitism, Lutzomyia, Leishmania tropica
Annonce publiée le 23-09-2025
Institut Pasteur
Batiment Lwoff, salle Retrovirus, -
Discover how you can explore biology at unprecedented depth with Element and the AVITI24 platform. One integrated platform, AVITI24 seamlessly integrates single-cell, spatial co-detection of RNA, protein, and morphology. And next-gen sequencing - all powered by our innovative avidite base chemistry (ABC). With just a single platform, you can unlock direct , in situ sequencing in single cells without library prep and access flexible, high-quality, affordable sequencing workflow. Join us to learn how one platform can power limitless discoveries.
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Tags: Molecular biology, Biotechnology, Sequencing, DNA sequencing, RNA sequencing, Single-cell sequencing, Sanger sequencing
Annonce publiée le 31-07-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Invite par: Jerome Gros
This conference brings together scientists studying gastrulation, the process where pluripotent stem cells internalize and differentiate into embryonic germ layers while establishing the embryo’s main axes. It covers fundamental biology topics such as gene ...
Plus d'infos...
Tags: Developmental biology, Embryology, Gastrulation, Biotechnology, Stem cell, Embryo, Germ layer, Cellular differentiation
Annonce publiée le 05-09-2025
Institut Pasteur
Batiment CIS, salle , -
Invite par: Denis Duboule
This lecture will explore the deep history of our bodies, one that extends billions of years. As we uncover new fossils, understand the patterns and mechanisms that form diverse animal bodies, and compare the anatomy of organ systems of creatures alive today, we find that every structure in our bodies contains artifacts of our branch of the tree of life. Our limbs are based on the pattern of bones first seen in ancient fish as is the patterns of nerves, muscles, and organs in our circulatory, excretory, and nervous systems. The profound connections we share with the rest of life of our planet also inform biomedical studies. Analyses of fish play important roles in understanding and treating diverse human diseases.
Plus d'infos...
Tags: Ichthyology, Animal anatomy, Anatomical terminology, Anatomy, Morphology, Fish, Neil Shubin, Fin
Annonce publiée le 12-09-2025
College de France
au College de France - Amphitheatre Guillaume Bude 11 place Marcelin Berthelot - 75005 Paris -
Invited by Julie Cocquet and Alberto de la Iglesia.
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Tags: European Molecular Biology Laboratory, Heidelberg
Annonce publiée le 04-04-2025
Institut Cochin
Salle Rosalind Franklin -
Neural stem cell (NSC) populations ensure the production of neurons and astroglial cells in the vertebrate adult brain. NSC activity persists at long-term in zebrafish, but exhausts rapidly in mouse from the young adult stage. Using long-term genetic clonal tracing and intravital imaging in the zebrafish adult pallium (dorsal telencephalon), we revealed that two distinct NSC sub-populations cooperate to ensure population maintenance and neurogenesis (1, 2). These sub-populations are endowed with self-renewal vs neurogenesis capacity and are organized in a functional hierarchy. Using sc-omics, we and others observed that these sub-population are themselves molecularly heterogeneous (3-6). The biological significance and regulation of these heterogeneities are unknown, as well as how they remain balanced in time and space over a lifetime. I will show our latest results on these questions, showing how we are taking in situ approaches and readouts of Notch3 signaling to decipher individual NSC trajectories and their coordination within the transcriptomic and physical spaces. References 1. E. Than-Trong, B. Kiani, N. Dray, S. Ortica, B. Simons, S. Rulands, A. Alunni, L. Bally-Cuif, Lineage hierarchies and stochasticity ensure the long-term maintenance of adult neural stem cells. Sci Adv 6, eaaz5424 (2020). 2. L. Mancini, B. Guirao, S. Ortica, M. Labusch, F. Cheysson, V. Bonnet, M. S. Phan, S. Herbert, P. Mahou, E. Menant, S. Bedu, J.-Y. Tinevez, C. Baroud, E. Beaurepaire, Y. Bellaiche, L. Bally-Cuif, N. Dray, Apical size and deltaA expression predict adult neural stem cell decisions along lineage progression (2023) p. eadg7519. 3. D. Morizet, I. Foucher, A. Alunni, L. Bally-Cuif, Reconstruction of macroglia and adult neurogenesis evolution through cross-species single-cell transcriptomic analyses. Nat Commun 15, 3306 (2024). 4. D. Morizet, I. Foucher, I. Mignerey, A. Alunni, L. Bally-Cuif, Notch signaling blockade links transcriptome heterogeneity in quiescent neural stem cells with reactivation routes and potential. Sci. Adv. 11, eadu3189 (2025). 5. M. I. Cosacak, P. Bhattarai, S. Reinhardt, A. Petzold, A. Dahl, Y. Zhang, C. Kizil, Single-Cell Transcriptomics Analyses of Neural Stem Cell Heterogeneity and Contextual Plasticity in a Zebrafish Brain Model of Amyloid Toxicity. Cell Rep 27, 1307-1318.e3 (2019). 6. N. Mitic, A. Neuschulz, B. Spanjaard, J. Schneider, N. Fresmann, K. T. Novoselc, T. Strunk, L. Munster, P. Olivares-Chauvet, J. Ninkovic, J. P. Junker, Dissecting the spatiotemporal diversity of adult neural stem cells. Mol Syst Biol 20, 321-337 (2024).
