Lundi 08 Juin 2026 0:00

Cancers gynecologiques : de la pratique clinique a la biologie


Ce cours avance de trois jours offre un apercu complet des derniers developpements en matiere de pratique clinique, de recherche et d innovation therapeutique. Les participants exploreront les donnees scientifiques de pointe, les technologies emergentes, et les defis lies aux soins gynecologiques. Concu pour les professionnels experimentes, le programme met l accent sur des connaissances approfondies et des perspectives d avenir dans les cancers gynecologiques. Plus d'infos... Annonce publiée le 04-03-2026

	Institut Curie Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e

Lundi 08 Juin 2026 9:00

From AMR to Emerging Threats: Understanding Pathogens for Effective Control


Invite par: Aude Bernheim A Joint Symposium by Labex IBEID et Pasteur 2030 Priority 1 The program will be uploaded soon. Plus d'infos... Tags: Infectious diseases, Microbiology, Pathogen, Zoonoses, Evolutionary biology Annonce publiée le 20-02-2026

	Institut Pasteur Batiment: Amphitheatre Duclaux

Lundi 08 Juin 2026 11:00

Scientific lectures: May The Force Be With You! Piezo Channels in Mechanosensory Biology
Ardem Patapoutian | Department of Neuroscience, Scripps Research - Presidential Endowed Chair


Mechanotransduction was perhaps the last major sensory modality not understood at the molecular level. Proteins/ion channels that sense mechanical force are postulated to play critical roles in sensing touch/pain (somatosensation), sound (hearing), shear stress (cardiovascular function), etc.; however, the identity of ion channels involved in sensing mechanical force had remained elusive. The Patapoutian lab identified PIEZO1 and PIEZO2, mechanically activated cation channels that are expressed in many mechanosensitive cell types. Genetic studies established that PIEZO2 is the principal mechanical transducer for touch, proprioception, baroreception, bladder, and lung stretch, and that PIEZO1 mediates blood-flow sensing, which impacts vascular development and iron homeostasis. Clinical investigations have confirmed the importance of these channels in human physiology. Current work in Patapoutian continues to explore the role of mechanosensation and interoception in physiology and disease. Plus d'infos... Tags: Transmembrane proteins, Sensory systems, PIEZO2, Ardem Patapoutian, PIEZO1, Piezo, Mechanosensation, Mechanotransduction, Proprioception, Sense, Somatosensory system, Ion channel Annonce publiée le 07-04-2026

	I. Cerveau et de la Moelle Institut du cerveau

Mardi 09 Juin 2026 9:30

Chloroplast gene expression is required for heterochromatin assembly in Arabidopsis thaliana
Clara Richet-Bourbousse


The importance of nuclear organization dynamics in cell specialization and transcriptional reprogramming is increasingly recognized in eukaryotic species. In plants and mammals, a key redeployment of chromatin organization during cell differentiation is the formation of repressive heterochromatin. This process has long been proposed as an instructive force that stabilizes new transcriptional programs. Unlike mammals, in which heterochromatin is established rapidly after fertilization, in the model plantArabidopsis thalianathis reorganization occurs during post-embryonic development. We previously found that the acquisition of such ?mature-type' nuclear organization is tightly linked to light availability, as nuclear expansion and aggregation of pericentromeric regions, resulting in chromocenter formation, is poised until embryonic leaves perceive light. This light-triggered nuclear shift coincides with a global increase in nuclear transcription and transcriptome size. Light serves as both the primary energy source for photosynthesis and a critical signal that controls plant development. One of the most spectacular light-controlled transitions is the switch to photomorphogenesis in germinating seedlings, where light triggers embryonic leaf expansion, greening, chloroplast biogenesis and the transition to photoautotrophy-marking a switch from a quiescent? to an active? metabolic state. However, the relationships between large-scale nuclear dynamics and chloroplast and metabolic transitions remain unknown. Here, we reveal a previously unrecognized role of plastid organelles in shaping Arabidopsis nuclear architecture and epigenomic landscape. Using cytogenetics and quantitative chromatin profiling, we found that blocking plastid gene expression profoundly alters heterochromatin assembly and centromere cohesion in a cell-type-specific manner, and that these nuclear defects are associated with large-scale epigenomic alterations. We have also begun exploring how metabolic sensors and the chloroplast signals contribute to the global increase in RNA-Pol II-mediated transcription. Plus d'infos... Tags: Molecular genetics, Cellular processes, Photosynthesis, Nuclear organization, Heterochromatin, DNA, Chromatin, Chloroplast, Cellular differentiation, Plastid DNA, RNA-induced transcriptional silencing, Constitutive heterochromatin Annonce publiée le 30-05-2026

	Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie

Mardi 09 Juin 2026 11:30

"CANCELLED"
Dr Laurent Seugnet


Invite par: CIRB-College de France Plus d'infos... Annonce publiée le 06-01-2026

	College de France au College de France - Salle D2 - 11 place Marcelin Berthelot - 75005 Paris

Mardi 09 Juin 2026 11:30

Postnatal maturation of brain pericytes
Dr Annika Keller | University Hospital Zurich


Invite par: CIRB-College de France Plus d'infos... Annonce publiée le 29-04-2026

	College de France au College de France - Salle D2 -11 place Marcelin Berthelot - 75005 Paris

Mercredi 10 Juin 2026 11:00

Reframing Epigenetics: Metabolism, Mitochondria, and Redox as Core Regulatory Layers
Laurent Chatre | STCT, UMR6030 CNRS, Universite de Caen Normandie


Invite par: Dounia DJEGHLOUL Plus d'infos... Tags: Cellular respiration, Mitochondrion, Epigenetics, Metabolism Annonce publiée le 31-05-2026

	Epigenetique et Destin Cellulaire salle des seminaires de l'IJM (RB-18B), 15 rue Helene Brion - 75013 ou en visio-conference

Mercredi 10 Juin 2026 11:30

Advancing Single-Molecule Imaging
Aleksandra Radenovic


In this talk, I will demonstrate how advancements in imaging methods can open new avenues for research at solid-liquid interfaces and also applications in single molecule biophysics. In the first part, I will discuss our efforts to explore nanophotonics at the single-molecule level, with a focus on the optical dynamics and conformations of individual emitters at the solid-liquid interface and in confined environments. In our recent work, we employed fluorescence microscopy to monitor electrochemical reactions at the single-molecule scale, achieving a wide field of view and high temporal resolution. Additionally, we introduced an advanced bifocal polarization single-molecule localization microscopy (pSMLM) to enable real-time, multi-dimensional observations of quantum emissions formed by organic molecules and h-BN native defects. Our findings reveal a strong correlation between the orientation of quantum emitters and the symmetry of the h-BN lattice. I will also discuss the use of SPAD cameras for single-particle tracking applications, as well as in high-throughput single-molecule fluorescence lifetime imaging (smFLIM). Finally, we highlight the compatibility of these approaches with the SPiFFI (Single-Frame Super-Resolution Imaging) method developed in our laboratory, which enables ~80 nm spatial resolution from a single acquisition frame using a simple optical implementation. 1. Ronceray, Nathan, Yi You, Evgenii Glushkov, Martina Lihter, Benjamin Rehl, Tzu-Heng Chen, Gwang-Hyeon Nam et al. "Liquid-activated quantum emission from pristine hexagonal boron nitride for nanofluidic sensing." Nature Materials 22, no. 10 (2023): 1236-1242. 2. Mayner, Eveline, Nathan Ronceray, Martina Lihter, Tzu-Heng Chen, Kenji Watanabe, Takashi Taniguchi, and Aleksandra Radenovic. "Monitoring electrochemical dynamics through single-molecule imaging of hBN surface emitters in organic solvents." ACS nano 18 (40), 27401-27410 3. Guo, Wei, Tzu-Heng Chen, Nathan Ronceray, Eveline Mayner, Kenji Watanabe, Takashi Taniguchi, and Aleksandra Radenovic. "Dipole orientation reveals single-molecule interactions and dynamics on 2D crystals." arXiv preprint arXiv:2408.01207 (2024). 4. Guo, Wei, Lely Feletti, and Aleksandra Radenovic. "Spatial Polarization-Induced Fluorescence Fluctuation Imaging (SPIFFI) Enables Single-shot Super-Resolution and Multidimensional Imaging." bioRxiv (2025): 2025-12. Plus d'infos... Tags: Microscopy, Single-molecule experiment, Spectroscopy, Aleksandra Radenovic, Single-particle tracking, Optical microscopy Annonce publiée le 03-06-2026

	Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie

Jeudi 11 Juin 2026 0:00

Carrasco Yolanda (invited by Paolo Pierobon)


Plus d'infos... Annonce publiée le 23-05-2026

	Institut Cochin Salle Rosalind Franklin

Jeudi 11 Juin 2026 0:00

Comprendre le role de la DGK dans la reponse immunitaire des lymphocytes B : un mediateur important en aval de la signalisation CD40.
Carrasco Yolanda


