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Mercredi 11 Fevrier 2026    9:00
Join us for a focused one-day seminar at the Institut Curie in Paris, dedicated to the latest advancements in spatial analysis and transcriptomics.
Immerse yourself in cutting-edge research, methodologies, and tools, focusing on the Visium V2/HD platform. Hear from experts from key institutes and join interactive discussions.
Join us for a day of networking, learning, and unlocking new insights in spatial biology!
Make sure to reserve your seat:https://pages.10xgenomics.com/WEB-2026-02-EVENT-EMEA-INSTITUT-CURIE-SEMINAR-REGISTRATION-PAGE_LP.html Plus d'infos...
Tags: Biology, Spatial biology, Spatial analysis, Insight, Curie Institute
Annonce publiée le 20-12-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e
Mercredi 11 Fevrier 2026    11:30
Liquid-liquid phase separation (LLPS) has emerged as a key mechanism in living cells, underlying the formation of biomolecular condensates that dynamically organize cellular matter, regulate reactions, and interact with membranes. Reproducing these features in minimal synthetic models remains a central challenge. In this talk, I will present coacervate droplets as minimal models of dynamic cellular compartments. I will first describe how light can be used as an external energy input to program coacervate phase behaviour. Using photoswitchable DNA-azobenzene systems, we achieve reversible and spatially controlled coacervation, enabling precise regulation of droplet formation and dissolution. By combining these systems with droplet-based microfluidics, we quantitatively dissect the kinetics of light-induced phase transitions and uncover non-equilibrium behaviours, such as budding and self-division. I will further illustrate how coacervates can function as reactive compartments, promoting and regulating simple chemical reactions, and how reaction-driven changes in molecular composition feed back onto phase behaviour. Finally, I will briefly discuss recent advances on coacervate-vesicle interactions, showing how condensates selectively wet phase-separated lipid membranes, a key step toward hybrid synthetic cells that integrate both membraneless and membrane-bound organization. Overall, this work shows how coacervate droplets provide minimal yet informative platforms to investigate dynamic compartmentalization principles relevant to biomolecular condensates and synthetic protocells. Plus d'infos...
Centre de recherche - Paris - Amphitheatre Marie Curie
Mercredi 11 Fevrier 2026    13:00
Invite par: Philosophie@Imagine Annonce publiée le 08-02-2026
IMAGINE
auditorium du 6eme etage, 24 boulevard du Montparnasse - 75015
Mercredi 11 Fevrier 2026    17:00
Invite par: InIdex GR-Ex Tags: Hematology
Annonce publiée le 08-02-2026
InIdex GR-Ex
online.
Contact lien = sandra.manceau at aphp.fr
Jeudi 12 Fevrier 2026    0:00
Séminaire en français, à l'invitation de Raphaël Scharfmann. Les helminthes, ces petits vers intestinaux avec lesquels nous avons co-évolué pendant plusieurs millions d’années, sont des maîtres de l’immunité. Ce sont de puissants immuno-modulateurs qui induisent une réponse Th2 contrôlée et réduisent les réponses Th1/Th17. Ils émettent également des centaines de molécules qui agissent à de multiples niveaux pour éviter leur rejet et maintenir leur hôte en bonne santé. Cette présentation vise à mieux comprendre cette thérapie qui pourrait être une piste prometteuse pour de nombreuses maladies à composante inflammatoire. Jacques Le Marois, après une formation scientifique en biologie à l’Ecole Normale Supérieure, a bifurqué ensuite vers l’entreprenariat pendant 27 ans, puis a créé en 2023 une fondation qui vise à financer des projets de recherche et d’études sur des thérapies basées sur du vivant comme la phagothérapie et l’helmintho-thérapie. Plus d'infos...
Annonce publiée le 06-12-2025
Institut Cochin
Salle Rosalind Franklin
Jeudi 12 Fevrier 2026    10:00
Towards detection of enhancer and promoter activities in single cells The majority of disaese-associated genetic variants fall into intergenic, regulatory regions rather than the genes they control. Hence, the path towards identifying the cell types and developmental stages that are altered by genetic variants inevitably leads through locating and quantitatively assessing these regulatory regions and the enhancers and promoters they harbor. However, studying the activity of regulatory regions genome-wide in specific cells has been challenging. State-of-the-art approaches have low sensitivity, require extensive input material, or are limited to cell lines rather than disease-relevant tissue samples. Also, the lack of benchmarks has caused inconsistent accuracy estimates and thus an inability to compare assays and computational methods. To address these issues, we devised a new, combined approach based on the enrichment of nuclear, capped RNAs (nucCAGE) and a light-gradient boosting machine algorithm (PRIMEloci). This allowed to detect transcriptionally active regulatory regions with unmatched sensitivity and to map enhancers and promoters enriched in fine-mapped eQTLs, pathogenic GWAS variants, and CRISPRi loci. Based on the FANTOM5 enhancer atlas, we drastically expanded the landscape of known enhancers, mapped them in a cell type-specific manner and outlined inter-organ mechanisms for genetic variants influencing physiological and disease traits. In parallel, we develop experimental and computational methods to record active regulatory elements over time andin vivoon the level of genomic DNA rather than RNA via DNA adenine methylation identification (DamID). As a first step, we benchmarked all existing software dealing with DamID data. This framework allowed developing the most sensitive model for DamID data analysis and aids ongoing efforts to record enhancer and promoter activities in single cells. Together, our methods aim to link regulatory elements to their cell-type specific biological functions, facilitate variant interpretation and advance insights into gene regulation during development and disease progression. Plus d'infos...
Tags: Gene expression, Enhancer, DNA adenine methyltransferase identification, Regulatory sequence, Promoter, Transcription, FANTOM, Regulation of gene expression, STARR-seq, Super-enhancer
Annonce publiée le 15-01-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)
Jeudi 12 Fevrier 2026    11:00
Human embryonic stem cell (hESC) fate decisions require tight coordination between cellular metabolic states and transcriptional programs, yet the mechanisms that integrate these layers remain incompletely understood. In this work, we investigate how global metabolic and redox states act as regulatory inputs that couple the cellular bioenergetic environment to transcriptional control during differentiation.By integrating single-cell transcriptomics (scRNA-seq), proteomics, and directed differentiation protocols, together with organoid-based models, we identify metabolic pathways and gene regulatory networks that are coordinately engaged during the transition from pluripotency toward neural and adipogenic lineages. Our organoid approaches provide a platform to explore how metabolic regulation influences tissue organization and functional maturation during development.Overall, our work establishes a mechanistic framework linking cellular metabolism to gene regulation in hESC differentiation, offering new perspectives on how bioenergetic signals guide human tissue formation. Plus d'infos...
