|
Given the ongoing climate crisis, for this 2026 edition, we have decided to create a symposium maximising the possibility for invited speakers to travel by train or a short flight. We are nevertheless happy to host attendees from any place in the world. As we are aware of the tension between reducing carbon footprint and maintaining a diversity of countries, our model for SBDM may be reconsidered in next editions. The hope is to strike a right balance between sustainability and inclusivity across the years. Plus d'infos... Tags: Academic conference, Symposium Annonce publiée le 20-03-2026 |
  |
| I. Cerveau et de la Moelle Mehdi Khamassi (CNRS / ISIR, Sorbonne Universite, Paris, France) |
Pour afficher les séminaires d'un seul institut, appuyer d'abord sur 'None' puis sur l'institut de votre choix.
-
-
Invite par: Bertrand Cosson
Plus d'infos...
Tags: Epigenetics
Annonce publiée le 16-05-2026
Epigenetique et Destin Cellulaire
salle des seminaires de l'IJM (RB-18B), 15 rue Helene Brion - 75013 ou en visioconference -
Invite par: CIRB-College de France
Plus d'infos...
Annonce publiée le 15-12-2025
College de France
au College de France - Salle D2 - 11 place Marcelin Berthelot - 75005 Paris -
Our lab investigates how plasmodesmata (PD) regulate cell-to-cell communication in plants. These membrane-lined pores create cytoplasmic, plasma membrane (PM), and endoplasmic reticulum (ER) continuity between neighboring cells, allowing the direct exchange of proteins, RNAs, hormones, and metabolites. PD are central to the organization of plant multicellularity, yet their regulation remains poorly defined. We focus on the molecular mechanisms that shape PD specialization and function, with particular emphasis on their unique membrane architecture and its impact on intercellular trafficking. Using lipidomics, proteomics, super-resolution, electron tomography and expansion microscopy, molecular dynamics, and plant genetics, we address fundamental questions such as: What defines PD membrane domains? What role do lipids play in PD function? How do ER-PM contacts within PD control trafficking? Our work has revealed lipids as functional regulators of PD, uncovered the plasticity of their 3D structure, and demonstrated that PD act as specialized ER-PM membrane contact sites with dedicated tethering proteins. More recently, we showed that PD form through ER-dependent incomplete cytokinesis, redefining the role of the ER in establishing intercellular continuity. Together, these findings reshape our view of how plant cells connect and communicate.
Plus d'infos...
Tags: Organelles, Membrane biology, Plant anatomy, Cell biology, Cellular processes, Plasmodesma, Cytokinesis, Cell, Endoplasmic reticulum, Biological membrane, Lipidomics, Membrane contact site
Annonce publiée le 17-04-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Plus d'infos...
Tags: Coulter, Surnames, Beckman, Draft:Beckman Coulter Life Sciences, Blood tests, Wallace H. Coulter
Annonce publiée le 27-03-2026
Centre de Recherche des Cordeliers -
Glucocorticoid hormones have powerful effects on the brain, in the context of circadian alignment and adaptation to stress. These have been linked to mood, cognition and to related neuro-psychiatric diseases. Data from mouse models suggest a strong contribution of endogenous glucocorticoids to neurodegenerative processes. The use of glucocorticoids as anti-inflammatory drugs may recapitulate some of those effects. Glucocorticoids act via two receptor types, in many neuronal and non-neuronal cell types. This widespread, pleiotropic activity has hindered our mechanistic understanding, as well as the clinical separation of beneficial and detrimental consequences of glucocorticoid-based treatments. The presentation will cover data on benefits and detrimental effects of glucocorticoids, with a focus on non-neuronal cells as their target. It will also cover approaches for more specific targeting of glucocorticoid-effects on cell types and/or biological processes, using new glucocorticoid based therapeutic approaches in neurodegenerative disease.
Plus d'infos...
Tags: Corticosteroids, Glucocorticoids, Neurodegenerative disease, Corticotropic cell, Psychoneuroimmunology
Annonce publiée le 16-05-2026
Saints Peres Neuroscience
salle de conferences R229, Campus Saint Germain des Pres de l'Universite de Paris Cite, 45 rue des Saints Peres 75006 -
Invite par l'equipe Greenberg et l'equipe Konstantinides, Joaquin Navajas Acedo (Postdoc, Schier Lab at the University of Basel, Switzerland) presentera un seminaire de l'Institut Jacques Monod sur le theme : SpatiotemporalEmergence of Somatosensory Neuron Diversity Resume : My work uses a population of somatosensory neurons in the zebrafish spinal cord -the Rohon-Beard (RB) neurons- to address a fundamental question in neuroscience: How do cellular factors combine in space and time to generate robustly the diverse neuron types of a functional circuit?Live imaging and deep single-cell transcriptomics across development show that contrary to a ~150-year-old assumption, RB neurons do not disappear by programmed cell death and are heterogeneous at 3 levels: their transcriptome, their axial distribution, and inter-individual pattern. Combining in totocell lineage reconstruction and a custom whole-mount spatial transcriptomics -in the same animal- my work shows RB neurons possess extremely simple cell lineages and link them to dozens of transcription factors and somatosensory genes in space. Spatiotemporal analysis of RB subtype emergence reveals that it follows a staggered-layer logic, with a ?pan-RB program' preceding a stochastic ?hybrid neurotrophin receptor' state that resolves into mutually-exclusive subclasses, followed by specialized functional subtypes. I also define the regulatory mechanism by transcription factors underlying the seemingly stochastic, yet robust emergence of the observed neuronal subtypes across time. I also discuss this mechanism is likely conserved across Anamniotes. This work demonstrates that zebrafish RB neurons are an excellent model to study the precise molecular mechanisms underlying the development of neuron diversity at the single-cell level.
Plus d'infos...
Tags: Somatosensory system, Neurotrophin, Neuron, Computational neuroscience
Annonce publiée le 23-04-2026
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Invite par: EEB External Seminar Series
Plus d'infos...
Tags: Bacteriophages, Bacteriophage, Genomics, ASO, Molecular biology, Phage ecology
Annonce publiée le 19-05-2026
IBENS
salle Favard, IBENS 46 rue d'Ulm 75005 Paris -
Plus d'infos...
Tags: Fibrosis
Annonce publiée le 17-05-2026
CRSA
grand amphitheatre de la Faculte de Sante de l 75012 -
Plus d'infos...
Tags: Immunology, Cytokine
Annonce publiée le 17-05-2026
CRSA
grand amphitheatre de la Faculte de Sante de l'Hopital Saint-Antoine, 27 rue de Chaligny 75012 -
The commonality of many neurodegenerative disorders is the progressive temporal and spatial aggregation of specific proteins in the brain. The quintessential proteopathy is Alzheimer's disease (AD), in which the aggregation and seeded propagation of amyloid peptide triggers AD pathogenesis, including neuronal Tau inclusions and neurodegeneration. Current therapeutic strategies focus on early disease stages and aim ta inactivate seed propagation before the onset of neurodegeneration. However, ta develop such primary prevention approaches a mechanistic understanding of early disease stages is essential.
Plus d'infos...
Tags: Alzheimer's disease, Amyloidosis, Biomarkers, Neurological disorders, Histopathology, Neurodegenerative disease, Amyloid beta, Amyloid, Tau protein, Mathias Jucker, Proteinopathy, Biochemistry of Alzheimer's disease
Annonce publiée le 10-04-2026
I. Cerveau et de la Moelle
Institut du cerveau -
La journee scientifique annuelle du Club de Developpement des Reseaux Neuronaux a pour objectif de promouvoir les travaux des chercheurs de la communaute. Elle aura lieu le 2 juin 2026. Le programme est construit sur la base des resumes soumis pour communications orales. Les communications, en anglais, seront reparties en troissessions scientifiques , intercalees avec lesseminaires de conferenciers invites experts dans le domaine du neurodeveloppement. Les inscriptions pour la journee du club DRN sont ouvertesjusqu'au 19 mai 2026 via le site de l'evenement. L'inscription est obligatoire pour pouvoir participer aux conferences Le club Developpement des Reseaux Neuronaux a pour vocation de rassembler les chercheurs de differentes disciplines des neurosciences (developpement, physiologie, biochimie, pharmacologie?) interesses dans la construction des reseaux de neurones. Chaque annee, le club Developpement des Reseaux Neuronaux organise une journee scientifique dans le but de rassembler ces chercheurs, pour renforcer leurs interactions et mieux representer ce domaine de recherche au niveau des neurosciences francaises.