(invited by Paolo Pierobon) Plus d'infos... Annonce publiée le 27-05-2026

	Institut Cochin Salle Rosalind Franklin

Jeudi 11 Juin 2026 11:00

Staphylococcus epidermidis DnaK alters biofilm formation and proteome in S. aureus CIP 107093
Yoan Konto-Ghiorghi


Invite par: Philippe Gaudu Staphylococcusaureus and Staphylococcusepidermidis, two Gram-positive members of the skin microbiota, form biofilms involved in dysbiosis and inflammatory skin diseases. We investigated the role of the molecular chaperone DnaK from S.epidermidis in biofilm formation. Recombinant DnaK modulates biofilm formation in a strain-dependent manner: it increases biofilm biomass in commensal strains but significantly reduces it in the clinical S.aureus strain CIP107093. Using point mutants of DnaK, we show that the substrate-binding domain is required for this inhibitory effect. Proteomic analysis indicates that recombinant DnaK, added extracellularly, alters the biofilm proteome of S.aureus, affecting protein degradation systems and biofilm regulators, thus revealing a cross-species regulatory role within the skin microbiota. Plus d'infos... Tags: Gram-positive bacteria, Pathogenic bacteria, Bacteriology, Environmental microbiology, Human microbiome, Staphylococcus epidermidis, Staphylococcus aureus, Biofilm, Hsp70, Skin flora, Staphylococcus Annonce publiée le 18-03-2026

	Institut Micalis Auditorium 442 - Institut Micalis

Jeudi 11 Juin 2026 12:00

Deciphering molecular and cellular determinants of liver tumors mutated for beta-catenin signaling
Angelique Gougelet


Plus d'infos... Tags: Catenins, Signal transduction, -Catenin, Catenin beta-1, Tumor suppressor genes, Kang-Yell Choi, TCF7L1 Annonce publiée le 29-05-2026

	Centre de Recherche des Cordeliers Amphi Gustave Roussy

Vendredi 12 Juin 2026 11:00

The self-renewing celfhow actin networks are built, sized, and dismantled
Manuel Thery


Invite par l'equipe Romet-Lemonne/Jegou, Manuel Thery (Directeur de Recherche CEA, Cytomorpholab, ESPCI/IPGG, Paris) etLaurent Blanchoin (Directeur de Recherche CNRS, Cytomorpholab, IRIG/LPCV, Grenoble) presenteront un seminaire de l'Institut Jacques Monod sur le theme : The self-renewing celfhow actin networks are built, sized, and dismantled Resume : The actin cytoskeleton continuously assembles and disassembles its filaments, a process of self-renewal essential for cell shape, movement, and response to the environment. Yet how the cell coordinates this renewal across multiple coexisting actin structures, and what sets the rate at which individual networks turn over, remains poorly understood. Using a minimal reconstituted system with either unlimited or limited monomer availability, we show that when monomers are scarce, competition between distinct actin architectures profoundly disrupts turnover: as competition increases, the turnover rate of individual networks decreases. Actin turnover is therefore not an intrinsic property of individual networks but an emergent outcome dictated by the competitive balance between coexisting architectures. We then show that this principle operates in living cells: when cells increase their spreading area, the expanding cytoskeleton monopolizes available monomers, forcing a slowing of turnover at the whole-cell scale. Together, these results establish competition between actin structures as a fundamental determinant of turnover, revealing how the global cytoskeletal state collectively shapes the dynamic properties of each individual network Plus d'infos... Tags: Actin, Autoantigens, Actin inhibitors, Protein families Annonce publiée le 02-06-2026

	Institut Jacques Monod Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France

Vendredi 12 Juin 2026 11:30

Neurobiological mechanisms of social behaviour.
Camilla Bellone


Invite par: BOUVIER Guy Plus d'infos... Annonce publiée le 21-04-2026

	NeuroPSI Salle de conference Albe-Fessard

Vendredi 12 Juin 2026 14:00

Guarded by Barriers, Driven by Flow: The Brain's Fluid Secrets
Nathalie JURISCH-YAKSI


Invite par: IBENS Developmental Biology Seminar Plus d'infos... Annonce publiée le 19-05-2026

	IBENS salle Favard, IBENS 46 rue d'Ulm 75005 Paris

Vendredi 12 Juin 2026 14:00

Soutenance HDR - Hugo Wioland


Hugo Wioland (equipe Romet-Lemonne/Jegou) va defendre son Habilitation a Diriger des recherche : Actin biochemical and mechanical diversity Le jury sera compose de : NicolasJoly, President Laurent Blanchoin, Rapporteur Peter Bieling, Rapporteur Aurelie Bertin, Examinatrice Patricia Bassereau, Examinatrice Plus d'infos... Tags: Habilitation, Actin, Bieling, Romet Annonce publiée le 23-05-2026

	Institut Jacques Monod Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France

Lundi 15 Juin 2026 11:00

"Equivalent learning emerges from distinct population dynamics across brain networks"
Flavio DONATO | University of Basel - Biozentrum the center for molecular life sciences


Learning requires identifying population activity patterns associated with desired outcomes and acquiring the ability to volitionally recruit them. Whether such processes rely on shared or circuit-specific population dynamics across the brain remains unresolved. A fundamental challenge is that different brain regions typically underpin distinct behaviors, making it difficult to disentangle circuit-specific learning mechanisms from region-specific behavioral demands. Here, we overcome this limitation using a brain-computer interface (BCI) to impose an identical, population-defined learning problem across brain networks. By making reward contingent directly on neuronal population activity, we apply the same associative learning paradigm under identical conditions to two regions with prominent recurrent connectivity but fundamentally distinct dynamical regimes: primary motor cortex (M1) and hippocampal area CA3. Mice acquired robust volitional control in both regions, demonstrating that distinct circuits can support equivalent goal-directed learning. In both M1 and CA3, learning drove progressive sparsification of population activity and greater population-level representation of the reward state. The underlying population dynamics, however, diverged. M1 showed sustained pre-reward excitation and population trajectories that flowed continuously through the reward state, with manifold geometry separating behavioral states. CA3 exhibited a learning-dependent temporal reversal, shifting from pre-reward excitation to post-reward inhibition, with population trajectories converging onto the reward state before rapidly resetting to baseline, and distinct behavioral states collapsing onto a shared manifold subspace. Recurrent network models with distinct connectivity architectures and dynamical constraints, matched to each region, recapitulated these population-level dynamics, linking intrinsic circuit structure to the geometry of learned activity. These findings demonstrate that equivalent learning outcomes can arise from fundamentally different population-level implementations, reflecting intrinsic circuit constraints rather than conserved population-level strategies. This principled degeneracy indicates that learning emerges not from a single canonical solution, but from multiple circuit-specific implementations shaped by local dynamics. Plus d'infos... Tags: Hippocampus, Limbic system, Reward system, Brain, Network neuroscience Annonce publiée le 10-04-2026

	I. Cerveau et de la Moelle Institut du cerveau

Lundi 15 Juin 2026 11:00

Galectins as Multifunctional Glyco-Checkpoints: A Sweet Future for Immunotherapy?
Gabriel RABINOVICH


Gabriel Rabinovich is Director of the Glycoimmunology Program at the Institute of Biology and Experimental Medicine (IBYME-CONICET) in Buenos Aires, Argentina, Senior Group Leader at the CaixaResearch Institute in Barcelona, Spain and Plenary Professor of Immunology at the University of Buenos Aires. He completed his undergraduate and doctoral training at the Faculty of Chemical Sciences, National University of Cordoba, Argentina. Dr. Rabinovich is member of the U.S. National Academy of Sciences (NAS; 2016), the European Molecular Biology Organization (EMBO, 2021), the Latin American Academy of Sciences, The World Academy of Sciences (TWAS), the Argentine Academy of Sciences, and the Argentine Academy of Exact and Natural Sciences. His work has been recognized with more than 200 awards, including the Hakomori Award (International Glycoconjugate Organization, 2025), the Karl Meyer Award (Society for Glycobiology, USA, 2023), the TWAS Prize in Medical Sciences (Italy 2018), the John Simon Guggenheim Fellowship, the Bunge & Born Prize in Medical Sciences, the Konex Diamond Prize for the most outstanding scientist of the decade in Argentina (2014-2024), the Mizutani Foundation Award for Glycosciences, and the Bernardo Houssay Award, among others. Dr. Rabinovich has published over 350 peer-reviewed articles, many in leading journals including Cell, Nature, Cancer Cell, Immunity, Nature Immunology, Nature Medicine, PNAS, and Science Translational Medicine. He has also authored invited reviews in highly influential journals such as Nature Reviews Immunology, Annual Review of Immunology, and Nature Reviews Drug Discovery. His work has received more than 51,000 citations, with an h-index of 101 (Google Scholar). He is the inventor of 11 patents filed in the United States, Europe, the United Kingdom, Japan, and Argentina, and serves as Associate Editor and Editorial Board member for several international journals. Together with his team, Dr. Rabinovich established a novel conceptual framework demonstrating that protein-glycan interactions (glycocheckpoints) can orchestrate immunoregulatory and vascular programs. His work revealed that galectins, a family of soluble ?-galactoside-binding proteins, translate glycan-encoded information into regulatory circuits that control inflammation, suppress autoimmune pathology, and enable tumor immune evasion, angiogenesis, and metastasis. These discoveries have opened new therapeutic avenues in cancer, chronic inflammation, and autoimmune diseases. In 2023, Dr. Rabinovich co-founded Galtec, a biotechnology spin-off dedicated to translating galectin-based discoveries into novel therapeutic strategies. He has supervised or co-supervised 32 PhD students, 28 postdoctoral fellows, and 20 associate researchers, and has delivered more than 450 invited lectures worldwide. He has organized numerous international scientific meetings and training courses and has played a leading role in advancing immunology and glycosciences globally. Dr. Rabinovich has received 12 Doctor Honoris Causa degrees from national and international universities and has served as Visiting Professor at institutions including the University of Maryland, Dana-Farber Cancer Institute, Institut Jacques Monod/Universite de Paris, and the University of Miami. His research has been supported by major international funding agencies, including the Wellcome Trust (UK), the National Institutes of Health/National Cancer Institute (USA), the Lounsbery Foundation (USA), the Cancer Research Institute (USA), the Kenneth Rainin Foundation (USA), the Multiple Sclerosis Society (USA), the Mizutani Foundation for Glycosciences (Japan), the Prostate Cancer Foundation (UK), and Argentinean science agencies. Plus d'infos... Tags: Gabriel A. Rabinovich, Galectin, Immunology Annonce publiée le 03-06-2026

