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Invite par: IBENS Neuroscience Seminar Plus d'infos... Tags: Sleep disorders, Behavior, Human behavior, Sleep Annonce publiée le 26-06-2026 |
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| IBENS salle Favard, IBENS 46 rue d'Ulm 75005 Paris |
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The arousal construct underlies a spectrum of behaviors that include sleep, exploration, feeding, sexual activity and adaptive stress. Pathological arousal conditions include stress, anxiety disorders, and addiction. In the past few years we have used optogenetics to interrogate neuronal circuits underlying transitions between arousal states. In particular, I will talk about two new circuits identified in our laboratory: one predicts the onset and duration of REM sleep with unprecedented precision; another induces sleep in response to inflammatory cytokines. I will also present a novel method that displays cortex-wide fluctuations in membrane voltage using TEMPO imaging. Finally, I will discuss noninvasive neuromodulation methods for sleep intervention.
Plus d'infos...
Tags: Neurophysiology, Neuromodulation, Rapid eye movement sleep, Brain
Annonce publiée le 08-04-2026
I. Cerveau et de la Moelle
Institut du cerveau -
Invite par: Jeremie Gautheron
Dr Ganna Panasyuk is a principal investigator at the Institute Necker Enfants Malades (INEM, INSERM U1151, Paris), where she leads the Lab of Nutrient Sensing Mechanisms. Her research explores how nutrient and metabolic signaling pathways control cell adaptation, identity, and disease, with a strong focus on liver metabolism and liver pathophysiology. Dr. Panasyuk trained in molecular biology in Kyiv, Ukraine, and later specialized in growth-control signaling, including mTOR/PI3K pathways, during postdoctoral work at University College London and INSERM Paris. Since 2019, she has served as INSERM Research Director at INEM. Her laboratory investigates class 3 PI3K, an evolutionarily conserved lipid kinase and nutrient sensor, using cell systems, patient-derived organoids, multi-omics approaches, subcellular metabolomics, and transgenic in vivo models. Her work is supported by national and European funding, including an ERC Consolidator Grant. In this seminar, Dr. Panasyuk will discuss how class 3 PI3K coordinates liver adaptation to fasting and metabolic stress. While acute nutrient deprivation activates cytosolic catabolic pathways such as autophagy, prolonged fasting requires transcriptional and epigenetic rewiring. Recent work from her team shows that class 3 PI3K not only regulates autophagy and lysosomal activity, but also interacts with RNA polymerase II, associates with active transcription sites, and supports liver metabolic rhythmicity. These findings position nuclear class 3 PI3K signaling as a key regulator of hepatic metabolic homeostasis, with implications for liver disease, metabolic syndrome, and cancer.
Plus d'infos...
Tags: Signal transduction, Immunology, Cell biology, Organelles, Vesicles, MTOR, Autophagy, Nutrient sensing, Lysosome, Phosphoinositide 3-kinase, Metabolism
Annonce publiée le 21-06-2026
CRSA
salle des conferences au RDC du batiment Kourilsky, 184 rue du Faubourg Saint-Antoine - 75012 -
Invite par: Seminaires Anim'Pharma
Annonce publiée le 21-06-2026
Faculte de Pharmacie de Paris
salle des Actes de la Faculte de Pharmacie de Paris, 4 avenue de l'Observatoire 75006. Inscription OBLIGATOIRE aupres de luciechevillard at gmail.com -
Over the past decade, aqueous humor liquid biopsy has emerged as a transformative tool in ocular oncology, enabling minimally invasive molecular profiling of intraocular tumors from small-volume aqueous samples. Pioneered in retinoblastoma, this work demonstrated that cell-free DNA and ctDNA correlate with disease activity and prognosis, and that RB1 mutations can be reliably tracked across treatment - findings that established the clinical foundation for the LBSeq4Kids platform. Serial aqueous sampling has since proven valuable for guiding therapy and identifying patients at risk for metastatic progression without systemic biopsy. Now, this liquid biopsy framework is being extended to uveal melanoma, where modeled aqueous humor protein concentrations are opening a new avenue for biomarker discovery and non-invasive disease characterization.
Plus d'infos...
Tags: Biomarkers, Rare diseases, Medical signs, Pediatric cancers, Melanoma, Uveal melanoma, Cancer biomarker, Retinoblastoma, Circulating tumor DNA, Liquid biopsy, Uvea, Eye neoplasm
Annonce publiée le 30-05-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Structural Maintenance of Chromosomes (SMC) complexes are conserved molecular machines that help organize genomes in organisms ranging from bacteria to humans. They perform two essential tasks: they establish DNA-DNA interactions and extrude DNA loops, thereby shaping chromosome architecture and supporting faithful chromosome segregation. In this talk, I will discuss recent single-molecule studies from our group that reveal how these machines work under force. Using optical tweezers combined with fluorescence microscopy, we directly measure how strongly individual SMC complexes interact with DNA while visualizing their activity. We find that cohesin and condensin can form highly stable DNA connections capable of resisting the forces generated during cell division. By contrast, cohesin-mediated loop extrusion depends on much weaker and more dynamic DNA interactions, allowing loops to be readily remodelled. Comparisons with bacterial SMC complexes show that these machines can be stronger and more efficient loop extruders than their eukaryotic counterparts. Together, these findings suggest that SMC complexes have evolved different mechanical properties to match their specific roles in chromosome folding, maintenance, and segregation.