Plus d'infos...
Annonce publiée le 11-05-2026
Institut Jacques Monod
Institut Jacques Monod Amphitheatre Buffon, 15 rue Helene Brion, Paris, France -
Invite par: Ludovic Sauguet
Dr. Svetlana Dodonova EMBL, Heidelberg, Germany External attendees wishing to participate in the seminar are required to contact the following email address dbsc@pasteur.fr in order to obtain access to the Institut Pasteur premises at least one week ...
Plus d'infos...
Tags: Cell biology, Cryogenic electron microscopy, Protein structure, Extremophiles, Archaea, Cryo
Annonce publiée le 12-02-2026
Institut Pasteur
Batiment Duclaux , salle Duclaux Auditorium, -
Invite par: CIRB-College de France
Plus d'infos...
Annonce publiée le 23-03-2026
College de France
au College de France - Salle D2-11 place Marcelin Berthelot - 75005 Paris -
Invite par: IBENS - Equipe Laurent BOURDIEU
Plus d'infos...
Annonce publiée le 05-05-2026
IBENS
salle Favard, IBENS 46 rue d'Ulm 75005 Paris -
Invite par: Slobodan Culina
Join us for the 2nd edition of an in-depth look at the newest technologies in the protein biomarker discovery field
Plus d'infos...
Tags: Biomarkers, Biomarker discovery, Cancer biomarker
Annonce publiée le 08-05-2026
Institut Pasteur
Batiment: Metchnikoff building Salle: Salle Jules Bordet -
Invite par: Valerie Mezger
The hallmarks of aging framework, introduced over a decade ago and cited nearly 20,000 times, became quantifiable in 2018 through transcriptional counterparts. However, fundamental questions persist about what these hallmarks reveal regarding aging&'s nature. Using our laboratory&'s biphasic aging model, we demonstrate that aging hallmarks manifest not progressively, but through an abrupt transition. As individuals age, they face increasing probability of undergoing the "Smurf transition" detected via in vivo intestinal permeability assessment. Strikingly, transcriptional and physiological hallmarks of aging appear almost exclusively in this expanding subpopulation experiencing barrier dysfunction. These findings challenge conventional paradigms: Are aging hallmarks primarily markers of terminal decline rather than chronological aging? What implications does this discontinuous model hold for understanding aging mechanisms and age-related disease etiology? Our work suggests reconceptualizing aging hallmarks as end-of-life transitions markers may unlock novel insights into therapeutic interventions and disease prevention strategies.
Plus d'infos...
Tags: Old age, Senescence, Ageing, Cellular processes, Hallmarks of aging
Annonce publiée le 25-05-2026
Epigenetique et Destin Cellulaire
salle des seminaires de l&'IJM (RB-18B), 15 rue Helene Brion - 75013 ou en visioconference -
L'Institut Jacques Monod, l'Unite de Biologie Fonctionnelle et Adaptative (Universite Paris Cite | CNRS ) et l'association L'Arbre des Connaissances ont le plaisir de vous inviter au Congres des Apprentis Chercheurs 2026 qui se tiendra le Mercredi 3 Juin 2026 ! A cette occasion, les collegiens et lyceens presenteront le projet scientifique sur lequel ils ont travaille toute l'annee en etant accompagnes par les scientifiques des laboratoires.
Plus d'infos...
Annonce publiée le 23-05-2026
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Cystic fibrosis is a genetic disease characterized by a dehydration of airway mucus leading to increased viscosity, significant inflammation, lung infections and tissue damage. Because progression of the disease cannot be solely explained by genetic factors, some studies are now interested in the intrinsic and extrinsic factors that exacerbate CF symptoms. Among those factors, reduced levels of specialized proresolving lipid mediators (SPM) in CF airway and exposure to air pollution have been reported. In addition, some pollutants have been shown to impact SPM biosynthesis. However, the possible role of air pollution on SPM metabolism dysregulation in CF and the role of SPM in protecting CF airways from air pollution induced damages have not been explored. In our project, we use Scnn1b transgenic mice as a model for CF airway disease. In collaboration with the LISA (Interuniversity Laboratory of Atmospheric Systems / Laboratoire Interuniversitaire des Systèmes Atmosphériques), we study how exposure to a polluted atmosphere can impact the SPM and, more generally, the resolution of inflammation in the airway. Paris postdoc seminar series
Plus d'infos...
Tags: Lung disorders, Channelopathies, Cystic fibrosis, Fibrosis
Annonce publiée le 18-12-2025
Institut Cochin
Salle Rosalind Franklin -
On the occasion of the inauguration of the Paris Brain Institute as a new ZEISS Labs@location, we are pleased to invite you to a mini-symposium on the theme "Imaging the Brain: New Probes and Approaches".
Plus d'infos...
Tags: Neural engineering, Neuroimaging, Cognitive neuroscience
Annonce publiée le 16-04-2026
I. Cerveau et de la Moelle
09:00 - 09:15 -
Ovulation is essential for reproduction. During ovulation, an egg is released from an ovarian follicle into the oviduct. Once released, the egg can be fertilised by the sperm and give rise to a new embryo. Ovulation takes place inside the body, impeding studies of its progression. The exact mechanisms that control ovulation have therefore remained unclear. In this work, we devised methods to study the entire process of ovulation live in isolated ovarian follicles from mice using a long-term culture and imaging system. A combined approach of confocal and two-photon microscopy allowed for the study of ovarian processes at both the cellular and whole follicle scale. We show that ovulation proceeds through three distinct phases, follicle expansion (I), contraction (II), and rupture (III), culminating in the release of the egg. Follicle expansion is driven by the secretion of hyaluronic acid, and an osmotic gradient-directed influx of fluid into the follicle. Subsequently, smooth muscle cells in the outer follicle drive follicle contraction. Follicle rupture is initiated by the formation of a stigma in the thinnest region of the follicle wall, followed by the exit of follicular fluid and cumulus cells, and finally, the rapid release of the egg. Taken together, these results establish a mechanistic framework for ovulation, a process of fundamental importance to reproduction
Plus d'infos...
Tags: Menstrual cycle, Mammal female reproductive system, Midwifery, Human female reproductive system, Women's health, Ovulation, Ovarian follicle, Ovary, Stigma, Follicle, Cumulus oophorus, Ovarian follicle dominance
Annonce publiée le 05-05-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
Plus d'infos...
Tags: Lambrechts, Diether, Charles Joseph Mathieu Lambrechts, Diether of Nassau
Annonce publiée le 06-02-2026
Centre de Recherche des Cordeliers -
Invite par l'equipe Ladoux/Mege, Prof. Chwee Teck Lim ( Mechanobiology Institute, National University of Singapore ) presentera un seminaire de l'Institut Jacques Monod sur le theme : How Geometry Drives Collective Cell Migration Resume : Cells that migrate as sheets or large cohorts exhibit behaviors that differ markedly from those of individually migrating cells, particularly when subjected to geometric constraints, physical confinement, or out-of-plane topography. Collective cell migration underlies many essential biological processes, including wound healing, maintenance of the intestinal epithelium, embryonic development, and cancer invasion and metastasis. Understanding these collective behaviors therefore offers valuable insights into tissue repair mechanisms and the design of regenerative medicine strategies. Here, we investigate the kinematic properties of collectively migrating cell cohorts under a range of well-defined geometric and physical constraints, including migration along narrow strips and across out-of-plane curved surfaces, to elucidate how confinement and surface geometry shape collective cell dynamics. Bio : Professor Lim is the NUS Society Chair Professor and Director of the Institute for Health Innovation and Technology at NUS. He is also the Founding Director of the Singapore Health Technologies Consortium. His research interests include human disease mechanobiology and the development of microfluidic and wearable technologies for healthcare applications. He is a prolific researcher having co-authored over 500 journal publications and delivered more than 550 plenary/keynote/invited lectures. He is also a serial entrepreneur having started six companies with one public listed in 2018. Professor Lim is an Elected Fellow of the Royal Society (UK), Royal Academy of Engineering (UK), National Academy of Inventors (US), IUPESM, AIMBE, IAMBE, ASEAN Academy of Engineering and Technology, Academy of Engineering, Singapore, Singapore National Academy of Science and the Institution of Engineers. He and his team have garnered over 100 research awards and honours including the President's Science Award, Otto Schmitt Award, Nature Lifetime Achievement Award for Mentoring in Science, Asia's Most Influential Scientist, Highly Cited Researcher, IES Prestigious Engineering Achievement Award, ASEAN Outstanding Engineering Achievement Award, Asian Scientists 100, Credit Suisse Technopreneur of the Year Award, Wall Street Journal Asian Innovation Award (Gold), President's Technology Award, and the Distinguished Alumni Award among others.