	Institut Curie Hopital site de Paris - Amphitheatre Helene Martel-Massignac (BDD)

Mardi 16 Juin 2026 9:00

4th nICE Day symposium of Cryo-EM users


Invite par: Francesca Gubellini The Structural Biology and Chemistry Department together with the Center for Technological Resources and Research C2RT will run the nICE-Day? event on June 16th from 9am to 6pm in the Duclaux lecture hall. This ... Plus d'infos... Tags: Protein structure, Cell biology, Cryogenic electron microscopy, Structural biology, Fellows of the Royal Society Annonce publiée le 07-05-2026

	Institut Pasteur Salle Amphi Duclaux,

Mardi 16 Juin 2026 11:30

TBA
Dr Guy Bouvier | NeuroPSI


Invite par: CIRB-College de France Plus d'infos... Annonce publiée le 29-04-2026

	College de France au College de France - Salle a venir -11 place Marcelin Berthelot - 75005 Paris

Mardi 16 Juin 2026 14:00

Stromal heterogeneity and fibroblast specialization during mammary gland morphogenesis
Zuzana Sumbalova Koledova


The mammary gland is a highly dynamic organ whose development depends on coordinated interactions between epithelial cells and the surrounding stroma. While fibroblasts are recognized as critical regulators of tissue morphogenesis, their diversity, regulation and specific functions during mammary gland development have been incompletely understood. Recently we identified previously unrecognized heterogeneity among mammary fibroblast populations during postnatal development. In particular, we unraveled a transient niche-forming population of specialized contractile fibroblasts (peri-TEB fibroblasts) that exclusively localize around the tips of the growing mammary epithelium and are recruited from preadipocytes in the surrounding fat pad stroma. In this talk, I will present our ongoing efforts to uncover the molecular mechanisms regulating the establishment or maintenance of these specialized fibroblasts. Our preliminary findings point to a role for WNT signaling and hormonal cues in controlling the peri-TEB fibroblast state, revealing new links between systemic developmental signals, local stromal regulation, and epithelial morphogenesis. Together, these findings provide new insight into stromal specification during organ development and may have broader implications for understanding fibroblast plasticity in breast disease and cancer. Plus d'infos... Tags: Breast anatomy, Exocrine system, Glands, Mammal anatomy, Mammary gland, Breast development, Morphogenesis, Fibroblast, Stroma, Mouse models of breast cancer metastasis Annonce publiée le 30-05-2026

	Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie

Mercredi 17 Juin 2026 9:30

Cytoskeleton club


La prochaine reunion du cytoskeleton club aura lieu mercredi 15 octobre a l’Institut Jacques Monod : Izeta Kankadze (PhD student, Fassier/Nicol's team, Institut de la Vision) presentera «Compartmentalized Second Messenger Signals Contribute to Cytoskeletal Remodeling in Axon Guidance» Veronique MARTHIENS (Researcher, R. Basto's team, Institut Curie) presentera «Brain biomechanics governs mitotic fidelity of embryonic neural stem cells» Plus d'infos... Tags: Developmental neuroscience, Axon guidance, Cytoskeleton, Axon Annonce publiée le 03-10-2025

	Institut Jacques Monod Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France

Mercredi 17 Juin 2026 10:30

Convergence-Divergence of Cerebro-Cerebellar Pathways and Functional Considerations.
Zhenyu Gao


Invite par: EGO-STENGEL Valerie Plus d'infos... Tags: Cerebellum, Cerebro Annonce publiée le 27-05-2026

	NeuroPSI Salle de conference Albe-Fessard

Mercredi 17 Juin 2026 14:00

Integration somatosensori-motrice corticale lors de l'apprentissage moteur, etudiee a l'aide d'une interface cerveau-machine en boucle fermee.
Alexandre Tolboom | NeuroPSI - Unverite Paris-Saclay


Plus d'infos... Annonce publiée le 14-05-2026

	NeuroPSI Salle de conference Albe-Fessard

Jeudi 18 Juin 2026 9:00

Artificial Intelligence in Biology et Health


Invite par: Laurent Essioux The Institut Pasteur is organizing its 3rd edition of its SymposiumArtificial Intelligence in Biology and Health. It will be held on 4thOctober 2024 in the Emile Duclaux lecture hall at the Institut Pasteur campus. ... Plus d'infos... Tags: COVID-19 pandemic in France, Pasteur Institute, mile Duclaux, Louis Pasteur Annonce publiée le 14-02-2026

	Institut Pasteur Batiment: Duclaux Salle: Duclaux lecture hall

Jeudi 18 Juin 2026 11:00

Surface-based cell-free platform to characterize host-pathogen interactions
Aurore Dupin


Invite par: Joshua Ricouvier The immune system is one of the most complex systems of the human body. At its core, it uses protein-protein interactions to achieve the emergent property of differentiating self from other. Synthetic biology aims to implement biological functions of natural living systems, to test hypothesis and to expand them beyond their current limits. Here, we mimic key protein-protein interactions and functions of the immune system using a cell-free surface-based approach. We use innovative silicon chips to parallelize antigen display and antibody epitope screening. Linear DNA sequences are immobilized in micrometer-sized carved compartments. Phenotype and genotype are linked in every compartment by localized on-chip expression and capture of antigens. Binding to a panel of viral antigens is assessed with high specificity for monoclonal antibodies and for polyclonal antibodies in human serum, revealing a rich picture of epitopes and individual immune profiles. This platform mimics and extends the function of antigen-presenting cells, allowing us to interrogate protein-protein interaction between host receptor, pathogenic antigen and immune system. Plus d'infos... Tags: Immune system, Immunology, Epitope, Polyclonal antibodies, Antigen, Antibody, Monoclonal antibody, Immune receptor, Polyclonal B cell response, Immunomics Annonce publiée le 07-04-2026

	Institut Micalis Auditorium 442 - Institut Micalis

Jeudi 18 Juin 2026 12:30

From the M1/M2 paradigm, to spatial determinism of tumor-associated macrophageheterogeneity
Alexandre Boissonnas


This presentation proposes that TAM heterogeneity and functions are determined by their origin and localization in distinct tumor sub-anatomic niches and challenges the association with the M1/M2 binary model.BOISSONNAS Alexandre, Principal Investigator- (Directeur de recherche Inserm) Team leader Spatio-temporal organization and regulation of myeloid cells STORM. Institut Mondor de Recherche Biomedicale IMRB U955, Universite Paris-Est Creteil.Alexandre Boissonnas is an immunologist and Research Director at the French National Institute of Health and Medical Research (Inserm). He obtained his PhD in 2004, during which he investigated the role of antigen in the homeostasis of peripheral T lymphocytes. He then joined Sebastien Amigorena In 2009, he was recruited by Inserm at CIMI-Paris where he established and has since led his own research team focusing on monocyte and macrophage biology. He recently moved to IMRB in Creteil, continuing his investigations on the dynamics of the mononuclear phagocyte system in inflammatory diseases and cancer. His laboratory combines high-dimensional immunomonitoring with advanced imaging technologies to unravel the spatio-temporal organization and regulation of the macrophage compartment, as well as its responses to tissue injury and neoplastic transformation. Plus d'infos... Tags: Macrophages, Immune system, Oncology, Tumor-associated macrophage, Macrophage Annonce publiée le 09-04-2026