Plus d'infos...
Tags: Stem cells, Developmental neuroscience, Biotechnology, Developmental biology, Neural stem cell, Adult neurogenesis, Neurogenesis, Zebrafish
Annonce publiée le 24-09-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
TBA
Plus d'infos...
Annonce publiée le 11-09-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407 -
Invite par: Olivier BORKOWSKI
Biological systems are inherently dynamic, stochastic, and complex. Traditionally, manipulating and engineering such systems in a predictable manner has been challenging, but advances in supervised machine learning have revolutionized fields like protein engineering, drug discovery, and image analysis in microscopy. Even more promising, recent developments in synthetic biology and laboratory automation have set the stage for the use of powerful frameworks such as reinforcement and active learning that directly interact with biological processes. These frameworks can not only lead to significant improvements in learning efficiency but also enable real-time, precise control of complex biological systems.
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Tags: Cybernetics, Bioinformatics, Definition, Learning, Machine learning, Synthetic biology
Annonce publiée le 25-09-2025
Institut Micalis
Auditorium 442 - Institut Micalis -
Plus d'infos...
Tags: Analysis, Decision-making, Neuropsychological assessment, Prediction, Cognition
Annonce publiée le 16-09-2025
NeuroPSI
Salle de conference Albe-Fessard -
Apres le succes de notre premiere edition sur la menopause, votre Service de Prevention et Sante au Travail est ravi d'accueillir a nouveau OMENA pour une conference qui promet d'etre tout aussi passionnante ! Cette fois, cap sur les liens entre menopause, risque cardiovasculaire et troubles musculosquelettiques - des sujets essentiels pour mieux comprendre et accompagner cette etape de vie. Avec la participation du Dr Letombe (gynecologue medicale) et Mathilde Neme (OMENA). Rendez-vous le 16 octobre a 16h, dans l'Amphitheatre de la BDD ou en ligne via Teams.
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Annonce publiée le 25-09-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
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Annonce publiée le 14-05-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Vendredi 17 octobre, Bruno Lemaitre (Global Health Institute, School of Life Science, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland) presentera une conference de l’Institut Jacques Monod : A retrospective analysis of 400 publications reveals patterns of irreproducibility across an entire life sciences research field Resume : Research on Drosophila immunity has not only transformed our understanding of innate immunity but has also influenced studies on insect pests and disease vectors. Yet, as in many rapidly developing fields, some published findings have proven irreproducible. While certain results have been explicitly contradicted, many others remain untested, often due to limited follow-up or a lack of incentive to publish negative findings. To address this gap, we conducted a systematic conceptual reproducibility project evaluating claims from articles on Drosophila immunity published before 2011. From 400 papers, we extracted key claims and assessed their verifiability by cross-referencing the literature and, in selected cases, experimentally testing unchallenged? claims without prior replication (https://ReproSci.epfl.ch/. Our approach provides, uniquely, a field-wide assessment-14 years later-of the replicability of nearly all publications within an experimental life science community. We found that high-impact journals and top-ranked institutions are more likely to publish challenged claims. In line with the reproducibility crisis narrative, the rates of both challenged and unchallenged claims increased over time, especially as the field gained popularity. We characterized the uneven distribution of irreproducibility among first and last authors. Group leaders, who had prior experience as first authors in another Drosophila immunity team, had lower irreproducibility rates, underscoring the importance of early-career training. Finally, authors with a more exploratory, short-term engagement with the field exhibited slightly higher rates of challenged claims and a markedly higher proportion of unchallenged ones. We also did interviews with principal investigators to further shed light on how researchers navigate issues of reproducibility in practice. This systematic, field-wide retrospective study offers meaningful insights into the ongoing discussion on reproducibility in experimental life sciences.