Plus d'infos...
Tags: Education in Singapore, Cells, Collective cell migration, Oncology, National University of Singapore, Asian Scientist 100, Lim Chwee Teck
Annonce publiée le 13-05-2026
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Invite par: Anna-Bella Failloux
Grand challenges in vector-borne diseases Controlling vectors in the context of climate and environmental changes June 5th 2026 ? Institut Pasteur, Paris, France Registration is free but mandatory Registration form As part of the ...
Plus d'infos...
Tags: Infectious diseases, Epidemiology, Vector calculus, Disease transmission, Disease vector, Parasitology, Vector, Euclidean vector, Climate change and infectious diseases
Annonce publiée le 07-11-2025
Institut Pasteur
Batiment: Duclaux Salle: Amphitheatre Duclaux -
Invite par l'Institut Jacques Monod et l'Unite Epigenetique et Destins Cellulaire, Alexander Meissner (Directeur, Max Planck Institute for Molecular Genetics) presentera une conference de l'Institut Jacques Monod sur le theme : Epigenetic regulation in development and disease Resume : In vertebrates, somatic cells stably maintain globally high DNA methylation levels and protect CpG island promoters, features that are extensively altered within mammalian extraembryonic tissues and the majority of human cancers.I will present recent insights from various models to explore the non-canonical regulation of DNA methylation Publications Ming-Kang Lee, Sebastian D. Mackowiak, Daniel Felismino, Jeron Venhuizen, Maria Walther, Alexander Meissner. Temporal degradation of PRC2 uncovers specific developmental dependencies. bioRxiv 2026.04.18.719361 Taguchi A, Magalhaes AP, Bolondi A, Lee MK, Kretzmer H, Wittler L, Hnisz D, Meissner A. Single-cell activation screen identifies hepatic maturation regulators with zonal resolution. Dev Cell. 2026 Mar 11;61(3):553-570.e9. Hetzel S, Hodis E, Torlai Triglia E, Kovacsovics A, Steinmann K, Gnirke A, Cui M, McQuaid D, Weigert R, Pohl G, Muzumdar MD, Leyvraz S, Keilholz U, Yaspo ML, Regev A, Kretzmer H, Smith ZD, Meissner A. Direct genetic transformation bypasses tumor-associated DNA methylation alterations. Genome Biol. 2025 Jul 17;26(1):212. Guckelberger P, Haut L, Tornisiello R, Kretzmer H, Meissner A. HELLS is required for maintaining proper DNA modification at human satellite repeats. Genome Biol. 2025 Jul 17;26(1):211. Batki J, Hetzel S, Schifferl D, Bolondi A, Walther M, Wittler L, Grosswendt S, Herrmann BG, Meissner A. Extraembryonic gut endoderm cells undergo programmed cell death during development. Nat Cell Biol. 2024 Jun;26(6):868-877. Sampath Kumar A, Tian L, Bolondi A, Hernandez AA, Stickels R, Kretzmer H, Murray E, Wittler L, Walther M, Barakat G, Haut L, Elkabetz Y, Macosko EZ, Guignard L, Chen F, Meissner A. Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis. Nat Genet. 2023 Juf?5(7):1176-1185. Weigert R, Hetzel S, Bailly N, Haggerty C, Ilik IA, Yung PYK, Navarro C, Bolondi A, Kumar AS, Anania C, Brandl B, Meierhofer D, Lupianez DG, Muller FJ, Aktas T, Elsasser SJ, Kretzmer H, Smith ZD, Meissner A. Dynamic antagonism between key repressive pathways maintains the placental epigenome. Nat Cell Biol. 2023 Apr;25(4):579-591. Hetzel S, Mattei AL, Kretzmer H, Qu C, Chen X, Fan Y, Wu G, Roberts KG, Luger S, Litzow M, Rowe J, Paietta E, Stock W, Mardis ER, Wilson RK, Downing JR, Mullighan CG, Meissner A. Acute lymphoblastic leukemia displays a distinct highly methylated genome. Nat Cancer. 2022 Jun;3(6):768-782. doi: 10.1038/s43018-022-00370-5.
Plus d'infos...
Tags: Epigenetics, Post-translational modification, DNA, Gene expression, Methylation, DNA methylation, Regulation of gene expression, Epigenome, Transcription, Alexander Meissner, Max Planck Institute for Molecular Genetics
Annonce publiée le 14-05-2026
Institut Jacques Monod
Institut Jacques Monod Amphitheatre Buffon, 15 rue Helene Brion, Paris, France -
Plus d'infos...
Tags: Fricker, Desdemona
Annonce publiée le 19-08-2025
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
Ce cours avance de trois jours offre un apercu complet des derniers developpements en matiere de pratique clinique, de recherche et d innovation therapeutique. Les participants exploreront les donnees scientifiques de pointe, les technologies emergentes, et les defis lies aux soins gynecologiques. Concu pour les professionnels experimentes, le programme met l accent sur des connaissances approfondies et des perspectives d avenir dans les cancers gynecologiques.
Plus d'infos...
Annonce publiée le 04-03-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
Invite par: Aude Bernheim
A Joint Symposium by Labex IBEID et Pasteur 2030 Priority 1 The program will be uploaded soon.
Plus d'infos...
Tags: Infectious diseases, Microbiology, Pathogen, Zoonoses, Evolutionary biology
Annonce publiée le 20-02-2026
Institut Pasteur
Batiment: Amphitheatre Duclaux -
Mechanotransduction was perhaps the last major sensory modality not understood at the molecular level. Proteins/ion channels that sense mechanical force are postulated to play critical roles in sensing touch/pain (somatosensation), sound (hearing), shear stress (cardiovascular function), etc.; however, the identity of ion channels involved in sensing mechanical force had remained elusive. The Patapoutian lab identified PIEZO1 and PIEZO2, mechanically activated cation channels that are expressed in many mechanosensitive cell types. Genetic studies established that PIEZO2 is the principal mechanical transducer for touch, proprioception, baroreception, bladder, and lung stretch, and that PIEZO1 mediates blood-flow sensing, which impacts vascular development and iron homeostasis. Clinical investigations have confirmed the importance of these channels in human physiology. Current work in Patapoutian continues to explore the role of mechanosensation and interoception in physiology and disease.
Plus d'infos...
Tags: Transmembrane proteins, Sensory systems, PIEZO2, Ardem Patapoutian, PIEZO1, Piezo, Mechanosensation, Mechanotransduction, Proprioception, Sense, Somatosensory system, Ion channel
Annonce publiée le 07-04-2026
I. Cerveau et de la Moelle
Institut du cerveau -
Invite par: CIRB-College de France
Plus d'infos...
Annonce publiée le 06-01-2026
College de France
au College de France - Salle D2 - 11 place Marcelin Berthelot - 75005 Paris -
Invite par: CIRB-College de France
Plus d'infos...
Annonce publiée le 29-04-2026
College de France
au College de France - Salle D2 -11 place Marcelin Berthelot - 75005 Paris -
Plus d'infos...
Annonce publiée le 23-05-2026
Institut Cochin
Salle Rosalind Franklin -
Invite par: Philippe Gaudu
Staphylococcusaureus and Staphylococcusepidermidis, two Gram-positive members of the skin microbiota, form biofilms involved in dysbiosis and inflammatory skin diseases. We investigated the role of the molecular chaperone DnaK from S.epidermidis in biofilm formation. Recombinant DnaK modulates biofilm formation in a strain-dependent manner: it increases biofilm biomass in commensal strains but significantly reduces it in the clinical S.aureus strain CIP107093. Using point mutants of DnaK, we show that the substrate-binding domain is required for this inhibitory effect. Proteomic analysis indicates that recombinant DnaK, added extracellularly, alters the biofilm proteome of S.aureus, affecting protein degradation systems and biofilm regulators, thus revealing a cross-species regulatory role within the skin microbiota.