	Centre de Recherche des Cordeliers Amphi Gustave Roussy

Vendredi 19 Juin 2026 11:00

Adaptive immunity to the commensal microbiota
Ivanov Ivaylo


1. Gelsinger DR ... Ivanov II#, Sternberg SH#, Wang HH#. Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases. Science 2025. #co-corresponding author 2. Araujo LP ... Ivanov II. Context-dependent role of group 3 innate lymphoid cells in mucosal protection. Science Immunology 2024. 3. Brockmann L ... Ivanov II. Intestinal microbiota-specific Th17 cells possess regulatory properties and suppress effector T cells via c-MAF and IL-10. Immunity 2023. 4. Kawano Y ... Ivanov II. Dietary sugar-induced microbiota imbalance disrupts immune-mediated protection from metabolic syndrome. Cell 2022. 5. Ladinsky MS ... Bjorkman PJ#, Ivanov II#. Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis. Science 2019. #co-corresponding author 1. Gelsinger DR ... Ivanov II#, Sternberg SH#, Wang HH#. Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases. Science 2025. #co-corresponding author 2. Araujo LP ... Ivanov II. Context-dependent role of group 3 innate lymphoid cells in mucosal protection. Science Immunology 2024. 3. Brockmann L ... Ivanov II. Intestinal microbiota-specific Th17 cells possess regulatory properties and suppress effector T cells via c-MAF and IL-10. Immunity 2023. 4. Kawano Y ... Ivanov II. Dietary sugar-induced microbiota imbalance disrupts immune-mediated protection from metabolic syndrome. Cell 2022. 5. Ladinsky MS ... Bjorkman PJ#, Ivanov II#. Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis. Science 2019. #co-corresponding author Plus d'infos... Tags: Immune system, Bacteriology, Microbiomes, T cells, Microbiology, Intestinal epithelium, T helper 17 cell, Microbiota, Human microbiome, Gut microbiota, Innate lymphoid cell, Gut-associated lymphoid tissue Annonce publiée le 06-05-2026

	Institut Curie Centre de recherche - Orsay - Amphitheatre du Batiment 111

Lundi 22 Juin 2026 11:00

"The hippocampal latent diffusion engine: a computational framework for memory, perception, and cognitive dysfunction"
Michael BREAKSPEAR | University of New Castle school of Science.


The hippocampus is a cognitive hub whose functions are disrupted in most major neurodegenerative dementias. Drawing on recent advances in generative artificial intelligence and systems neuroscience, we conceptualize the hippocampus as a latent diffusion engine that compresses sensory, internal, and cognitive inputs into low-dimensional representations and then regenerates percepts, episodic memories, and imagined scenes for cortical integration. Travelling waves of cortico-hippocampal oscillations, aligned with large-scale functional gradients, schedule and structure this generative process, organizing distributed neural activity into coherent, semantically grounded constructs. We also demonstrate how major neurodegenerative dementias - including the Alzheimer&'s disease spectrum - can be interpreted as selective breakdowns of the anatomical and computational components of this proposed architecture. Plus d'infos... Tags: Cognitive disorders, Aging-associated diseases, Learning disabilities, Limbic system, Dementia, Hippocampus, Alzheimer's disease Annonce publiée le 07-04-2026

	I. Cerveau et de la Moelle Institut du cerveau

Mardi 23 Juin 2026 9:00

Stroma immunite et cancer


Cette journee sera consacree aux recherches fondamentales et appliquees dans le domaine en pleine expansion des interactions entre cellules stromales (en particulier les fibroblastes et les cellules endotheliales) et cellules immunitaires au sein du microenvironnement tumoral (TME). Au cours de la derniere decennie, le stroma tumoral est devenu une cible therapeutique prometteuse dans le cancer, les fibroblastes associes au cancer (CAF) jouant un role cle dans la structuration du TME, la regulation de la croissance tumorale, l'evasion immunitaire et la resistance aux chimiotherapies et immunotherapies. Le nombre d'experts en France travaillant dans ce domaine ne cesse de croitre, et nous ressentons le besoin d'organiser un symposium qui reunisse des chercheurs experimentes et des debutants afin de favoriser la creation d'une communaute. Inspire par les initiatives fructueuses des dernieres decennies autour de la recherche sur les lymphocytes et les cellules myeloides, ce symposium vise a aider un cercle pluridisciplinaire d'experts interesses par les fibroblastes du TME a etablir des consensus sur les pratiques experimentales, proposer des nomenclatures unifiees, partager des resultats et echanger des modeles. L'objectif de ce symposium est de renforcer les collaborations naissantes et d'accroitre la visibilite internationale de l'Institut Curie et de la France dans le domaine de l'etude du stroma dans le cancer. Il s'adresse a des personnes disposant d'au moins des connaissances de base en biologie ou immunologie (niveau recommande : Master). Cet evenement sera egalement une opportunite pour faire progresser la recherche translationnelle et le developpement de traitements anticancereux ciblant specifiquement les composants stromaux. Le symposium se tiendra le mardi 23 juin 2026, de 8h30 a 20h, dans l'Amphitheatre Constant Burg (12 rue Lhomond, 75005 Paris, niveau -1), le plus spacieux et confortable de l'Institut Curie, avec ses 196 places. Nous esperons accueillir entre 120 et 150 participants. Les scientifiques que nous avons invites et qui ont confirme leur participation pour presenter leurs projets et leurs resultats les plus recents dans le domaine du stroma, de l'immunite et du cancer, sont listes ci-dessous par ordre alphabetique : CONFERENCIERS PRINCIPAUX (KEYNOTE SPEAKERS) Alexandra Naba - Etats-Unis Shannon Turley - Etats-Unis INTERVENANTS (SPEAKERS) Corinne Bousquet - France Cedric Gaggioli - France Fatima Mechta-Grigoriou - France Lucie Peduto - France Helene Salmon - France Karine Tarte - France Danijela Vignjevic - France En complement, trois jeunes postdocs/chercheurs (1 venant de l'UE, 1 hors Paris et 1 parisien) seront selectionnes pour des presentations courtes (10 minutes + 5 minutes de questions). La selection se fera sur la base des resumes des posters soumis lors de l'inscription. Nous veillerons autant que possible a respecter la parite hommes-femmes parmi les intervenants. L'inscription au symposium sera gratuite mais obligatoire. Nous diffuserons largement l'annonce afin de maximiser la visibilite et d'attirer des chercheurs, etudiants, medecins et ingenieurs internationaux, qui devront prendre en charge leurs frais de voyage et d'hebergement. Une session de posters accompagnee d'un « vin et fromage » sera organisee en fin de symposium, mais les posters pourront etre affiches des le matin a proximite de l'espace cafe/dejeuner pour favoriser les echanges tout au long des pauses. L'IHU Cancers de femmes de l'Institut Curie sponsorise cet evenement, dont la thematique correspond a l'un de ses axes de recherche. Plus d'infos... Annonce publiée le 08-11-2025

	Institut Curie Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e

Mardi 23 Juin 2026 9:00

Colloque : Stroma immunite et cancer


Cet evenement d'une journee sera consacre a la recherche fondamentale et appliquee dans le domaine en pleine expansion des interactions entre cellules stromales (notamment fibroblastes et cellules endotheliales) et cellules immunitaires au sein du microenvironnement tumoral (TME). Au cours de la derniere decennie, le stroma tumoral est apparu comme une cible therapeutique prometteuse dans le cancer, les fibroblastes associes au cancer (CAF) jouant un role cle dans la structuration du TME, la regulation de la croissance tumorale, la promotion de l'evasion immunitaire et la contribution a la resistance auxchimiotherapie et auximmunotherapies. Les scientifiques que nous avons invites et qui ont confirme leur participation pour presenter leurs projets et leurs resultats les plus recents dans le domaine du stroma, de l'immunite et du cancer sont listes ci-dessous par ordre alphabetique : CONFERENCIERS INVITES (KEYNOTE) Alexandra Naba - USA Shannon Turley - USA INTERVENANTS Corinne Bousquet - France Cedric Gaggioli - France Fatima Mechta-Grigoriou - France Lucie Peduto - France Helene Salmon - France Karine Tarte - France Danijela Vignjevic - France En plus de ces intervenants, trois jeunes post-doctorants/chercheurs (1 de l'UE, 1 hors Paris et 1 de Paris) seront selectionnes pour des presentations courtes (10 minutes + 5 minutes de questions). La selection se fera sur la base des resumes de posters soumis lors de l'inscription. Nous veillerons a assurer un equilibre hommes-femmes parmi les intervenants. L'inscription au symposium sera gratuite mais obligatoire. Nous diffuserons largement l'annonce du symposium afin de maximiser sa visibilite et d'attirer des chercheurs, etudiants, medecins et ingenieurs internationaux, qui prendront en charge leurs frais de deplacement et d'hebergement. Une session poster accompagnee de vin et fromage se tiendra a la fin du symposium, mais les posters seront affiches des le matin pres de la zone cafe/dejeuner pour encourager les echanges tout au long des pauses. L'IHU Cancers des Femmes de l'Institut Curie sponsorise l'evenement, car le theme s'inscrit dans l'une de ses priorites de recherche. Inscription gratuite mais obligatoire avant le 10 juin 2026:https://forms.office.com/e/pMdqmCLZcP Plus d'infos... Annonce publiée le 14-11-2025