Plus d'infos...
Tags: Mitosis, Cell cycle, Nuclear organization, Condensin, Cohesin, Loop extrusion, SMC protein, Chromosome, DNA, Chromosome condensation
Annonce publiée le 08-05-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Invite par: IBENS Developmental Biology seminar
Abstract: The development of the human central nervous system starts by the closure of the neural tube between day 23 to 30 of gestation. This event leads to the formation of two important regions: the brain in the rostral part and the spinal cord in the caudal part. The brain is a complex organ that control and process thought, memory, emotion, sensation, movement etc. and the spinal cord is the relay between the body and the brain and conduct sensory and motor information. During my PhD and my first postdoc, I tried to understand how newborn neurons migrate to settle in the appropriate region of the brain in mice and how their migration is affected in some diseases such as ciliopathies or prenatal alcohol exposure. However, animal models present significant limitations in the understanding of human development. Therefore, to fully understand the human central nervous system development and recapitulate human diseases, new experimental models need to be developed. During my second postdoctoral project, I developed organ-on-chip approaches to model human spinal cord development in vitro. The spinal cord provides a powerful system to study how morphogens generate cellular diversity, as opposing signaling centers organize the neural tube into 11 molecularly distinct progenitor domains. Using engineered human spinal cord models with precise spatial and temporal control of morphogen delivery, we generated a 2D model of spinal cord recapitulating both the cellular diversity and the spatial organisation of progenitors observed in the ventral neural tube. Our ventral human spinal cord is perfectly suitable to investigate a fundamental question in developmental biology: how morphogens are transported through developing tissues to generate robust and reproducible patterns such as the respective contributions of diffusion, transcytosis, and cytoneme-mediated transport to morphogen propagation and neural tissue organization.
Plus d'infos...
Tags: Motor system, Skeletal system, Spinal cord, Neural tube, Development of the nervous system, Central nervous system, Brain, Neuromere, Neural organoid
Annonce publiée le 25-06-2026
IBENS
salle Favard, IBENS 46 rue d'Ulm 75005 Paris -
Septins are a conserved family of GTPase proteins, found from yeast to humans, that assemble into filaments and rings. They play essential roles in cell division, polarity, and the maintenance of membrane organization, particularly at intercellular bridges during cytokinesis. In this seminar, I will present bottom-up in vitro reconstitution approaches developed with septins. Using various model membrane systems, I will show that septins are sensitive to micrometric curvatures, a particularly unusual behavior, as the vast majority of curvature sensing proteins recognize nanometric curvatures! I will then present results demonstrating that septins can act as lateral diffusion barriers within membranes. Finally, I will share preliminary results on the reconstitution of intercellular bridges in microfluidics, opening new perspectives for studying cytokinesis in a controlled environment.
Plus d'infos...
Tags: Cell biology, Cell cycle, Cellular processes, Proteins, Cytoskeleton, Septin, Cytokinesis, Membrane curvature, Intercellular communication, Cell, GTPase, Fluid mosaic model
Annonce publiée le 25-06-2026
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407 -
TBA
Plus d'infos...
Tags: LJP, National Youth Council of Latvia, Liberty and Justice Party
Annonce publiée le 11-12-2023
Laboratoire Jean Perrin
Laboratoire Jean Perrin - Campus Jussieu - T 22-32- 4e et. - P407 -
Invite par: Nazarii Sabat
Prof. Michal Hocek, PhD DSc. Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences ABSTRACT The lecture will summarize recent results of the Hocek group in syntheses of base-modified nucleotides, as ...
Plus d'infos...
Tags: Nucleic acids, DNA, Biotechnology, Peptides, RNA, Michal Hocek, Aptamer, Nucleotide, Bioanalysis
Annonce publiée le 17-06-2026
Institut Pasteur
Batiment F. Jacob , salle F. Jacob Auidtorium , -
Invite par: CIRB-College de France
Plus d'infos...
Annonce publiée le 29-04-2026
College de France
au College de France - Salle D2 -11 place Marcelin Berthelot - 75005 Paris -
Invite par: Rencontre Clinico Biologique
Plus d'infos...
Tags: Imaging
Annonce publiée le 18-06-2026
Institut Cochin
salle Rosalind Franklin, 22 rue Mechain - 75014 -
Invite par: IBENS Developmental Biology seminar
Abstract: A fundamental challenge in developmental biology is to understand how positional information is translated into the coordinated processes of cell fate specification, tissue patterning, and morphogenesis. Hox genes are key regulators of positional identity, yet the mechanisms by which combinatorial HOX activities instruct the formation of complex tissues remain poorly understood. To address this question, I recently established a Hox-null mouse embryonic stem cell platform that enables the synthetic reconstruction of HOX-dependent developmental programs in gastruloid and organoid systems. In this seminar, I will present recent advances from this work and discuss a research program aimed at reconstructing developmental gene regulatory networks to establish a predictive understanding of how positional identity drives the generation of organized tissues.