Plus d'infos...
Tags: Gram-positive bacteria, Pathogenic bacteria, Bacteriology, Environmental microbiology, Human microbiome, Staphylococcus epidermidis, Staphylococcus aureus, Biofilm, Hsp70, Skin flora, Staphylococcus
Annonce publiée le 18-03-2026
Institut Micalis
Auditorium 442 - Institut Micalis -
Invite par: BOUVIER Guy
Plus d'infos...
Annonce publiée le 21-04-2026
NeuroPSI
Salle de conference Albe-Fessard -
Invite par: IBENS Developmental Biology Seminar
Plus d'infos...
Annonce publiée le 19-05-2026
IBENS
salle Favard, IBENS 46 rue d'Ulm 75005 Paris -
Hugo Wioland (equipe Romet-Lemonne/Jegou) va defendre son Habilitation a Diriger des recherche : Actin biochemical and mechanical diversity Le jury sera compose de : NicolasJoly, President Laurent Blanchoin, Rapporteur Peter Bieling, Rapporteur Aurelie Bertin, Examinatrice Patricia Bassereau, Examinatrice
Plus d'infos...
Tags: Habilitation, Actin, Bieling, Romet
Annonce publiée le 23-05-2026
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Learning requires identifying population activity patterns associated with desired outcomes and acquiring the ability to volitionally recruit them. Whether such processes rely on shared or circuit-specific population dynamics across the brain remains unresolved. A fundamental challenge is that different brain regions typically underpin distinct behaviors, making it difficult to disentangle circuit-specific learning mechanisms from region-specific behavioral demands. Here, we overcome this limitation using a brain-computer interface (BCI) to impose an identical, population-defined learning problem across brain networks. By making reward contingent directly on neuronal population activity, we apply the same associative learning paradigm under identical conditions to two regions with prominent recurrent connectivity but fundamentally distinct dynamical regimes: primary motor cortex (M1) and hippocampal area CA3. Mice acquired robust volitional control in both regions, demonstrating that distinct circuits can support equivalent goal-directed learning. In both M1 and CA3, learning drove progressive sparsification of population activity and greater population-level representation of the reward state. The underlying population dynamics, however, diverged. M1 showed sustained pre-reward excitation and population trajectories that flowed continuously through the reward state, with manifold geometry separating behavioral states. CA3 exhibited a learning-dependent temporal reversal, shifting from pre-reward excitation to post-reward inhibition, with population trajectories converging onto the reward state before rapidly resetting to baseline, and distinct behavioral states collapsing onto a shared manifold subspace. Recurrent network models with distinct connectivity architectures and dynamical constraints, matched to each region, recapitulated these population-level dynamics, linking intrinsic circuit structure to the geometry of learned activity. These findings demonstrate that equivalent learning outcomes can arise from fundamentally different population-level implementations, reflecting intrinsic circuit constraints rather than conserved population-level strategies. This principled degeneracy indicates that learning emerges not from a single canonical solution, but from multiple circuit-specific implementations shaped by local dynamics.
Plus d'infos...
Tags: Hippocampus, Limbic system, Reward system, Brain, Network neuroscience
Annonce publiée le 10-04-2026
I. Cerveau et de la Moelle
Institut du cerveau -
Invite par: Francesca Gubellini
The Structural Biology and Chemistry Department together with the Center for Technological Resources and Research C2RT will run the nICE-Day? event on June 16th from 9am to 6pm in the Duclaux lecture hall. This ...
Plus d'infos...
Tags: Protein structure, Cell biology, Cryogenic electron microscopy, Structural biology, Fellows of the Royal Society
Annonce publiée le 07-05-2026
Institut Pasteur
Salle Amphi Duclaux, -
TBA
Plus d'infos...
Tags: LJP, National Youth Council of Latvia, Liberty and Justice Party
Annonce publiée le 11-12-2023
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407 -
Invite par: CIRB-College de France
Plus d'infos...
Annonce publiée le 29-04-2026
College de France
au College de France - Salle a venir -11 place Marcelin Berthelot - 75005 Paris -
Plus d'infos...
Annonce publiée le 14-05-2026
NeuroPSI
Salle de conference Albe-Fessard -
Invite par: Laurent Essioux
The Institut Pasteur is organizing its 3rd edition of its SymposiumArtificial Intelligence in Biology and Health. It will be held on 4thOctober 2024 in the Emile Duclaux lecture hall at the Institut Pasteur campus. ...
Plus d'infos...
Tags: COVID-19 pandemic in France, Pasteur Institute, mile Duclaux, Louis Pasteur
Annonce publiée le 14-02-2026
Institut Pasteur
Batiment: Duclaux Salle: Duclaux lecture hall -
Invite par: Joshua Ricouvier
The immune system is one of the most complex systems of the human body. At its core, it uses protein-protein interactions to achieve the emergent property of differentiating self from other. Synthetic biology aims to implement biological functions of natural living systems, to test hypothesis and to expand them beyond their current limits. Here, we mimic key protein-protein interactions and functions of the immune system using a cell-free surface-based approach. We use innovative silicon chips to parallelize antigen display and antibody epitope screening. Linear DNA sequences are immobilized in micrometer-sized carved compartments. Phenotype and genotype are linked in every compartment by localized on-chip expression and capture of antigens. Binding to a panel of viral antigens is assessed with high specificity for monoclonal antibodies and for polyclonal antibodies in human serum, revealing a rich picture of epitopes and individual immune profiles. This platform mimics and extends the function of antigen-presenting cells, allowing us to interrogate protein-protein interaction between host receptor, pathogenic antigen and immune system.
Plus d'infos...
Tags: Immune system, Immunology, Epitope, Polyclonal antibodies, Antigen, Antibody, Monoclonal antibody, Immune receptor, Polyclonal B cell response, Immunomics
Annonce publiée le 07-04-2026
Institut Micalis
Auditorium 442 - Institut Micalis -
This presentation proposes that TAM heterogeneity and functions are determined by their origin and localization in distinct tumor sub-anatomic niches and challenges the association with the M1/M2 binary model.BOISSONNAS Alexandre, Principal Investigator- (Directeur de recherche Inserm) Team leader Spatio-temporal organization and regulation of myeloid cells STORM. Institut Mondor de Recherche Biomedicale IMRB U955, Universite Paris-Est Creteil.Alexandre Boissonnas is an immunologist and Research Director at the French National Institute of Health and Medical Research (Inserm). He obtained his PhD in 2004, during which he investigated the role of antigen in the homeostasis of peripheral T lymphocytes. He then joined Sebastien Amigorena In 2009, he was recruited by Inserm at CIMI-Paris where he established and has since led his own research team focusing on monocyte and macrophage biology. He recently moved to IMRB in Creteil, continuing his investigations on the dynamics of the mononuclear phagocyte system in inflammatory diseases and cancer. His laboratory combines high-dimensional immunomonitoring with advanced imaging technologies to unravel the spatio-temporal organization and regulation of the macrophage compartment, as well as its responses to tissue injury and neoplastic transformation.
Plus d'infos...
Tags: Macrophages, Immune system, Oncology, Tumor-associated macrophage, Macrophage
Annonce publiée le 09-04-2026
Centre de Recherche des Cordeliers -
1. Gelsinger DR ... Ivanov II#, Sternberg SH#, Wang HH#. Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases. Science 2025. #co-corresponding author 2. Araujo LP ... Ivanov II. Context-dependent role of group 3 innate lymphoid cells in mucosal protection. Science Immunology 2024. 3. Brockmann L ... Ivanov II. Intestinal microbiota-specific Th17 cells possess regulatory properties and suppress effector T cells via c-MAF and IL-10. Immunity 2023. 4. Kawano Y ... Ivanov II. Dietary sugar-induced microbiota imbalance disrupts immune-mediated protection from metabolic syndrome. Cell 2022. 5. Ladinsky MS ... Bjorkman PJ#, Ivanov II#. Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis. Science 2019. #co-corresponding author 1. Gelsinger DR ... Ivanov II#, Sternberg SH#, Wang HH#. Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases. Science 2025. #co-corresponding author 2. Araujo LP ... Ivanov II. Context-dependent role of group 3 innate lymphoid cells in mucosal protection. Science Immunology 2024. 3. Brockmann L ... Ivanov II. Intestinal microbiota-specific Th17 cells possess regulatory properties and suppress effector T cells via c-MAF and IL-10. Immunity 2023. 4. Kawano Y ... Ivanov II. Dietary sugar-induced microbiota imbalance disrupts immune-mediated protection from metabolic syndrome. Cell 2022. 5. Ladinsky MS ... Bjorkman PJ#, Ivanov II#. Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis. Science 2019. #co-corresponding author
Plus d'infos...