Plus d'infos...
Tags: Scientific method, Metascience, Statistical reliability, Criticism of science, Replication crisis, Bruno Lemaitre, Drosophila, Reproducibility
Annonce publiée le 18-09-2025
Institut Jacques Monod
Institut Jacques Monod Amphitheatre Buffon, 15 rue Helene Brion, Paris, France -
Plus d'infos...
Annonce publiée le 11-06-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
The ability to walk is fundamental to human lives. Like all our biological features walking has a complex and deep history. It is most commonly thought that walking arose as fish made the evolutionary transition to land, shifting from an aquatic environment to a terrestrial one. In this view, the transition out of water meant that animals now had to evolve new mechanisms to deal with gravitational loads. As a consequence, they developed more mobile joints, arm and leg bones with robust connections for expanded locomotory muscles, and other structures to allow them to move about. Surprising, this very intuitive view is not supported either by comparative anatomy or the fossil record. The closest fish relatives to terrestrial vertebrates were capable of walking with four appendages, a fact seen in the structure of the bones and joints in their fins. Moreover, walking either on four appendages or two is commonly seen in aquatic fish ranging from sharks, lobe fin fishes, and diverse ray finned fishes. Indeed, many of these fish use alternating gaits and appendage motions in aquatic settings that are similar to terrestrial tetrapods. This observation leaves open the question of why fish walk in water instead of swimming. To answer these questions scientists have developed underwater treadmills, experiments training fish to walk, and robots that simulate walking behaviors. One major factor in the origin of fish walking, hence our own, is energetics: at slow speeds, and in certain environmental conditions is it energetically more efficient to walk than swim.
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Tags: Ichthyology, Zoology, Terrestrial locomotion, Animal anatomy, Fin, Rocketry, Tetrapod, Animal locomotion, Fish anatomy, Vertebrate, Walking, Evolution of fish
Annonce publiée le 12-09-2025
College de France
au College de France - Amphitheatre Guillaume Bude 11 place Marcelin Berthelot - 75005 Paris -
Invite par: Philippe Sansonetti
Francois Leulier and his team study how protein malnutrition during the critical period of weaning alters the physiology of juveniles. They recently uncover striking sex-specific physiological trade-offs between growth, metabolism and sexual maturation during ...
Plus d'infos...
Tags: Limbic system, Malnutrition, Motivation, Neuropsychology, Proteinenergy malnutrition, Protein, Nutrition
Annonce publiée le 05-09-2025
Institut Pasteur
Batiment: Francois Jacob Salle: Auditorium -
The integration of electronic health record (EHR)-linked biobanks with large-scale clinical, genotyping, sequencing, and multi-omics datasets have created new opportunities for advancing genomic medicine. These data resources enable the development of computational approaches aimed at improving disease prediction and phenotyping, genetic discovery, population-based penetrance estimation and drug target prioritization. In this talk, I will highlight recent research focusing on four key areas: i) Using machine learning and EHR-derived clinical data to improve coronary artery disease risk estimation; ii) Demonstrating how digital markers of disease can enhance the discovery of rare coding variants; iii) Developing a machine learning-based approach to estimate population-based penetrance of genetic variants; and iv) Developing genetics-based prioritization frameworks to predict drug outcomes. These efforts demonstrate how data-driven approaches can generate biological and clinical insights from large-scale population datasets to advance genomic medicine.
Plus d'infos...
Tags: Genomics, Molecular biology, Multiomics, Personalized medicine, Eimear Kenny, Cancer systems biology
Annonce publiée le 24-09-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Invite par: Darragh Duffy
23rd of October 2025 at Institut Pasteur | Paris The LabEx Milieu Interieur is sponsoring the EFIS Sex Differences group conference. Keynote Speakers: Resgitration ans abstract submission is now closed. Agenda - EFIS Sex ...
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Tags: Avionics, Display technology, Electronic flight instrument system, Glass cockpit, Louis Pasteur, Pasteur Institute
Annonce publiée le 05-09-2025
Institut Pasteur
Batiment: Duclaux Salle: Amphitheater -
Invite par: Anne-Caroline Deletoille
The Data Management Core Facility, the Hearing Institute Data Acquisition and Signal Processing Facility, and the Scientific Information Resources Center (CeRIS) invite you to an event designed for anyone who would like to learn ...