Invite par: Scientific conference - Robert Debre Intact GABAergic development is a key trigger for the initiation of multiple regionally specific critical periods of synaptic plasticity during the postnatal brain development. These postnatal critical periods occur in succession and staggered from the sensory cortex to the limbic system. The hippocampus critical period of postnatal synaptic plasticity evolves in multiple waves. Neonatal hypoxic-ischemic (HI) brain injury results in disruption of many of the main events governing the progression of the hippocampal critical period of synaptic plasticity, which we have described in detail by our lab. This understanding allows the design of temporally precise treatment strategies to prevent memory impairments, which persist after neonatal HI despite cooling Plus d'infos...
Invite par: Gerard Eberl Ivaylo Ivanov obtained a B.Sc. in Biotechnology and M.Sc. in Molecular Biology from Sofia University in his native Bulgaria. He obtained his Ph.D. in Cell and Molecular Biology from The University of Alabama at ... Plus d'infos...
Invite par: Auditorium 1 Presentation topic: Rat Duchenne muscular dystrophy models to decipher disease mechanisms and preclinical studies
I completed my Ph.D. in molecular and cellular developmental biology at the Mount Sinai School of Medicine (New York) in the laboratory of Prof. David Sassoon, where I studied the genetic regulation of skeletal muscle development and differentiation. I then pursued postdoctoral training at the Institut Pasteur in Paris in the laboratory of Prof. Margaret Buckingham, focusing on the molecular control of skeletal muscle development and muscle stem cell biology. I was recruited by INSERM in 2000 and became an INSERM Research Director in 2006, after being awarded an INSERM AVENIR program that allowed me to establish my own independent research group at the Myology Institute (Pitie-Salpetriere, Paris). Since 2015, I am a Full Professor (PU-PH) at Universite Paris-Est Creteil and serve as Vice-Dean for Research of the Faculty of Medicine and Health. I lead the research team "Muscle Stem cells and therapies" at the IMRB (Inserm U955) and head the AFM-Telethon strategic research pole Translamuscle, coordinating large multidisciplinary programs dedicated to muscle stem cells, neuromuscular diseases, preclinical modeling and development of innovative therapies. My research focuses on the regulation of skeletal muscle stem cell during development, regeneration, and disease, with particular emphasis on PAX3/7 transcription factors, stem cell quiescence, and translational approaches for Duchenne muscular dystrophy. My work has been supported by major national and international funding agencies, and has resulted in over 140 peer-reviewed publications in leading journals. Through both my scientific and institutional roles, I am actively involved in shaping the fields of muscle biology, regenerative medicine, and translational neuromuscular research at the international level.
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Invite par: Anna Zhukova Real-time estimation of outbreak transmission dynamics using deep-learning-based phylodynamics Reconstructing epidemic dynamics in real-time has become crucial for effective disease management, as demonstrated by the COVID-19 pandemic. Most methods rely on epidemiological time series ... Plus d'infos...
Tags: Draft:Toopy and Binoo: The Movie, Draft:Vacation with Derek
Annonce publiée le 15-01-2026
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407
Mardi 17 Fevrier 2026    11:45
Maria Laura Rojas (Universite Paris Cite, INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades, Paris, France) presentera le prochain Paris postdoc seminar sur le theme : Organelle Crosstalk and Mitochondrial Renewal in Metabolic Adaptation to Shear Stress Kidney epithelial cells play a central role in maintaining body water and electrolytes balance, a function that critically depends on continuous urinary flow to maintain metabolic homeostasis and support kidney differentiation. Data from our lab have shown that urinary flow activates the autophagic machinery in kidney epithelial cells, promoting lipid droplets (LDs) catabolism and the transfer of free fatty acids to mitochondria. This process, in turn, promotes mitochondrial biogenesis and ATP production through oxidative phosphorylation. Despite these insights, how mitochondrial remodeling and inter-organelle communication are coordinated during this metabolic transition remains poorly understood. Here, we found that physiological fluid flow triggers mitochondrial membrane remodeling and turnover during shear stress adaptation, suggesting that mitochondrial renewal is essential during metabolic shift. During mitochondrial specialization, inter-organelle crosstalk occurs, particularly with LDs and the endoplasmic reticulum (ER), where tethering and lipid transfer proteins regulate mitochondrial structure and function. In this context, we identify a transient stabilization of ER-LD-mitochondria contact sites at early stages of fluid flow, required to mediate fatty acid transfer from LDs to mitochondria during shear stress, highlighting the importance of early organelle membrane mobilization in enabling cellular metabolic adaptation to mechanical cues. Plus d'infos...
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France
Mercredi 18 Fevrier 2026    9:30
La prochaine reunion du cytoskeleton club aura lieu mercredi 15 octobre a l’Institut Jacques Monod : Izeta Kankadze (PhD student, Fassier/Nicol's team, Institut de la Vision) presentera «Compartmentalized Second Messenger Signals Contribute to Cytoskeletal Remodeling in Axon Guidance» Veronique MARTHIENS (Researcher, R. Basto's team, Institut Curie) presentera «Brain biomechanics governs mitotic fidelity of embryonic neural stem cells» Plus d'infos...
salle des seminaires de l'IJM (RB-18B), 15 rue Helene Brion 75013 ou en visioconference : contact = sophie.polo at univ-paris-diderot.fr
Mercredi 18 Fevrier 2026    11:30
Many biological systems are very sensitive to small input signals. A tempting hypothesis is that these systems operate close to bifurcation or critical points, where the system s response exhibits a diverging susceptibility to the control parameter, and small signals are amplified into a large collective response. However, a common concern is that being close to these points requires fine-tuning of parameters, which seems impossible for noisy biological systems subject to varying environments. Based on several examples ranging from snake thermosensing and E. coli chemosensing to fly olfaction, we have investigated a feedback motif that robustly maintains these systems close to their respective critical or bifurcation point. The key ingredient is that the collective response feeds back onto the control parameter. Such a feedback scheme works well if just a single control parameter needs tuning. But robust critical behavior has also been found in high-dimensional systems like plasma membranes made up from thousands of components and in mammalian hearing where local activity of hair cells brings the whole cochlea to the edge of instability. Here we argue how these systems could find the critical manifold in the high-dimensional parameter space and why critical behavior might occur naturally in high-dimensional systems. Plus d'infos...