	Institut Curie Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e

Mardi 23 Juin 2026 11:00

TBA
| LJP


TBA Plus d'infos... Tags: LJP, National Youth Council of Latvia, Liberty and Justice Party Annonce publiée le 11-12-2023

	Laboratoire Jean Perrin Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407

Mardi 23 Juin 2026 11:30

Immunity in context: how tissues instruct immune responses


Invite par: Pierre Guermonprez Laura Mackay Peter Doherty Institute for Infection and Immunity, Australia ABSTRACT Immune responses are often inferred from blood, yet many T cells reside long-term within tissues, where local context shapes their behaviour. Tissue-resident memory ... Plus d'infos... Tags: Immune system, Immunology, Laura Mackay, T cell, Nonspecific immune cell, Mucosal immunology Annonce publiée le 23-04-2026

	Institut Pasteur Salle AGNES ULLMAN AUDITORIUM ,

Mardi 23 Juin 2026 12:30

Macrophages master regulators of health and inflammation
Miriam Merad


Plus d'infos... Tags: Merad, Miriam, The President Annonce publiée le 10-04-2026

	Centre de Recherche des Cordeliers Amphi Biski-Pasquier

Mercredi 24 Juin 2026 11:30

Mechanotransdcution of epithelial density: from cell adhesions to the nucleus
Nicolas Borghi


In multicellular organisms, the perception of cell density within a cohesive tissue is thought to underlie the regulation of tissue growth, homeostasis and regeneration. However, the mechanisms by which cells sense and adapt their behaviour to their density within the tissue remain largely unknown. To address this question, we used genetically encoded biosensors of protein mechanics and enzymatic activity, genetic and pharmacological perturbations, and quantitative fluorescence microscopy on cultured model epithelia to study mechanotransduction pathways downstream of cell density. We found that epithelial cells respond to density by integrating a combination of force-gated enzymatic activations and protein translocations that occur in cell adhesion complexes and at the nuclear envelope. Ultimately, chemical and mechanical signals converge into a nuclear mechanotransduction pathway that controls cell migration and may also coordinate nuclear activities across the tissue. Plus d'infos... Tags: Cell signaling, Cell adhesion, Mechanotransduction, Epithelium, Cell biology, Cadherin-1, Madin-Darby canine kidney cells Annonce publiée le 30-05-2026

	Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie

Mercredi 24 Juin 2026 16:30

Titre à venir
Clement Carre/Laure Teysset's Lab and Reini Luco


TBC soon - stay tuned! Plus d'infos... Tags: Reini, Luco, Stay Tuned, Laure Annonce publiée le 16-03-2026

	Paris RNA Club Auditorium Gallois - 45 rue d Ulm, 75005 Paris

Jeudi 25 Juin 2026 0:00

Jean-Pierre Leonard (invite par les CSCA)


Plus d'infos... Annonce publiée le 23-05-2026

	Institut Cochin Salle Rosalind Franklin

Jeudi 25 Juin 2026 10:00

Adjusting the timing of mammalian development.
Aydan Karslioglu


Pluripotency provides the foundation of embryonic development and regenerative medicine. Pluripotency is also remarkably dynamic, as it can alternate between different states and can be promptly resolved to allow lineage specification. As such, e mbryonic development relies on stem cell function in balance with differentiation. We investigate how this balance is maintained in coordination with the environment and the protective measures the embryos take at times of scarcity. Our mission is to decode the process of dormancy and identify the genetic, epigenetic, and metabolic mechanisms that govern this fascinating phenomenon. Plus d'infos... Tags: Developmental biology, Biotechnology, Cell biology, Stem cells, Cloning, Cellular differentiation, Cell potency, Adult stem cell Annonce publiée le 09-04-2026

	Institut Curie Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)

Jeudi 25 Juin 2026 12:00

The many faces of doxorubicin and how to improve it for new cancer therapies
Sjaak Neefjes


Anthracyclines like doxorubicin are still cornerstones in the treatment of a series of tumors. They should act by poisoning topoisomerase II causing DNA double stranded breaks. However, they also evict histones at defined sites in chromatin. We chemically separated these two activities to show that histone eviction was the most cytotoxic activity. Doxorubicin variants acting through histone eviction are active cancer drugs but have lost various toxic side effects including dose-dependent cardiotoxicity. These variants can still be used in the treatment of relapsed cancer patients and can strongly improve their overall survival. New activities in old cancer drugs can thus be explored to control toxicities, allow chronic treatment and improve the quality of life of cancer survivors. Plus d'infos... Tags: Anthracyclines, Antineoplastic drugs, Doxorubicin, Teratogens, Anthracycline, Chemotherapy, Cardiotoxicity, Histone, CytRx, Zoptarelin doxorubicin Annonce publiée le 24-04-2026

	Centre de Recherche des Cordeliers Amphi Gustave Roussy

Jeudi 25 Juin 2026 15:30

Silencing the Past ? Enabling the Future: HUSH-Mediated Regulation of Retroelements
Paul J Lehner


Abstract Retrotransposition - the reverse flow of genetic information from RNA to DNA provides the major route by which new genetic material enters our genome, with retroelements comprising over 40% of human DNA. This process drives innovation but threatens genome integrity, demanding effective regulation. Our discovery of the Human Silencing Hub (HUSH) revealed a genome-wide transcriptional immunosurveillance system that detects and epigenetically silences invading DNA. How HUSH distinguishes self from invading DNA was unclear. We found that HUSH discriminates ?self' from ?non-self' based on cellular introns: The majority of cellular genes are intron-containing, while RNA-derived retroelements are intronless, marking their cDNA as foreign. This intron-based recognition mechanism uncovers an unexpected innate immune surveillance system that protects the genome from the reverse flow of genetic information. Our ongoing work on HUSH-mediated epigenetic repression will be further discussed. Plus d'infos... Tags: Molecular biology, Non-coding DNA, RNA splicing, DNA, Mobile genetic elements, Intron, Retrotransposon, RNA, Human genome, Complementary DNA, Transposable element, Epigenetics Annonce publiée le 14-05-2026

	Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie

Vendredi 26 Juin 2026 10:00

Mechanoregulation of Cytotoxic Lymphocyte Function
Morgan Huse


I trained as a structuralbiologist/peptide chemist, with John Kuriyan and Tom Muir at Rockefeller University, before carrying out postdoctoral research with Mark Davis and Stanford. There, I became interested in the structure and function of immune cell-cell interactions. I joined the Immunology Program at Memorial Sloan Kettering Cancer Center in 2007. My lab has primarily focused on the cytotoxic immune synapse, which is the specialized junction used by cytotoxic lymphocytes to destroy infected or transformed target cells. Over the past decade, we have become particularly interested in the mechanobiology of this interface, in particular how physical forces and mechanical properties shape its potency and specificity. My talk will address the role of lymphocyte mechanosensing in anti-tumor immune responses. Plus d'infos... Tags: Immune system, Lymphocyte, Immunological synapse, T cell Annonce publiée le 08-05-2026

	Institut Curie Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e

Vendredi 26 Juin 2026 11:00

Titre à venir
Seminaire du comite EGO


Plus d'infos... Tags: Comite Creek Annonce publiée le 22-05-2026

	NeuroPSI Salle de conference Albe-Fessard

Vendredi 26 Juin 2026 11:45

Biomolecular Condensates at the Nuclear Envelope: From Mechanism to Therapeutic Modulation
Christian Schlieker