Plus d'infos...
Tags: Evolutionary developmental biology, Tissue engineering, Stem cells, Hox gene, Gastruloid, Morphogenesis, Organoid, Morphogen, Developmental biology, Homeobox protein CDX-4, Robb Krumlauf
Annonce publiée le 25-06-2026
IBENS
salle Favard, IBENS 46 rue d'Ulm 75005 Paris -
Notice biographique Le Dr Antonio Curti (MD, PhD) est médecin-chercheur et praticien à l'Institut d'hématologie « L. & A. Seràgnoli » de l'Université de Bologne. Il dirige des programmes de recherche portant sur l'immunobiologie des leucémies et sur des études cliniques consacrées aux leucémies aiguës, en se concentrant tout particulièrement sur les interactions entre les cellules tumorales et le microenvironnement immunitaire. Ses travaux couvrent les domaines de l'immunologie fondamentale et translationnelle, incluant l'étude des mécanismes d'échappement immunitaire dans les leucémies et le développement de stratégies d'immunothérapie innovantes, telles que les thérapies fondées sur les cellules NK alloréactives. Auteur de plus de 160 publications, le Dr Curti est un membre actif de réseaux de recherche en hématologie, tant à l'échelle nationale qu'internationale. Invité par Diana Passaro
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Annonce publiée le 19-06-2026
Institut Cochin
Salle Rosalind Franklin -
Invite par: Jong Eun Ihm
Start-meup? is an annual two-day event that explores the latest trends in the life sciencesand health innovation ecosystem while guiding participants through the startup creation journey. This year’s expert talks session focuses on how ...
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Tags: Entrepreneurship, Business incubators, Private equity, Startup company, Innovation
Annonce publiée le 04-03-2026
Institut Pasteur
Batiment: Centre Francois Jacob Salle: Auditorium -
Plus d'infos...
Tags: Boye, Hans Boye, Come, Thou Fount of Every Blessing
Annonce publiée le 29-04-2026
Centre de Recherche des Cordeliers
Amphi Gustave Roussy -
Invite par: Laure Bally-Cuif
Dr Kirkeby has many years of expertise in generating accurately regionalised human neural cells from pluripotent stem cells (hPSCs) and has been responsible for the preclinical development of the first European hPSC-derived dopamine cell ...
Plus d'infos...
Tags: Stem cells, Biotechnology, Cell biology, Cloning, Developmental biology
Annonce publiée le 15-06-2026
Institut Pasteur
Batiment Monod, salle Amphi Ullmann, -
Invite par l'Institut Jacques Monod, Prof Jordan Raff, (Sir William Dunn School of Pathology, University of Oxford) presentera une conference de l'Institut Jacques Monod : How do cells build complicated organelles? Resume: A key feature of all living things is their ability to assemble complicated structures using dilute building blocks present in the cell. How cells achieve this remarkable feat of bioengineering is largely unknown. Centrosomes are major microtubule (MT) organising centres and important signalling hubs in many cells. They are an excellent model for studying organelle biogenesis as they comprise 10s-100s of copies of several hundred different types of protein yet, like the DNA, they precisely duplicate once per cell cycle. We have recently reconstituted centrosome duplication on synthetic beads programmed to recruit core centrosome assembly proteins when injected intoDrosophilaembryos. These beads generate structures that appear to be functionally indistinguishable from centrosomes: they recruit centriole/centrosome proteins, organise MTs and proceed through multiple rounds of high-fidelity duplication, all in synchrony with the endogenous centrosomes. The beads function as seeds that recruit biogenesis-promoting proteins to stimulate the assembly of relatively simple scaffolds that direct centrosome self-assembly. This Seed-Scaffold-Self-Assemble? mechanism may represent a general principle of organelle biogenesis, explaining how simple molecular inputs can generate complex structures without the need to copy a pre-existing template.
Plus d'infos...