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Tags: Hearing, Otology, Auditory system, Audiology, Acoustics, Neuroscience, Computational audiology
Annonce publiée le 05-09-2025
Institut Pasteur
Batiment: Ágnes Ullmann Amphitheater (morning) - Fernbach building (afternoon) -
Les galaxies ne voguent pas de façon désordonnée dans l’Univers mais forment un véritable réseau en bulles de savon que l’on appelle la toile cosmique. Cette toile est composée de grands vides entourés par des filaments le long desquels les galaxies se meuvent avant de terminer leur course aux noeuds où de gigantesques amas de galaxies se forment. A l'occasion de cette conférence, nous arpenterons l'Univers sur des milliards d'années lumière afin de comprendre comme se tisse cette toile cosmique, quelles sont ses origines, comment elle influence la naissance et l'évolution des galaxies et en quoi elle représente une sonde cosmologique formidable nous permettant de comprendre l'Histoire et la composition de l’Univers.
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Annonce publiée le 03-07-2025
Institut Cochin
Salle Rosalind Franklin -
Invite par: Darragh Duffy
24th OCTOBER 2025 | INSTITUT PASTEUR | FRANCE We are happy to announce the 2025 yearly meeting of the Milieu Interieur LabEx. Join us on the 24th of October at 9h Amphitheater Duclaux at ...
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Tags: Corruption in France, Organized crime in France, Courtray Design Biennale Interieur, Pasteur Institute
Annonce publiée le 05-09-2025
Institut Pasteur
Batiment: Duclaux Salle: Amphitheatre Duclaux -
Cells can adopt distinct states independently of genetic alterations, a biological process commonly referred to as ?cell-state transition'. Acquisition of distinct cell states is characterized by the upregulation of the plasma membrane glycoprotein CD44 in development, immunity and cancer. Although often described as a cell-surface marker, the molecular function of CD44 has remained elusive for half-a-century. We found that CD44 mediates the uptake of specific metals, including copper and iron using hyaluronate carriers in various tissue types. This glycan-mediated metal endocytosis mechanism enables immune cell activation and acquisition of a drug-tolerant state of cancer cells (cell adaptation). Increase of copper(II) in mitochondria sustains NAD(H) redox cycling, promoting the production of metabolites that co-regulate the epigenetic programming of cell identity. In contrast, increase of iron in the cell nucleus fuels the activity of specific iron- and ketoglutarate-dependent demethylases, enabling specific transcriptional programs. We developed new classes of small molecules that selectively interfere with these metal-catalyzed chemical processes in cells. Inactivating mitochondrial copper(II) prevents acute inflammation in vivo demonstrating that control of cell-state transition confers therapeutic benefits. Pharmacological activation of lysosomal iron, on the other hand, induces ferroptosis in drug-tolerant persister cancer cells, impacting tumor progression. These findings illuminate a universal metal ion uptake mechanism and the critical role of metal ions as regulators of cell adaptation, paving the way towards the development of next generation therapeutics.
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Tags: Immunology, CD44, Glycoproteins, Transfusion medicine, Ferroptosis, T cell, Persister cells, Hyaluronic acid, Mitochondrion, Ironomycin, Cancer stem cell
Annonce publiée le 24-09-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Invite par: Denis Duboule
Teeth and bones are fundamental features of vertebrate organisms. The earliest vertebrates date from fossils that are over 500 million years old and existed at the time of the Cambrian Explosion, a great burst of innovation in the evolutionary history. The first creatures with tissues similar to our teeth and bones arenin the bony exoskeletons of our jawless fish ancestors. Inside this exoskeletal armor are small structures that are distinctly toothlike. Detailed comparisons of these features among living and fossil vertebrates and invertebrates reveal that the earliest teeth likely had a sensory function in the external tissues of these fish. Assessing diverse fossil fish reveals that many distinct features of our bones and teeth, such as the capacity to remodel, originally came about in jawless fish. : The Evolutionary Origins of Bones and Teeth
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Tags: Animal anatomy, Paraphyletic groups, Ichthyology, Infraphyla, Evolution of fish, Vertebrate, Tooth, Jaw, Skeleton, Agnatha, Fossil, Fish
Annonce publiée le 12-09-2025
College de France
au College de France - Amphitheatre Guillaume Bude 11 place Marcelin Berthelot - 75005 Paris -
Invited by Anne Hosmalin.
Plus d'infos...