Tags: Immune system, Bacteriology, Microbiomes, T cells, Microbiology, Intestinal epithelium, T helper 17 cell, Microbiota, Human microbiome, Gut microbiota, Innate lymphoid cell, Gut-associated lymphoid tissue
Annonce publiée le 06-05-2026
Institut Curie
Centre de recherche - Orsay - Amphitheatre du Batiment 111 -
The hippocampus is a cognitive hub whose functions are disrupted in most major neurodegenerative dementias. Drawing on recent advances in generative artificial intelligence and systems neuroscience, we conceptualize the hippocampus as a latent diffusion engine that compresses sensory, internal, and cognitive inputs into low-dimensional representations and then regenerates percepts, episodic memories, and imagined scenes for cortical integration. Travelling waves of cortico-hippocampal oscillations, aligned with large-scale functional gradients, schedule and structure this generative process, organizing distributed neural activity into coherent, semantically grounded constructs. We also demonstrate how major neurodegenerative dementias - including the Alzheimer&'s disease spectrum - can be interpreted as selective breakdowns of the anatomical and computational components of this proposed architecture.
Plus d'infos...
Tags: Cognitive disorders, Aging-associated diseases, Learning disabilities, Limbic system, Dementia, Hippocampus, Alzheimer's disease
Annonce publiée le 07-04-2026
I. Cerveau et de la Moelle
Institut du cerveau -
Cette journee sera consacree aux recherches fondamentales et appliquees dans le domaine en pleine expansion des interactions entre cellules stromales (en particulier les fibroblastes et les cellules endotheliales) et cellules immunitaires au sein du microenvironnement tumoral (TME). Au cours de la derniere decennie, le stroma tumoral est devenu une cible therapeutique prometteuse dans le cancer, les fibroblastes associes au cancer (CAF) jouant un role cle dans la structuration du TME, la regulation de la croissance tumorale, l'evasion immunitaire et la resistance aux chimiotherapies et immunotherapies. Le nombre d'experts en France travaillant dans ce domaine ne cesse de croitre, et nous ressentons le besoin d'organiser un symposium qui reunisse des chercheurs experimentes et des debutants afin de favoriser la creation d'une communaute. Inspire par les initiatives fructueuses des dernieres decennies autour de la recherche sur les lymphocytes et les cellules myeloides, ce symposium vise a aider un cercle pluridisciplinaire d'experts interesses par les fibroblastes du TME a etablir des consensus sur les pratiques experimentales, proposer des nomenclatures unifiees, partager des resultats et echanger des modeles. L'objectif de ce symposium est de renforcer les collaborations naissantes et d'accroitre la visibilite internationale de l'Institut Curie et de la France dans le domaine de l'etude du stroma dans le cancer. Il s'adresse a des personnes disposant d'au moins des connaissances de base en biologie ou immunologie (niveau recommande : Master). Cet evenement sera egalement une opportunite pour faire progresser la recherche translationnelle et le developpement de traitements anticancereux ciblant specifiquement les composants stromaux. Le symposium se tiendra le mardi 23 juin 2026, de 8h30 a 20h, dans l'Amphitheatre Constant Burg (12 rue Lhomond, 75005 Paris, niveau -1), le plus spacieux et confortable de l'Institut Curie, avec ses 196 places. Nous esperons accueillir entre 120 et 150 participants. Les scientifiques que nous avons invites et qui ont confirme leur participation pour presenter leurs projets et leurs resultats les plus recents dans le domaine du stroma, de l'immunite et du cancer, sont listes ci-dessous par ordre alphabetique : CONFERENCIERS PRINCIPAUX (KEYNOTE SPEAKERS) Alexandra Naba - Etats-Unis Shannon Turley - Etats-Unis INTERVENANTS (SPEAKERS) Corinne Bousquet - France Cedric Gaggioli - France Fatima Mechta-Grigoriou - France Lucie Peduto - France Helene Salmon - France Karine Tarte - France Danijela Vignjevic - France En complement, trois jeunes postdocs/chercheurs (1 venant de l'UE, 1 hors Paris et 1 parisien) seront selectionnes pour des presentations courtes (10 minutes + 5 minutes de questions). La selection se fera sur la base des resumes des posters soumis lors de l'inscription. Nous veillerons autant que possible a respecter la parite hommes-femmes parmi les intervenants. L'inscription au symposium sera gratuite mais obligatoire. Nous diffuserons largement l'annonce afin de maximiser la visibilite et d'attirer des chercheurs, etudiants, medecins et ingenieurs internationaux, qui devront prendre en charge leurs frais de voyage et d'hebergement. Une session de posters accompagnee d'un « vin et fromage » sera organisee en fin de symposium, mais les posters pourront etre affiches des le matin a proximite de l'espace cafe/dejeuner pour favoriser les echanges tout au long des pauses. L'IHU Cancers de femmes de l'Institut Curie sponsorise cet evenement, dont la thematique correspond a l'un de ses axes de recherche.
Plus d'infos...
Annonce publiée le 08-11-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
Cet evenement d'une journee sera consacre a la recherche fondamentale et appliquee dans le domaine en pleine expansion des interactions entre cellules stromales (notamment fibroblastes et cellules endotheliales) et cellules immunitaires au sein du microenvironnement tumoral (TME). Au cours de la derniere decennie, le stroma tumoral est apparu comme une cible therapeutique prometteuse dans le cancer, les fibroblastes associes au cancer (CAF) jouant un role cle dans la structuration du TME, la regulation de la croissance tumorale, la promotion de l'evasion immunitaire et la contribution a la resistance auxchimiotherapie et auximmunotherapies. Les scientifiques que nous avons invites et qui ont confirme leur participation pour presenter leurs projets et leurs resultats les plus recents dans le domaine du stroma, de l'immunite et du cancer sont listes ci-dessous par ordre alphabetique : CONFERENCIERS INVITES (KEYNOTE) Alexandra Naba - USA Shannon Turley - USA INTERVENANTS Corinne Bousquet - France Cedric Gaggioli - France Fatima Mechta-Grigoriou - France Lucie Peduto - France Helene Salmon - France Karine Tarte - France Danijela Vignjevic - France En plus de ces intervenants, trois jeunes post-doctorants/chercheurs (1 de l'UE, 1 hors Paris et 1 de Paris) seront selectionnes pour des presentations courtes (10 minutes + 5 minutes de questions). La selection se fera sur la base des resumes de posters soumis lors de l'inscription. Nous veillerons a assurer un equilibre hommes-femmes parmi les intervenants. L'inscription au symposium sera gratuite mais obligatoire. Nous diffuserons largement l'annonce du symposium afin de maximiser sa visibilite et d'attirer des chercheurs, etudiants, medecins et ingenieurs internationaux, qui prendront en charge leurs frais de deplacement et d'hebergement. Une session poster accompagnee de vin et fromage se tiendra a la fin du symposium, mais les posters seront affiches des le matin pres de la zone cafe/dejeuner pour encourager les echanges tout au long des pauses. L'IHU Cancers des Femmes de l'Institut Curie sponsorise l'evenement, car le theme s'inscrit dans l'une de ses priorites de recherche. Inscription gratuite mais obligatoire avant le 10 juin 2026:https://forms.office.com/e/pMdqmCLZcP
Plus d'infos...
Annonce publiée le 14-11-2025
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
Invite par: Pierre Guermonprez
Laura Mackay Peter Doherty Institute for Infection and Immunity, Australia ABSTRACT Immune responses are often inferred from blood, yet many T cells reside long-term within tissues, where local context shapes their behaviour. Tissue-resident memory ...
Plus d'infos...