L'ADN et la diversité génétique humaine sont au cœur de nombreux débats de sociétés, y compris au-delà des questions de santé. Comme pour d'autres domaines scientifiques aujourd'hui, ces débats sont brouillés par une méconnaissance de la méthode scientifique utilisée en génétique des populations humaines pour produire des connaissances sur l'histoire de notre évolution biologique. Nous proposons dans ce séminaire de présenter comment les généticiens reconstruisent l'histoire de nos origines et de notre évolution à partir de la diversité génétique humaine telle qu'elle est observée aujourd'hui à travers le monde. Nous verrons dans ce récit que les catégories raciales n'expliquent ni la diversité génétique humaine ni l'histoire de notre évolution. Nous verrons également comment la culture est une force fondamentale de l'évolution biologique de notre espèce. Cette conférence s’adresse à tout le personnel de l’Institut Cochin sans exception et sera suivie d'un moment convivial autour d’un buffet. Au plaisir de vous y retrouver…
Laurence Bénit, Clotilde Randriamampita et Laetitia Waast
Pour le Comité Trans-Sciences Plus d'infos...
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e
Jeudi 19 Fevrier 2026    10:00
Invite par: Institut Necker Enfants Malades - Room 4, Floor -1 Seminar topic: Eco-evolutionary dynamics of bacterial strains across Human gut microbiotasHugo did his bachelor's in Biology followed by a master in Applied Microbiology, both at Faculdade de Ciencias da Universidade de Lisboa in Portugal. His master's thesis was focused on the type VII secretion system of Bacillus subtilis. He then did his PhD in Instituto Gulbenkian de Ciencia in Portugal, in which he followed the evolution of Escherichia coli in the mouse gut in the context of host aging. After the PhD, Hugo moved to Institut Cochin in Paris to start working with Human gut microbiotas in an in vitro system and how fiber consumption affects the microbiota composition. During his PostDoc, he was awarded a Marie Sk?odowska-Curie Post-doctoral Fellowship to study colonization resistance in Human gut microbiotas using both in vitro and in vivo models and barcoded Escherichia coli as the invading bacteria.Please join us to discuss and exchange ideas regarding Maria ____________What is PPS?A cross-institute seminar series where postdocs are invited to present their work in an institute other than their own. While the speakers are postdocs, the seminars are open to the entire institute. This creates a unique opportunity for postdocs to showcase their work to a broad audience, foster scientific exchange, and potentially spark future collaborations or even find their next lab.Launched in 2023 with just six institutes, the initiative has grown remarkably this year, 15 institutes take part in it and extend the seminar series beyond the Paris region. Thanks to this expanding network, the PPS has become a vibrant platform for postdocs to share their research and discover scientific communities across institutes._____________
Plus d'infos...
Tags: Bacteriology, Environmental microbiology, Microbiomes, Calouste Gulbenkian Foundation, Instituto Gulbenkian de Cincia, Escherichia, Gut microbiota, Human microbiome
Annonce publiée le 05-02-2026
Institut Necker Enfants Malades
Hugo Barreto
Jeudi 19 Fevrier 2026    10:30
Invite par l'equipe Courtier, SangYoun Park, Soongsil University in Seoul, presentera un seminaire sur le theme : The Insect Egg Glue Proteins of Human Lice, Bed Bugs, and Giant Toe-biters Resume : SangYoun Park's main tool of research is using X-ray to determine protein structures, and he has also been working on identification and characterization of various insect egg glue proteins. So far, he has worked on the egg glue protein of the human head/body louse (https://doi.org/10.1038/s41598-018-36913-z), which have been extended to the analogs of the pubic louse, chimpanzee louse, and gorilla louse (https://doi.org/10.1038/s41598-025-24011-w). He has also looked into the egg glue proteins of the bed bug (https://doi.org/10.1016/j.ijbiomac.2023.126004)and very recently of the aquatic water bugs (https://doi.org/10.1016/j.actbio.2025.12.052). Le seminaire se deroulera dans la salle 430B de l'Institut Jacques Monod. Plus d'infos...
Tags: Lice, Ectoparasites, Sexually transmitted diseases and infections, Body louse, Louse, Crab louse, Insect
Annonce publiée le 10-02-2026
Institut Jacques Monod
Institut Jacques Monod, 15 rue Helene Brion, Paris, France
Jeudi 19 Fevrier 2026    11:00
Invite par: Scientific conference - Robert Debre Hypnosis suffers from a controversial public image that simultaneously fuels unreasonable expectations regarding its potential and an a priori skepticism about its very existence. This presentation aims at reviewing the main findings established over more than a century of experimental research on hypnosis, before highlighting the current developments proposed by our team.
The first part will address the longstanding challenge of defining hypnosis, the most robustly established findings, and the main theoretical approaches that seek to provide them with a mechanistic foundation. We will flag a critical limitation common to these theories: the assumption that a single common cause underlies the heterogeneity of hypnotic phenomena. Addressing this issue constitutes the core of our research program, which is articulated around interaction loops between inference and reinforcement mechanisms. We will illustrate this approach through two ongoing projects focusing respectively on the sense of agency (i.e., the feeling of being the author of one&'s actions) and on peripheral thermoregulation. Plus d'infos...