Tags: Vaccine-preventable diseases, Influenza, Orthomyxoviridae, Live attenuated influenza vaccine, Influenza vaccine
Annonce publiée le 28-06-2025
Institut Cochin
Salle Rosalind Franklin -
Invite par: Jean-Loup Faulon
This talk will introduce the vision of a Self-Driving Lab (SDL): an integrated platform that combines advanced automation, synthetic biology, and human-interpretable AI to transform how we design, build, and test biological systems. By closing the loop between hypothesis generation, automated experimentation, and data-driven learning, SDLs can dramatically accelerate metabolic engineering, reducing timelines from years to weeks. I will outline the foundational tools-such as automated DNA assembly and digital-twin models-that enable this step-change, and show how they are being applied to engineer microbes for the sustainable production of valuable compounds essential to a resilient bioeconomy.
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Tags: Biotechnology, Bioeconomy, Engineering, Synthetic biology
Annonce publiée le 26-09-2025
Institut Micalis
Auditorium 442 - Institut Micalis -
TBA
Plus d'infos...
Tags: Lydia, Draft:The walk (2015 tv series(, The New Adventures of Kimba The White Lion
Annonce publiée le 11-09-2025
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407 -
Invite par: Denis Duboule
When we look at the history of life at a grand scale, from the earliest single celled organism to complex animals alive today, we see a past filled with great revolutions. Major transformations pervade this history, involving new features, new developmental processes, new ways of living, and new ecological interactions. In our own lineage, over the past 500 million years some fish evolved to live on land, reptiles evolved to fly, and primates evolved the ability to talk, walk, and think. For each of these major transitions we recognize features that allowed them to happen. The standard view is that these innovations were enablers for a major revolution: for example, feathers arose for flight, lungs, for life on land, etc. But this view couldn&'t be farther from the truth. Lungs evolved in fish well before they ever took steps on land, feathers arose in dinosaurs before they could fly, and so on. The features that play a role in great evolutionary changes arise by repurposing existing features for new functions. This view of evolutionary tinkering, first pioneered by Francois Jacob in the 1970's, carries profound implications for modern molecular and paleontological evolutionary biology.
Plus d'infos...
Tags: Feather, Evolution, Fossil, Animal, Evolutionary biology
Annonce publiée le 12-09-2025
College de France
au College de France - Amphitheatre Guillaume Bude 11 place Marcelin Berthelot - 75005 Paris -
In clinical practice, 18-FDG PET/CT scans are widely used to detect tumoral or inflammatory pathologies through visual assessment and semi-quantitative metrics based on SUVs. These quantification methods are quick to obtain, but they require clinicians to manually draw regions of interest. Moreover, they focus only on the most intense voxels, which leads to less accurate, less reproducible, and less robust results. To address this, we developed a methodology for the automatic detection and quantification of metabolic abnormalities in 18-FDG PET/CT images. Specifically, we constructed an organ-by-organ normative atlas of 18-FDG uptake from a representative dataset of healthy subjects. This atlas enables the automatic identification of abnormal metabolic activity. We validated this approach in patients with lung cancer undergoing immunotherapy. While immunotherapy has shown promising results across various cancers, including lung cancer, it is also associated with immune-related adverse events, emphasizing the need for their early detection. In this context, the normative atlas was applied to automatically identify both tumoral and inflammatory metabolic abnormalities in these patients.
Plus d'infos...
Tags: Neuroimaging, Medical physics, Medicinal radiochemistry, PETCT, Standardized uptake value, Positron emission tomography, Fluorodeoxyglucose
Annonce publiée le 12-09-2025
Institut Curie
Centre de recherche - Orsay - Webinar -
Invite par: Drs A. Pierani G Huberfield
Hippocampal circuits are instrumental for memory function. They are specifically affected in conditions such as temporal lobe epilepsy and Alzheimer's disease. Here, we discuss mechanisms and functional markers of normal and pathological hippocampal circuit operations using large scale recordings and advanced computational analysis. We show how cell type specific subcircuits play roles in hippocampal memory representations and how their distortion in epilepsy may lead to the associated cognitive comorbidities.
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Tags: Memory, Neuronal circuits, Epilepsy
Annonce publiée le 17-09-2025
Institut de Psychiatrie et Neurosciences de Paris
Room D Levy, Institut de Psychiatrie et Neurosciences de Paris (IPNP) UMR 1266 INSERM - Universite Paris Cite, 102-108 Rue de la Sante - 75014 Paris -
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Tags: Vetere, Gisella, ESPCI Paris, Gerard Dreyfus, Cuccaro
Annonce publiée le 19-08-2025
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
L'un des enjeux fondamentaux de la biologie est la comprehension de la relation entre les multiples echelles spatiales et temporelles observees dans un systeme biologique. Des molecules a une fonction cellulaire, d'une collection de cellules a un organisme, ou d'individus a une population, les interactions complexes entre elements singuliers peuvent donner naissance a des proprietes «emergentes» au niveau de l'ensemble. Dans quelle mesure l'ordre spatial et temporel vu au niveau du systeme peut-il etre explique par des proprietes de sous-echelle?ObjectifsCet enseignement a pour objectif de presenter les outils physiques qui ont ete recemment developpes pour decrire cette integration d'echelle (le matin) et de les mettre en application sur des exemples biologiques dans le cadre de seminaires (l'apres-midi).