Tags: Centrosome, Cell biology, Organelles, Organelle biogenesis, Microtubule, Centriole, Cell, Organelle, Centrosome cycle, Aster
Annonce publiée le 11-06-2026
Institut Jacques Monod
Institut Jacques Monod Amphitheatre Buffon, 15 rue Helene Brion, Paris, France -
Invite par: Dr F Koukouli
The vagus nerve has emerged as central hub of brainbody communication and a promising target for psychiatric research. Across a range of mental disorders, including depression, anxiety, and stress-related conditions, alterations in autonomic regulation and vagal functioning have been linked to symptom expression, disease trajectories, and treatment outcomes. At the same time, vagus nerve stimulation has attracted growing interest as a therapeutic approach capable of modulating neural circuits implicated in affective and cognitive processes. In this talk, I will trace the emergence of the vagus nerve as a focus of psychiatric research, from early theoretical accounts of autonomic regulation and emotion to contemporary investigations of vagal biomarkers and neuromodulation-based interventions. Drawing on evidence accumulated over the past decades, I will examine how findings from human studies have shaped our understanding of vagal functioning across development and psychopathology, and how these observations have informed the development of invasive and non-invasive treatment approaches. Particular attention will be given to the promises, limitations, and evolving mechanistic frameworks that have accompanied this progression. I will argue that future progress requires a stronger reverse-translational framework that moves beyond largely correlational biomarker research in humans. Clinical observations in patients should increasingly guide mechanistic investigations in experimental models, while insights from basic neuroscience can inform hypothesis-driven studies in humans. At the same time, advancing the field will require novel methodological approaches that move beyond the current reliance on proximal and indirect indices of vagal function. Such an iterative exchange between clinical psychiatry and basic neuroscience, may provide a more mechanistic understanding of vagal signaling in mental health and support the development of targeted and personalized interventions.
Plus d'infos...
Annonce publiée le 16-06-2026
Institut de Psychiatrie et Neurosciences de Paris
Room D Levy, Institut de Psychiatrie et Neurosciences de Paris (IPNP) UMR 1266 INSERM - Universite Paris Cite, 102-108 Rue de la Sante - 75014 Paris -
Les inscriptions pour le DIF day 2026 sont ouvertes ! Rendez-vous sur le site d'inscriptions pour pouvoir y participer : https://sites.google.com/view/dif2026/accueil_2026?authuser=0
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Annonce publiée le 21-05-2026
Institut Jacques Monod
Institut Jacques Monod Amphitheatre Buffon, 15 rue Helene Brion, Paris, France -
Invite par: CIRB-College de France
Plus d'infos...
Annonce publiée le 29-04-2026
College de France
au College de France Salle D2 - 11 place Marcelin Berthelot - 75005 Paris -
Despite advances in mRNA-based cancer vaccines, therapeutic responses remain limited by poorly immunogenic tumors that fail to support effective T cell infiltration, expansion, and function. Epigenetic therapies can enhance tumor immunogenicity by reactivating transposable elements (TEs), triggering innate sensing of immunogenic nucleic acids through a process known asviral mimicry.In this seminar, I will discuss how the DNA methyltransferase inhibitors induces viral mimicry in preclinicaltumourmodels, leading to type I interferon responses, enhanced antigen presentation, and remodeling of the immunosuppressive tumor microenvironment. This response depends on cancer-intrinsic nucleic acid sensors and supports the expansion and function of vaccine antigen-specific T cells within tumors.Together, these findings identify viral mimicry as a strategy to license therapeutic cancer vaccination and improve anti-tumor immunity.
Plus d'infos...
Tags: Immunology, Oncology, Immune system, Biotechnology, Immunogenicity, Cancer vaccine, Antigen, Tumor microenvironment, Glioma 261, Cancer immunotherapy
Annonce publiée le 06-05-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
Raphid diatoms exhibit rapid gliding motility with remarkable directional flexibility, yet the underlying mechanisms remain poorly understood. Using Craspedostauros australis as a model, we combine phylogenomics, live-cell imaging, and high-resolution microscopy to dissect both force generation and trajectory control. We find that raphe-associated actin bundles do not show directional turnover, arguing against a direct role of actin dynamics in force production. Instead, we identify diatom-specific myosins (CaMyoB-D) that display coordinated movement during gliding, consistent with a motor function. At the cellular level, diatoms dynamically modulate their trajectories by switching between one- and two-raphe contact with the substrate. This switching controls path curvature, with single-raphe gliding producing curved paths and dual-raphe gliding resulting in straighter motion. Together, our results suggest a mechanism in which myosin-driven force generation is coupled to dynamic regulation of cell-substrate contact, enabling flexible navigation in complex environments.
Plus d'infos...