Tags: Immune system, Immunology, Laura Mackay, T cell, Nonspecific immune cell, Mucosal immunology
Annonce publiée le 23-04-2026
Institut Pasteur
Salle AGNES ULLMAN AUDITORIUM , -
Plus d'infos...
Tags: Merad, Miriam, The President
Annonce publiée le 10-04-2026
Centre de Recherche des Cordeliers -
TBC soon - stay tuned!
Plus d'infos...
Tags: Reini, Luco, Stay Tuned, Laure
Annonce publiée le 16-03-2026
Paris RNA Club
Auditorium Gallois - 45 rue d Ulm, 75005 Paris -
Plus d'infos...
Annonce publiée le 23-05-2026
Institut Cochin
Salle Rosalind Franklin -
Pluripotency provides the foundation of embryonic development and regenerative medicine. Pluripotency is also remarkably dynamic, as it can alternate between different states and can be promptly resolved to allow lineage specification. As such, e mbryonic development relies on stem cell function in balance with differentiation. We investigate how this balance is maintained in coordination with the environment and the protective measures the embryos take at times of scarcity. Our mission is to decode the process of dormancy and identify the genetic, epigenetic, and metabolic mechanisms that govern this fascinating phenomenon.
Plus d'infos...
Tags: Developmental biology, Biotechnology, Cell biology, Stem cells, Cloning, Cellular differentiation, Cell potency, Adult stem cell
Annonce publiée le 09-04-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
Anthracyclines like doxorubicin are still cornerstones in the treatment of a series of tumors. They should act by poisoning topoisomerase II causing DNA double stranded breaks. However, they also evict histones at defined sites in chromatin. We chemically separated these two activities to show that histone eviction was the most cytotoxic activity. Doxorubicin variants acting through histone eviction are active cancer drugs but have lost various toxic side effects including dose-dependent cardiotoxicity. These variants can still be used in the treatment of relapsed cancer patients and can strongly improve their overall survival. New activities in old cancer drugs can thus be explored to control toxicities, allow chronic treatment and improve the quality of life of cancer survivors.
Plus d'infos...
Tags: Anthracyclines, Antineoplastic drugs, Doxorubicin, Teratogens, Anthracycline, Chemotherapy, Cardiotoxicity, Histone, CytRx, Zoptarelin doxorubicin
Annonce publiée le 24-04-2026
Centre de Recherche des Cordeliers -
Abstract Retrotransposition - the reverse flow of genetic information from RNA to DNA provides the major route by which new genetic material enters our genome, with retroelements comprising over 40% of human DNA. This process drives innovation but threatens genome integrity, demanding effective regulation. Our discovery of the Human Silencing Hub (HUSH) revealed a genome-wide transcriptional immunosurveillance system that detects and epigenetically silences invading DNA. How HUSH distinguishes self from invading DNA was unclear. We found that HUSH discriminates ?self' from ?non-self' based on cellular introns: The majority of cellular genes are intron-containing, while RNA-derived retroelements are intronless, marking their cDNA as foreign. This intron-based recognition mechanism uncovers an unexpected innate immune surveillance system that protects the genome from the reverse flow of genetic information. Our ongoing work on HUSH-mediated epigenetic repression will be further discussed.
Plus d'infos...
Tags: Molecular biology, Non-coding DNA, RNA splicing, DNA, Mobile genetic elements, Intron, Retrotransposon, RNA, Human genome, Complementary DNA, Transposable element, Epigenetics
Annonce publiée le 14-05-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
I trained as a structuralbiologist/peptide chemist, with John Kuriyan and Tom Muir at Rockefeller University, before carrying out postdoctoral research with Mark Davis and Stanford. There, I became interested in the structure and function of immune cell-cell interactions. I joined the Immunology Program at Memorial Sloan Kettering Cancer Center in 2007. My lab has primarily focused on the cytotoxic immune synapse, which is the specialized junction used by cytotoxic lymphocytes to destroy infected or transformed target cells. Over the past decade, we have become particularly interested in the mechanobiology of this interface, in particular how physical forces and mechanical properties shape its potency and specificity. My talk will address the role of lymphocyte mechanosensing in anti-tumor immune responses.
Plus d'infos...
Tags: Immune system, Lymphocyte, Immunological synapse, T cell
Annonce publiée le 08-05-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
Plus d'infos...
Tags: Comite Creek
Annonce publiée le 22-05-2026
NeuroPSI
Salle de conference Albe-Fessard -
Invite par l'equipe Palancade, Christian Schlieker (Department of Molecular Biophysics and Biochemistry, Yale University, USA) presentera un seminaire de l'Institut Jacques Monod sur le theme : Biomolecular Condensates at the Nuclear Envelope: From Mechanism to Therapeutic Modulation Christian started his scientific training as an undergraduate at the University of Bonn in Germany, with a research stay at the University of New South Wales in Sydney, Australia. He then earned his Ph.D. in the laboratory of Dr. Bernd Bukau at the Center for Molecular Biology (ZMBH) of Heidelberg University, where he used biochemical and biophysical approaches to uncover how Clp/HSP100 AAA+ ATPases counteract proteotoxic stress. Christian continued his training as an EMBO postdoctoral fellow with Dr. Hidde Ploegh at Harvard Medical School and the Whitehead Institute/MIT, where he explored the ubiquitin-proteasome system and discovered a novel role for a ubiquitin-like modifier in RNA biology. Christian joined the Department of Molecular Biophysics and Biochemistry at Yale University in 2009, where he is currently Professor and Director of Undergraduate Studies, with a secondary appointment in the Department of Cell Biology. He is a recipient of the NIH Director's New Innovator Award and has served on the scientific advisory board of the Dystonia Medical Research Foundation and reviewed for the NIH, the Department of Defense, the German Excellence Initiative, ANR and the European Research Council, among others. At Yale, he has chaired the Committee on Majors for Yale College and currently serves on the Advisory Board of the Yale Center for Molecular Discovery. Starting in July 2026, he will chair the Department of Molecular Biophysics and Biochemistry. Brief synopsis We explore how cells build and safeguard two the nuclear envelope and the endoplasmic reticulum. Our work focuses on how disruptions in membrane organization and phase separation drive the formation of aberrant condensates that are increasingly implicated in neurological disease. To tackle these questions, we develop and apply new tools that allow us to probe and modulate these processes across scales, from the dynamics of individual proteins and condensates to genome-wide functional screens. By integrating cell biology, biochemistry, and computational approaches with patient-derived and animal model systems, we aim to uncover fundamental principles of cellular organization and translate these discoveries into novel therapeutic strategies for movement disorders and related conditions. We recently developed a high-content platform and computational pipeline to screen modulators of nuclear condensates across chemical and genetic space. This effort identified novel players in nuclear condensates formation, along with small molecules that modualte proteotoxic condensates. Application of the platform in a genome-wide CRISPR knockout screen revealed strong enrichment of candidate genes linked to primary microcephaly and related neurodevelopmental disorders, pointing to condensate dysregulation as a shared molecular axis across disease. A complementary line of work asks how the nuclear pore complex itself contributes to protein quality control. Co-translational folding allows nascent proteins to begin folding as they are synthesized, reducing the risk of aggregation and avoiding energy-intensive unfolding steps. We propose that karyopherins and flexible FG-nucleoporins not only safeguard the nuclear permeability barrier but also generate a supportive environment - a folding phase? - that promotes correct folding of proteins entering the nucleus. This perspective offers new insight into how disruptions in nuclear transport and protein quality control may contribute to neurological disease. Together, these efforts may inform biotechnological advances in protein stability and targeted therapeutics for diseases of disrupted folding. Selected publications Prophet SM, Rampello AJ, Niescier RF, Gentile JE, Mallik S, Koleske AJ, Schlieker C: Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities. Nat Cell Biol 2022, 24:1630-1641. Poch D, Mukherjee C, Mallik S, Todorow V, Kuiper EFE, Dhingra N, Surovtseva YV, Schlieker C: Integrative Chemical Genetics Platform Identifies Condensate Modulators Linked to Neurological Disorders. bioRxiv 2025, doi:10.1101/2025.06.07.658469. Rampello AJ, Laudermilch E, Vishnoi N, Prophet SM, Shao L, Zhao C, Lusk CP, Schlieker C: Torsin ATPase deficiency leads to defects in nuclear pore biogenesis and sequestration of MLF2. J Cell Biol 2020, 219:e201910185. Mallik S, Poch D, Burick S, Schlieker C: Protein folding and quality control during nuclear transport. Curr Opin Cell Biol 2024, 90:102407.