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Annonce publiée le 12-06-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Invite par: Philippe Sansonetti
Human milk lives at the very intersection of maternal and infant health. Yet, it remains poorly understood and highly understudied. The presentation outlines the many benefits of breastfeeding and human milk for both the ...
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Tags: Breastfeeding, Breast milk, Milk, Oligosaccharide, Infant
Annonce publiée le 05-09-2025
Institut Pasteur
Batiment: Duclaux Building Salle: Duclaux Amphitheater -
CpG dinucleotides are hotspots for mutagenesis by spontaneous deamination of 5-methylcytosine (5mC) into thymine, resulting in T:G mismatches that can lead to C>T transitions. These mutations are not only a hallmark of aging and cancer but also a major force shaping the evolution of vertebrate genomes. We have previously uncovered MBD4 as the primary base excision repair (BER) glycosylase responsible for 5mC deamination repair in both CpG and non-CpG contexts, with a striking preference for guarding active chromatin and early-replicating DNA. In this study, we employ a targeted base-editing system—comprising an APOBEC1 deaminase fused to a catalytically dead Cas9—to induce precise and strand-specific cytosine deamination and track its repair. This approach allows us to systematically investigate the cellular components required for efficient 5mC deamination repair in human cells. Our data reveal that MBD4 cooperates with the mismatch repair (MMR) pathway outside of S-phase, implicating non-canonical MMR in the repair of this form of DNA damage. Using AI-based structural predictions alongside biochemical validation, we identify a previously unrecognized complex including MBD4 and MMR components, positioning them as key players in a coordinated repair response. Finally, we analyze thousands of tumor whole-genomes to show that MMR deficiency leads to CpG hypermutagenesis lacking replication strand asymmetry, further supporting a role for replication-independent MMR activity in 5mC deamination repair. Altogether, we uncover a novel function of non-canonical MMR that underscores its interplay with BER in safeguarding genomic integrity in mammalian cells. Paris postdoc seminar series
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Tags: DNA, Mutation, Molecular genetics, Senescence, Base excision repair, CpG site, Deamination, 5-Methylcytosine, MBD4, DNA repair, DNA damage, Transition
Annonce publiée le 06-09-2025
Institut Cochin
Salle Rosalind Franklin -
Plus d'infos...
Tags: Digital violence, Moral law
Annonce publiée le 02-09-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Invite par: Maria Teresa Teixeira
Plus d'infos...
Annonce publiée le 10-09-2025
IBPC
Conference room IBPC, 13 rue Pierre et Marie Curie 75005 Paris, Ile de France -
Le cours est dedie aux connaissances les plus actuelles articulant la biologie du developpement et l etude cellulaire et moleculaire des cancers. Les cretes neurales et les melanomes, depuis leur formation jusqu a leur migration (metastases), ainsi que les cancers pediatriques d'origine embryonnaires tels que les medulloblastomes et neuroblastomes sont pris comme exemples. Le cours beneficie d une approche multidisciplinaire a multiples echelles (embryologie sur des modeles varies, biophysique, biologie cellulaire, transcriptomique, imagerie...). Il aborde egalement des approches therapeutiques. Le cours est ponctue par des tables rondes sur les carrieres dans le milieu academique ou dans l industrie,sur la publication d articles scientifiques ainsi que sur l ethique en experimentation animale.Des sessions posters de doctorants sont egalement organises et des prix pour les meilleurs posters seront decernes par les participants aux cours.
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Annonce publiée le 04-09-2025
Institut Curie
Centre de recherche - Orsay - Amphitheatre du Batiment 111 -
Invite par: Michaela Muller-Trutwin
As part of the annual meetings of the Coordinated Action on Host-Virus Interactions: Basic and Translational HIV Research, the TheGeVec Group is hosting its first symposium on November 28th 2025: Shaping the Future of ...