Tags: Protein families, Actin, Autoantigens, Myosin, Diatom, Gliding motility
Annonce publiée le 24-04-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
La kinase HRI (eIF2?) dans l'immunité innée, la protéostasie et le stress mitochondrial Damien Arnoult est Directeur de Recherche (DR2) au CNRS. Ses travaux portent sur les mécanismes cellulaires et moléculaires qui contrôlent les réponses au stress, l’immunité innée et la mort cellulaire. Au cours des deux dernières décennies, il a étudié le rôle central des mitochondries comme plateformes de signalisation impliquées dans les réponses antivirales et inflammatoires. Ses recherches ont notamment permis d’éclairer les liens entre dynamique mitochondriale, homéostasie cellulaire, activation des voies de l’immunité innée et pathologies associées à l’inflammation chronique. Ses travaux se situent à l’interface de la biologie cellulaire, de l’immunologie et du métabolisme cellulaire. Il développe actuellement des approches visant à mieux comprendre comment les mitochondries coordonnent les réponses adaptatives des cellules face aux stress environnementaux et aux agressions infectieuses. invité par Véronique WITKO-SARSAT
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Annonce publiée le 16-06-2026
Institut Cochin
Salle Rosalind Franklin -
Proteopathy and synaptic dysfunction accumulates over decades in Alzheimer's disease (AD), accompanied by marked mitochondrial changes and oxidative stress. Adaptive metabolic programs may oppose degeneration, such as the pentose phosphate pathway (PPP), a major source of NADPH required for antioxidant defence. But the PPP, and upper-glycolytic pathways in general are poorly characterised in extant AD metabolomic workflows, because phosphorylated metabolites (characteristic of upper glycolysis metabolites) have low volatility, hydrophilicity, and ionization efficiency. Phosphate groups also interfere with the protonation or deprotonation of metabolites during the ionisation process in MS, leading to poor sensitivity and resolution, resulting in deficient metabolic profiling of the AD brain. To address this, we performed the largest integrated (phospho)metabolomic and proteomic analyses in human brain tissue spanning the AD clinicopathological spectrum (n = 625) accompanied with proteomics to reconstruct the molecular natural history of AD. We identified the PPP as the metabolomic pathway most strongly associated with AD, alongside enrichment of the Warburg effect and fructose and mannose catabolism. Discriminative Events-Based Modelling revealed that metabolites capable of being diverted into the PPP transitioned to abnormal states at an early event stage in AD, proximal to amyloid accumulation and synaptic dysregulation. Decreased mitochondrial oxidative phosphorylation represented the final event stage, most proximal to iron accumulation glutathione depletion and evidence of oxidative stress. Therefore, the molecular natural history of AD is characterized by early preservation of the PPP that supports redox homeostasis but may occur at the cost of progressive N-glycosylation loss in aggregation-prone synaptic proteins. Prolonged central carbon flux diversion into the PPP later manifests in mitochondrial protein loss and oxidative stress in the degenerative phase of the disease.
Plus d'infos...
Tags: Biochemistry, Bioenergetics, Biophysics, Cell biology, Energy, Mitochondrion, Pentose phosphate pathway, MTOR
Annonce publiée le 12-06-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e -
In animal development, timing matters. Phenomena operating within distinct levels-those of molecules, organelles, cells, or tissues, span the extremes of timescales and give rise to the clock work of development. Developmental programs are under genetic controf?however, the physical basis of these processes lie within the components that drive it - molecules, organelles, cells, supracellular assemblies. Capturing these mechanisms requires imaging approaches that can span different scales, molecular to tissue level processes demand both high spatial and temporal resolutions simultaneously. In the first part, I will introduce light-sheet microscopy and exemplify cell biological studies using endosomal timekeeping of biochemical reactions at single cell levels. However, these approaches are limited by the absence of physiological context as cells are investigated in isolation. In the second part, I will describe imaging approaches based on Airy beam-based light sheet microscopy of organelles in tens to hundreds of cells in a few hundred micrometre-wide tissue environments that will enable. This approach achieves a typical resolution of 320 nm over 266 × 266 × 100 ?m3 volumes at a temporal rate of 0.05 Hz that now allows tracking molecules and organelles in large living tissues. I will detail out how such imaging across scales allows discovering new phenomena in tissue morphogenesis using Drosophila as a model system, where we address how during germ band extension, the monolayer of cells from the central side wrap around the high curvature posterior pole onto the dorsal surface. We discover an interplay between curvature, waves of cell divisions within domains and tissue fluidization that work together to preserve segment boundaries. Finally, I will conclude by addressing data challenges, including visualization and analysis, and outlook on the future of biological problems that these approaches unravel.
Plus d'infos...
Tags: Cell, In science, Organelle, Tissue, Organelles, Laboratory techniques, Draft:Spatial Proteomics, Live-cell imaging
Annonce publiée le 18-06-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
The first day will be devoted to presentations by international experts on methods, applications and issues related to longitudinal data. The second day will offer practical tutorials around open-source software in R and Python, including Leaspy, JMbayes2, lcmm and saemix.
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Tags: Social research, Design of experiments, Longitudinal study, Nursing research, Observational study
Annonce publiée le 02-06-2026
I. Cerveau et de la Moelle
Day 1 - Thursday September 3, 2026 -
Invite par: Giulia Manina
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains one of the deadliest infectious diseases worldwide. Meanwhile, non-tuberculous mycobacteria (NTM) are an increasing global health concern. NTM infections often resemble TB clinically, which can lead to ...
Plus d'infos...