Tags: Hypnosis
Annonce publiée le 08-02-2026
NeuroDiderot
salle de conferences 6eme etage du batiment Bingen, Point Rouge, Hopital Robert Debre, 48 boulevard Serurier - 75019 et en visioconference
Jeudi 19 Fevrier 2026    12:00
Invite par: Jessica Bryant Abstract : In the mosquito, Plasmodium parasites undergo a highly divergent mitosis as they form eight gametes out of a single precursor cell. Here, three rapid rounds of endomitosis are followed by a single ... Plus d'infos...
au College de France - Salle 2 - 11 place Marcelin Berthelot - 75005 Paris
Vendredi 20 Fevrier 2026    11:45
Invitee par l’equipe Ribes / Nedelec, Dr Vicki Metzis, head of the Development and Transcriptional Control Group, MRC LMS, Imperial, va presenter un seminaire de l’Institut Jacques Monod sur le theme : Fine-tuning gene expression to build the body plan Resume : Vicki Metzis is a developmental biologist investigating how cells establish and maintain their identity during development. Her lab studies how gene expression dynamics are regulated by cis-regulatory elements and their impact on the variety of cell types that emerge in the developing body plan. A central focus of this work is the transcription factor CDX2, whose transient expression is essential for caudal body formation and Hoxgene patterning. In this seminar, Vicki will present the latest findings from the group revealing regulatory strategies constraining Cdx2, and the broader impact of CDX factors on the developing body plan. Plus d'infos...
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France
Vendredi 20 Fevrier 2026    12:00
Invite par: Institut Necker Enfants Malades - Auditorium 3 Seminar topic: Multi-Omic data for patient stratification and personalized medicine in immuno-inflammatory diseases Vassili Soumelis was trained in Clinical Hematology and Immunology. His academic career started as a researcher-physician at the Institut Curie (2004-2018), followed by a Professor of Immunology (PUPH) position at Universite Paris Cite and Hopital St Louis. He made important contributions to the fields of human immunology, dendritic cell and T cell biology, cytokine biology, disease physiopathology, including HIV infection, allergy, autoimmunity and cancer. His academic research combines expertise in immunology, systems biology, computational biology, data science and medicine. In 2022 he joined Owkin, France, a HealthTech and Biotech company using artificial intelligence for personalized medicine, as their first Chief Medical Officer. Recently, he joined ArcaScience as Chief Medical Officer in order to spearhead the medical strategy of the company and contribute to the development of AI products to analyze, optimize and predict the risk-benefit of drugs and other therapeutic interventions. Vassili Soumelis coordinated a European FP6 Excellence Grant (2005-2009), coordinated bioinformatics and systems biology in the European consortium MAARS (FP7), and received ERC consolidator (IT-DC) and proof-of-concept (DrugSynergy) grants. He has been the global coordinator of the H2020 project ImmunAID, using multi-omics data integration for the diagnostic classification of rare auto-inflammatory diseases. V. Soumelis has published 144 scientific articles in international journals (h-index: 64). He has been serving as a reviewer for many research journals, including Nature, Immunity, Nature Immunology, Nature Genetics, Nature Computational Science, Nature Communications, the Journal of Experimental Medicine. Mark your calendars and make sure to join!
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Invite par: Institut Necker Enfants Malades - Auditorium 3 Seminar topic: Control of genic and extragenic transcription in inflammation and cancer.
Gioacchino Natoli obtained his Medical Degree with honors from the University of Rome La Sapienza in 1991, with a thesis on the role of the Hepatitis B Virus X protein in hepatocellular carcinoma. He completed a residency in Internal Medicine at La Sapienza and pursued research training in molecular biology and gene regulation, including postdoctoral work at the University of California, San Diego, in the laboratory of Prof. Michael Karin.In 2000, Dr. Natoli established his first independent research group at the Institute for Research in Biomedicine (IRB) in Bellinzona, Switzerland. He later served as Group Leader at the European Institute of Oncology (IEO) in Milan (20052016), Professor of Biochemistry at Humanitas University School of Medicine (20162019), and returned to IEO in 2020, where he currently leads a research group."Research in my lab is focused on molecular mechanisms of transcriptional and epigenetic regulation in three different areas. a) How cell type-specific transcriptional responses to inflammatory stimuli are mounted in immune cells and particularly macrophages, the key mediators of innate immunity. Among other findings, we showed that transcription factors driving and maintaining myeloid lineage differentiation specify the cell type-specific repertoire of genomic regions where transcription factors activated in response to environmental stimuli are recruited, thereby establishing the basis for tissue-specific, stimulus-induced gene expression. b) Mechanisms that control extragenic Pol II activity Following the serendipitous discovery in 2010 of enhancer RNAs in activated macrophages, we became strongly interested in mechanisms that control extragenic Pol II activity, which led us to identify the Restrictor complex, today a central focus of our research. c) The third and most recent research branch aims to understand the regulatory basis of the massive loss of lineage identity observed in pancreatic cancer, which underlies the extensive non-genetic heterogeneity characteristic of this tumor."
Mark your calendars and make sure to join!
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Invitee par l'equipe Palacande, Catherine H. Freudenreich (Professor of Biology, School of Arts & Sciences, Tufts University, Medford, MA, USA) presentera un seminaire de l'Institut Jacques Monod sur le theme : Overcoming natural replication barriers formed by DNA structures and the role of repositioning to the nuclear periphery Resume : All cells encounter replication barriers upon genome duplication and must overcome those barriers to survive. Many repeat sequences can form alternative DNA structures that interfere with replication and repair. This can lead to disease-causing repeat expansions. Alternatively, breaks within structure-forming repeats cause chromosome deletions and rearrangements, which are common in cancer cells undergoing replication stress. One strategy that cells use to overcome some types of replication barriers or difficult-to-repair lesions is repositioning to the nuclear periphery. I will describe research from my lab on how structure-forming DNA repeats are replicated and repaired and the role of relocation to the nuclear pore in these processes. Recent results on the mechanisms used to move damaged chromosomes to the nuclear pore and the role of this pathway in protecting genome instability will be covered. Plus d'infos...