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Tags: Gene delivery, Biotechnology, Molecular biology, Applied genetics, Bioethics, Gene therapy, Pasteur Institute, Therapy
Annonce publiée le 05-09-2025
Institut Pasteur
Batiment: Centre Francois Jacob Salle: Auditorium Francois Jacob -
Despite major advances in systemic therapies, outcomes for patients with metastatic uveal melanoma remain poor. Since up to 90% of patients develop liver metastases, the liver has become the primary target for locoregional treatment strategies. This lecture will review the evolution and future of these approaches, focusing on isolated hepatic perfusion (IHP) and percutaneous hepatic perfusion (PHP). Data from registry studies, randomized controlled trials such as SCANDIUM, and the recent FOCUS trial highlight the capacity of locoregional therapy to provide meaningful benefits. Emerging evidence also indicates that regional treatments may trigger immunogenic cell death, creating opportunities for rational combinations with systemic immunotherapy. Recent trials, including CHOPIN and SCANDIUM III, are evaluating the safety and efficacy of combining PHP with immune checkpoint inhibitors, with endpoints spanning survival, progression, quality of life, and biomarker discovery. Together, these efforts are redefining the role of locoregional therapy from liver-directed palliation toward integrated multimodal treatment, with the potential to extend survival in patients beyond what is achievable with systemic therapy alone. Teams link: https://teams.microsoft.com/l/meetup-join/19%3ameeting_YTE3NWRmNjktMjFkOC00NjBkLWE2ZGMtNWEzMmQ4NmNhYTA1%40thread.v2/0?context=%7b%22Tid%22%3a%22183ad437-6002-48ad-8886-c5885ce9be1a%22%2c%22Oid%22%3a%221ed1e97e-4bdf-4145-b23a-9858c31bd9e7%22%7d
Plus d'infos...
Tags: Hepatology, Uveal melanoma, Percutaneous hepatic perfusion, Melanoma, Liver metastasis, DecisionDx-UM
Annonce publiée le 26-09-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
Invite par: Maria Teresa Teixeira
The DNA Damage Response (DDR) is a complex signaling cascade elicited in the cell by damaged DNA, orchestrated by apical protein kinases, assisted by sensors and effectors. The two master kinases upstream of the DDR, ATR and ATM, are thought to mainly respond to single-stranded DNA and double strand breaks, respectively. However, non-canonical types of DDR have been reported (compact chromatin, mechanical or oxidative stress, among others), meaning that there exist stimuli equally capable of launching the DDR, yet in the absence of actual DNA damage. Overall, it remains poorly understood which is the actual signal, or signals, engaging these kinases. Building on the knowledge that ATM and ATR belong to the phosphatidyl-inositol-3-phosphate (PI3P)-kinase-related kinase family, we interrogated in the past if ATM and / or ATR can bind to, or be influenced by, phosphoinositides or other types of lipids. Of note, ATR has been found, in at least four previous studies, to sense the physico-chemical properties of phospholipids. We have discovered that ATM binds phosphatidyl-inositol-4-phosphate (PI4P) at the Trans Golgi, which allows it to remain anchored in an inactive (and non-phosphorylated) status. Activated ATM working in the nucleus can be titrated by the Golgi if PI4P levels at this location increase. Reciprocally, if PI4P levels decrease at the Golgi, ATM becomes more available to readily respond to DNA lesions inside the nucleus. Concerning ATR, we found thatATR combines its ability to sense DNA damage and phospholipid profiles to finetune the response to DNA lesions in a manner dependent on metabolic cues. We are confronting at present an even more surprising (yet simple) rule: DNA damage can be felt by membranes without the intermediate action of a DDR protein cascade. Inspired by compelling examples occurring in the mitochondria during the quality control of mitochondrial DNA, we are defining now general principles of this DNA-membrane signaling axis in the nucleus. Overall, I will discuss how the lipid profile of the nuclear envelope and other cellular membranes, which evolve in time and space, exerts a control over the response to DNA damage.