Tags: Acid-fast bacilli, Bacterial diseases, Tuberculosis, Pathogenic bacteria, Infectious causes of cancer, Nontuberculous mycobacteria, Mycobacterium, Mycobacterium fortuitum, Mycobacterial cervical lymphadenitis
Annonce publiée le 26-02-2026
Institut Pasteur
Batiment CIS, salle , -
The Conference Jacques Monod » The mechanistic and evolutionary basis of programmed DNA elimination» will take place fromMonday, September 21, 2026 toFriday, September 25, 2026 in Roscoff (Bretagne, France). Abstracts submission deadline :Tuesday, May 5, 2026 Deadline for payment of registration fees :July 2, 2026 Deadline for return of completed forms :July 2, 2026 Registration and abstract submission website Beyond mutations, the genetic content of an organism is generally constant across cells throughout development. Programmed DNA elimination (PDE) - a process in which specific cell lineages lose DNA segments or whole chromosomes - represents is a striking deviation to this principle. PDE is widespread in eukaryotes and plays roles in a variety of cellular processes, including gene silencing, germline differentiation, genome defence, and non-Mendelian inheritance. It manifests in diverse biological contexts, including the formation of germline-limited genomes, meiotic elimination of parental chromosomes, and sex determination via X-chromosome loss. In recent years, it has become increasingly clear that PDE occurs across a wide range of phylogenetic groups, and involves diverse mechanisms. These findings underscore the overlooked plasticity of genome integrity, and reveal significant gaps in our understanding of why PDE has evolved repeatedly and is maintained across the Tree of Life. This conference is designed to present the latest research on the mechanisms and evolution of PDE - from the molecular pathways that control genome stability and chromosome segregation, to genomic conflictsand the long-term evolutionary consequences of PDE on population dynamics and species diversification.We also welcome researchers studying related phenomena, such as meiotic drive, B chromosomes, and those that work on the mechanisms and regulation of genome stability, chromosome segregation and germline development. The meeting will address the following key topics: Mechanisms and regulation of genome stability and instability Mechanisms of chromosome segregation and missegregation Genomic conflicts Evolutionary dynamics of programmed DNA elimination
Plus d'infos...
Tags: Evolutionary biology, Molecular genetics, Molecular evolution, Cell cycle, Meiosis, Mutation, Intragenomic conflict
Annonce publiée le 28-03-2026
Institut Jacques Monod
Roscoff, Roscoff, France -
L heterogeneite observee entre les tumeurs de differents patients, et meme entre les cellules cancereuses d'un meme patient, complique considerablement le developpement de traitements. La medecine « personnalisee » ou « de precision » vise a surmonter ce probleme en proposant un traitement adapte a chaque patient, en fonction de son profil genetique individuel et de la signature moleculaire de sa tumeur. Cet objectif ambitieux necessite une caracterisation moleculaire approfondie du cancer chez le patient, a l'aide de technologies a haut debit et de techniques d'imagerie avancees. Beaucoup de donnees multi-echelles sur le cancer deviennent disponibles, mais elles restent encore largement sous-exploitees pour elucider les mecanismes sous-jacents et ainsi guider la stratification des patients et le choix des traitements. L'analyse integrative multimodale des donnees omiques et cliniques offre un fort potentiel pour elucider les bases moleculaires des differents types de cancer. L'integration multimodale des donnees sur la maladie est particulierement prometteuse pour mettre en evidence les relations complexes entre les mecanismes moleculaires qui contribuent collectivement a la maladie.
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Annonce publiée le 18-04-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
The Postdoc Appreciation Week will be back for its second edition this September: the opportunity to celebrate the unique contribution of the postdoctoral community to science. Postdoc Appreciation Week (PAW) is a global tradition ...
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Tags: Academic administration, Postdoctoral researcher, National Postdoctoral Association
Annonce publiée le 11-06-2026
Institut Pasteur
Batiment: Center Francois Jacob Salle: CFJ auditorium & Atrium -
Every year, the Centre de Recherche des Cordeliers organises a scientific day where its young researchers, students and post-docs present their work.Prestigious speakers are also invited to take part.This year, we will be welcoming:This event is open to the entire scientific community.
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Tags: Inquiry, Observation, Science, European Research Council
Annonce publiée le 27-02-2026
Centre de Recherche des Cordeliers -
EM tomography and membrane remodeling
Plus d'infos...
Tags: Medical imaging, Tomography, Crista, Volumetric Electron Microscopy
Annonce publiée le 29-04-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Plus d'infos...
Tags: Malaria, Plasmodium, Antimalarial medication
Annonce publiée le 17-05-2026
Institut Cochin
- -
Plus d'infos...
Tags: Malaria, Plasmodium, Antimalarial medication
Annonce publiée le 19-05-2026
Institut Cochin
- -
James H. Hurleyis a leading structural biologist ( https://vcresearch.berkeley.edu/faculty/james-hurley), whose work has transformed our understanding of the interplay between proteins and membrane lipids. He is especially known for seminal studies to uncover molecular mechanism ofthe ESCRTmachinery, HIVtrafficking, retrograde trafficking by retromer, and the autophagycore complexes, combining crystallography, cryo-EM, and reconstitution on model membranes to explain how cells sort cargo, remodel membranes, and initiate autophagy ( https://scholar.google.com/citations?user=SoNEZA8AAAAJ&hl=en).
Plus d'infos...