Tags: DNA replication, Mutation, Biotechnology, Chromosomes, Molecular genetics, DNA, Genome instability, Viral replication, Repeated sequence, Eukaryotic DNA replication, Origin of replication
Annonce publiée le 29-01-2026
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France
Mardi 03 Mars 2026    11:00
Invite par: Marie-Agnes Petit The Microverse is the intricate and interconnected network of microbiomes that covers the Earth and all things on it. A key aim of our research is to understand the drivers of microbiome composition and dynamics, and understand how different biomes select for different microbes. By recycling >22k public metagenomics datasets from 140 different biomes, we charted the first map of the Microverse, providing a unique global overview of the ecological affiliations of different bacteria. Using the Microverse map as a guide, I will present examples of mechanisms that underlie the distribution of microbes and discuss their importance in microbial ecology. Plus d'infos...
Proteins that assemble into condensates in solution can also condense into surface phase domains when a subset of condensate components are tethered to or interact with fluid membranes. These domains are dynamic, effectively two-dimensional, and considered prewet? because they occur well outside of the coexistence region of the condensate system alone. We show that proximity to the membrane phase transition dramatically potentiates biopolymer prewetting through a combination of theory, simulation, and experiments in well-defined reconstituted systems. When taken into cells, we show that protein prewetting at the plasma membrane inner leaflet is sensitive to perturbations of plasma membrane composition and structure. More generally, we speculate that prewetting at membranes represents a general protein assembly mechanism involved in a broad array of cell processes and sensitive to both membrane and protein properties. Plus d'infos...
Tags: Membrane biology, Organelles, Biological membrane, Soft matter, Cell membrane, Cell, Sarah Veatch, Peripheral membrane proteins, Biomolecular condensate, Oxysterol-binding protein
Annonce publiée le 30-01-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre IPGG - 6 rue Jean Calvin, Paris 5e
The complex network of proteins that regulate chromatin and DNA methylation landscapes is often disrupted in cancer. Clonal and subclonal mutations targeting a wide range of molecular functions are frequently observed across cancer types, and emerging evidence suggests that loss of robust epigenetic control promotes both cancer initiation and evolution, independently of context-specific effects. I will discuss how diverse genetic alterations that destabilize the epigenetic regulatory network converge into common phenotypes that confer a selected advantage to the affected cells. I will also discuss the implications of altered network topology and systemic epigenetic disorder for the evolution, vulnerability, and therapeutic resistance of cancers. Plus d'infos...
Tags: Epigenetics, DNA, Genetic mapping, Lamarckism, Carcinogenesis, Cancer, DNA methylation, Cancer epigenetics
Annonce publiée le 10-02-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie
Tags: Husson, Draft:Toopy and Binoo: The Movie, Draft:Vacation with Derek
Annonce publiée le 24-01-2026
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407
Mardi 10 Mars 2026    11:00
Invite par: Paola Arimondo Tiziana BONALDI Department of Experimental Oncology, European Institute of Oncology (IEO), Milano -Italy) External attendees wishing to participate in the seminar are required to contact the following email addressdbsc@pasteur.frin order to obtain access to ... Plus d'infos...
au College de France - Salle D2 - 11 place Marcelin Berthelot - 75005 Paris
Jeudi 12 Mars 2026    0:00
Chimeric antigen receptor (CAR) T cells have transformed the treatment of hematological malignancies but remain largely ineffective against solid tumors, highlighting the need for innovative strategies to enhance their activity. While recent CAR designs have focused on optimizing biochemical signaling, the biomechanical aspects of T cell activation have been widely overlooked. Yet, T cells are also regulated by the biophysical properties of their targets. Upon engagement, they form an immune synapse (IS) and sense mechanical cues through mechanosensitive receptors, which directly shape their cytotoxic function. These forces depend on target compliance and stiffness, which vary during cancer progression and may act as a “mechanical immune checkpoint” that facilitates tumor immune evasion. We hypothesize that CAR-T cells respond differently to biophysical cues compared with TCR-activated T cells, as suggested by their non-classical IS, morphological changes, and incomplete cytoskeletal remodeling. This reduced mechanosensitivity likely contributes to their limited efficacy in solid tumors. Our project aims to enhance CAR-T performance by (i) mapping how target mechanics influence activation and identifying key mechanosensitive proteins, and (ii) engineering CARs with enhanced force sensing. By integrating biomechanics into the CAR-T engineering toolkit, we aim to open new avenues for overcoming the barriers that currently limit their effectiveness against solid tumors. Paris postdoc seminar series Plus d'infos...
Annonce publiée le 12-12-2025
Institut Cochin
Salle Rosalind Franklin
Jeudi 12 Mars 2026    10:00
Microbial communities are important for health, industry and the environment. However, they contain many species and are difficult to understand and predict . Using a combination of theory and experiment, we study what it takes for bacteria to succeed in diverse communities and develop strategies to improve gut health. Plus d'infos...
Tags: Microbiomes, Bacteriology, Environmental microbiology, Microbiology, Microbiome, Kevin Foster, Human microbiome, Bacteria, Microorganism, Pharmacomicrobiomics, Developmental symbiosis
Annonce publiée le 24-01-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)
Invite par: Cecile Apert Women's health, Women in Health March 17th 2026 ? Institut Pasteur, Paris, France Registration and Poster application Fill the form The Institut Pasteur is pleased to invite you to the symposium Women's Health, Women ... Plus d'infos...
Tags: Grand Cross of the Legion of Honour, Louis Pasteur, Pasteur Institute, Pasteur station, Pasteur Network
Annonce publiée le 23-01-2026
Institut Pasteur
Batiment: CIS Salle: CIS
Mardi 17 Mars 2026    11:00
Invite par: Philipp Deist FAN LIU Leibniz-Forschungsinstitut fur Molekulare Pharmakologie (FMP) External attendees wishing to participate in the seminar are required to contact the following email address dbsc@pasteur.fr in order to obtain access to the Institut Pasteur premises ABSTRACT ... Plus d'infos...