Invite par l'equipe Palancade, Christian Schlieker (Department of Molecular Biophysics and Biochemistry, Yale University, USA) presentera un seminaire de l'Institut Jacques Monod sur le theme : Biomolecular Condensates at the Nuclear Envelope: From Mechanism to Therapeutic Modulation Christian started his scientific training as an undergraduate at the University of Bonn in Germany, with a research stay at the University of New South Wales in Sydney, Australia. He then earned his Ph.D. in the laboratory of Dr. Bernd Bukau at the Center for Molecular Biology (ZMBH) of Heidelberg University, where he used biochemical and biophysical approaches to uncover how Clp/HSP100 AAA+ ATPases counteract proteotoxic stress. Christian continued his training as an EMBO postdoctoral fellow with Dr. Hidde Ploegh at Harvard Medical School and the Whitehead Institute/MIT, where he explored the ubiquitin-proteasome system and discovered a novel role for a ubiquitin-like modifier in RNA biology. Christian joined the Department of Molecular Biophysics and Biochemistry at Yale University in 2009, where he is currently Professor and Director of Undergraduate Studies, with a secondary appointment in the Department of Cell Biology. He is a recipient of the NIH Director's New Innovator Award and has served on the scientific advisory board of the Dystonia Medical Research Foundation and reviewed for the NIH, the Department of Defense, the German Excellence Initiative, ANR and the European Research Council, among others. At Yale, he has chaired the Committee on Majors for Yale College and currently serves on the Advisory Board of the Yale Center for Molecular Discovery. Starting in July 2026, he will chair the Department of Molecular Biophysics and Biochemistry. Brief synopsis We explore how cells build and safeguard two the nuclear envelope and the endoplasmic reticulum. Our work focuses on how disruptions in membrane organization and phase separation drive the formation of aberrant condensates that are increasingly implicated in neurological disease. To tackle these questions, we develop and apply new tools that allow us to probe and modulate these processes across scales, from the dynamics of individual proteins and condensates to genome-wide functional screens. By integrating cell biology, biochemistry, and computational approaches with patient-derived and animal model systems, we aim to uncover fundamental principles of cellular organization and translate these discoveries into novel therapeutic strategies for movement disorders and related conditions. We recently developed a high-content platform and computational pipeline to screen modulators of nuclear condensates across chemical and genetic space. This effort identified novel players in nuclear condensates formation, along with small molecules that modualte proteotoxic condensates. Application of the platform in a genome-wide CRISPR knockout screen revealed strong enrichment of candidate genes linked to primary microcephaly and related neurodevelopmental disorders, pointing to condensate dysregulation as a shared molecular axis across disease. A complementary line of work asks how the nuclear pore complex itself contributes to protein quality control. Co-translational folding allows nascent proteins to begin folding as they are synthesized, reducing the risk of aggregation and avoiding energy-intensive unfolding steps. We propose that karyopherins and flexible FG-nucleoporins not only safeguard the nuclear permeability barrier but also generate a supportive environment - a folding phase? - that promotes correct folding of proteins entering the nucleus. This perspective offers new insight into how disruptions in nuclear transport and protein quality control may contribute to neurological disease. Together, these efforts may inform biotechnological advances in protein stability and targeted therapeutics for diseases of disrupted folding. Selected publications Prophet SM, Rampello AJ, Niescier RF, Gentile JE, Mallik S, Koleske AJ, Schlieker C: Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities. Nat Cell Biol 2022, 24:1630-1641. Poch D, Mukherjee C, Mallik S, Todorow V, Kuiper EFE, Dhingra N, Surovtseva YV, Schlieker C: Integrative Chemical Genetics Platform Identifies Condensate Modulators Linked to Neurological Disorders. bioRxiv 2025, doi:10.1101/2025.06.07.658469. Rampello AJ, Laudermilch E, Vishnoi N, Prophet SM, Shao L, Zhao C, Lusk CP, Schlieker C: Torsin ATPase deficiency leads to defects in nuclear pore biogenesis and sequestration of MLF2. J Cell Biol 2020, 219:e201910185. Mallik S, Poch D, Burick S, Schlieker C: Protein folding and quality control during nuclear transport. Curr Opin Cell Biol 2024, 90:102407. Plus d'infos... Tags: Organelles, Proteins, Membrane biology, Cell nucleus, Biomolecular condensate, Cell biology, Proteasome, Ubiquitin, Nuclear envelope, Chaperone, Endoplasmic reticulum, Nuclear pore complex Annonce publiée le 23-05-2026

	Institut Jacques Monod Institut Jacques Monod Salle Francois Jacob, 15 rue Helene Brion, Paris, France

Lundi 29 Juin 2026 11:00

"Neuromodulation of Brain States"
Luis DELECEA | Depart of Psychiatry & Behavorial Sciences Stanford University School of Medicine


The arousal construct underlies a spectrum of behaviors that include sleep, exploration, feeding, sexual activity and adaptive stress. Pathological arousal conditions include stress, anxiety disorders, and addiction. In the past few years we have used optogenetics to interrogate neuronal circuits underlying transitions between arousal states. In particular, I will talk about two new circuits identified in our laboratory: one predicts the onset and duration of REM sleep with unprecedented precision; another induces sleep in response to inflammatory cytokines. I will also present a novel method that displays cortex-wide fluctuations in membrane voltage using TEMPO imaging. Finally, I will discuss noninvasive neuromodulation methods for sleep intervention. Plus d'infos... Tags: Neurophysiology, Neuromodulation, Rapid eye movement sleep, Brain Annonce publiée le 08-04-2026

	I. Cerveau et de la Moelle Institut du cerveau

Lundi 29 Juin 2026 17:15

Exploration of Aqueous Biomarkers from Retinoblastoma to Uveal Melanoma
Jesse Berry


Over the past decade, aqueous humor liquid biopsy has emerged as a transformative tool in ocular oncology, enabling minimally invasive molecular profiling of intraocular tumors from small-volume aqueous samples. Pioneered in retinoblastoma, this work demonstrated that cell-free DNA and ctDNA correlate with disease activity and prognosis, and that RB1 mutations can be reliably tracked across treatment - findings that established the clinical foundation for the LBSeq4Kids platform. Serial aqueous sampling has since proven valuable for guiding therapy and identifying patients at risk for metastatic progression without systemic biopsy. Now, this liquid biopsy framework is being extended to uveal melanoma, where modeled aqueous humor protein concentrations are opening a new avenue for biomarker discovery and non-invasive disease characterization. Plus d'infos... Tags: Biomarkers, Rare diseases, Medical signs, Pediatric cancers, Melanoma, Uveal melanoma, Cancer biomarker, Retinoblastoma, Circulating tumor DNA, Liquid biopsy, Uvea, Eye neoplasm Annonce publiée le 30-05-2026

	Institut Curie Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)

Mardi 30 Juin 2026 9:30

Single-molecule mechanics of eukaryotic and bacterial SMC complexes
Maxim Molodtsov


Structural Maintenance of Chromosomes (SMC) complexes are conserved molecular machines that help organize genomes in organisms ranging from bacteria to humans. They perform two essential tasks: they establish DNA-DNA interactions and extrude DNA loops, thereby shaping chromosome architecture and supporting faithful chromosome segregation. In this talk, I will discuss recent single-molecule studies from our group that reveal how these machines work under force. Using optical tweezers combined with fluorescence microscopy, we directly measure how strongly individual SMC complexes interact with DNA while visualizing their activity. We find that cohesin and condensin can form highly stable DNA connections capable of resisting the forces generated during cell division. By contrast, cohesin-mediated loop extrusion depends on much weaker and more dynamic DNA interactions, allowing loops to be readily remodelled. Comparisons with bacterial SMC complexes show that these machines can be stronger and more efficient loop extruders than their eukaryotic counterparts. Together, these findings suggest that SMC complexes have evolved different mechanical properties to match their specific roles in chromosome folding, maintenance, and segregation. Plus d'infos... Tags: Mitosis, Cell cycle, Nuclear organization, Condensin, Cohesin, Loop extrusion, SMC protein, Chromosome, DNA, Chromosome condensation Annonce publiée le 08-05-2026

	Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie

Mardi 30 Juin 2026 11:30

TBA
Dr Nicolas Renier | ICM


Invite par: CIRB-College de France Plus d'infos... Annonce publiée le 29-04-2026

	College de France au College de France - Salle a venir -11 place Marcelin Berthelot - 75005 Paris

Jeudi 02 Juillet 2026 9:00

The 11th edition of Start-me up on July 2 et 3, 2026


Invite par: Jong Eun Ihm Start-meup? is an annual two-day event that explores the latest trends in the life sciencesand health innovation ecosystem while guiding participants through the startup creation journey. This year’s expert talks session focuses on how ... Plus d'infos... Tags: Entrepreneurship, Business incubators, Private equity, Startup company, Innovation Annonce publiée le 04-03-2026

	Institut Pasteur Batiment: Centre Francois Jacob Salle: Auditorium

Jeudi 02 Juillet 2026 12:00

Title to come
Kevin Boye


Plus d'infos... Tags: Boye, Hans Boye, Come, Thou Fount of Every Blessing Annonce publiée le 29-04-2026

	Centre de Recherche des Cordeliers

Lundi 06 Juillet 2026 0:00

DIF Day 2026


Les inscriptions pour le DIF day 2026 sont ouvertes ! Rendez-vous sur le site d'inscriptions pour pouvoir y participer : https://sites.google.com/view/dif2026/accueil_2026?authuser=0 Plus d'infos... Annonce publiée le 21-05-2026

	Institut Jacques Monod Institut Jacques Monod Amphitheatre Buffon, 15 rue Helene Brion, Paris, France

Lundi 06 Juillet 2026 11:30

TBA
Dr Jun Nagai | Riken Center for brain science


Invite par: CIRB-College de France Plus d'infos... Annonce publiée le 29-04-2026

	College de France au College de France Salle D2 - 11 place Marcelin Berthelot - 75005 Paris

Mardi 07 Juillet 2026 11:00

Harnessing Viral Mimicry in Cancer Vaccines
Nicolas VABRET


Despite advances in mRNA-based cancer vaccines, therapeutic responses remain limited by poorly immunogenic tumors that fail to support effective T cell infiltration, expansion, and function. Epigenetic therapies can enhance tumor immunogenicity by reactivating transposable elements (TEs), triggering innate sensing of immunogenic nucleic acids through a process known asviral mimicry.In this seminar, I will discuss how the DNA methyltransferase inhibitors induces viral mimicry in preclinicaltumourmodels, leading to type I interferon responses, enhanced antigen presentation, and remodeling of the immunosuppressive tumor microenvironment. This response depends on cancer-intrinsic nucleic acid sensors and supports the expansion and function of vaccine antigen-specific T cells within tumors.Together, these findings identify viral mimicry as a strategy to license therapeutic cancer vaccination and improve anti-tumor immunity. Plus d'infos... Tags: Immunology, Oncology, Immune system, Biotechnology, Immunogenicity, Cancer vaccine, Antigen, Tumor microenvironment, Glioma 261, Cancer immunotherapy Annonce publiée le 06-05-2026