Tags: Cell biology, Protein structure, Organelles, Autophagy, Cell death, Immunology, Cryogenic electron microscopy, Structural biology, Lysosome
Annonce publiée le 18-06-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Marie Curie -
Le cours est dedie aux connaissances les plus actuelles articulant la biologie du developpement et l etude cellulaire et moleculaire des cancers. Les cretes neurales et les melanomes, depuis leur formation jusqu a leur migration (metastases), ainsi que les cancers pediatriques d'origine embryonnaires tels que les medulloblastomes et neuroblastomes sont pris comme exemples. Le cours beneficie d une approche multidisciplinaire a multiples echelles (embryologie sur des modeles varies, biophysique, biologie cellulaire, transcriptomique, imagerie...). Il aborde egalement des approches therapeutiques et ainsi que la prise en compte des 3R en recherche avec l'invitation des chercheurs developpant des organoides et des modeles animaux alternatifs. Le cours est ponctue par des tables rondes sur les carrieres dans le milieu academique ou dans l industrie,sur la publication d articles scientifiques ainsi que sur l ethique en experimentation animale.Des sessions posters de doctorants sont egalement organises et des prix pour les meilleurs posters seront decernes par les participants aux cours.
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Annonce publiée le 10-04-2026
Institut Curie
Centre de recherche - Orsay - Amphitheatre du Batiment 111 -
Invite par: the Leukemia Institute
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Tags: Leukemia
Annonce publiée le 18-06-2026
College de France
amphitheatre Marguerite de Navarre du College de France -
Invite par: CIRB-College de France
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Annonce publiée le 10-06-2026
College de France
au College de France Salle D2 11 place Marcelin Berthelot - 75005 Paris -
Founded by leading researchers, Professors Stephanie Debette and Sudha Seshadri, this annual event brings together a vibrant global community for an immersive, cross?disciplinary training experience.
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Tags: Seshadri
Annonce publiée le 05-06-2026
I. Cerveau et de la Moelle
Institut du cerveau -
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Tags: Pasteur Institute, Yasmine Belkaid, Yasmin, Aboubakr Belkaid, Lurie Prize in Biomedical Sciences
Annonce publiée le 04-03-2026
Centre de Recherche des Cordeliers -
Previous editions have explored topics ranging from mechanotransduction the mechanical forces that shape brain development to the physics of neurotransmission, spatial mechanotranscriptomics, and the emerging field of mechanomedicine. Building on these advances, this year&'s symposium will delve deeper into the physical principles that govern brain metabolism and function, continuing to expand the frontiers of neuroscience.
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Tags: Neurology, Nervous system, Neurophysiology, Neuroscience
Annonce publiée le 09-06-2026
I. Cerveau et de la Moelle
Exciting developments in quantum biology highlighted by an inaugural conference featuring Sonia Contera, Professor of Biological Physics at the University of Oxford.Physical approach to brain metabolism, incorporating thermodynamic principles and the emerging concept of photons as synaptic transmitters.A pioneering discipline at the intersection of biophysics, metabolism and medicine, focusing on mechanodiseases.A thought-provoking closing lecture on the relationship between metabolism and cognition. -
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Tags: Institute of Science and Technology Austria, Ista, Lora, International Seed Testing Association
Annonce publiée le 04-06-2026
NeuroPSI
Salle de conference Albe-Fessard -
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Tags: Tooze, Titre
Annonce publiée le 19-05-2026
Institut Cochin
Salle Rosalind Franklin -
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Tags: Jeremie, Jeremi
Annonce publiée le 06-03-2026
Centre de Recherche des Cordeliers -
From Stem Cells to Morphogenesis Ce cours intensif combine une formation theorique et pratique afin d'explorer les concepts fondamentaux, les defis et les technologies de la biologie du developpement moderne. Le programme couvre des sujets allant de la regulation de l'expression genique et des interactions cellulaires a la formation d'un embryon multicellulaire organise. Les participants sont inities a une variete de modeles embryonnaires, incluant des organismes modeles genetiques tels que Drosophila, C. elegans, la souris et le poisson zebre, ainsi que des modeles classiques d'embryologie experimentale tels que le Xenopeet le poulet. Ces modeles sont etudies a l'aide de methodologies et de technologies de pointe. Les etudiants peuvent beneficier a la fois d'un enseignement theorique (10 jours de cours magistraux) et d'une formation experimentale (3 semaines de travaux pratiques) portant sur les aspects normaux et pathologiques du developpement. À noter que le module de cours magistraux de 10 jours peut etre suivi seul ou en combinaison avec le module de travaux pratiques. Les cours magistraux sont dispenses par des chercheurs de renommee internationale et abordent des thematiques telles que la specification et la differenciation cellulaires, la biologie des cellules souches, la morphogenese et l'organogenese, la signalisation intracellulaire, ainsi que la regulation de l'expression genique au cours du developpement. Le cycle de conferences se conclut par un congres scientifique international de 1,5 jour consacre a la morphogenese, offrant a de nombreux participants l'opportunite d'assister a leur premiere conference scientifique. OBJECTIF(S) L'objectif est de familiariser les etudiants avec les concepts recents de la Biologie du developpement en soulignant plus particulierement leur importante contribution aux domaines des cellules souches et des sciences cliniques. Differents champs de la Biologie du developpement sont presentes en relation avec les cellules souches, non seulement a travers la diversite des modeles embryonnaires mais aussi a travers les approches recentes developpees dans ces domaines (approches a grande echelle, modelisation mathematique, approches biophysiques?). Plus d informations
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Annonce publiée le 06-06-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Invite par: Darragh Duffy
Thursday 29th Oct 26 | Institut Pasteur KEYNOTE SPEAKERS ? Prof. Yasmine Belkaid President of the Institut Pasteur (Paris), Professor Yasmine Belkaid is an internationally recognized immunologist specializing in host-microbiota interactions and tissue immunity. ...