Tags: COVID-19 pandemic in France, Pasteur Institute, Louis Pasteur, Structure, Leibniz-Forschungsinstitut fr Molekulare Pharmakologie
Annonce publiée le 22-01-2026
Institut Pasteur
Batiment F. Jacob Auditorium, salle ,
Jeudi 19 Mars 2026    0:00
The wide range of muscle morphologies found across the animal kingdom enables intricate movements essential for various behaviors, such as feeding, mating, or even tasks like writing a summary for a seminar. Many animals rely on appendages for their locomotion, which feature multifiber muscles with diverse morphologies enabling unique functions. Despite extensive study and understanding of the general program of muscle development (how myoblasts produce muscles), the specific program controlling the diversity of muscle morphologies in multifiber muscles (how myoblasts produce unique muscles) remains unknown. Using Drosophila leg muscles as a model system, we have revealed that myoblasts, in parallel with the general program of myogenesis, express distinct transcriptional programs that specify muscle morphologies. Moreover, we found that the spatiotemporal progression of these programs is regulated by morphogenes secreted by the underlying epithelium. To achieve these conclusions, we used unique genetic and computational tools combined with single-cell sequencing. Our findings provide a framework for the developmental and evolutionary origins of appendicular muscles and may help explain the selective vulnerability of specific muscles in muscular dystrophies. I would also give a couple of words of a pipeline of 3D Spatial transcriptomic (3D MERFISH) we have developed in the context of The Equipex+, Spatial Cell ID. Jonathan Enriquez is invited by Pascal Maire. Plus d'infos...
Invite par l'equipe Minc, Pablo Meyer Rojas, Manager of Biological Analytics and Modeling group and Senior Research Scientist IBM Research USA, presentera un seminaire de l'Institut Jacques Monod sur le theme : Pre-training DNA language modelsto make them understand Biology Resume : Large language models (LLMs) trained on text demonstrated remarkable results on natural language processing (NLP) tasks. These models have been adapted to decipher the language of DNA, where sequences of nucleotides act as words? that encode genomic functions. However, the human genome differs fundamentally from natural language, as it lacks clearly defined words or a consistent grammar. DNA language models (DNALMs) such as EVO or DNABERT, have achieved a high level of performance on genome-related biological tasks using DNA sequences as input. Deep learning (DL) models trained for specific tasks such as Alpha-Genome or the ones developed through the DREAMcrowdsourcing challenges often surpass DNALMs. However, neither DNALMs nor DL models have explanations for how they encode the biological functions they are good at predicting. To address this problem, we pre-train foundation models that effectively integrate sequence variations, in particular Single Nucleotide Polymorphisms (SNPs), as they underlie important biological functions and disease. We show that integrating this and other biological knowledge into the pre-training of DNALMs brings better and interpretable performance of the models. Plus d'infos...
Tags: DNA, Genetic mapping, Genomics, DNA large language model, Biotechnology, Large language model, ENCODE, Human genome, Genome, DNA annotation
Annonce publiée le 10-02-2026
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France
au College de France - Salle D2
11 place Marcelin Berthelot - 75005 Paris
Mercredi 25 Mars 2026    0:00
Vers une comprehension quantitative de la dynamique nucleaire au cours du developpement et des maladies Les objectifs de ce cours sont de fournir un apercu des mecanismes epigenetiques et de leurs liens avec la chromatine. Les differentes fonctions du noyau impliquant le genome et son organisation seront discutees en insistant sur les limites technologiques et les nouvelles approches experimentales developpees. Les liens entre la perte des fonctions du noyau et le developpement de pathologies humaines seront presentes. Cette annee ce cours abordera plus amplement les aspects physiologiques et pathologiques de l'epigenetique, en lien avec le metabolisme et la determination et maintien de l'identite cellulaire. Le succes de ce cours repose sur une forte contribution des participants qui doivent assister de facon tres proactive a l'ensemble des activites organises, tels que les sessions de presentations de posters, les analyses d'articles (Journal Club), et les ateliers. (voir section Travail personnel et le Programme pour plus d information). Une session speciale sera aussi dediee a aux presentations et echanges avec 1-2 alumni du cours qui ont poursuivi leur carriere dans le domaine de l'epigenetique. Plus d'infos...
Annonce publiée le 11-11-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)
Mercredi 25 Mars 2026    11:30
The microtubule cytoskeleton is an active network that adopts distinct architectures at different cell cycle stages. Using microscopy-based bottom-up reconstitutions and computer simulations, we build minimal self-organizing microtubule networks that mimic cellular architectures, focusing especially on the role of molecular motors, nucleators and microtubule dynamics for network organization. We uncover physical design principles of the architecture of mitotic spindles during cell division that ensure that at metaphase minus motors focus microtubule minus ends into exactly two spindle poles whereas plus motors organize a central array of antiparallel microtubules. Plus d'infos...
Centre de recherche - Paris - Amphitheatre Marie Curie
Jeudi 26 Mars 2026    0:00
The second meeting of theFBI Mechanobiology WGwill take place on the26 and 27 of March 2026at theInstitut de Biologie Paris Seineand theInstitut Jacques Monodin Paris. The programme will include aseminar by Kate Miroshnikova(NIDDK/NIH, Bethesda USA and Max Planck Institute for Molecular Biomedicine, Munster, Germany),presentations by participantsandpractical mechanobiology workshops(a choice of 4 workshops from a dozen:optical tweezers, micro/nano-fabrication, microfluidics, AFM, micropipette aspiration, mechanical confinement, force measurements, etc?). Preliminary program: Day 1 - 26/03/2026, Paris 5e(IBPS / Curie / IPGG) Morning: scientific presentations, small group discussion Afternoon : 2 sessions of practical workshops on real set-ups in participating labs (Paris 5e) Day 2 - 27/03/2026, Paris 13e(IJM / MSC / LIED) Morning: scientific presentations, poster session Afternoon : 2 sessions of practical workshops on real set-ups in participating labs (Paris 13e) Infos & registration: Registration is free,but places arelimitedandprioritywill be given to contributors whoseabstracts have been selected. Restration link : here Plus d'infos...
Tags: Institut Pierre-Gilles de Gennes, Paris Sciences et Lettres University, Bioimaging, IJM, Institut Jacques Monod
Annonce publiée le 28-11-2025
Institut Jacques Monod
Institut Jacques Monod Amphitheatre Buffon, 15 rue Helene Brion, Paris, France
au College de France - Salle D2
11 place Marcelin Berthelot - 75005 Paris
Mercredi 08 Avril 2026    0:00
Ce cours etudiera le spectre complet de la biologie du genome, de l'organisation et de l'imagerie de la chromatine a l'epigenetique, a l'ADN mobile et a la dynamique evolutive. Au cours de six sessions ciblees, des experts de renommee internationale presenteront leurs dernieres decouvertes liees a l'identification et a la caracterisation fonctionnelle du genome non codant et discuteront de nouveaux concepts de regulation et d'evolution du genome, en mettant l'accent sur les outils experimentaux et informatiques. Les sessions thematiques comprendront des approches unicellulaires et translationnelles de pointe pour demeler la plasticite et l'heterogeneite cellulaires, interroger la regulation des genes et suivre l'evolution du genome dans la physiologie et la maladie. Ce cours offrira aux jeunes etudiants et aux chercheurs l'occasion d'elargir leurs connaissances et de discuter de leurs travaux avec une communaute scientifique internationale dans un environnement chaleureux et stimulant a l'Institut Curie a Paris. Plus d'infos...
Annonce publiée le 23-10-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e
Jeudi 09 Avril 2026    0:00
Intermittent hyperglycemia, characterized by fluctuations in blood glucose levels, has been proposed as a stronger driver of vascular damage than sustained hyperglycemia. This project aims to investigate its role in the development of atherosclerosis. We will use low-density lipoprotein receptor-deficient (Ldlr-/-) mice, a well-established model of atherosclerosis, maintained on a cholesterol-enriched diet to promote lesion formation. To mimic clinical glycemic variability, mice will receive drinking water supplemented with fructose and glucose either continuously or discontinuously, generating sustained versus intermittent hyperglycemia, respectively. We will monitor metabolic parameters, inflammatory markers, and gut microbiota composition to assess systemic and intestinal responses. Atherosclerotic burden will be quantified by histological and morphometric analyses of the aortic root and en face preparations of the aorta.
We hypothesize that intermittent hyperglycemia will exacerbate systemic inflammation and accelerate atherosclerotic lesion development compared with continuous exposure, potentially through enhanced oxidative stress and microbiota dysbiosis. This study will provide mechanistic insights into how glycemic fluctuations influence cardiovascular risk, with implications for the management of diabetic patients. Paris postdoc seminar series Plus d'infos...
Tags: Otome games, Video games developed in Japan, Shjo manga, Angelique, Anglique, Angelique Luminarise, Koi suru Tenshi Angelique
Annonce publiée le 23-01-2026
Centre de Recherche des Cordeliers
Vendredi 10 Avril 2026    9:45
Invite par: Francois Bontems ReCombinaisons se veut un espace de rencontre et de discussion entre chercheuses et chercheurs (biologie-sante, sciences humaines et sociales, philosophie), autrices, auteurs et artistes de science-fiction, et public le plus large possible, pour reflechir ... Plus d'infos...
au College de France Amphi Delmas-Marty - 11 place Marcelin Berthelot - 75005 Paris
Lundi 20 Avril 2026    14:00
Invite par: Benoit Marteyn Shigella was the leading cause of diarrheal disease during World War One; and more than 100 years later, it continues to cause approximately 200 million cases and 216,000 deaths per year around the globe. Shigella is a ... Plus d'infos...
au College de France - Salle D2 - 11 place Marcelin Berthelot - 75005 Paris
Lundi 18 Mai 2026    0:00
We are happy to announce theopening of registrations for the 16th edition of the French 3R meetingReplication, Recombination, Repair?! The meeting will take place fromMay 18 to 21, 2026, at the Belambra Club Presqu'ile du Ponant,La Grande Motte near Montpellier, France. Please visit the meeting website:https://www.2026.3r-meeting.fr/ Registrations will be open fromJanuary 12, to March 23, 2026. Deadline for abstract submission: 2nd of March 2026 Early birdregistrations fees are proposed until2nd of March 2026as following (tax-free): PhD students and postdocs (shared accommodation): 400 € Researchers, engineers, permanent staff (shared accommodation): 480 € Researchers, engineers, permanent staff (single accommodation): 550 € Sponsors and non-academic participants (without accommodation): 300 € Single accommodation is available in limited numbers and will be allocated on a first-come, first-served basis. Shared accommodation consists of two separate bedrooms and one bathroom. Full pricesafter the 2nd of March 2026 as following: PhD students and postdocs (shared accommodation): 480 € Researchers, engineers, permanent staff (shared accommodation): 560 € Researchers, engineers, permanent staff (single accommodation): 630 € Sponsors and non-academic participants (without accommodation): 300 € Please share this message with anyone who might be interested. We hope to see you all at the meeting! The organizing committee Flyer Plus d'infos...
au College de France - Salle D2 - 11 place Marcelin Berthelot - 75005 Paris
Jeudi 04 Juin 2026    0:00
Cystic fibrosis is a genetic disease characterized by a dehydration of airway mucus leading to increased viscosity, significant inflammation, lung infections and tissue damage. Because progression of the disease cannot be solely explained by genetic factors, some studies are now interested in the intrinsic and extrinsic factors that exacerbate CF symptoms. Among those factors, reduced levels of specialized proresolving lipid mediators (SPM) in CF airway and exposure to air pollution have been reported. In addition, some pollutants have been shown to impact SPM biosynthesis. However, the possible role of air pollution on SPM metabolism dysregulation in CF and the role of SPM in protecting CF airways from air pollution induced damages have not been explored.
In our project, we use Scnn1b transgenic mice as a model for CF airway disease. In collaboration with the LISA (Interuniversity Laboratory of Atmospheric Systems / Laboratoire Interuniversitaire des Systèmes Atmosphériques), we study how exposure to a polluted atmosphere can impact the SPM and, more generally, the resolution of inflammation in the airway. Paris postdoc seminar series Plus d'infos...