	Institut Curie Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e

Mercredi 08 Juillet 2026 11:30

Gliding Motion of Diatoms: Motors, Filaments, and Dynamic Trajectory Control
Stefan Diez


Raphid diatoms exhibit rapid gliding motility with remarkable directional flexibility, yet the underlying mechanisms remain poorly understood. Using Craspedostauros australis as a model, we combine phylogenomics, live-cell imaging, and high-resolution microscopy to dissect both force generation and trajectory control. We find that raphe-associated actin bundles do not show directional turnover, arguing against a direct role of actin dynamics in force production. Instead, we identify diatom-specific myosins (CaMyoB-D) that display coordinated movement during gliding, consistent with a motor function. At the cellular level, diatoms dynamically modulate their trajectories by switching between one- and two-raphe contact with the substrate. This switching controls path curvature, with single-raphe gliding producing curved paths and dual-raphe gliding resulting in straighter motion. Together, our results suggest a mechanism in which myosin-driven force generation is coupled to dynamic regulation of cell-substrate contact, enabling flexible navigation in complex environments. Plus d'infos... Tags: Protein families, Actin, Autoantigens, Myosin, Diatom, Gliding motility Annonce publiée le 24-04-2026

	Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie

Jeudi 03 Septembre 2026 9:00

Challenges from Longitudinal Data


The first day will be devoted to presentations by international experts on methods, applications and issues related to longitudinal data. The second day will offer practical tutorials around open-source software in R and Python, including Leaspy, JMbayes2, lcmm and saemix. Plus d'infos... Tags: Social research, Design of experiments, Longitudinal study, Nursing research, Observational study Annonce publiée le 02-06-2026

	I. Cerveau et de la Moelle Day 1 - Thursday September 3, 2026

Lundi 14 Septembre 2026 14:00

EMBO Workshop The complexity of mycobacterial infections: From research to real-world impact


Invite par: Giulia Manina Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains one of the deadliest infectious diseases worldwide. Meanwhile, non-tuberculous mycobacteria (NTM) are an increasing global health concern. NTM infections often resemble TB clinically, which can lead to ... Plus d'infos... Tags: Acid-fast bacilli, Bacterial diseases, Tuberculosis, Pathogenic bacteria, Infectious causes of cancer, Nontuberculous mycobacteria, Mycobacterium, Mycobacterium fortuitum, Mycobacterial cervical lymphadenitis Annonce publiée le 26-02-2026

	Institut Pasteur Batiment CIS, salle ,

Lundi 21 Septembre 2026 0:00

Conference Jacques Monod - The mechanistic and evolutionary basis of programmed DNA elimination


The Conference Jacques Monod » The mechanistic and evolutionary basis of programmed DNA elimination» will take place fromMonday, September 21, 2026 toFriday, September 25, 2026 in Roscoff (Bretagne, France). Abstracts submission deadline :Tuesday, May 5, 2026 Deadline for payment of registration fees :July 2, 2026 Deadline for return of completed forms :July 2, 2026 Registration and abstract submission website Beyond mutations, the genetic content of an organism is generally constant across cells throughout development. Programmed DNA elimination (PDE) - a process in which specific cell lineages lose DNA segments or whole chromosomes - represents is a striking deviation to this principle. PDE is widespread in eukaryotes and plays roles in a variety of cellular processes, including gene silencing, germline differentiation, genome defence, and non-Mendelian inheritance. It manifests in diverse biological contexts, including the formation of germline-limited genomes, meiotic elimination of parental chromosomes, and sex determination via X-chromosome loss. In recent years, it has become increasingly clear that PDE occurs across a wide range of phylogenetic groups, and involves diverse mechanisms. These findings underscore the overlooked plasticity of genome integrity, and reveal significant gaps in our understanding of why PDE has evolved repeatedly and is maintained across the Tree of Life. This conference is designed to present the latest research on the mechanisms and evolution of PDE - from the molecular pathways that control genome stability and chromosome segregation, to genomic conflictsand the long-term evolutionary consequences of PDE on population dynamics and species diversification.We also welcome researchers studying related phenomena, such as meiotic drive, B chromosomes, and those that work on the mechanisms and regulation of genome stability, chromosome segregation and germline development. The meeting will address the following key topics: Mechanisms and regulation of genome stability and instability Mechanisms of chromosome segregation and missegregation Genomic conflicts Evolutionary dynamics of programmed DNA elimination Plus d'infos... Tags: Evolutionary biology, Molecular genetics, Molecular evolution, Cell cycle, Meiosis, Mutation, Intragenomic conflict Annonce publiée le 28-03-2026

	Institut Jacques Monod Roscoff, Roscoff, France

Lundi 21 Septembre 2026 0:00

Biologie des Systemes du Cancer | 9e edition


L heterogeneite observee entre les tumeurs de differents patients, et meme entre les cellules cancereuses d'un meme patient, complique considerablement le developpement de traitements. La medecine « personnalisee » ou « de precision » vise a surmonter ce probleme en proposant un traitement adapte a chaque patient, en fonction de son profil genetique individuel et de la signature moleculaire de sa tumeur. Cet objectif ambitieux necessite une caracterisation moleculaire approfondie du cancer chez le patient, a l'aide de technologies a haut debit et de techniques d'imagerie avancees. Beaucoup de donnees multi-echelles sur le cancer deviennent disponibles, mais elles restent encore largement sous-exploitees pour elucider les mecanismes sous-jacents et ainsi guider la stratification des patients et le choix des traitements. L'analyse integrative multimodale des donnees omiques et cliniques offre un fort potentiel pour elucider les bases moleculaires des differents types de cancer. L'integration multimodale des donnees sur la maladie est particulierement prometteuse pour mettre en evidence les relations complexes entre les mecanismes moleculaires qui contribuent collectivement a la maladie. Plus d'infos... Annonce publiée le 18-04-2026

	Institut Curie Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)

Jeudi 24 Septembre 2026 9:00

CRC Scientific Day 2026


Every year, the Centre de Recherche des Cordeliers organises a scientific day where its young researchers, students and post-docs present their work.Prestigious speakers are also invited to take part.This year, we will be welcoming:This event is open to the entire scientific community. Plus d'infos... Tags: Inquiry, Observation, Science, European Research Council Annonce publiée le 27-02-2026

	Centre de Recherche des Cordeliers

Jeudi 24 Septembre 2026 12:00

Investigating Plasmodium myosins to identify antimalarial targets
Julien ROBERT-PAGANIN, UMR144, Institut Curie, Paris


Plus d'infos... Tags: Malaria, Plasmodium, Antimalarial medication Annonce publiée le 17-05-2026

	Institut Cochin -

Jeudi 24 Septembre 2026 12:00

REPORTE - Investigating Plasmodium myosins to identify antimalarial targets
Julien ROBERT-PAGANIN, UMR144, Institut Curie, Paris


Plus d'infos... Tags: Malaria, Plasmodium, Antimalarial medication Annonce publiée le 19-05-2026

	Institut Cochin -

Lundi 28 Septembre 2026 0:00

Developpement amp; Cancer - 16e edition


Le cours est dedie aux connaissances les plus actuelles articulant la biologie du developpement et l etude cellulaire et moleculaire des cancers. Les cretes neurales et les melanomes, depuis leur formation jusqu a leur migration (metastases), ainsi que les cancers pediatriques d'origine embryonnaires tels que les medulloblastomes et neuroblastomes sont pris comme exemples. Le cours beneficie d une approche multidisciplinaire a multiples echelles (embryologie sur des modeles varies, biophysique, biologie cellulaire, transcriptomique, imagerie...). Il aborde egalement des approches therapeutiques et ainsi que la prise en compte des 3R en recherche avec l'invitation des chercheurs developpant des organoides et des modeles animaux alternatifs. Le cours est ponctue par des tables rondes sur les carrieres dans le milieu academique ou dans l industrie,sur la publication d articles scientifiques ainsi que sur l ethique en experimentation animale.Des sessions posters de doctorants sont egalement organises et des prix pour les meilleurs posters seront decernes par les participants aux cours. Plus d'infos... Annonce publiée le 10-04-2026

	Institut Curie Centre de recherche - Orsay - Amphitheatre du Batiment 111

Lundi 05 Octobre 2026 0:00

Neurepiomics 2026


Founded by leading researchers, Professors Stephanie Debette and Sudha Seshadri, this annual event brings together a vibrant global community for an immersive, cross?disciplinary training experience. Plus d'infos... Tags: Seshadri Annonce publiée le 05-06-2026

	I. Cerveau et de la Moelle Institut du cerveau

Jeudi 08 Octobre 2026 12:00

Title to come
Yasmine Belkaid


Plus d'infos... Tags: Pasteur Institute, Yasmine Belkaid, Yasmin, Aboubakr Belkaid, Lurie Prize in Biomedical Sciences Annonce publiée le 04-03-2026