Plus d'infos...
Tags: Organelles, Proteins, Membrane biology, Cell nucleus, Biomolecular condensate, Cell biology, Proteasome, Ubiquitin, Nuclear envelope, Chaperone, Endoplasmic reticulum, Nuclear pore complex
Annonce publiée le 23-05-2026
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
The arousal construct underlies a spectrum of behaviors that include sleep, exploration, feeding, sexual activity and adaptive stress. Pathological arousal conditions include stress, anxiety disorders, and addiction. In the past few years we have used optogenetics to interrogate neuronal circuits underlying transitions between arousal states. In particular, I will talk about two new circuits identified in our laboratory: one predicts the onset and duration of REM sleep with unprecedented precision; another induces sleep in response to inflammatory cytokines. I will also present a novel method that displays cortex-wide fluctuations in membrane voltage using TEMPO imaging. Finally, I will discuss noninvasive neuromodulation methods for sleep intervention.
Plus d'infos...
Tags: Neurophysiology, Neuromodulation, Rapid eye movement sleep, Brain
Annonce publiée le 08-04-2026
I. Cerveau et de la Moelle
Institut du cerveau -
Structural Maintenance of Chromosomes (SMC) complexes are conserved molecular machines that help organize genomes in organisms ranging from bacteria to humans. They perform two essential tasks: they establish DNA-DNA interactions and extrude DNA loops, thereby shaping chromosome architecture and supporting faithful chromosome segregation. In this talk, I will discuss recent single-molecule studies from our group that reveal how these machines work under force. Using optical tweezers combined with fluorescence microscopy, we directly measure how strongly individual SMC complexes interact with DNA while visualizing their activity. We find that cohesin and condensin can form highly stable DNA connections capable of resisting the forces generated during cell division. By contrast, cohesin-mediated loop extrusion depends on much weaker and more dynamic DNA interactions, allowing loops to be readily remodelled. Comparisons with bacterial SMC complexes show that these machines can be stronger and more efficient loop extruders than their eukaryotic counterparts. Together, these findings suggest that SMC complexes have evolved different mechanical properties to match their specific roles in chromosome folding, maintenance, and segregation.
Plus d'infos...
Tags: Mitosis, Cell cycle, Nuclear organization, Condensin, Cohesin, Loop extrusion, SMC protein, Chromosome, DNA, Chromosome condensation
Annonce publiée le 08-05-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Invite par: CIRB-College de France
Plus d'infos...
Annonce publiée le 29-04-2026
College de France
au College de France - Salle a venir -11 place Marcelin Berthelot - 75005 Paris -
Invite par: Jong Eun Ihm
Start-meup? is an annual two-day event that explores the latest trends in the life sciencesand health innovation ecosystem while guiding participants through the startup creation journey. This year’s expert talks session focuses on how ...
Plus d'infos...
Tags: Entrepreneurship, Business incubators, Private equity, Startup company, Innovation
Annonce publiée le 04-03-2026
Institut Pasteur
Batiment: Centre Francois Jacob Salle: Auditorium -
Plus d'infos...
Tags: Boye, Hans Boye, Come, Thou Fount of Every Blessing
Annonce publiée le 29-04-2026
Centre de Recherche des Cordeliers -
Les inscriptions pour le DIF day 2026 sont ouvertes ! Rendez-vous sur le site d'inscriptions pour pouvoir y participer : https://sites.google.com/view/dif2026/accueil_2026?authuser=0
Plus d'infos...
Annonce publiée le 21-05-2026
Institut Jacques Monod
Institut Jacques Monod Amphitheatre Buffon, 15 rue Helene Brion, Paris, France -
Invite par: CIRB-College de France
Plus d'infos...
Annonce publiée le 29-04-2026
College de France
au College de France Salle D2 - 11 place Marcelin Berthelot - 75005 Paris -
Despite advances in mRNA-based cancer vaccines, therapeutic responses remain limited by poorly immunogenic tumors that fail to support effective T cell infiltration, expansion, and function. Epigenetic therapies can enhance tumor immunogenicity by reactivating transposable elements (TEs), triggering innate sensing of immunogenic nucleic acids through a process known asviral mimicry.In this seminar, I will discuss how the DNA methyltransferase inhibitors induces viral mimicry in preclinicaltumourmodels, leading to type I interferon responses, enhanced antigen presentation, and remodeling of the immunosuppressive tumor microenvironment. This response depends on cancer-intrinsic nucleic acid sensors and supports the expansion and function of vaccine antigen-specific T cells within tumors.Together, these findings identify viral mimicry as a strategy to license therapeutic cancer vaccination and improve anti-tumor immunity.
Plus d'infos...
Tags: Immunology, Oncology, Immune system, Biotechnology, Immunogenicity, Cancer vaccine, Antigen, Tumor microenvironment, Glioma 261, Cancer immunotherapy
Annonce publiée le 06-05-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
Raphid diatoms exhibit rapid gliding motility with remarkable directional flexibility, yet the underlying mechanisms remain poorly understood. Using Craspedostauros australis as a model, we combine phylogenomics, live-cell imaging, and high-resolution microscopy to dissect both force generation and trajectory control. We find that raphe-associated actin bundles do not show directional turnover, arguing against a direct role of actin dynamics in force production. Instead, we identify diatom-specific myosins (CaMyoB-D) that display coordinated movement during gliding, consistent with a motor function. At the cellular level, diatoms dynamically modulate their trajectories by switching between one- and two-raphe contact with the substrate. This switching controls path curvature, with single-raphe gliding producing curved paths and dual-raphe gliding resulting in straighter motion. Together, our results suggest a mechanism in which myosin-driven force generation is coupled to dynamic regulation of cell-substrate contact, enabling flexible navigation in complex environments.
Plus d'infos...
Tags: Protein families, Actin, Autoantigens, Myosin, Diatom, Gliding motility
Annonce publiée le 24-04-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Invite par: Giulia Manina
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains one of the deadliest infectious diseases worldwide. Meanwhile, non-tuberculous mycobacteria (NTM) are an increasing global health concern. NTM infections often resemble TB clinically, which can lead to ...
Plus d'infos...
Tags: Acid-fast bacilli, Bacterial diseases, Tuberculosis, Pathogenic bacteria, Infectious causes of cancer, Nontuberculous mycobacteria, Mycobacterium, Mycobacterium fortuitum, Mycobacterial cervical lymphadenitis
Annonce publiée le 26-02-2026
Institut Pasteur
Batiment CIS, salle , -
The Conference Jacques Monod » The mechanistic and evolutionary basis of programmed DNA elimination» will take place fromMonday, September 21, 2026 toFriday, September 25, 2026 in Roscoff (Bretagne, France). Abstracts submission deadline :Tuesday, May 5, 2026 Deadline for payment of registration fees :July 2, 2026 Deadline for return of completed forms :July 2, 2026 Registration and abstract submission website Beyond mutations, the genetic content of an organism is generally constant across cells throughout development. Programmed DNA elimination (PDE) - a process in which specific cell lineages lose DNA segments or whole chromosomes - represents is a striking deviation to this principle. PDE is widespread in eukaryotes and plays roles in a variety of cellular processes, including gene silencing, germline differentiation, genome defence, and non-Mendelian inheritance. It manifests in diverse biological contexts, including the formation of germline-limited genomes, meiotic elimination of parental chromosomes, and sex determination via X-chromosome loss. In recent years, it has become increasingly clear that PDE occurs across a wide range of phylogenetic groups, and involves diverse mechanisms. These findings underscore the overlooked plasticity of genome integrity, and reveal significant gaps in our understanding of why PDE has evolved repeatedly and is maintained across the Tree of Life. This conference is designed to present the latest research on the mechanisms and evolution of PDE - from the molecular pathways that control genome stability and chromosome segregation, to genomic conflictsand the long-term evolutionary consequences of PDE on population dynamics and species diversification.We also welcome researchers studying related phenomena, such as meiotic drive, B chromosomes, and those that work on the mechanisms and regulation of genome stability, chromosome segregation and germline development. The meeting will address the following key topics: Mechanisms and regulation of genome stability and instability Mechanisms of chromosome segregation and missegregation Genomic conflicts Evolutionary dynamics of programmed DNA elimination
Plus d'infos...