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Annonce publiée le 10-09-2025
IBPC
Conference room IBPC, 13 rue Pierre et Marie Curie 75005 Paris -
Escherichia coli is an important opportunistic bacterial pathogen and one of the most frequent causes of Urinary Tract Infections (UTIs). One of the key survival strategies of E. coli is its ability to form “biofilm”, in which the bacteria are encased in extracellular polymeric substances. This makes them highly resistant to standard antibiotics treatment and also frequently lead to chronic or relapsing infections. Therefore, there is a dire need for novel alternative therapeutics to treat such bacterial infections. In my research work, I have shown that the FDA-approved antifungal drug, 5-fluorocytosine (5-FC), can effectively disarm E. coli, stripping off the virulence factors essential for its pathogenesis and hamper biofilm formation. Most importantly, I identified that when 5-FC is combined with common penicillin-like antibiotics (beta-lactams), it creates a powerful synergy that can kill even the highly protected bacteria residing within the biofilm shield. This novel "Sabotage and Strike" strategy—dismantling the bacteria's defenses and striking with antibiotics—represents a promising approach to combat persistent infections and tackle the global challenge of antibiotic resistance. Paris postdoc seminar series
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Tags: Bacteriology, Biological matter, Environmental soil science, Membrane biology, Environmental microbiology, Biofilm, Antivirulence, Antimicrobial resistance, Escherichia coli, Extracellular polymeric substance, Biofilm prevention, Dispersin B
Annonce publiée le 20-09-2025
Institut Cochin
Salle Rosalind Franklin -
Invite par: Sylvie Rabot
How the gut microbiota and its host communicate and react together to environmental stimuli is essential to understand a mammalian holobiont. In a biomedical context, such communication might be a reason for staying healthy, if it is balanced, or associated with diseases when the communication is disrupted. Microbiota and host produce metabolites that can regulate and limit epigenetic enzymes, controlling epigenetic marks in the host. Using a germ-free mouse model, including males and females, we investigated how biological sex and microbiota status influenced the microbiota-nutrient metabolism-host epigenetic? axis of communication. We studied microbes, metabolism, epigenetic marks and gene expression in the host, focusing on the liver as target tissue, through a multi-omics and correlational analysis approach. Our results show the interaction of biological sex and microbiota in controlling the levels of DNA methylation in an additive manner. Where males are hypomethylated compared to females, and where the presence of microbiota accentuates this pattern in both sexes, being more pronounced in males. Males without microbiota present a feminised pattern of gene DNA methylation and expression. We have also observed a strong positive correlation between the levels of host DNA methylation in genes involved in testosterone degradation, and the Ruminococcaceae family, more abundant in males than females. Altogether, we propose Ruminococcaceae as a key ecological player in the holobiont ecosystem, influencing host gene regulation in a sex-dependent manner, through the modulation of DNA methylation levels of steroids degradation genes.
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Tags: Epigenetics, DNA, Bacteriology, Microbiomes, Post-translational modification, DNA methylation, Microbiota, Methylation, Gut microbiota, Regulation of gene expression, Ecological evolutionary developmental biology, Cancer epigenetics
Annonce publiée le 22-08-2025
Institut Micalis
Auditorium 442 - Institut Micalis -
Invite par: Morgane Bomsel - Frederic Bouillaud - Sandrine Bourdoulous - Catherine Postic - Dominique Salmon - Dominique Zeliszewski
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Tags: Long COVID, Post-acute infections
Annonce publiée le 05-09-2025
Institut Cochin
Amphitheatre Luton de la Faculte de Medecine, 24 rue du Fg St Jacques - 75014 -
Invite par: Paola Arimondo
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Tags: Screening, Drug discovery, Society for Biomolecular Sciences, Draft:Vipergen
Annonce publiée le 16-09-2025
Institut Pasteur
Batiment Duclaux, salle Duclaux amphitheater, -
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Annonce publiée le 14-05-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
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Annonce publiée le 14-05-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
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Tags: Villette, Ens
Annonce publiée le 19-08-2025
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
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Annonce publiée le 14-05-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
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Tags: Sergent, Enea Benedetto
Annonce publiée le 19-08-2025
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
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Annonce publiée le 02-09-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
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Tags: Ens, Carlos Costa
Annonce publiée le 19-08-2025
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
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Tags: Ens, cole normale suprieure
Annonce publiée le 30-08-2025
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
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Tags: Operas, Ulisse, Flavio Manzoni, Ulisse Cantagalli
Annonce publiée le 19-08-2025
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
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Tags: Bregaglia, ItalySwitzerland border, Pizz Gallagiun
Annonce publiée le 23-09-2025
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Invite par: Francois Bontems
ReCombinaisons se veut un espace de rencontre et de discussion entre chercheuses et chercheurs (biologie-sante, sciences humaines et sociales, philosophie), autrices, auteurs et artistes de science-fiction, et public le plus large possible, pour reflechir ...
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Annonce publiée le 26-09-2025
Institut Pasteur
Batiment: CIS Salle: Auditorium -
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Tags: Ranft, Ens
Annonce publiée le 19-08-2025
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
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Tags: Saclay, Paris-Saclay University
Annonce publiée le 19-08-2025
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
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Tags: Fricker, Desdemona
Annonce publiée le 19-08-2025
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris