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TBA Plus d'infos... Tags: Cochet, Draft:Valley Vista Elementary School Annonce publiée le 12-09-2026 |
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| Laboratoire Jean Perrin Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407 |
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Seminaire mensuel-Colloque. Accueil a partir de 8h15 - Amphi 3 de la Faculte de Sante pour les communications orales, et Salle de Conferences du BRB pour les communications affichees. Contact : Franck Maillochon
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Annonce publiée le 01-11-2026
IMRB
Amphi 3 de la Faculte de Sante pour les communications orales, et Salle de Conferences du BRB pour les communications affichees. - IMRB, Faculte de Sante, 8 rue du General Sarrail, 94000 Creteil -
Invite par: Frederic LEMOINE
The ShareFAIR days are a two-day gathering uniting our project partners and the broader scientific community to advancing the reproducibility of neuro-vascular research. As we navigate the complexities of massive, multi-scale health data, we ...
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Tags: Metascience, Scientific method, Statistical reliability, Measurement, Reproducibility, Tests
Annonce publiée le 17-07-2026
Institut Pasteur
Batiment Batiment Duclaux, salle Amphitheatre Duclaux, -
Invite par: Frederic LEMOINE
The ShareFAIR days are a two-day gathering uniting our project partners and the broader scientific community to advancing the reproducibility of neuro-vascular research. As we navigate the complexities of massive, multi-scale health data, we ...
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Tags: Metascience, Scientific method, Statistical reliability, Measurement, Reproducibility, Tests
Annonce publiée le 20-07-2026
Institut Pasteur
Batiment Batiment Duclaux, salle Amphitheatre Duclaux, -
Gene expression is tuned by enhancer-promoter interactions (EPIs) within a three-dimensional genome that is constantly in motion. Neurons take this problem to its limit: they are post-mitotic and long-lived, and they depend on regulatory elements acting across megabase distances. Consequently, mutations in chromatin regulators and alterations in genome topology cause neurodevelopmental disorders, and in other contexts as cancer. However, the principles governing how EPIs are established, maintained, and lost during differentiation remain poorly understood, largely because most measurements are static snapshots of fixed cell populations. This seminar follows a single question from disease genetics to biophysics to engineering: which chromatin-regulator genes are responsible for neurodevelopmental disorders and what the downstream phenotypic consequences of their mutations are; how those regulators physically act in single living cells, where chromatin contacts prove to be dynamic, rare, and short-lived rather than stable structures; and whether that mechanistic picture can be inverted into design, engineering EPIs and 3D genome architecture in neurons. Together, these lines of inquiry chart a multidisciplinary path from disease-gene discovery, through single-molecule biophysics, to chromatin engineering in the cells where it matters most.
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Tags: Molecular biology and Biochemistru, Biology, Molecular biology, Genomics, Genetic mapping, Genome, Gene, Gene expression
Annonce publiée le 09-09-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Invite par: Paris Postdoc Seminar
Invite par l'Institut Jacques Monod, Alberto de la Iglesia, Ph.D. Institut Cochin (Inserm U1016 - CNRS UMR8104 - Universite Paris Cite) Dr. Julie Cocquet Group Epigenetics Spermatogenesis, part of the VAIMAN Team From Gametes to Birth: Genomics, Epigenetics, and Physiopathology of Reproduction?presentera un Paris Postdoc Seminar sur le theme : Exploring the role of metabolism-dependent histone acylations during male germ cell differentiation and their sensitivity to metabolic perturbations Resume : The paternal epigenome is established during spermatogenesis and is particularly responsive to environmental cues. In line with the POHaD paradigm (Paternal Origins of Health and Disease), increasing evidence shows that environmentally induced paternal epigenetic alterations can have effects beyond fertilization, which is the case of paternal obesity. Within this context, our lab is interested in a type of epigenetic marks named histone acylations, whose abundance depends upon the availability of their precursor metabolites and, hence, are sensitive to the cell metabolic status. To better understand the effects of a metabolic stress on coordinated metabolo-epigenetic signatures in male germ cells, we have established a mouse model of Western style diet-induced obesity (WD; high-fat/high-sugar, 16 weeks). WD males exhibited an altered testicular metabolome, characterized by metabolites involved in pathways related with energy metabolism and the generation of precursors of epigenetic marks. In parallel, we identified higher acetylation (ac) levels in male germ cells of WD mice, suggesting a link between the observed metabolomic and epigenetic alterations. Among other acylations, our lab has described that the recently identified histone lactylation (la) modifies several histone residues in the wild-type mouse testis (PMID 42285509). Unpublished CUTTag results revealed that H3K18la and H3K56la are mostly retained at the promoter of active genes and at distal regulatory regions. Besides, their different dynamics across spermatogenesis suggest distinct effects of both marks during the process. Ongoing multi-omics approaches in WD mice are currently being analyzed to study the sensitivity of Kla to metabolic changes in male germ cells. Thus, our work supports that the testis can sense metabolic disturbances, leading to dysregulations in developing male germ cells at the metabolic and epigenetic levels. These alterations could be at the onset of the effects of male obesity beyond fertilization described in the POHaD framework.
Plus d'infos...
Tags: Branches of biology, Biology, Epigenetics, Developmental biology, Genetic mapping, Lamarckism, Spermatogenesis, Cellular differentiation, Germ cell, Nutriepigenomics, Cancer epigenetics
Annonce publiée le 14-10-2026
Institut Jacques Monod
Institut Jacques Monod #8211; Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Invite par l'Institut Jacques Monod, Alberto de la Iglesia, Ph.D. Institut Cochin (Inserm U1016 - CNRS UMR8104 - Universite Paris Cite) Dr. Julie Cocquet Group «Epigenetics & Spermatogenesis», part of the VAIMAN Team From Gametes to Birth: Genomics, Epigenetics, and Physiopathology of Reproduction?presentera un Paris Postdoc Seminar sur le theme : Exploring the role of metabolism-dependent histone acylations during male germ cell differentiation and their sensitivity to metabolic perturbations Resume : The paternal epigenome is established during spermatogenesis and is particularly responsive to environmental cues. In line with the POHaD paradigm (Paternal Origins of Health and Disease), increasing evidence shows that environmentally induced paternal epigenetic alterations can have effects beyond fertilization, which is the case of paternal obesity. Within this context, our lab is interested in a type of epigenetic marks named histone acylations, whose abundance depends upon the availability of their precursor metabolites and, hence, are sensitive to the cell metabolic status. Among the different histone acylations, we have recently characterized that lactylation modifies several histone lysine residues in wild-type mouse testis by proteomics approaches (Manessier et al., 2026; PMID 42285509). To better understand the effects of a metabolic stress on coordinated metabolo-epigenetic signatures in male germ cells, we established a mouse model of Western style diet-induced obesity (WD; high-fat/high-sugar, 16 weeks). WD males exhibit an altered testicular metabolome, characterized by changes in pathways related to energy metabolism and the generation of precursors of epigenetic marks. In parallel, we identified altered histone acylation levels in male germ cells of WD mice, suggesting a link between the observed metabolomic and epigenetic alterations. Multi-omics approaches in WD mice are currently being analyzed to determine the sensitivity to metabolic changes in male germ cells. Thus, our work supports that the testis can sense metabolic disturbances, leading to dysregulations in developing male germ cells at the metabolic and epigenetic levels. These alterations could contribute to the effects of male obesity beyond fertilization described in the POHaD framework.
Plus d'infos...
Tags: Physiology and Metabolism, Histone lactylation, Male germ cells, Metabolic stress
Annonce publiée le 31-10-2026
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
The genetics of complex traits has been fundamentally transformed by the dramatic reduction in short-read sequencing costs, leading to a dramatic reversal in the relative costs of genotyping versus phenotyping. We explore this new scientific landscape by examining key experimental strategies that leverage inexpensive sequencing, including low-coverage whole-genome sequencing with imputation (lcWGS + I) for genotyping large cohorts. Although somewhat limited in outbred populations, lcWGS + I can be extremely effective in multiparent populations and in founder-unknown closed colonies, where imputation accuracy can exceed 98%. We further explore pooled-sequencing approaches for dissecting complex traits, such as Evolve and Resequence for tracking adaptive changes in allele frequency over several generations, and extreme quantitative trait loci mapping that identifies loci by contrasting pooled samples from phenotypic extremes. We show that extreme quantitative trait loci mapping in multiparent populations, by testing for shifts in founder haplotype frequencies across small genomic windows, can be extremely powerful and cost-effective. Finally, we discuss methods where sequencing reads serve as the phenotype itself. DNA barcoding enables massive-scale fitness assays, while the *-seq? toolkit (e.g. RNA-seq, ATAC-seq) allows for mapping molecular quantitative trait loci, though this introduces a significant multiple testing burden. Systems leveraging certain breeding designs in concert with low cost sequencing can greatly accelerate progress toward a mechanistic understanding of the genotype-phenotype relationship.
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Tags: Genetics and Genomics, Complex traits, Multi-parent panels, Low-coverage sequencing
Annonce publiée le 29-10-2026
IDEEV
IDEEV - Salle Rosalind Franklin -
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Annonce publiée le 30-10-2026
Academie des Sciences
Grande salle des seances de l'Institut de France, 23 quai de Conti - 75006 -
When sugar runs out, cells of budding yeast that shift their metabolism from fermentation to respiration exhibit faster growth and improved adaptation. Those cells capable of predicting future scarcity by sensing both the concentration and variation of nutrients should therefore have less lag in growth. To address whether cells can predict future environments, we developed new tools: a microfluidic device combining single-cell ALCATRAS traps with a serpentine micro-mixer for high-resolution imaging during dynamic but controlled sugar concentrations, and a convolutional neural network for efficient, accurate, high-throughput quantification of transcription factor relocation. Using these tools together and by following translocating transcription factors, we show that yeast cells likely predict low glucose levels typically an hour before they happen.
Plus d'infos...
Tags: Cell Biology, Yeast metabolism, Transcription factor relocation, Nutrient sensing
Annonce publiée le 31-10-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre IPGG - 6 rue Jean Calvin, Paris 5e -
Plus d'infos...
Tags: Salou, Paget, Salou Ibrahim
Annonce publiée le 15-09-2026
Centre de Recherche des Cordeliers -
Invite par: ParisPostDocs seminars
In the distal colon, a subpopulation of macrophages has been recently described to perform a quality control of the water absorbed by the epithelium via balloon-like protrusions (BLPs) inserted in between apical epithelial cells. Upon sensing of fungal products, they instruct the gut to stop water absorption to prevent them from poisoning (Chikina et al., 2020). These BLP macrophages are at the interface between the luminal content and blood vessels on top of which they're sitting. We wondered then if they could form a physical barrier to prevent harmful products to enter the blood circulation. By destabilizing epithelial cell-cell junctions (using an inflammatory model or a conditional KO), we demonstrated that BLPs morphology depends on the tightness of epithelial cells and adopt a fill-the-gap shape if the cells are looser. In this situation, neutrophils are recruited in small numbers and are constrained to the lamina propria. By interfering with BLPs formation, we could show that neutrophils are now able to cross the lamina propria to invade the epithelium and thus, cause more damage. Overall, we uncovered a new cloaking phenotype where macrophages prevent neutrophil swarming by ensuring gut permeability.
Tags: Immunology, Macrophages, Neutrophil swarming, Gut permeability
Annonce publiée le 30-10-2026
Institut Cochin
salle Rosalind Franklin, 2eme etage, 22 rue Mechain 75014 contact : mary.daude-presse at inserm.fr -
Le sang a toujours fascine les hommes. Symbole de vie, de filiation, de sacrifice et d alliance, il a longtemps releve du mythe avant de devenir objet de science. De la decouverte par William Harvey de sa circulation dans les vaisseaux a l observation des globules au microscope, puis a l identification de ses cellules et de ses proteines, sa comprehension a eclaire de nombreux processus physiologiques et pathologiques, de l oxygenation des tissus a l immunite, de la coagulation a l inflammation. De ces avancees est nee l hematologie, discipline qui incarne la medecine experimentale telle que l a concue Claude Bernard, ou l observation du malade suscite l hypothese et ou l experimentation revient eclairer le soin. Fort d'une double formation de clinicien et de chercheur, je montrerai comment recherche fondamentale et recherche clinique se sont mutuellement enrichies en hematologie. Leur alliance a transforme le pronostic des leucemies, des lymphomes, des myelomes et de nombreuses maladies non malignes. Elle a reduit la toxicite des traitements, ameliore leur tolerance et la qualite de vie, et permet de plus en plus aux patients de retrouver une vie sociale et professionnelle normale. En etudiant le sang, qui relie et reflete chaque organe, l hematologie peut aussi eclairer de nombreux autres domaines, de la cardiologie a la nephrologie, des maladies metaboliques a la neurologie et a la psychiatrie, mais aussi avoir des impacts societaux, par exemple avec la transfusion et le dopage sanguin. Poursuivre ce mouvement suppose plusieurs conditions. Il faut garantir une ethique exigeante et une conduite rigoureuse des essais cliniques chez l animal en lui rendant ce qu&'il nous a apporte et chez l homme, mobiliser des financements publics et prives a la hauteur des enjeux, et repenser l organisation des soins pour que chaque progres beneficie rapidement a tous les patients. Il faut enfin encadrer l intelligence artificielle, qui peut et doit accelerer le diagnostic et l innovation, et definir sa place dans le soin, afin qu elle serve le patient sans jamais se substituer a la relation humaine qui fonde la medecine.
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Tags: hematology
Annonce publiée le 18-10-2026
College de France
amphitheatre Marguerite de Navarre -
How does a stem cell produce two daughters with different identities? Current models emphasise that unequal inheritance of molecules determinesganglionmother cell (GMC) fate in the developing Drosophila central nervous system. This ensures that one daughter, the neuroblast, retains stem cell identity while the GMC embarks on differentiation. But what if something as simple as cell size could override these molecular instructions? Drosophila neural stem cells, called neuroblasts, this process generates daughters that differ in fate but also dramatically in size. Understanding how this physical asymmetry emerges reveals an intricate interplay between cell polarity, cortical mechanics and membrane dynamics. Spatially controlled actomyosin contractility and local membrane expansion work together to shape dividing cells, translating molecular organisation into differences in daughter-cell size. Intriguingly, cell size is more than a passive consequence of asymmetric division. It can actively influence developmental decisions, even challenging the instructions provided by inherited fate determinants. At least in the type I neuroblast lineage size seems integral to how the identity of ganglion mother cells are specified. In this seminar I will summarise our findings and sketch our direction of travel on the regulation of cell size asymmetry and its contribution on cell fate.
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Tags: Developmental Biology and Stem Cells, Cell size asymmetry, Drosophila neuroblasts, Cell fate determination
Annonce publiée le 24-10-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Plus d'infos...
Tags: Other
Annonce publiée le 31-10-2026
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Plus d'infos...
Tags: Developmental biology and Stem cells, Senescence, Healing, Regeneration, Institut Jacques Monod, Helen Blau, Blastema
Annonce publiée le 29-07-2026
NeuroPSI
Salle de conference Albe-Fessard -
Invite par l'Institut Jacques Monod et le laboratoire d'Epigenetique et Destin Cellulaire, Gilles Degremont (Pole Universitaire d'Innovation Valocite Universite Paris Cite) presentera un seminaire de l'Institut Jacques Monod sur le theme : Intellectual Property and patent issues in the field of health and life science Resume : Specialiste de Propriete Intellectuelle (PI), ingenieur en mecanique de formation (INSA Lyon), Gilles a debute sa carriere en cabinet de Propriete Intellectuelle en 1996 avant de basculer en 2001 vers l'industrie parapetroliere au sein de Coflexip devenue Technip, une societe Francaise cotee au CAC 40 avant son rachat par FMC Technologies en 2016_2017. Il y dirige le departement Propriete Intellectuelle pendant une vingtaine d'annee. Apres une parenthese professionnelle de trois ans hors de la PI il rejoint l'universite Paris Cite dans le cadre de la mise en place du PUI Valocite (Pole Universitaire d'Innovation) pour occuper un poste d'ingenieur PI en charge des aspects PI du Pole. Le seminaire detaillera les differents actifs PI qui peuvent etre mis en œuvre dans une strategie PI ainsi que les potentiels et voies de valorisation de chacun d'eux. Apres une revue succincte des fondamentaux de la PI, les dispositifs mis en œuvre par l'universite seront presentes ainsi que les informations pratiques et les bons reflexes a acquerir en matiere de protection de la PI pour ne pas compromettre une valorisation potentielle. On discutera egalement des differentes problematiques PI que vous pourriez rencontrer dans une carriere de doctorant ou de chercheur ainsi que les differentes manieres d'y faire face. Enfin, un focus sur la brevetabilite des dispositifs medicaux et des medicaments ainsi que sur la brevetabilite du vivant et notamment les differences USA/Europe devrait conclure ce temps d'echange avec bien evidemment un moment dedie aux questions pour finir.
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Annonce publiée le 14-10-2026
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Seminaire mensuel-Colloque. Yoann ALDON (AFMB CNRS UMR7257, Marseille) 12h - Modulaire M0011 de la Faculte de Sante Contact : Ophelia Godin, Emmanuel Dornier
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Annonce publiée le 01-11-2026
IMRB
Modulaire M0011 de la Faculte de Sante - IMRB, Faculte de Sante, 8 rue du General Sarrail, 94000 Creteil -
Invite par: Dr V Tolle
Anorexia nervosa (AN) is the psychiatric disorder with the highest mortality. Around 60% of the background is attributed to genetics and significant negative genetic correlations with several metabolic traits including BMI are established. Indeed, a puzzling feature of AN is the paradoxical physiological response to negative energy balance, leading to continued loss of and maintained low body weight. Intricate neuronal circuits originating in the hypothalamus are fundamental for proper appetite signaling and ensuring our energetic needs, and accumulating reports support microglia located at the vicinity of the hypothalamic circuits as crucial in regulating energy balance. We hypothesize that a genetic vulnerability in AN resides with a dysfunction of hypothalamic microglia, resulting in aberrant signaling of hypothalamic circuits regulating food intake, and maintained negative energy balance. We intend to identify neurobiological mechanisms and define drug targets for sustainable renourishment, weight gain as well as maintenance. By establishing and utilizing patient-derived stem cell (iPSC) models, we explicate the function of microglia and their interaction with hypothalamic neurons, including microglia-driven synaptic pruning, in AN. Among others, we reveal reduced microglia engulfment of hypothalamic-, but not cortical synapses, in AN. We show that the phagocytic capacity of AN microglia, contrary to healthy microglia is non-responsive to GLP1 stimulation. Our results indicate that deviant communication between microglia and hypothalamic neurons are involved in maintenance of starvation in AN. By further explicating these interactions we may define new drug targets for the treatment of the disorder.
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Annonce publiée le 22-10-2026
Institut de Psychiatrie et Neurosciences de Paris
Room D Levy, Institut de Psychiatrie et Neurosciences de Paris (IPNP) UMR 1266 INSERM - Universite Paris Cite, 102-108 Rue de la Sante - 75014 Paris -
Invite par: Laurence Arbibe - Plasticite du genome et infections
Maria Eriksson - Somatic genomic variation in vascular aging After completing my Ph.D. at Karolinska Institutet, in 2001 with professor Maria Anvret, I joined the National Human Genome Research Institute, at the National Institutes of Health, Bethesda, US as a Postdoctoral fellow in the laboratory of Dr Francis Collins in 2001. I have been awarded an assistant professor position grant by, the Swedish research council in Medicine and Health, and started my own research group at the Karolinska Institutet in 2003 to study the very rare premature aging disorder Hutchinson-Gilford progeria syndrome in 2003. I am now a professor of molecular genetics focusing on aging at the Department of Medicine, Karolinska Institutet, and Center for Innovative Medicine. Our work secured a five-year ERC Advanced Grant (2023-2028) to investigate the role of somatic mutations in age-related cardiovascular disease. Using human tissues and transgenic mouse models, we map somatic genomic alterations and their functional impact on disease and aging. Mark your calendars and make sure to join! Please note that photography during seminars is unauthorized. We kindly ask you to respect this policy to maintain the confidentiality and intellectual property rights of the speakers and their work.
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Tags: Genetics and Genomics, Somatic mutations, Vascular aging, Cardiovascular disease
Annonce publiée le 01-11-2026
Institut Necker Enfants Malades
Institut Necker Enfants Malades - Auditorium 2 -
Invite par: Hugues Aschard
Plus d'infos...
Tags: Eating disorders, Hyperalimentation, Human behavior, National Eating Disorders Association, Articles, Binge eating disorder
Annonce publiée le 30-09-2026
Institut Pasteur
Batiment CIS, salle Conference Center, -
Invite par: Hugues Aschard
Ever felt the urge to do something you shouldn’t, resisted, and failed? Then this day is for you! That small moment of failure says something important: what we do is not fixed, and it ...
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Tags: Behaviorism, Behavior, Psychology, Human behavior, Behavior modification, Abnormal psychology, Industrial and organizational psychology, Life coaching, National Eating Disorders Association
Annonce publiée le 30-09-2026
Institut Pasteur
Batiment CIS, salle Conference Center, -
Children learn very diverse skills with remarkable autonomy, efficiency and open-endedness despite limited time and energy: I will discuss the central roles of mechanisms of curiosity in this extraordinary feat. Drawing on theory, AI modeling, and behavioural experiments, I will present three complementary accounts:
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Tags: Articles, Academic disciplines, Human behavior, Computational neuroscience, Behavioural sciences, Pierre-Yves Oudeyer, Curiosity, Artificial intelligence, Ai, Developmental psychology
Annonce publiée le 08-10-2026
I. Cerveau et de la Moelle
Paris Brain Institute auditorium -
Plus d'infos...
Tags: Immunology, CGAS, Viral detection, Chromatin
Annonce publiée le 26-10-2026
Institut de Biologie Integrative de la Cellule
B21-N0-00 - Auditorium, I2BC CNRS Gif -
Invite par: Pierre-Jean Corringer
Plus d'infos...
Tags: Neuroscience, Jean-Pierre Changeux, Neuroscientists, Allosteric regulation, Jean-Pierre, Ruth Nussinov, DehaeneChangeux model
Annonce publiée le 30-04-2026
Institut Pasteur
Batiment Duclaux, salle Amphitheatre, -
Invite par: Fred RELAIX
Seminaire mensuel-Colloque. Yvan TORRENTE (Stem Cell Laboratory Department of Pathophysiology and Transplantation Universita degli Studi di Milano) Invite par Fred RELAIX 10h - Salle Conferences du BRB Contact : Ophelia Godin, Emmanuel Dornier
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Annonce publiée le 01-11-2026
IMRB
Salle Conferences du BRB - IMRB, Faculte de Sante, 8 rue du General Sarrail, 94000 Creteil -
Invite par: Ariane Briegel
Morgan Beeby Imperial College, London, UK Abstract Many bacteria swim using helical propellers called flagella. Although most work to understand flagella have focused onEscherichia coliand closely-relatedSalmonella entericasv. Typhimurium, some bacteria are capable of swimming ...
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Tags: Microbiology and Infectious Diseases, Cell biology, Bacteriology, Bacteria, Organelles, Domains, Gram-negative bacteria, Flagellum, Salmonella
Annonce publiée le 17-08-2026
Institut Pasteur
Batiment F. Jacob, salle F. Jacob Auditorium, -
Invite par: Francois Legoux
Natasha Fisher-Pearson is PostDoc at the Klenerman Lab and Oxford Centre for Microbiome Studies, University of Oxford, UK
Plus d'infos...
Tags: Immunology, MAIT cells, Human gut microbiome, Phenotype drivers
Annonce publiée le 29-10-2026
Institut Cochin
Salle Cassini, 3ème étage -
Invite par: Manish Kushwaha
Engineered microbial systems have a range of potential applications in healthcare, the chemicals industry and environmental science. However, host microbe constraints often lead to degraded functionality or even complete failure of genetic devices. Here we developed a unified dynamic mathematical framework of E. coli which integrates including metabolic constraints, stress-responses, ribosomal limitations and growth mediated feedback. We use this framework to design new control strategies which act to enhance both yield and growth of microbial cell factories and show that at by accounting for host constraints we can actually simplify the genetic controller designs by taking advantage of the cell's natural feedback mechanisms. We couple our host design framework with evolutionary simulations to investigate how to enhance long term performance of gene circuits. We will discuss our recent work developing similar frameworks for S. cerevisiae and P. putida.
Plus d'infos...
Tags: Molecular biology and Biochemistry, Biotechnology, Molecular genetics, Molecular biology, Pseudomonadales, Pseudomonas putida, Evolution, Genetic engineering, Microorganism, Synthetic biology
Annonce publiée le 05-09-2026
Institut Micalis
Auditorium 442 - Institut Micalis -
Invite par: Catherine Lavazec
Malaria is a mosquito-borne parasitic disease responsible for more than half a million deaths per year, the majority being children. The causative agents of this disease are Apicomplexan parasites from the genus Plasmodium. Despite intensive research efforts and funds invested to fight malaria, Plasmodium parasites are developing resistances to all the existing treatments. There is an urgent need for the identification of novel pharmaceutical targets in order to develop a new generation of antimalarial treatments. Recent studies on the complex lifecycle of Apicomplexan parasites have demonstrated the essentiality of a macromolecular complex, the glideosome, for parasite motility and invasion. This complex is organized around a divergent actomyosin complex containing the atypical myosin A (MyoA) and short and unstable filaments of actin 1 (Act1). Our work on Plasmodium falciparum MyoA (PfMyoA) shows how an unforeseen phosphorylatable N-terminal extension can tune the force produced by the motor and adapt it to the different stages of Plasmodium. Interestingly, conditional knock-out of PfMyoA demonstrates that PfMyoA is essential for red blood cell invasion by the parasite. These results, along with the high-resolution structure of the PfMyoA/PfAct1 system solved by cryo-electron microscopy, allow us to describe how the glideosome produces the force necessary for host-cell invasion. Ultimately, the more recent study of KNX-002, a first-in-class inhibitor of PfMyoA, confirms that the glideosome is a promising pharmaceutical target.
Plus d'infos...
Tags: Infectious diseases, Medical specialties, Malaria, Plasmodium, Antimalarial medication
Annonce publiée le 06-10-2026
Institut Cochin
- -
Generally speaking, in conventional catabolite repression (CCR) in Gram-positive bacteria, the metabolism of hexoses such as glucose is prioritised, and as a result, the expression of genes encoding other carbon source metabolism is repressed. However, we have discovered that in the thermophilic Gram-positive bacterium Geobacillus kaustophilus (GK), an atypical CCR operates that does not prioritise the metabolism of hexoses; instead, the metabolism of pentoses, such as ribose, is prioritised [1]. In this atypical CCR, the involvement of HPr-which plays a central role in conventional CCRs-is extremely limited, and it is thought that its paralogue, Crh, functions as the primary regulatory factor.
Plus d'infos...
Tags: Microbiology and Infectious Diseases, Catabolite repression, Geobacillus kaustophilus, Pentose metabolism
Annonce publiée le 28-10-2026
Institut Micalis
Auditorium 442 - Institut Micalis -
The symposium will also host the CLARA Science Cafe, designed to encourage scientific exchange among early-career researchers. Participants will have the opportunity to present their research through posters and short pitches, discuss their work with other scientists, and develop connections with established researchers working across neuroscience and artificial intelligence.
Plus d'infos...
Tags: Articles, Emerging technologies, Computational neuroscience, Academic disciplines, Technology, Artificial intelligence, Cybernetics, Symposium
Annonce publiée le 09-10-2026
I. Cerveau et de la Moelle
Institut du cerveau -
Invite par: Julie Helft, Diana Passaro, Luca Simula, Yannick Simoni
The program features two keynote lectures (opening and closing) alongside three scientific sessions on Metabolism, Microenvironment, and Personalized Medicine. Each session includes presentations from international researchers, with scheduled coffee and lunch breaks in between. The event spans a full day of talks, networking, and discussion.
Plus d'infos...
Tags: Cancer Immunotherapy
Annonce publiée le 21-10-2026
Institut Cochin
amphitheatre Luton, UFR de Medecine site Cochin, 24 rue du Fg St Jacques, 75014 -
Invite par l'equipe Konstantinides, Philipp Brand (Group leader of the Evolutionary Neuroscience and Behavior Group, Max Planck Institute for Brain Research) : Behavioral evolution in a complex world: From environment to neural circuits Resume : From dancing birds to singing flies, animals have evolved an astounding diversity of behaviors to attract and choose mating partners. Guided by innate preferences and aversions, the brain filters complex environments for cues and signals to successfully navigate these reproductive behaviors in appropriate spatial, temporal, and social contexts. To understand how the natural environment shapes sensory evolution and contributes to the diversification of neural circuits controlling mating behaviors, my lab studies the highly tractable nervous system of Drosophila as an inroad. In Drosophila, courtship and mating occurs on fermenting food where many individuals congregate. Replicating this naturalistic context in the lab, we discovered striking differences in the sensory dependence of mating behaviors across species. Most notably, the host specialist Drosophila erecta requires the presence of food to engage in courtship and only mates in social groups. Harnessing the power of cross-species neurogenetics, we reveal that sexual arousal in D. erecta is uniquely gated by food odors that switch the valence of visual stimuli driving courtship. This provides a possible neural mechanism underlying the environmental modulation of reproductive behaviors, highlighting how social behaviors are shaped by the natural environments in which they evolve.
Plus d'infos...
Tags: Branches of biology, Biology, Organisms, Neuroscience, Animal models, Animal anatomy, Brain, Organs, Neurogenetics, Drosophila, Genetics of social behavior
Annonce publiée le 15-10-2026
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Invite par: Peter Van Endert - Immunite normale et pathologique
Inigo Martincorena - Somatic mutations in ageing and autoimmune disease Abstract Somatic mutations underpin cancer development and have long been speculated to contribute to ageing and chronic diseases, including autoimmunity. However, the difficulty of detecting somatic mutations in highly polyclonal cell populations has prevented in-depth studies of the role of somatic mutations in classical polyclonal autoimmune diseases. In this talk, I will briefly summarise our work over the past decade describing the extent of somatic mutation in normal tissues before presenting our current work in autoimmunity. Applying advanced single-molecule and single-cell DNA sequencing methods, we have recently described a rich landscape of convergent somatic mutations in immune checkpoint genes in thyroid autoimmunity. We found many B cell clones convergently acquiring loss-of-function mutations in the key immune checkpoint genes TNFRSF14 (HVEM) and CD274 (PD-L1), as well as less frequent mutations in other immune genes. In highly inflamed biopsies, we detected tens to hundreds of independent immune-checkpoint-mutant B cell clones, with widespread TNFRSF14 biallelic loss, and some clones with as many as 4-6 driver mutations. Our results support the hypothesis that somatic mutations in autoimmune B cells may allow them to escape tolerance constraints through a polyclonal cascade of somatic evolution, providing new insights into the molecular basis of autoimmune disease. Martincorena et al, 2015. https://www.science.org/doi/10.1126/science.aaa6806 Martincorena et al, 2018. https://www.science.org/doi/10.1126/science.aau3879 Abascal et al, 2021. https://www.nature.com/articles/s41586-021-03477-4 Nicola, Lawson et al, 2026. https://www.nature.com/articles/s41586-026-10493-9 Biography Dr Inigo Martincorena has been a group leader at the Sanger Institute (Cambridge, UK) since 2016. He graduated in biology and biochemistry in Spain in 2007, followed by a PhD at the University of Cambridge in 2008-2012 on evolutionary genomics, and a postdoc with Peter Campbell at the Sanger Institute in 2013-2016. Over the last 12 years, Inigo and his collaborators have shown that mutant clones with cancer-driver mutations colonise human solid tissues throughout life. His group is largely focused on understanding the extent and impact of this phenomenon in ageing tissues and a range of diseases, with a particular recent focus on autoimmune diseases. https://www.sanger.ac.uk/person/martincorena-inigo/ Mark your calendars and make sure to join! Please note that photography during seminars is unauthorized. We kindly ask you to respect this policy to maintain the confidentiality and intellectual property rights of the speakers and their work.
Plus d'infos...
Tags: Immunology, Somatic mutations, Autoimmune disease, B cells
Annonce publiée le 01-11-2026
Institut Necker Enfants Malades
Institut Necker Enfants Malades - Auditorium 2 -
The title and abstract of this talk will be announced soon.
Plus d'infos...
Tags: Neuroscience
Annonce publiée le 26-08-2026
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
Le 8e cours «?Biologie cellulaire et cancer»?explorera comment les formes biologiques emergent a differentes echelles, de l'organisation intracellulaire jusqu'aux tissus et aux organismes entiers. Il mettra l'accent sur des processus cellulaires cles tels que la dynamique du cytosquelette et le trafic intracellulaire, et sur la maniere dont ces processus faconnent des structures cellulaires complexes. Le cours abordera egalement la formation de patterns, la morphogenese et les comportements collectifs des cellules a l'echelle des tissus, dans le contexte de la mecanobiologie et de la biologie du developpement.
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Tags: Cell biology
Annonce publiée le 07-05-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Epigenome editing is a rapidly emerging field that has the potential to revolutionise genomic medicine by offering new ways to precisely program gene expression and treat a range of diseases. Precision control of the epigenome and gene activity is further unlocking key mechanistic insights into a wide variety of molecular and cellular processes. The potential of epigenome editing technologies for both research and therapeutic applications has thus led to widespread excitement over the last five years, in areas ranging from neurobiology, to high-throughput (epi)genomics to agriculture. As the technologies continue to emerge and the epigenome editing field begins to coalesce, we feel now is the time to bring interdisciplinary experts and leaders in the field together. This will enable, for the first time, epigenome editors and related disciplines to collectively discuss the technology, its applications and ethics, and the exciting scientific insights being generated. Such a symposium will help to accelerate progress in this field by facilitating collaborations between researchers and providing a platform for the dissemination of new discoveries and techniques. It will also help to raise broader awareness of this exciting emerging science and its potential to transform precision medicine. Time and Place The meeting will take place fromNovember 16-17atInstitut Jacques Monodin the heart of Paris, France We will have two half day sessions, and a poster session over cocktails and light bites Key Dates Abstract Submission:October 1, 2026 Registration:November 9, 2026 Invited Speakers ? Gabriella Ficz (QMUL, UK) ? Charles Gersbach (Duke University, USA) ? Jamie Hackett (EMBL Rome, Italy) ? Jake Harris (Cambridge University, UK) ?Angelo Lombardo (San Raffaele University, Italy) ? Reini Luco (Institut Curie, France) ?Mariane Rots (UMCG, Netherlands) ?Edda Schulz (MPI Berlin, Germany) ?Stefan Stricker (Helmholtz Munich, Germany) More speakers will be selected from abstracts! You can find all the informations regarding the symposium, the registration and abstract submission here Flyer of the event: here
Plus d'infos...
Tags: Genetics and Genomics, Epigenetics, Epigenome editing, Edit, Epigenome, Genome editing, Omics
Annonce publiée le 10-03-2026
Institut Jacques Monod
Institut Jacques Monod Amphitheatre Buffon, 15 rue Helene Brion, Paris, France -
Arousal is difficult to study causally in humans: most evidence rests on pupillometry, which tracks arousal as it fluctuates rather than manipulating it. Transcutaneous auricular vagus nerve stimulation (taVNS) changes this: neuroimaging and animal work indicate that it engages the ascending arousal circuitry, including the locus coeruleus, and brief four-second trains reliably evoke phasic pupil dilation. I will present a series of studies using this protocol to trace how such an engagement shapes behavior, from resting motor excitability to perceptual decision and online motor control.
Plus d'infos...
Tags: Eye, Pupillary response, Sexual arousal, Pupillometry, Locus coeruleus, Branches of biology, Neuroscience, Nervous system
Annonce publiée le 13-10-2026
I. Cerveau et de la Moelle
Paris Brain Institute auditorium -
Invitee par l'equipe Ladoux/Mege, Prof. Karin Forsberg-Nilsson (Uppsala University, Sweden) presentera un seminaire de l'Institut Jacques Monod sur le theme : Leveraging non-coding mutations with evolutionary constraint to discover novel driver genes in solid tumors Resume : Cancer genomics has been biased against non-coding mutations, which account for 98% of all mutations, and driver mutations outside exons remain underrepresented. We hypothesized that evolutionary constraint could be used to identify functional cancer mutations. In our previous work, we successfully identified functionally active non-coding constraint mutations (NCCMs) in glioblastoma. The Zoonomia Consortium has since published single-base (phyloP) constraint scores from whole-genome alignments of 240 mammals. Through comparisons with previous large-scale genome annotations and datasets such as ClinVar, we provide proof of concept that evolutionarily constrained positions are enriched for disease-associated variants, including those implicated in medulloblastoma. We next examined whether NCCMs and their associated genes exert functional effects across multiple tumor types. To investigate this, we mapped evolutionary constraint annotations to somatic single-nucleotide variants (SNVs) and insertions/deletions across more than 2,500 tumors representing 19 tumor types in the ICGC-PCAWG dataset. This analysis identified 56 pan-cancer and 132 cancer-type-specific putative driver genes enriched for NCCMs. Notably, genes with a high NCCM load rarely harbor protein-coding mutations, suggesting that distinct selective pressures preserve protein integrity while altering gene expression regulation. Collectively, these findings demonstrate the power of evolutionary constraint to decode non-coding genome function and identify candidate regulatory drivers of cancer. Biography : Karin Forsberg-Nilsson is Professor of Stem Cell Research in the Department of Immunology, Genetics and Pathology at Uppsala University, Sweden. Her research brings together stem cell biology and cancer genomics, with a focus on brain tumors and the identification of cancer driver genes. She obtained her PhD at Uppsala University in 1992 and conducted postdoctoral research at the US National Institutes of Health. She served as Head of Department from 2014 to 2020 and Dean of the Faculty of Medicine from 2020 to 2026. In 2015, she was a visiting professor at the College de France.
Plus d'infos...
Tags: Cancer, Non-coding mutations, Evolutionary constraint, Driver genes
Annonce publiée le 29-10-2026
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Invite par: Romain Levayer
Gordana Vunjak-Novakovic Columbia University, New York, NY All tissues and organs in the human body originate from populations of stem and progenitor cells that grow, differentiate, and assemble into functional structures in response to ...
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Tags: Branches of biology, Biology, Life sciences, Gordana Vunjak-Novakovic, Developmental biology, Induced stem cells, Tissue, Organ, Cellular differentiation, Regeneration in humans
Annonce publiée le 24-10-2026
Institut Pasteur
Batiment: Monod Salle: Amphitheatre Agnes Ullmann -
Invite par: Young-Kyoung Park, Manish Kushwaha, Olivier Borkowski
The past decade has witnessed the tremendous power of systems and synthetic biology in the creation of genetic parts, devices, and systems, which helps understand complex biological systems. However, its potential for real-world applications has not been fully exploited. One of its promising applications is the construction of programmable cells that integrate multiple environmental signals and implement synthetic control over biological processes. My research interests are focused on developing microbes and microbiota that can process multiple input signals and generate user-defined outputs. Specifically, I aim to build genetic programs to control various bacterial processes such as gene expression, chemical reactions, and evolution. I will present published and unpublished results of my selected research projects by discussing the potential and challenges of systems and synthetic biology to address global problems, including plastic and agricultural waste issues, non-invasive diagnostics and disease treatment using smart probiotics and microbiota engineering, sustainable bioproduction, and biocontainment of genetically engineered microbes.
Plus d'infos...
Tags: Molecular biology and Biochemistry, Bacteriology, Microbiomes, Microbiology, Environmental microbiology, Bioinformatics, Synthetic biology, Human microbiome, Microbiota, Probiotic
Annonce publiée le 04-09-2026
Institut Micalis
Auditorium 442 - Institut Micalis -
Plus d'infos...
Tags: Developmental Biology and Stem Cells, Sea cucumber, Metamorphosis, Tissue reprogramming
Annonce publiée le 31-10-2026
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Invite par: CIRB-College de France
Plus d'infos...
Tags: Neuroscience
Annonce publiée le 24-09-2026
College de France
au College de France Salle D2 - 11 place Marcelin Berthelot - 75005 Paris -
While recurring epidemics have highlighted viruses for their potential to cause disease, this conference will focus on aspects related to their overall impact on the evolution of species.
Plus d'infos...
Tags: Evolution and Ecology, Viral genome integration, Horizontal gene transfer, Eukaryotic evolution
Annonce publiée le 24-10-2026
Academie des Sciences
Grande salle des seances - Institut de France - 23 quai de Conti -
Invite par: Hafida Fsihi
The Translational Research Day is an event organised by the Medical Department that brings together leading scientists and clinicians in biomedical research. The upcoming Translational Research Day will take place on November 18, 2026 ...
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Tags: Medical specialties, Medicine, Neonatology, Health, RTT, Infections specific to the perinatal period, Infectious diseases, Intensive care medicine, Necrotizing enterocolitis, Neonatal sepsis, Sepsis, Enterocolitis
Annonce publiée le 24-10-2026
Institut Pasteur
Batiment Duclaux, salle Lecture hall, -
Plus d'infos...
Tags: Genetics and Genomics, Gene silencing, Neurospora crassa, ATRX
Annonce publiée le 31-10-2026
Epigenetique et Destin Cellulaire
Institut Jacques Monod, salle Francois Jacob (RB-18B). Batiment Buffon, 15 rue Helene Brion, Paris 13 -
My group uses cryo-electron tomography (cryo-ET) to understand the structural basis of fundamental cellular mechanisms and their pathological alterations within native environments. In this lecture, I will introduce the basics of cryo-ET imaging, and illustrate its potential through some of our recent studies. First, I will discuss how proteostatic stress remodels the mitochondrial protein biogenesis machinery in human cells. Moving to native nervous tissues, I will share our ongoing efforts to map the nanoscale endomembrane architecture of neurons and glia.
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Tags: Structural Biology and Biophysics, Cryo-electron tomography, Mitochondrial protein biogenesis, Neuronal endomembrane architecture
Annonce publiée le 31-10-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Seminaire mensuel-Colloque. Semaine europeenne pour l'emploi des personnes handicapees Programme detaille et inscription Accueil des 13h00, fin a 18h00 Faculte de Sante de Creteil, batiment BRB, salle Conferences Contact : Karine GROS
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Annonce publiée le 01-11-2026
IMRB
Faculte de Sante de Creteil, batiment BRB, salle Conferences - IMRB, Faculte de Sante, 8 rue du General Sarrail, 94000 Creteil -
Fetal growth restriction affects one in seven pregnancies. It is often accompanied by brain sparing - a compensatory redistribution of growth that prioritizes the brain over peripheral organs. This is a critical adaptive response but how it works has remained unclear. For several years, our lab has sought to identify cellular and molecular mechanisms for brain sparing in Drosophila and mammals. Recently, we characterized brain sparing in maternal malnutrition and hypoxia models of fetal growth restriction in mice. In both models, we find that the embryonic tempo of neurogenesis is slowed. This strategy conserves proliferative neural stem cells (radial glia), enabling late-born progeny neurons and glia to catch up during subsequent development. We also recently identified an allostatic signaling mechanism for brain sparing in mice, revealing how neural stem cells temporally adapt to metabolic stress to safeguard the developing brain. To understand brain sparing with greater precision, we are now developing new tools for tagging and tracing metabolism at single-cell resolution.
Plus d'infos...
Tags: Developmental Biology and Stem Cells, Neural stem cells, Metabolic stress, Brain sparing
Annonce publiée le 28-10-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
Plus d'infos...
Tags: Taieb, Julien, Le Monde doit m'arriver, Taieb Fassi Fihri
Annonce publiée le 15-09-2026
Centre de Recherche des Cordeliers -
Ce colloque reviendra sur les grandes avancees issues du sequencage du genome humain, en explorant ses zones desormais eclaircies, la dynamique evolutive du genome et les nouvelles technologies revelant la complexite du cerveau et de la regulation genetique.
Plus d'infos...
Tags: Genetics and Genomics, Human genome sequencing, Genetic regulation, Evolutionary dynamics
Annonce publiée le 24-10-2026
Academie des Sciences
Auditorium Andre et Liliane Bettencourt - 3 rue Mazarine - Institut de France -
Invite par: Francesca Gubellini
The cryo-EM Users n.ICE community is happy to welcome Sarah Townend, Project Manager at Instruct-ERIC, for a special online seminar entitled : Instruct-ERIC: Funded Access to Technologies for Structural Biology On Friday Nov 20th ...
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Tags: Structural Biology and Biophysics, Cryo-EM, Funded access, Structural biology
Annonce publiée le 28-10-2026
Institut Pasteur -
Invite par: Francesca Gubellini
The cryo-EM Users n.ICE community is pleased to welcome our next seminar speaker: Sarah Townend, Project Manager at Instruct-ERIC. Her seminar, Instruct-ERIC: Funded Access to Technologies for Structural Biology? will be held online only ...
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Tags: Structural Biology and Biophysics, Cryo-EM, Funded access, Technologies
Annonce publiée le 29-10-2026
Institut Pasteur -
Plus d'infos...
Tags: Neuroscience, NMDA receptors, Hippocampal plasticity, Anxiety behaviors
Annonce publiée le 31-10-2026
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Plus d'infos...
Tags: Immunology, Allergology, Allergy, Immune system
Annonce publiée le 29-07-2026
NeuroPSI
Salle de conference Albe-Fessard -
Invite par: Marco Pontoglio - Epigenetics and Development
Thomas Worzfeld - Molecular mechanisms of epithelial adaptation and maladaptation to tissue injury After completing my M.D. at Heidelberg University, Germany, in 2007 with Dr Stefan Offermanns, I worked as Postdoc at Heidelberg University and, starting in 2009, as Postdoc at the Max-Planck-Institute for Heart and Lung Research in Bad Nauheim, Germany. In 2012, I became a Group Leader at the Max-Planck-Institute for Heart and Lung Research, before joining Marburg University, Germany, in 2014 as an Associate Professor for Pharmacology. Since 2019, I am Full Professor and Director of the Institute of Pharmacology, Marburg University. At the Medical Faculty of Marburg University, I serve as Vice Dean since 2025. Mark your calendars and make sure to join! Please note that photography during seminars is unauthorized. We kindly ask you to respect this policy to maintain the confidentiality and intellectual property rights of the speakers and their work.
Plus d'infos...
Tags: Physiology and Metabolism, Epithelial cells, Tissue injury, Adaptation mechanisms
Annonce publiée le 01-11-2026
Institut Necker Enfants Malades
Institut Necker Enfants Malades - Auditorium 2 -
The developmental instability-sexual selection hypothesis postulates fluctuating asymmetry (FA) in individuals as a readout of their developmental instability, and that it is thus a reliable cue to assess the genetic quality of potential mates and competitors. Innumerable studies across the taxa have tested this hypothesis over the last four decades, but the experimental data is heterogeneous and largely inconclusive. The hypothesis remained a highly controversial topic in biology with several criticisms levied against it. The observed heterogeneity in the vast amount of empirical data, is biologically relevant and needs to be understood. By revisiting this empirical data, I propose a new theory that re-establishes the idea that FA is indeed a target for sexual selection; explains satisfactorily the heterogeneity in data so far; and addresses the criticisms levied against some postulates of the original hypothesis. Using Drosophila melanogaster, a species wherein females identify symmetric males through their song and preferentially mate with them, I empirically validate this new theory.
Plus d'infos...
Tags: Evolution and Ecology, Fluctuating asymmetry, Sexual selection, Drosophila melanogaster
Annonce publiée le 25-10-2026
IDEEV
IDEEV - Salle Rosalind Franklin -
Invite par: Pierre-Damien Coureux
Structural Bioinformatics often requires delicate analysis of (ensembles) or structures and/or predictions. To this end, we have been developing the Structural Bioinformatics Library, a comprehensive environment for modeling static and dynamic structures, relying on a set of coherent data structures and representations. To ease the adoption of the proposed algorithms, we also developed a pipeline automatically generating plugins for VMD, pymol, web servers, etc. This ensures a minimalist development cost and a coherent user experience across all platforms. Plugins and the underlying command-line executables can be easily installed on linux and Mac-OS systems using conda/pixi. In this talk, I will present the SBL and its plugins, with demos for various applications: A1. Modeling and comparing protein interfaces; A2. Assessing AlphaFold models; A3. Generating conformational ensembles for flexible loops; A4. Modeling dynamics of complex biomolecules involving rigid domains. For those interested in using the SBL ecosystem, I will also help users perform the installs and get started. [RESOURCES AND REFERENCES] [SBL and plugins] * The Structural Bioinformatics Library; Bioinformatics, 2017; doi.org/10.1093/bioinformatics/btw752; https://sbl.inria.fr/ * Plugins, list + doc: https://sbl.inria.fr/doc/sbl-plugins-guide.html * Plugins, youtube channefhttps://www.youtube.com/@SBL-Plugins * Plugins, web servers: https://sbl.inria.fr/plugins/ [A1] Modeling protein interfaces * Modeling Macro-Molecular Interfaces with Intervor; Bioinformatics 2010; 10.1093/bioinformatics/btq052 * Boosting the analysis of protein interfaces with Multiple Interface String Alignment; Proteins, 2022; doi.org/10.1002/prot.26279 [A2] Assessing AlphaFold predictions * Fold or flop: quality assessment of AlphaFold predictions on whole proteomes; Bioinformatics Advances, 2026; doi.org/10.1093/bioadv/vbag190 * Characterizing the fragmentation of AlphaFold predictions; Bioinformatics Advances (in press), 2026; https://www.biorxiv.org/content/10.64898/2025.12.19.695436v2 [A3] Generating conformational ensembles for flexible loops * Enhanced conformational exploration of protein loops, J. Comp. Chem, 2023; 10.1002/jcc.27067 [A4] Modeling dynamics of complex biomolecules involving rigid domains * Studying dynamics without explicit dynamics: a structure-based study of the export mechanism by AcrB; Proteins, 2021; 10.1002/prot.26012 * Motion planning in high dimensional spaces hybridizing RRT and HAR via position-direction decoupling, Submitted, 2026; https://inria.hal.science/hal-05646929v2
Plus d'infos...
Tags: Structural Biology and Biophysics, Protein interfaces, AlphaFold predictions, Conformational ensembles
Annonce publiée le 26-10-2026
Institut de Biologie Integrative de la Cellule
B26-N2-000, I2BC CNRS Gif -
If you would like to meet the speaker, please contact us.
Plus d'infos...
Tags: Bioinformatics, College of Physicians and Surgeons
Annonce publiée le 13-10-2026
I. Cerveau et de la Moelle
Paris Brain Institute auditorium -
Elucidating the developmental processes of organisms requires a comprehensive understanding of cell lineages across spatial, temporal, and molecular dimensions. Advances in imaging and omics technologies allow us to generate technically challenging multidimensional datasets that capture developmental dynamics at unprecedented resolution and across scales (from molecule to organism). In this talk, I will describe how we integrate light-sheet microscopy with scRNAseq, yielding a time-resolved multimodal atlas of zebrafish development named Zebrahub (zebrahub.org). I will showcase its application in elucidating the differentiation of complex late pluripotent progenitors. Finally, I will show our recent effort leveraging Multiomic assays and tracking data to perform in silico experiments and gain mechanistic insights into development and differentiation.
Plus d'infos...
Tags: Developmental Biology and Stem Cells, Zebrafish development, Multimodal imaging, Single-cell RNA sequencing
Annonce publiée le 24-10-2026
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407 -
General information The Paris Cytoskeleton Day is a scientific one-day symposium open to all types of cytoskeletal components and all types of approaches. This year is the 6th edition. Itwill take place onTuesday, November 24, 2026. The meeting will be entirely in-person inAuditorium Buffon (Institut Jacques Monod, Paris) DEADLINES Registration and abstract submission are open : https://pcd2026.sciencesconf.org/ Abstract submission closes on 2 November Registration (45 euros) closes on 16 November KEYNOTE SPEAKERS Charlotte Aumeier(Universite de Geneve, CH) Stefan Raunser(Max Planck Institute, Dortmund, DE) INVITED SPEAKERS Alexandre Baffet(Institut Curie, Paris) Rut Carballido-Lopez(INRAE, Jouy-en-Josas) Guillaume Dumenil(Institut Pasteur, Paris) Magali Suzanne (Universite de Toulouse) SHORT TALKS Several short presentations will be selected from abstracts. POSTERS A poster session will take place during the day.
Plus d'infos...
Tags: Cell biology, European Molecular, Biology Organization, Stefan Raunser, Cytoskeleton, Jouy-en-Josas, Jouy
Annonce publiée le 02-09-2026
Institut Jacques Monod
Institut Jacques Monod Amphitheatre Buffon, 15 rue Helene Brion, Paris, France -
Invite par: Marcel Hollenstein
Rebecca Buller Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Switzerland Abstract Chemical synthesis of small molecules can be profitably complemented by enzymatic catalysis. In optimal settings, enzymes can facilitate complex reactions ...
Plus d'infos...
Tags: Molecular biology and Biochemistry, Catalysis, Chemical kinetics, Biomolecules, Metabolism, Chemical synthesis, Enzyme, Protein, Synergistic catalysis, Protein engineering
Annonce publiée le 24-07-2026
Institut Pasteur
Batiment Monod, salle Agnes Ullmann, -
Stalled replication forks are processed in post-replication repair by homologous recombination, fork regression, and translesion DNA synthesis. However, the regulation of pathway usage is not fully understood. Rad51 protein maintains genomic stability through its roles in recombination and in protecting stalled replication forks. We report isolation of mutations in Saccharomyces cerevisiae Rad51 that shift post-replication repair from recombination to alternate pathways including mutagenic translesion synthesis. Rad51-E135D and Rad51-K305N show near normal in vitro recombination despite changes in their DNA binding profiles, in particular to dsDNA. The mutants lead to a defect in Rad51 recruitment to stalled forks in vivo as well as a defect in the protection of dsDNA from degradation by Dna2-Sgs1 and Exo1 in vitro. Together, the evidence suggests that Rad51 binding to duplex DNA is critical to control pathway usage at stalled replication forks.
Plus d'infos...
Tags: Branches of biology, DNA repair, Biology, RAD51, Homologous recombination, Sgs1, S phase, RAD52, Synthesis-dependent strand annealing
Annonce publiée le 08-10-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Mucosal Associated Invariant T (MAIT) cells are abundant innate-like T cells restricted by the non-classical MHC molecule MR1. Both MR1 and the T cell receptor alpha (TCRa) chain of MAIT cells first appeared in mammals and remained strikingly conserved in evolution. The MAIT cell transcriptional program is also conserved across species, indicating that MAIT cells probably fulfill conserved function(s) linked to antigen recognition. The MAIT TCR recognizes riboflavin pathway-derived (5-OP/E-RU) and bile acid-derived (CA7S) metabolites that are constantly produced by the intestinal microbiota and lacking in germ-free mice, suggesting a role for MAIT cells in host-microbiota interactions. We hypothesized that MAIT cell function under selection pressure may relate to the recognition of microbiota-derived ligands. We will present our published and non-published work on the origin, regulation and dynamics of microbiota-derived MAIT ligands in vivo and speculate on how MAIT cell activation in barrier tissues may provide a fitness advantage to the host.
Plus d'infos...
Annonce publiée le 11-10-2026
Institut Cochin
Salle Rosalind Franklin -
Plus d'infos...
Tags: Cancer, Metastasis, Cancer cell migration, Tumor biomechanics
Annonce publiée le 31-10-2026
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Mucosal Associated Invariant T (MAIT) cells are abundant innate-like T cells restricted by the non-classical MHC molecule MR1. Both MR1 and the T cell receptor alpha (TCRa) chain of MAIT cells first appeared in mammals and remained strikingly conserved in evolution. The MAIT cell transcriptional program is also conserved across species, indicating that MAIT cells probably fulfill conserved function(s) linked to antigen recognition. The MAIT TCR recognizes riboflavin pathway-derived (5-OP/E-RU) and bile acid-derived (CA7S) metabolites that are constantly produced by the intestinal microbiota and lacking in germ-free mice, suggesting a role for MAIT cells in host-microbiota interactions. We hypothesized that MAIT cell function under selection pressure may relate to the recognition of microbiota-derived ligands. We will present our published and non-published work on the origin, regulation and dynamics of microbiota-derived MAIT ligands in vivo and speculate on how MAIT cell activation in barrier tissues may provide a fitness advantage to the host.
Plus d'infos...
Tags: Branches of biology, Medical specialties, Medicine, Bacteriology, Environmental microbiology, Immune system, Microbiology, Immunology, T cell, MAIT, Human gastrointestinal microbiota, Mucosal associated invariant T cell
Annonce publiée le 13-10-2026
Institut Cochin
Salle Rosalind Franklin -
Invite par: Daan Noordermeer
The human genome reference sequence is a quarter century old, and the ongoing challenge is to interpret the variation in it. While predicting structures and mutation effects for protein coding genes is making rapid strides, there remains a gap in our understanding of the remaining 99% that is non-coding. This gap is due to the number of nucleotides to measure in an assay, and the rarity of signals outside exons. I will talk about three projects to address this gap. First, we used a chromosome transfer strain with extensive genomic characterization to discover how 200Mb of evolutionarily distant sequence function in a human cell. These data also allowed us to probe the limits of current AI approaches - where do the huge models succeed and fail in predicting the output of a chromosome in a cell? Second, we attempted to generate qualitatively novel types of data at scale to address the gaps in models' abilities to account for distal gene regulation. To do so, we created randomized regulatory regions by inserting recombinase sites around enhancer elements, and induced rearrangements with the recombinase. We applied our approach to dissect a distal super-enhancer of the OTX2 gene, generating over 100 alternative regulatory configurations in a single experiment, and establishing how they drive gene expression and chromatin accessibility as well as the individual contributions of its elements to this activity. Third, we used paired prime editing in pooled screens to delete multiple kilobases of sequence in a massively parallel way. We discovered hundreds of non-coding regions with fitness effects, and validated deletions with impact as well as tolerated ones in regions with functional annotations. Together, these approaches can scale to shed light on the non-coding genome dispensability, resolve many human gene regulatory landscapes, and clarify the limitations of the current predictability of genome function, ultimately paving the way to writing desired functions directly into DNA at scale.
Plus d'infos...
Tags: Genetics and Genomics, Non-coding genome, Gene regulation, AI prediction models
Annonce publiée le 26-10-2026
Institut de Biologie Integrative de la Cellule
B26-N2-000, I2BC CNRS Gif -
Plus d'infos...
Tags: Neuroscience, Excitatory synapse, Neural synapse, Glutamate, Ionotropic glutamate receptors, Neuroplasticity, Excitatory amino acid receptor ligand, GRIK3
Annonce publiée le 29-07-2026
NeuroPSI
Salle de conference Albe-Fessard -
Invitee par l'equipe Konstantinides, Idoia Quintana Urzainqui ( Universite Paris Saclay, France) presentera un seminaire de l'Institut Jacques Monod sur le theme : Studying the shark embryo at the single cell level to understand the origin and evolution of the vertebrate telencephalon Resume : Much of what we know about vertebrate brain evolution comes from studying mammals. Cartilaginous fish, such as sharks, have been largely missing from this picture. They emerged around 450 million years ago, at a pivotal transition in vertebrate history: the shift from jawless to jawed vertebrates. Many new features appeared in these animals, including in the brain, probably linked to an increasingly complex lifestyle as active predators. Yet sharks have never been classic model organisms, as they have long been challenging to work with in the lab. As a result, there is a major gap in our knowledge: we still do not know which brain innovations truly emerged at that time, and we have virtually no understanding of how they arose at the molecular and cellular level. Working with catshark embryos, we found surprising similarities with mammals in brain development, including cell types such as basal progenitors and Cajal-Retzius cells, long thought to be mammalian or amniote innovations. These observations, made over only a short window of development, suggest that key features of the developing brain arose much earlier in vertebrate history than previously assumed. With my newly established group at NeuroPSI, we now aim to go beyond these first insights and reconstruct how the jawed vertebrate brain formed and diversified, combining single-cell and spatial multiomics, cross-species comparisons, developmental biology and gene editing in the shark. In this seminar, I will present the data that led to the establishment of the group, as well as the main lines of our recently awarded ERC project, EvoBrainShark.
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Tags: Developmental Biology and Stem Cells, Shark embryo, Telencephalon evolution, Single-cell analysis
Annonce publiée le 29-10-2026
Institut Jacques Monod
Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France -
Invite par: Fabiola Terzi - Mechanisms and Therapeutic Strategies of Chronic Kidney Disease
Lluis Quintana-Murci - Immune Response Variation Through the Lens of Population and Single-Cell Genomics After completing my Ph.D. at the University of Pavia (Italy), I joined the Institut Pasteur in Paris as an FRM-funded postdoctoral fellow, with additional research training at the University of Arizona (USA) and the University of Cambridge (UK). Since 2007, I have headed the Unit of Human Evolutionary Genetics at the Institut Pasteur, where I also served as Scientific Director from 2016 to 2017. My research, which has been funded by the ERC, focuses on the demographic and adaptive history of human populations, particularly how pathogens have shaped the human genome and the genetic and environmental factors driving variation in immune responses, with implications for precision medicine. Since 2019, I have also been Professor at the College de France, and I am an elected member of EMBO, Academia Europaea, and the French Academy of Sciences. Mark your calendars and make sure to join! Please note that photography during seminars is unauthorized. We kindly ask you to respect this policy to maintain the confidentiality and intellectual property rights of the speakers and their work.
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Tags: Genetics and Genomics, Immune response variation, Population genomics, Single-cell genomics
Annonce publiée le 01-11-2026
Institut Necker Enfants Malades
Institut Necker Enfants Malades - Auditorium 4 -
Invite par: Benoit Chassaing
International launch of the Integrative Microbiome Program at Pasteur 30 November - 1 December 2026 ? Institut Pasteur, Paris, France ?? This event will take place in person only. ? Registration Open Public Registration ...
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Tags: Learned societies, National academies, Grand Croix of the Lgion d'honneur, Louis Pasteur, Pasteur Institute, Awards, Microbiology, Human Microbiome Project
Annonce publiée le 30-09-2026
Institut Pasteur
Batiment CIS, salle CIS, -
Invite par: Benoit Chassaing
To officially launch this major programme, the Pasteur Institute invites you to a two-day series of talks featuring speakers from around the world as well as from the Pasteur Institute. Further details on the ...
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Tags: Microbiology and Infectious Diseases, Microbiome, Pasteur Institute, Louis Pasteur, Bioinformatics, Human Microbiome Project
Annonce publiée le 09-06-2026
Institut Pasteur
Batiment: CIS Salle: CIS -
Psychedelics are increasingly being studied for their potential to produce lasting changes in mood and behaviour, but we still know relatively little about how their effects depend on the state of the brain at the time of treatment. In this talk, I will present our work in mice examining how stress and recovery from stress shape the effects of psilocybin and LSD.
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Tags: Organ systems, Hallucinations, Psychedelic drug, Nervous system, Lysergic acid diethylamide, Stress, Branches of biology, Psychological stress
Annonce publiée le 13-10-2026
I. Cerveau et de la Moelle
Paris Brain Institute auditorium -
Plus d'infos...
Tags: Other
Annonce publiée le 29-10-2026
Institut de Biologie Integrative de la Cellule
B24-N2-315, I2BC CNRS Gif -
TBA
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Tags: Cell biology
Annonce publiée le 07-09-2026
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407 -
Seminaire technique. Mardi 1er decembre 2026 - A partir de 9h - Salle Conferences du BRB Avec la participation de nos partenaires OLINK, ILLUMINA, QUANTERIX, MSD, MERCK MILLIPORE, TEBU, ALAMAR, MABTECH, BIOTECHNE Seminaire de la Plateforme Biomarqueurs Contact : Mathieu SURENAUD
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Annonce publiée le 01-11-2026
IMRB
Salle Conferences du BRB - IMRB, Faculte de Sante, 8 rue du General Sarrail, 94000 Creteil -
Invite par: Paola Arimondo
Claire MINOLETTI-HOCHEPIED Sanofi RetD, Integrated Drug Discovery, SMIRNA/CADD Abstract The exponential growth of chemical libraries demands advanced computational approaches beyond traditional virtual screening methods. Here is presented the integration of chemographic exploration via Generative ...
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Tags: Articles, Health sciences, Academic disciplines, Computational neuroscience, Drug discovery, Emerging technologies, Pharmaceutics, Bioinformatics, Artificial intelligence, Virtual screening
Annonce publiée le 25-09-2026
Institut Pasteur
Batiment F. Jacob , salle F. Jacob Auditorium , -
Invite par: CIRB-College de France
Plus d'infos...
Tags: Cell biology
Annonce publiée le 10-06-2026
College de France
au College de France Salle D2 11 place Marcelin Berthelot - 75005 Paris -
Entre determinisme et imprevisibilite, cette conference explore les limites de la prediction scientifique et les formes d'incertitude qui emergent dans les systemes complexes.
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Tags: Other
Annonce publiée le 24-10-2026
Academie des Sciences
Grande Salle des seances | 23 Quai de Conti 75006 Paris -
Repairing DNA double-strand breaks is crucial for maintaining genome integrity, which occurs primarily through homologous recombination (HR) in S. cerevisiae. Nucleosomes, composed of DNA wrapped around a histone octamer, present a natural barrier to end-resection to initiate HR, but the impact on the downstream HR steps of homology search, DNA strand invasion and repair synthesis remain to be determined. Using the D-loop capture (DLC) and D-loop extension (DLE) assays to track HR intermediates, we revealed that H2B mono-ubiquitylation (H2Bubi) affects multiple steps during HR repair. We infer that H2Bubi modulates chromatin structure, not only promoting histone degradation for nascent D-loop formation but also stabilizing extended D-loops through nucleosome assembly. Furthermore, H2Bubi regulates DNA resection via Rad9 recruitment to suppress a feedback control mechanism that dampens D-loop formation and extension at hyper-resected ends. Through physical and genetic assays to determine repair outcomes, we demonstrate that H2Bubi plays a crucial role in preventing break-induced replication and thus promoting genomic stability.
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Tags: Branches of biology, Biology, DNA repair, Telomeres, Molecular genetics, Cellular processes, Genetics, Homologous recombination, D-loop, Genetic recombination, Chromatin, Synthesis-dependent strand annealing
Annonce publiée le 08-10-2026
Institut Curie
Centre de recherche - Orsay - Amphitheatre du Batiment 111 -
Invite par: Cecile Sauvanet
Plus d'infos...
Tags: Other
Annonce publiée le 26-10-2026
Institut de Biologie Integrative de la Cellule
B26-N2-000, I2BC CNRS Gif -
The program brings together neuroscientists, physiologists, computational biologists, and clinicians to discuss the multidirectional interactions that regulate homeostasis, emotions, and cognitionhighlighting how bodily states shape brain function.
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Tags: Neuroscience
Annonce publiée le 10-08-2026
I. Cerveau et de la Moelle
Institut du Cerveau, Campus Hospitalier Pitie-Salpetriere, Paris 13 -
Butterfly wings display great variations of colourations and patterns both between and among species sharing the same habitat (i.e. sympatric species). In Morpho butterflies in particular, angle-dependant changes of wing colouration can be observed due to light-reflecting nanostructures (i.e. iridescence). The evolution of these visual traits is likely influenced by selective pressures exerted by the visual sensitivities and preferences of predators and other butterflies living in the same habitat. However, disentangling the effects of these biotic interactions from other evolutionary pressures is challenging. In this talk, I will present my research on the relative contributions of ecological interactions on the coevolution of visual traits in sympatric Morpho butterflies. Investigating (i) the variation of the iridescent wings signals between allopatric and sympatric Morpho population, (ii) the evolution of their visual system, and (iii) their mate preferences, allowed me to understand the relative contribution of predation or sexual selection in the evolution of wing iridescence in sympatry.
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Tags: Evolution and Ecology, Butterfly, Iridescence, Sympatric speciation
Annonce publiée le 25-10-2026
IDEEV
IDEEV - Salle Rosalind Franklin -
The title and abstract of this talk will be announced soon.
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Tags: Neuroscience
Annonce publiée le 26-08-2026
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
?Dr. Fudi Wang is a world-leading scholar in cell-resolved metal biology. He founded Ferrology, Zincology and Cuprology, establishing landmark frameworks for FerroLipid, FerroPlasticity and non-lethal ferroptotic signalling. His pioneering discoveries redefine core paradigms of mammalian metal homeostasis and decipher ferroptosis-mediated multi-organ pathogenesis, with seminal reviews in flagship Nature Reviews journals. ?He has published over 270 articles in premier journals including Cell and Nature, with over 30 cover features, more than 30,000 citations and an h-index of 87. A Clarivate?Elsevier Highly Cited Researcher and Stanford top 0.3? global scientist, he has earned distinguished international and national awards. He is a recipient of the National Science Fund for Distinguished Young Scholars and National Ten-Thousand Talents Program, alongside other top-tier national academic honors. He serves as Chief Scientist of China's National Key R&D Program and Principal Investigator of six major NSFC grants. ?He serves on the Board of Directors of the International BioIron Society and was Founder-President of the Bio-Trace Element Society of China. His editorial appointments include Founding Editor-in-Chief of Element, Deputy Editor of Research, and Advisory Board Member of Cell Metabolism. He is an Academician of the International Eurasian Academy of Sciences and Fellow of the Royal Academy of Sciences New Zealand.
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Tags: Cell Biology, Ferroptosis, Programmed cell death
Annonce publiée le 25-09-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Advances in high-throughput genomic approaches have significantly advanced research into the genetics of Alzheimer's disease in recent years. To date, more than 91 loci associated with an increased risk of developing the disease have been identified. However, this knowledge is only meaningful if we understand how these genetic factors contribute to the disease's pathophysiological processes. Alongside conducting large-scale studies to further characterise the missing genetic component of AD, we are developing research projects on other neurodegenerative diseases, such as vascular dementia, to determine whether neurodegenerative diseases overlap in any way, which could help us to identify relevant pathophysiological pathways. We are also developing induced pluripotent stem cells models edited for variants of interest to propose new pathophysiological hypotheses, particularly to go beyond the amyloid cascade. This led us to propose a genetically driven synaptic failure hypothesis.
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Tags: Genetics and Genomics, Alzheimer's disease, Genetic loci, Neurodegenerative diseases
Annonce publiée le 29-10-2026
I. Cerveau et de la Moelle
Paris Brain Institute auditorium -
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Tags: Developmental biology, Evolutionary developmental biology, Morphogenesis, Morphology, Morphogen, Ditte
Annonce publiée le 14-10-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
This workshop aims to bridge this gap by giving a theoretical and practical training on functional ultrasound imaging (fUSi) from recognized leaders in the field. It is primarily intended to PhD students and postdocs aiming to use fUSi in their experiment, but we also welcome untrained scientists eager to discover its principle and applications. No prerequisite is necessary. Through six interactive modules, we will cover the theoretical bases of ultrafast imaging (Module #1), training on surgical design and fUS preparation (Module #2), practical implementation of fUSi experiments in different contexts and species (Module #3), how to preprocess and analyze fUS data, using open-source tools developed by the community (Module #4). We will finally cover the specific developments of fUSi in clinical settings (Module #5) and ultrasound-based molecular imaging and manipulation tools that offer promising avenues for neuroscience (Module #6)
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Tags: Medical imaging, Acoustics, Medical equipment, Medical ultrasonography, Medicine, Medical ultrasound, Physical therapy, Ultrasound, Health care, Health
Annonce publiée le 09-10-2026
I. Cerveau et de la Moelle
Institut du cerveau -
The Optics Developers at Institut Pasteur and the Smart and Frugal Microscopy thematic group of GDR ImaBio are pleased to announce a symposium on technological advances in smart microscopy and AI, that will take ...
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Tags: Computational Biology, Microscopy, Artificial intelligence, Automation
Annonce publiée le 28-10-2026
Institut Pasteur
Batiment Francois Jacob, salle Amphitheater, -
Invite par: CIRB-College de France
Plus d'infos...
Tags: Neuroscience
Annonce publiée le 21-09-2026
College de France
au College de France - Salle D2 - 11 place Marcelin Berthelot - 75005 Paris -
Invite par: Cecile Sauvanet
Plus d'infos...
Tags: Other
Annonce publiée le 26-10-2026
Institut de Biologie Integrative de la Cellule
B21-N0-00 - Auditorium, I2BC CNRS Gif -
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Tags: Branches of biology, Biology, Developmental biology, Healing, Regeneration, Senescence, Neuroregeneration, Marine Biological Laboratory
Annonce publiée le 11-09-2026
NeuroPSI
Salle de conference Albe-Fessard -
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Tags: Other
Annonce publiée le 25-10-2026
IDEEV
IDEEV - Salle Vavilov -
Magnetic nanomaterials offer unique opportunities to interface with the nervous system by converting externally applied magnetic fields into local physical stimuli. In this talk, I will introduce different nanoscale pathways for wireless neuromodulation and show how magnetic materials can generate thermal, mechanical, and electrical signals capable of interacting with neurons.
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Tags: Neuroscience, Nanomaterials, Wireless neuromodulation, Magnetic fields
Annonce publiée le 29-10-2026
I. Cerveau et de la Moelle
Paris Brain Institute auditorium -
Olga Soutourina Professeur Universite Paris-Saclay - Groupe leader of the Regulatory RNAs in Clostridia team I2BC UMR 9198 Title: TBC Abstract: TBC Reini Luco Group Leader of the Chromatin & RNA splicing team Institut Curie (UMR3348-U1368) Title: TBC Abstract: TBC
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Tags: Molecular Biology and Biochemistry, RNA splicing, Spliceosome, Nucleic acids, Biotechnology, RNA, TBC, Reini
Annonce publiée le 28-08-2026
Paris RNA Club
Auditorium Gallois - 45 rue d Ulm, 75005 Paris -
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Tags: Physical sciences, Nobel laureates, Natural sciences, Mas, Surnames, Marie Curie, Baron Barlatier de Mas, Paul Franois Ignace de Barlatier de Mas
Annonce publiée le 01-10-2026
Centre de Recherche des Cordeliers -
Plasticity-the ability of cells to undergo phenotypic transitions-drives cancer progression and treatment resistance. Thus, plasticity is one of the most fundamental problems in cancer biology and one of the foremost challenges in clinical cancer management today. To date, targeting cancer plasticity has not succeeded in the clinic due to the lack of a fundamental understanding of the underlying mechanisms. Our recent published and ongoing work indicates that plasticity in lung cancer, pancreas cancer, and other carcinomas is concentrated in a minority subset of cancer cells, termed high plasticity cell states (HPCSs). Over the past several years, we have generated mouse models that allow for detection, longitudinal lineage-tracing, and ablation of the HPCS and other defined cancer cell states in lung and pancreas tumors in vivo. Using these systems, we have uncovered the HPCS cells are dedifferentiated but possess high capacity for cell state transitions, giving rise to both differentiated and advanced-stage cancer cells in situ in tumors. Longitudinal lineage tracing using secreted luciferases reveals HPCS-derived cells harbor more robust capacity for growth when compared to bulk cancer cells or another defined cancer cell state predicted to possess low plasticity. Suicide gene-mediated ablation of the HPCS in early-stage lesions abrogates tumor progression, whereas ablating HPCS cells in established tumors robustly reduces tumor burden. Leveraging these models, we have demonstrated that the HPCS gives rise to treatment-resistant cell states, whereas ablation of the HPCS abrogated resistance to chemotherapy and oncoprotein-targeted therapy. Furthermore, we show that the HPCS is a critical driver of a stromal cell circuit that drives immunosuppression, and cytoablation of the HPCS cells renders tumors vulnerable to immune attack. Interestingly, we find an HPCS-like state is ubiquitous in regenerating epithelia and carcinomas of multiple other tissues, revealing a convergence of plasticity programs in healthy and malignant epithelial tissues. In parallel studies, we have uncovered unexpected molecular drivers of this cell state, which operate system-wide in epithelial regenerative processes. These molecular mechanisms offer multiple therapeutic entry points, which may enable targeting of malignant plasticity in cancer patients. This work establishes the HPCS as a critical hub enabling reciprocal transitions between cancer cell states, including acquisition of states adapted to cancer therapies, and a critical driver of immunosuppressive tumor stroma. Targeting the HPCS may suppress cancer progression and eradicate treatment resistance.
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Tags: Cancer, Anatomical pathology, Carcinoma, Pancreatic cancer, Stem cells, Carcinogenesis
Annonce publiée le 23-07-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
Invite par: Vincent Goffin - Physiopathologie de la Prolactine et de l'Hormone de croissance
Dr. Jean-Jacques Lebrun is a Full Professor of Medicine at McGill University and cancer biologist at the Research Institute of the McGill University Health Centre in Montreal. Dr. Lebrun completed his PhD at Necker Hospital in Paris, France, before pursuing postdoctoral training at the prestigious Salk Institute in San Diego. He is internationally recognized for his pioneering contributions to cancer biology, functional genomics, and precision oncology. His research focuses on understanding the molecular mechanisms driving tumor progression, metastasis, and therapeutic resistance, with the ultimate goal of developing more effective cancer treatments. A major achievement of his laboratory has been the development of genome-wide in vivo CRISPR screening platforms to identify cancer vulnerabilities directly within living tumors. This pioneering work led to the concept of CRISPRized Medicine, an innovative approach integrating functional genomics, patient-derived tumor models, and pharmacological validation to accelerate the discovery of personalized cancer therapies. His research has led to important discoveries in aggressive cancers, particularly breast and pancreatic cancers, identifying novel therapeutic targets, mechanisms of metastasis, and opportunities for drug repurposing. Dr. Lebrun has authored over 100 scientific publications, trained more than 80 researchers, and held several academic leadership positions, including Vice Dean at McGill University. His scientific contributions have received national and international recognition, notably the Quebec Science Discovery of the Year Award.
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Tags: Cancer, CRISPR screening, Metastasis, Therapeutic resistance
Annonce publiée le 01-11-2026
Institut Necker Enfants Malades
Institut Necker Enfants Malades - Auditorium 2 -
The title and abstract of this talk will be announced soon.
Plus d'infos...
Tags: Neuroscience
Annonce publiée le 26-08-2026
Neural Networking Night
pub Le Piano Vache - 8 Rue Laplace, 75005 Paris -
Invite par: CIRB-College de France
Plus d'infos...
Annonce publiée le 21-09-2026
College de France
au College de France - Salle D2 - 11 place Marcelin Berthelot - 75005 Paris -
Invite par: CIRB-College de France
Annonce publiée le 21-09-2026
College de France
au College de France - Salle D2 - 11 place Marcelin Berthelot - 75005 Paris -
Helena Cruz de Carvalho Associate Professor (UPEC/IBENS) Ecole Normale Superieure Title: TBC Abstract: TBC open slot
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Tags: Carvalho, Surnames
Annonce publiée le 28-08-2026
Paris RNA Club
Auditorium Gallois - 45 rue d Ulm, 75005 Paris -
Invite par: Michaela Muller-Trutwin
Shaping the Future of Gene Therapy with New Vectors - The Second Symposium of TheGeVec Group The AC41 Host-Virus Interaction - Basic and Translational Research coordinated action, is excited to announce its second symposium ...
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Tags: Epidemiology, Infectious diseases, Infection, Pasteur Institute, Emerging infectious disease, Virus, Medical specialties, Branches of biology, Biology
Annonce publiée le 13-10-2026
Institut Pasteur
Batiment: Amphitheatre Duclaux -
Plus d'infos...
Tags: Other
Annonce publiée le 26-10-2026
Institut de Biologie Integrative de la Cellule
B22-N0-001 - Salle de Conferences, I2BC CNRS Gif -
Invite par: CIRB-College de France
Plus d'infos...
Annonce publiée le 24-09-2026
College de France
au College de France Salle D2 - 11 place Marcelin Berthelot - 75005 Paris -
Claudia Salinas PhD Student in Zeynep Baharoglu's team Team EPICS - REPONSES EPITRANSCRIPTOMIQUES ET TRADUCTIONNELLES AU STRESS ANTIBACTERIEN? - Institut Pasteur Title: Abstract: open slot Title: Abstract:
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Tags: Grand Cross of the Legion of Honour, Louis Pasteur, Salinas, California, Salinas, Pasteur Institute, Claudia
Annonce publiée le 28-08-2026
Paris RNA Club
Auditorium Gallois - 45 rue d Ulm, 75005 Paris -
Plus d'infos...
Tags: Evolution and Ecology, Environmental adaptation, Climate change, Biodiversity
Annonce publiée le 31-10-2026
Inst. Bio. Paris Seine
7-9 quai Saint Bernard, 75005 Paris -
Invite par: CIRB-College de France
Plus d'infos...
Annonce publiée le 20-10-2026
College de France
au College de France - Salle D2 - 11 place Marcelin Berthelot - 75005 Paris -
Drug-tolerant persisters (DTPs) are recognized as distinct cancer cell states with specific metabolic and redox adaptations, particularly involving iron-dependent vulnerabilities. DTPs also display a characteristic reliance on the lipid peroxidase GPX4 for protection from ferroptosis, an iron-driven, lipid peroxidationmediated cell death. During this lecture, we will discuss how organelle iron trafficking and metabolic pathways shape DTP&'s ferroptosis vulnerability and metastatic competence in the lymph node.
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Tags: Cancer, Cell Biology, Ferroptosis, Programmed cell death, Selenoproteins, GPX4, Cell death, Metabolism, Peroxidase, Lipid peroxidation, Organelle
Annonce publiée le 15-09-2026
Centre de Recherche des Cordeliers -
Invite par: CIRB-College de France
Annonce publiée le 20-10-2026
College de France
au College de France - Salle D2 - 11 place Marcelin Berthelot - 75005 Paris -
Leo Hardy Postdoctoral Researcher in Zeynep Baharoglu's team Team EPICS - REPONSES EPITRANSCRIPTOMIQUES ET TRADUCTIONNELLES AU STRESS ANTIBACTERIEN? - Institut Pasteur Title: Abstract: Nassim Meziane PhD Student in Clement Carre and Laure Teysset Team Transgenerational Epigenetics & Small RNA Biology? - Institut de Biologie Paris Seine Title: Abstract:
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Tags: Transgenerational, Pasteur Institute, Louis Pasteur, Epigenetics
Annonce publiée le 28-08-2026
Paris RNA Club
Auditorium Gallois - 45 rue d Ulm, 75005 Paris