	Centre de Recherche des Cordeliers

Vendredi 09 Octobre 2026 11:30

Evolution, Development, and Function of Motor Circuits.
Lora Sweeney | Assistant Professor, Institute of Science and Technology Austria (ISTA)


Plus d'infos... Tags: Institute of Science and Technology Austria, Ista, Lora, International Seed Testing Association Annonce publiée le 04-06-2026

	NeuroPSI Salle de conference Albe-Fessard

Mardi 13 Octobre 2026 11:30

EM tomography and membrane remodeling


EM tomography and membrane remodeling Plus d'infos... Tags: Medical imaging, Tomography, Crista, Volumetric Electron Microscopy Annonce publiée le 29-04-2026

	Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie

Jeudi 15 Octobre 2026 0:00

Seminaire Sharon Tooze (titre a venir)
Sharon Tooze


Plus d'infos... Tags: Tooze, Titre Annonce publiée le 19-05-2026

	Institut Cochin Salle Rosalind Franklin

Jeudi 15 Octobre 2026 12:00

Title to come
Jeremie Gautheron


Plus d'infos... Tags: Jeremie, Jeremi Annonce publiée le 06-03-2026

	Centre de Recherche des Cordeliers

Jeudi 29 Octobre 2026 9:00

Immune variability across the life course


Invite par: Darragh Duffy Thursday 29th Oct 26 \| Institut Pasteur KEYNOTE SPEAKERS ? Prof. Yasmine Belkaid President of the Institut Pasteur (Paris), Professor Yasmine Belkaid is an internationally recognized immunologist specializing in host-microbiota interactions and tissue immunity. ... Plus d'infos... Tags: Pasteur Institute, Yasmine Belkaid, Microbiology, Microbiomes, Bacteriology, Louis Pasteur, Variability, Human microbiome Annonce publiée le 24-02-2026

	Institut Pasteur Batiment: Duclaux

Vendredi 30 Octobre 2026 9:00

LabEx Milieu Interieur Annual Meeting 2026


Invite par: Darragh Duffy 30th OCTOBER 2026 \| INSTITUT PASTEUR \| FRANCE We are happy to announce the 2026 yearly meeting of Milieu Interieur LabEx Join un on the morning of the 30th of October at 9am at ... Plus d'infos... Tags: Corruption in France, Organized crime in France Annonce publiée le 22-05-2026

	Institut Pasteur Batiment: Duclaux Salle: Amphitheatre Duclaux

Vendredi 30 Octobre 2026 11:30

Denise Albe-Fessard
Philippe Vernier | Charge de mission Institut NeuroPSI


Plus d'infos... Annonce publiée le 04-06-2026

	NeuroPSI Salle de conference Albe-Fessard

Lundi 09 Novembre 2026 13:00

Allostery and brain science, a tribute to Jean-Pierre CHANGEUX


Invite par: Pierre-Jean Corringer Plus d'infos... Tags: Jean-Pierre Changeux, Neuroscientists, Allosteric regulation, Jean-Pierre, Ruth Nussinov, DehaeneChangeux model Annonce publiée le 30-04-2026

	Institut Pasteur Batiment Duclaux, salle Amphitheatre,

Lundi 16 Novembre 2026 0:00

8eme edition - Biologie Cellulaire et Cancer


Le 8e cours «?Biologie cellulaire et cancer»?explorera comment les formes biologiques emergent a differentes echelles, de l'organisation intracellulaire jusqu'aux tissus et aux organismes entiers. Il mettra l'accent sur des processus cellulaires cles tels que la dynamique du cytosquelette et le trafic intracellulaire, et sur la maniere dont ces processus faconnent des structures cellulaires complexes. Le cours abordera egalement la formation de patterns, la morphogenese et les comportements collectifs des cellules a l'echelle des tissus, dans le contexte de la mecanobiologie et de la biologie du developpement. Plus d'infos... Annonce publiée le 07-05-2026

	Institut Curie Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD)

Lundi 16 Novembre 2026 0:00

Ctrl+Epi+Edit, Engineering the Epigenome


Epigenome editing is a rapidly emerging field that has the potential to revolutionise genomic medicine by offering new ways to precisely program gene expression and treat a range of diseases. Precision control of the epigenome and gene activity is further unlocking key mechanistic insights into a wide variety of molecular and cellular processes. The potential of epigenome editing technologies for both research and therapeutic applications has thus led to widespread excitement over the last five years, in areas ranging from neurobiology, to high-throughput (epi)genomics to agriculture. As the technologies continue to emerge and the epigenome editing field begins to coalesce, we feel now is the time to bring interdisciplinary experts and leaders in the field together. This will enable, for the first time, epigenome editors and related disciplines to collectively discuss the technology, its applications and ethics, and the exciting scientific insights being generated. Such a symposium will help to accelerate progress in this field by facilitating collaborations between researchers and providing a platform for the dissemination of new discoveries and techniques. It will also help to raise broader awareness of this exciting emerging science and its potential to transform precision medicine. Time and Place The meeting will take place fromNovember 16-17atInstitut Jacques Monodin the heart of Paris, France We will have two half day sessions, and a poster session over cocktails and light bites Key Dates Abstract Submission:October 1, 2026 Registration:November 9, 2026 Invited Speakers ? Gabriella Ficz (QMUL, UK) ? Charles Gersbach (Duke University, USA) ? Jamie Hackett (EMBL Rome, Italy) ? Jake Harris (Cambridge University, UK) ?Angelo Lombardo (San Raffaele University, Italy) ? Reini Luco (Institut Curie, France) ?Mariane Rots (UMCG, Netherlands) ?Edda Schulz (MPI Berlin, Germany) ?Stefan Stricker (Helmholtz Munich, Germany) More speakers will be selected from abstracts! You can find all the informations regarding the symposium, the registration and abstract submission here Flyer of the event: here Plus d'infos... Tags: Epigenetics, Epigenome editing, Edit, Epigenome, Genome editing, Omics Annonce publiée le 10-03-2026

	Institut Jacques Monod Institut Jacques Monod Amphitheatre Buffon, 15 rue Helene Brion, Paris, France

Cancers gynecologiques : de la pratique clinique a la biologie

From AMR to Emerging Threats: Understanding Pathogens for Effective Control

Scientific lectures: May The Force Be With You! Piezo Channels in Mechanosensory Biology Ardem Patapoutian | Department of Neuroscience, Scripps Research - Presidential Endowed Chair

Chloroplast gene expression is required for heterochromatin assembly in Arabidopsis thaliana Clara Richet-Bourbousse

"CANCELLED" Dr Laurent Seugnet

Postnatal maturation of brain pericytes Dr Annika Keller | University Hospital Zurich

Reframing Epigenetics: Metabolism, Mitochondria, and Redox as Core Regulatory Layers Laurent Chatre | STCT, UMR6030 CNRS, Universite de Caen Normandie

Advancing Single-Molecule Imaging Aleksandra Radenovic

Carrasco Yolanda (invited by Paolo Pierobon)

Comprendre le role de la DGK dans la reponse immunitaire des lymphocytes B : un mediateur important en aval de la signalisation CD40. Carrasco Yolanda

Staphylococcus epidermidis DnaK alters biofilm formation and proteome in S. aureus CIP 107093 Yoan Konto-Ghiorghi

Deciphering molecular and cellular determinants of liver tumors mutated for beta-catenin signaling Angelique Gougelet

The self-renewing celfhow actin networks are built, sized, and dismantled Manuel Thery

Neurobiological mechanisms of social behaviour. Camilla Bellone

Guarded by Barriers, Driven by Flow: The Brain's Fluid Secrets Nathalie JURISCH-YAKSI

Soutenance HDR - Hugo Wioland

"Equivalent learning emerges from distinct population dynamics across brain networks" Flavio DONATO | University of Basel - Biozentrum the center for molecular life sciences

Galectins as Multifunctional Glyco-Checkpoints: A Sweet Future for Immunotherapy? Gabriel RABINOVICH

4th nICE Day symposium of Cryo-EM users

TBA Dr Guy Bouvier | NeuroPSI

Stromal heterogeneity and fibroblast specialization during mammary gland morphogenesis Zuzana Sumbalova Koledova

Cytoskeleton club

Convergence-Divergence of Cerebro-Cerebellar Pathways and Functional Considerations. Zhenyu Gao

Integration somatosensori-motrice corticale lors de l'apprentissage moteur, etudiee a l'aide d'une interface cerveau-machine en boucle fermee. Alexandre Tolboom | NeuroPSI - Unverite Paris-Saclay

Artificial Intelligence in Biology et Health

Surface-based cell-free platform to characterize host-pathogen interactions Aurore Dupin

From the M1/M2 paradigm, to spatial determinism of tumor-associated macrophageheterogeneity Alexandre Boissonnas

Adaptive immunity to the commensal microbiota Ivanov Ivaylo

"The hippocampal latent diffusion engine: a computational framework for memory, perception, and cognitive dysfunction" Michael BREAKSPEAR | University of New Castle school of Science.