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Tags: Pasteur Institute, Yasmine Belkaid, Microbiology, Microbiomes, Bacteriology, Louis Pasteur, Variability, Human microbiome
Annonce publiée le 24-02-2026
Institut Pasteur
Batiment: Duclaux -
Invite par: Darragh Duffy
30th OCTOBER 2026 | INSTITUT PASTEUR | FRANCE We are happy to announce the 2026 yearly meeting of Milieu Interieur LabEx Join un on the morning of the 30th of October at 9am at ...
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Tags: Corruption in France, Organized crime in France
Annonce publiée le 22-05-2026
Institut Pasteur
Batiment: Duclaux Salle: Amphitheatre Duclaux -
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Annonce publiée le 04-06-2026
NeuroPSI
Salle de conference Albe-Fessard -
Invite par: Pierre-Jean Corringer
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Tags: Jean-Pierre Changeux, Neuroscientists, Allosteric regulation, Jean-Pierre, Ruth Nussinov, DehaeneChangeux model
Annonce publiée le 30-04-2026
Institut Pasteur
Batiment Duclaux, salle Amphitheatre, -
Le 8e cours «?Biologie cellulaire et cancer»?explorera comment les formes biologiques emergent a differentes echelles, de l'organisation intracellulaire jusqu'aux tissus et aux organismes entiers. Il mettra l'accent sur des processus cellulaires cles tels que la dynamique du cytosquelette et le trafic intracellulaire, et sur la maniere dont ces processus faconnent des structures cellulaires complexes. Le cours abordera egalement la formation de patterns, la morphogenese et les comportements collectifs des cellules a l'echelle des tissus, dans le contexte de la mecanobiologie et de la biologie du developpement.
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Annonce publiée le 07-05-2026
Institut Curie
Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) -
Epigenome editing is a rapidly emerging field that has the potential to revolutionise genomic medicine by offering new ways to precisely program gene expression and treat a range of diseases. Precision control of the epigenome and gene activity is further unlocking key mechanistic insights into a wide variety of molecular and cellular processes. The potential of epigenome editing technologies for both research and therapeutic applications has thus led to widespread excitement over the last five years, in areas ranging from neurobiology, to high-throughput (epi)genomics to agriculture. As the technologies continue to emerge and the epigenome editing field begins to coalesce, we feel now is the time to bring interdisciplinary experts and leaders in the field together. This will enable, for the first time, epigenome editors and related disciplines to collectively discuss the technology, its applications and ethics, and the exciting scientific insights being generated. Such a symposium will help to accelerate progress in this field by facilitating collaborations between researchers and providing a platform for the dissemination of new discoveries and techniques. It will also help to raise broader awareness of this exciting emerging science and its potential to transform precision medicine. Time and Place The meeting will take place fromNovember 16-17atInstitut Jacques Monodin the heart of Paris, France We will have two half day sessions, and a poster session over cocktails and light bites Key Dates Abstract Submission:October 1, 2026 Registration:November 9, 2026 Invited Speakers ? Gabriella Ficz (QMUL, UK) ? Charles Gersbach (Duke University, USA) ? Jamie Hackett (EMBL Rome, Italy) ? Jake Harris (Cambridge University, UK) ?Angelo Lombardo (San Raffaele University, Italy) ? Reini Luco (Institut Curie, France) ?Mariane Rots (UMCG, Netherlands) ?Edda Schulz (MPI Berlin, Germany) ?Stefan Stricker (Helmholtz Munich, Germany) More speakers will be selected from abstracts! You can find all the informations regarding the symposium, the registration and abstract submission here Flyer of the event: here
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Tags: Epigenetics, Epigenome editing, Edit, Epigenome, Genome editing, Omics
Annonce publiée le 10-03-2026
Institut Jacques Monod
Institut Jacques Monod Amphitheatre Buffon, 15 rue Helene Brion, Paris, France -
Invite par: Benoit Chassaing
To officially launch this major programme, the Pasteur Institute invites you to a two-day series of talks featuring speakers from around the world as well as from the Pasteur Institute. Further details on the ...
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Tags: Microbiome, Pasteur Institute, Louis Pasteur, Bioinformatics, Human Microbiome Project
Annonce publiée le 09-06-2026
Institut Pasteur
Batiment: CIS Salle: CIS -
Invite par: CIRB-College de France
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Annonce publiée le 10-06-2026
College de France
au College de France Salle D2 11 place Marcelin Berthelot - 75005 Paris