Tags: Evolutionary biology, Molecular genetics, Molecular evolution, Cell cycle, Meiosis, Mutation, Intragenomic conflict
Annonce publiée le 28-03-2026
Institut Jacques Monod
Roscoff, Roscoff, France -
L heterogeneite observee entre les tumeurs de differents patients, et meme entre les cellules cancereuses d'un meme patient, complique considerablement le developpement de traitements. La medecine « personnalisee » ou « de precision » vise a surmonter ce probleme en proposant un traitement adapte a chaque patient, en fonction de son profil genetique individuel et de la signature moleculaire de sa tumeur. Cet objectif ambitieux necessite une caracterisation moleculaire approfondie du cancer chez le patient, a l'aide de technologies a haut debit et de techniques d'imagerie avancees. Beaucoup de donnees multi-echelles sur le cancer deviennent disponibles, mais elles restent encore largement sous-exploitees pour elucider les mecanismes sous-jacents et ainsi guider la stratification des patients et le choix des traitements. L'analyse integrative multimodale des donnees omiques et cliniques offre un fort potentiel pour elucider les bases moleculaires des differents types de cancer. L'integration multimodale des donnees sur la maladie est particulierement prometteuse pour mettre en evidence les relations complexes entre les mecanismes moleculaires qui contribuent collectivement a la maladie.
Plus d'infos...
Annonce publiée le 18-04-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Every year, the Centre de Recherche des Cordeliers organises a scientific day where its young researchers, students and post-docs present their work.Prestigious speakers are also invited to take part.This year, we will be welcoming:This event is open to the entire scientific community.
Plus d'infos...
Tags: Inquiry, Observation, Science, European Research Council
Annonce publiée le 27-02-2026
Centre de Recherche des Cordeliers -
Plus d'infos...
Tags: Malaria, Plasmodium, Antimalarial medication
Annonce publiée le 17-05-2026
Institut Cochin
- -
Plus d'infos...
Tags: Malaria, Plasmodium, Antimalarial medication
Annonce publiée le 19-05-2026
Institut Cochin
- -
Le cours est dedie aux connaissances les plus actuelles articulant la biologie du developpement et l etude cellulaire et moleculaire des cancers. Les cretes neurales et les melanomes, depuis leur formation jusqu a leur migration (metastases), ainsi que les cancers pediatriques d'origine embryonnaires tels que les medulloblastomes et neuroblastomes sont pris comme exemples. Le cours beneficie d une approche multidisciplinaire a multiples echelles (embryologie sur des modeles varies, biophysique, biologie cellulaire, transcriptomique, imagerie...). Il aborde egalement des approches therapeutiques et ainsi que la prise en compte des 3R en recherche avec l'invitation des chercheurs developpant des organoides et des modeles animaux alternatifs. Le cours est ponctue par des tables rondes sur les carrieres dans le milieu academique ou dans l industrie,sur la publication d articles scientifiques ainsi que sur l ethique en experimentation animale.Des sessions posters de doctorants sont egalement organises et des prix pour les meilleurs posters seront decernes par les participants aux cours.
Plus d'infos...
Annonce publiée le 10-04-2026
Institut Curie
Centre de recherche - Orsay - Amphitheatre du Batiment 111 -
Plus d'infos...
Tags: Pasteur Institute, Yasmine Belkaid, Yasmin, Aboubakr Belkaid, Lurie Prize in Biomedical Sciences
Annonce publiée le 04-03-2026
Centre de Recherche des Cordeliers -
EM tomography and membrane remodeling
Plus d'infos...
Tags: Medical imaging, Tomography, Crista, Volumetric Electron Microscopy
Annonce publiée le 29-04-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Plus d'infos...
Tags: Tooze, Titre
Annonce publiée le 19-05-2026
Institut Cochin
Salle Rosalind Franklin -
Plus d'infos...
Tags: Jeremie, Jeremi
Annonce publiée le 06-03-2026
Centre de Recherche des Cordeliers -
Invite par: Darragh Duffy
Thursday 29th Oct 26 | Institut Pasteur KEYNOTE SPEAKERS ? Prof. Yasmine Belkaid President of the Institut Pasteur (Paris), Professor Yasmine Belkaid is an internationally recognized immunologist specializing in host-microbiota interactions and tissue immunity. ...
Plus d'infos...
Tags: Pasteur Institute, Yasmine Belkaid, Microbiology, Microbiomes, Bacteriology, Louis Pasteur, Variability, Human microbiome
Annonce publiée le 24-02-2026
Institut Pasteur
Batiment: Duclaux -
Invite par: Darragh Duffy
30th OCTOBER 2026 | INSTITUT PASTEUR | FRANCE We are happy to announce the 2026 yearly meeting of Milieu Interieur LabEx Join un on the morning of the 30th of October at 9am at ...
Plus d'infos...
Tags: Corruption in France, Organized crime in France
Annonce publiée le 22-05-2026
Institut Pasteur
Batiment: Duclaux Salle: Amphitheatre Duclaux -
Invite par: Pierre-Jean Corringer
Plus d'infos...
Tags: Jean-Pierre Changeux, Neuroscientists, Allosteric regulation, Jean-Pierre, Ruth Nussinov, DehaeneChangeux model
Annonce publiée le 30-04-2026
Institut Pasteur
Batiment Duclaux, salle Amphitheatre, -
Le 8e cours «?Biologie cellulaire et cancer»?explorera comment les formes biologiques emergent a differentes echelles, de l'organisation intracellulaire jusqu'aux tissus et aux organismes entiers. Il mettra l'accent sur des processus cellulaires cles tels que la dynamique du cytosquelette et le trafic intracellulaire, et sur la maniere dont ces processus faconnent des structures cellulaires complexes. Le cours abordera egalement la formation de patterns, la morphogenese et les comportements collectifs des cellules a l'echelle des tissus, dans le contexte de la mecanobiologie et de la biologie du developpement.
Plus d'infos...
Annonce publiée le 07-05-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Epigenome editing is a rapidly emerging field that has the potential to revolutionise genomic medicine by offering new ways to precisely program gene expression and treat a range of diseases. Precision control of the epigenome and gene activity is further unlocking key mechanistic insights into a wide variety of molecular and cellular processes. The potential of epigenome editing technologies for both research and therapeutic applications has thus led to widespread excitement over the last five years, in areas ranging from neurobiology, to high-throughput (epi)genomics to agriculture. As the technologies continue to emerge and the epigenome editing field begins to coalesce, we feel now is the time to bring interdisciplinary experts and leaders in the field together. This will enable, for the first time, epigenome editors and related disciplines to collectively discuss the technology, its applications and ethics, and the exciting scientific insights being generated. Such a symposium will help to accelerate progress in this field by facilitating collaborations between researchers and providing a platform for the dissemination of new discoveries and techniques. It will also help to raise broader awareness of this exciting emerging science and its potential to transform precision medicine. Time and Place The meeting will take place fromNovember 16-17atInstitut Jacques Monodin the heart of Paris, France We will have two half day sessions, and a poster session over cocktails and light bites Key Dates Abstract Submission:October 1, 2026 Registration:November 9, 2026 Invited Speakers ? Gabriella Ficz (QMUL, UK) ? Charles Gersbach (Duke University, USA) ? Jamie Hackett (EMBL Rome, Italy) ? Jake Harris (Cambridge University, UK) ?Angelo Lombardo (San Raffaele University, Italy) ? Reini Luco (Institut Curie, France) ?Mariane Rots (UMCG, Netherlands) ?Edda Schulz (MPI Berlin, Germany) ?Stefan Stricker (Helmholtz Munich, Germany) More speakers will be selected from abstracts! You can find all the informations regarding the symposium, the registration and abstract submission here Flyer of the event: here
Plus d'infos...
Tags: Epigenetics, Epigenome editing, Edit, Epigenome, Genome editing, Omics
Annonce publiée le 10-03-2026
Institut Jacques Monod
Institut Jacques Monod Amphitheatre Buffon, 15 rue Helene Brion, Paris, France