Tags: Lambrechts, Diether, Charles Joseph Mathieu Lambrechts, Diether of Nassau
Annonce publiée le 06-02-2026
Centre de Recherche des Cordeliers
Vendredi 05 Juin 2026    9:30
Invite par: Anna-Bella Failloux Grand challenges in vector-borne diseases Controlling vectors in the context of climate and environmental changes June 5th 2026 ? Institut Pasteur, Paris, France Registration is free but mandatory Registration form As part of the ... Plus d'infos...
au College de France - Salle D2 - 11 place Marcelin Berthelot - 75005 Paris
Mardi 23 Juin 2026    9:00
Cette journee sera consacree aux recherches fondamentales et appliquees dans le domaine en pleine expansion des interactions entre cellules stromales (en particulier les fibroblastes et les cellules endotheliales) et cellules immunitaires au sein du microenvironnement tumoral (TME). Au cours de la derniere decennie, le stroma tumoral est devenu une cible therapeutique prometteuse dans le cancer, les fibroblastes associes au cancer (CAF) jouant un role cle dans la structuration du TME, la regulation de la croissance tumorale, l'evasion immunitaire et la resistance aux chimiotherapies et immunotherapies. Le nombre d'experts en France travaillant dans ce domaine ne cesse de croitre, et nous ressentons le besoin d'organiser un symposium qui reunisse des chercheurs experimentes et des debutants afin de favoriser la creation d'une communaute. Inspire par les initiatives fructueuses des dernieres decennies autour de la recherche sur les lymphocytes et les cellules myeloides, ce symposium vise a aider un cercle pluridisciplinaire d'experts interesses par les fibroblastes du TME a etablir des consensus sur les pratiques experimentales, proposer des nomenclatures unifiees, partager des resultats et echanger des modeles. L'objectif de ce symposium est de renforcer les collaborations naissantes et d'accroitre la visibilite internationale de l'Institut Curie et de la France dans le domaine de l'etude du stroma dans le cancer. Il s'adresse a des personnes disposant d'au moins des connaissances de base en biologie ou immunologie (niveau recommande : Master). Cet evenement sera egalement une opportunite pour faire progresser la recherche translationnelle et le developpement de traitements anticancereux ciblant specifiquement les composants stromaux. Le symposium se tiendra le mardi 23 juin 2026, de 8h30 a 20h, dans l'Amphitheatre Constant Burg (12 rue Lhomond, 75005 Paris, niveau -1), le plus spacieux et confortable de l'Institut Curie, avec ses 196 places. Nous esperons accueillir entre 120 et 150 participants. Les scientifiques que nous avons invites et qui ont confirme leur participation pour presenter leurs projets et leurs resultats les plus recents dans le domaine du stroma, de l'immunite et du cancer, sont listes ci-dessous par ordre alphabetique : CONFERENCIERS PRINCIPAUX (KEYNOTE SPEAKERS) Alexandra Naba - Etats-Unis Shannon Turley - Etats-Unis INTERVENANTS (SPEAKERS) Corinne Bousquet - France Cedric Gaggioli - France Fatima Mechta-Grigoriou - France Lucie Peduto - France Helene Salmon - France Karine Tarte - France Danijela Vignjevic - France En complement, trois jeunes postdocs/chercheurs (1 venant de l'UE, 1 hors Paris et 1 parisien) seront selectionnes pour des presentations courtes (10 minutes + 5 minutes de questions). La selection se fera sur la base des resumes des posters soumis lors de l'inscription. Nous veillerons autant que possible a respecter la parite hommes-femmes parmi les intervenants. L'inscription au symposium sera gratuite mais obligatoire. Nous diffuserons largement l'annonce afin de maximiser la visibilite et d'attirer des chercheurs, etudiants, medecins et ingenieurs internationaux, qui devront prendre en charge leurs frais de voyage et d'hebergement. Une session de posters accompagnee d'un « vin et fromage » sera organisee en fin de symposium, mais les posters pourront etre affiches des le matin a proximite de l'espace cafe/dejeuner pour favoriser les echanges tout au long des pauses. L'IHU Cancers de femmes de l'Institut Curie sponsorise cet evenement, dont la thematique correspond a l'un de ses axes de recherche. Plus d'infos...
Annonce publiée le 08-11-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e
Mardi 23 Juin 2026    9:00
Cet evenement d'une journee sera consacre a la recherche fondamentale et appliquee dans le domaine en pleine expansion des interactions entre cellules stromales (notamment fibroblastes et cellules endotheliales) et cellules immunitaires au sein du microenvironnement tumoral (TME). Au cours de la derniere decennie, le stroma tumoral est apparu comme une cible therapeutique prometteuse dans le cancer, les fibroblastes associes au cancer (CAF) jouant un role cle dans la structuration du TME, la regulation de la croissance tumorale, la promotion de l'evasion immunitaire et la contribution a la resistance auxchimiotherapie et auximmunotherapies. Les scientifiques que nous avons invites et qui ont confirme leur participation pour presenter leurs projets et leurs resultats les plus recents dans le domaine du stroma, de l'immunite et du cancer sont listes ci-dessous par ordre alphabetique : CONFERENCIERS INVITES (KEYNOTE) Alexandra Naba - USA Shannon Turley - USA INTERVENANTS Corinne Bousquet - France Cedric Gaggioli - France Fatima Mechta-Grigoriou - France Lucie Peduto - France Helene Salmon - France Karine Tarte - France Danijela Vignjevic - France En plus de ces intervenants, trois jeunes post-doctorants/chercheurs (1 de l'UE, 1 hors Paris et 1 de Paris) seront selectionnes pour des presentations courtes (10 minutes + 5 minutes de questions). La selection se fera sur la base des resumes de posters soumis lors de l'inscription. Nous veillerons a assurer un equilibre hommes-femmes parmi les intervenants. L'inscription au symposium sera gratuite mais obligatoire. Nous diffuserons largement l'annonce du symposium afin de maximiser sa visibilite et d'attirer des chercheurs, etudiants, medecins et ingenieurs internationaux, qui prendront en charge leurs frais de deplacement et d'hebergement. Une session poster accompagnee de vin et fromage se tiendra a la fin du symposium, mais les posters seront affiches des le matin pres de la zone cafe/dejeuner pour encourager les echanges tout au long des pauses. L'IHU Cancers des Femmes de l'Institut Curie sponsorise l'evenement, car le theme s'inscrit dans l'une de ses priorites de recherche. Inscription gratuite mais obligatoire avant le 10 juin 2026:https://forms.office.com/e/pMdqmCLZcP Plus d'infos...
Annonce publiée le 14-11-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e